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AIIHPC Structured Research Network APA Cycle 2 2019 Applied Partnership Awards Applying Research into Policy & Practice Postdoctoral Fellowships ARPP 2020 Cancer Prevention Fellowship Programme Cancer Prevention Fellowship Programme Reintegration Grant Capacity Building for Evidence Synthesis Clinical Research Facilities/Centres 2021 Cochrane Training Fellowships Collaborative Doctoral Awards Conference and Event Sponsorship Scheme COVID-19 2020 CSF 2020 DIFA - 2018 DIFA 2017 DIFA 2018 DIFA 2020 DIFA-2018 Doctoral Training Programme in Precision Medicine in Cancer Emerging Clinician Scientist Awards 2020 Emerging Investigator Awards Emerging Investigator Awards 2022 ERA-NET Cofund for Neuroscience Research (NEURON) ERA-NET Cofund for Personalised Medicine Framework for Safe Nurse Staffing and Skill Mix Fulbright-HRB Health Impact Awards Health Research Awards HRB Clinical Research Facilities HRB Collaboration in Ireland for Clinical Effectiveness Reviews HRB Postdoctoral Fellowships: ARPP 2023 HRB Postdoctoral Fellowships: CSF 2023 HRB Trials Methodology Research Network HRCI 2020 HRCI-HRB Joint Funding Scheme ICORG Statistics and Data Management Interdisciplinary Capacity Enhancement Awards Investigator Led Projects IPPOSI 2020 Irish Clinical Oncology Research Group Irish Platform for Patients Organisations Science and Industry Support Award Joint Programming Initiative Healthy Diet for a Healthy Life Joint Programming Initiative in Neurodegenerative Diseases Joint Programming Initiative on Antimicrobial Resistance Knowledge Exchange and Dissemination Scheme Knowledge Translation Awards Medical Research Charities Group Support Award MRCG-HRB Joint Funding Scheme National Children's Hospital Foundation Scheme National Clinical Trials Coordination Programme National integrated PhD programme for Medical Practitioners National Intellectual Disability Supplement to TILDA Patrick Quinn Awards for Parkinson's Research PPI Ignite Awards Project Development Grants Rare Diseases Research and Innovation Catalyst Awards (RDCat) 2023 RCQPS COVID-19 Research Collaborative for Quality and Patient Safety Research Collaborative in Quality and Patient Safety Research Training Fellowships for Healthcare Professionals RL FA 2020 RL PA 2020 Secondary Data Analysis Projects SFI-HRB-Wellcome Research Partnership Structured PhD Programme in Population Health and Health Services Research The Irish Longitudinal Study on Ageing Ulysses Research Visits US-Ireland R&D Partnership Awards WHO-SOLI-2020
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Host Institution
Atlantic Technological University DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Family Carers Ireland Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Katholieke Universiteit Leuven Limerick Institute of Technology Maynooth University Medical Research Charities Group Ltd National University of Ireland Galway National University of Ireland, Galway Our Lady's Hospice Queen’s University Belfast RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford UPMC Whitfield
Funding Awarded
187 awards
DEFINED: DEtermining Falls burden to INform carE Delivery
Background
Falls in later life are the most frequent reason for older people to present to acute care, and significantly increase the likelihood of adverse health outcomes. Many falls are potentially preventable however, with comprehensive falls care reducing the rate of further falls by 20%....
Targeting immunometabolism to protect children from Tuberculosis infection
Introduction
Tuberculosis is the top global infectious killer in the last decade. The neonatal period is the most susceptible time to TB infection, with increased risk of active and disseminated disease. TB treatments require months of multiple drugs and resistance to first line agents is increasing...
Priorities for future research on tapering psychiatric medicines: A collaborative workshop involving people with lived experience, family members, and healthcare professionals
A growing number of people with experience of mental health problems want to reduce and stop their use of psychiatric medicines, such as antidepressants and anti-anxiety tablets. There are many reasons for this ranging from side-effects to people feeling that the medicine is no longer needed. Tapering is the recommended process for...
Measuring Outcomes of Social Prescribing
Social Prescribing (SP) is a non-medical community-based service that links people with health-promoting activities and support services in their local community. SP is usually delivered by link workers who meet with individuals to identify their activity and/or support needs. Following this, the link worker either provides information...
The Science of Dementia for the Non-Scientist - An exploration of dementia and the brain
The focus of this event is to present the science of dementia to non-scientists, in order to build the understanding of the basic science of dementia. The event will be hosted by Dementia Research Network Ireland (DRNI) together with the Alzheimer Society of Ireland (ASI).
Dementia is an umbrella term for diseases of the brain...
Inaugral conference in Adult Safeguarding
Adult safeguarding in Ireland has been an increasing public health issue since undercover filming (Leas Cross, 2005; Aras Attracta, 2014) exposed poor care practices in residential care settings. Similar to other countries, abuse of adults in any setting continues to be recognised as a human rights issue and has both immediate and long...
PersonAlisation of RelApse risk in autoimmune DISEase "PARADISE"
Autoimmune disease affects 10% of adults, most of whom are women, and two of the top five medications with the highest cost globally are used to maintain these recurring conditions in remission. These medications act by suppressing the immune system, leaving the patient exposed to severe infection and at risk of cancer. Affected...
PARKIE: Parkinson's community Awareness of Research; emphasis on Knowledge and Information Exchange.
Our lab is studying the role of our immune system in the development of Parkinson's. Our immune system protects the body against attacks from viruses and bacteria but, when we look at blood samples of people with Parkinson's, we can see they have an increased amount of one immune cell type, namely a type of T-cell called Th17 cells. In...
National Patient Education and Research Engagement Programme.
Inflammation is a critical process in fighting infection. However, if uncontrolled, it can contribute to the development of autoimmune disease, including inflammatory forms of arthritis, which cause joint destruction and disability. Medicines available for patients with RA have improved a lot over the last 15-years, however a...
Integrated Knowledge Translation for Advanced Therapies: From Bench to Bedside.
The value of clinical research is to improve treatment outcomes for patients and to inform health policy. However, the knowledge gained from research only translates into impact for patients when new therapies become used as part of routine practice.
Advanced therapy medicinal products (ATMPs) are...
HD-knowhow.
A rare disease is a health condition that affects a small number of people compared with other prevalent diseases in the general population. Empirical research shows that patients with severe illnesses prefer the physician to dominate decision processes and provide the information needed. However, in rare diseases, due to the low...
Translating knowledge into care to enhance sensory-cognitive health of people in longterm care in Ireland
This Knowledge Translation (KT) project will convert our research into practice to improve sensory-cognitive health in residents with dementia (RwD) in nursing homes in Ireland. We are currently conducting a pilot clinical trial (‘SENSE-Cog Residential Care’) to evaluate whether enhancing sensory health (i.e. hearing/vision) in...
FUTURE-VASC
This project, FUTURE-VASC, aims to share knowledge from a research study called FAIRVASC, so that more people can benefit beyond the life of the original award. FAIRVASC has united scientists, clinicians and patients across Europe in a common goal of linking together data from several vasculitis registries (databases) to create one...
Building Circles of Support for people with intellectual disabilities.
The overall aim of the project is to use research information to develop resources to enhance the Circles of Support (COS) for adults with intellectual disabilities that can be used in person-centred planning processes. Person-centred planning puts the individual with intellectual disability at the centre of the process, and builds...
Teaching & Learning Trauma Informed Care for Health Settings.
While most people have experienced some form of psychological trauma at some point in their life, severe psychological trauma is particularly common in people who are socially excluded (i.e., through homelessness, addiction, poverty, incarceration and/or belonging to minority ethnic groups). Accessing healthcare in hospitals for those...
Defining how innate immune function is impacted long term in people who have had active Tuberculosis
The Problem:
Tuberculosis (TB) is a complex disease caused by a bacteria called Mycobacterium tuberculosis (Mtb) and claims the lives of 1.4 million people annually. When a person is exposed to Mtb, their immune response may clear the infection asymptomatically, contain it in a dormant state (called latent TB)...
Stromal cell subtypes define distinct pathogenesis in RA and PsA
Arthritis is a leading cause of disability affecting up to 15% of the Irish population. 2% suffer from inflammatory arthritis (IA) such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). The cost of treating patients with IA in Ireland is ~€20,000/patient/year.
Activation of our immune cells is a key mechanism by which...
Altered histone protein acetylation is associated with dysregulated NK cell metabolism in different cancer types
Fixing broken immune cells in a range of cancers.
Finding a way to stop cancer spreading (known as metastasis) remains a holy grail of scientific research. We know that we can use the immune system in anti-cancer therapies and this has opened up the possibility that patients can be cured using combinations of...
Analyzing the therapeutic potential of anti-inflammatory drugs in brain development, neuronal activity and long-term outcomes after birth asphyxia
Birth asphyxia or neonatal hypoxia is a medical condition resulting from deprivation of oxygen to a newborn infant that lasts long enough to cause harm, usually to the brain. It remains a serious condition which causes significant mortality and morbidity. Neonatal hypoxia is a global insult, which can damage all organs, but the brain...
A translational investigation of the anti-inflammatory and antidepressant effects of Psychedelics in Depression
There has been a renewed interest in the therapeutic potential of psychedelics. These substances (e.g. psilocybin, D-lysergic acid diethylamide, dimethyltryptamine) when given under psychiatric supervision and with psychological support have been shown to have therapeutic benefits for a range of disorders with restricted or maladaptive...
IMPRINT: Defining pathogen-specific IMmune PRedictors of bloodstream INfecTion outcomes
The past 20 months has provided a front row seat to the ravaging effects of a virus on the global population. During this time, scientists have responded with a momentous research effort, which has yielded unprecedented levels of understanding of how SARS-CoV-2 causes COVID-19 disease and importantly how our immune system responds to...
STARFISH: Sustained inflammaTion in preterm infAnts and multioRgan dysFunctIon correlateS witH long term outcomes
Preterm birth describes babies born before 37 weeks an is the world's leading cause of death in children less than 5 years old. Babies born before 32 weeks have higher risks of injury to their brain, kidneys, lungs, heart and more infections. Although clinical care of these issues in the neonatal period is well defined there are few...
Effective Subsets of Fine-Grained Network-based Neurophysiological Biomarkers for Early Stratification in Amyotrophic Lateral Sclerosis
Motor Neurone Disease (MND)/Amyotrophic Lateral Sclerosis (ALS) is a terminal neurological condition in which the neurons (neural cells) that control movement degenerate. The exiting drugs have very limited effects on the disease progression and those affected only survive for about 3-4 years after the symptoms begin.
More than...
Planning and design for quality of life and resilience in residential long-term care settings for older people in Ireland: Research and Universal Design Guidelines for new-build, adaption and retrofit
In Ireland, the provision of Residential Care Settings (RCS) for Older People is currently inadequate; putting pressure on the health system and undermining the care of many older people. As the population increases and ages, the number of people requiring RCS will increase. This is recognised by the Irish government in health...
The development of an intervention to improve the use of point-of-care diagnostics in the management of respiratory tract infections in primary care: a mixed methods study
Using antimicrobial medicines (e.g. antibiotics) too often, especially when they are not needed, is associated with increased antimicrobial resistance (AmR). AmR can weaken the effects of antimicrobials, which threatens our already vulnerable health systems. Sometimes, antibiotics (which kill bacteria) are used to treat viral...
Comprehensive characterisation of resistance mechanisms for the accurate detection of Helicobacter pylori antimicrobial resistance
Helicobacter pylori (H. pylori) infection is a public health issue. It remains one of the most common infections in adults in Ireland and is associated with significant disease as the main cause of stomach ulcers and stomach cancers. Despite significant work resulting in a better understanding of this bacterium (germ) and how it...
Ongoing examination of the PD-1:PD-L1 pathway throughout the evolution of Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic autoimmune disease which causes joint destruction, disability, and increased mortality. While treatment has improved, only 1:4 patients achieve full remission and predicting who will develop severe disease or who will respond to treatment is difficult. This research will examine an immune pathway...
Polyfunctional-T "" stromal cell crosstalk in the joint of patients with inflammatory arthritis
Over a million people in Ireland alone, with inflammatory arthritis and other autoimmune diseases know only too well the frustration of the trial-and-error approach in finding the right treatment. In many cases this entails enduring chronic pain over several years, before a successful drug is stumbled upon. Therefore, there are areas...
Cortical and Spinal Connectivity of Motor Units as a novel biomarker of Amyotrophic Lateral Sclerosis pathology
One in every 400 in Ireland is at risk of developing Motor Neurone Disease during their lifetime, with Ireland having the highest overall incidence of Amyotrophic lateral sclerosis (ALS) in Europe. ALS is a nervous system disease that causes a gradual loss of muscle control. It is characterised by the death of motor neurons, which are...
Stakeholder coalitions to guide future research directions for stuttering treatment: Shaping healthcare delivery and policy
This conference aims to provide current and innovative research and clinical practices in stuttering treatment, thus improving therapy services for those who stutter, informing health policies, and improving the quality of life for the international stuttering community. Stuttering treatment continues to be represented by a range of...
MIRANDA- Multidisciplinary Innovation and Research Advancing Neurological care in a Digital Age
Amyotrophic Lateral Sclerosis (ALS) or Motor Neurone Disease (MND) is a degenerative disease of the nervous system, which affects one in 300 people in Ireland. Those affected lose their ability to use their arms, legs and voice, and eventually their ability to breathe. Some people also experience changes in thinking.
There...
Advancing clinical research on ageing in Ireland
As the population of the world ages, there is a critical need to integrate research on aging into the medical training of clinicians. The goal of this program is to provide research development, training, and mentoring to physician-scientists in the newly established Master's of Medical Gerontology program at Trinity College...
Wellcome HRB Clinical Research Facility at St. James's Hospital
No summary available
Social Circumstances and Epigenomics: Promoting Health in Three Countries
This project proposes an integrated set of aims and analyses of existing social and epigenetic data from three national studies of aging in the family of Health and Retirement studies (the US Health and Retirement Study (HRS), the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), and the Irish Longitudinal Study of...
SENSE-Cog Care: A feasibility study of hearing and vision support to improve quality of life in care home residents with dementia
What is the need? Of the 55,000 people with dementia in Ireland, nearly 17,000 live in nursing homes. Over 90% of these residents have significant hearing and vision problems that are frequently undetected or under-corrected. Also, the sensory environment (noise, bad lighting) in many nursing homes may contribute to poor...
Manipulating macrophage bioenergetics to improve patient outcomes in TB infection
Tuberculosis (TB) is the most lethal infectious disease worldwide, causing 1.8 million deaths annually. For the last 4 years in Ireland, we have seen a doubling of TB cases after the use of immuno-suppressants called TNF blockers, and the emergence of drug resistant TB in Irish people for the first time in this regard. Targeting and...
Progressing Sláintecare delivery from proposal to implementation: Insights from palliative care in Ireland
Sláintecare, Ireland’s national ten-year reform plan recommends universal healthcare. This represents the biggest Irish health system reform since its inception. Using palliative care as an example this project examines the development universal palliative care internationally and applies these learnings to Ireland.
Through a...
Measures of wellbeing for use in economic evaluation: valuing and assessing health outcomes in Ireland
In Ireland, healthcare decisions primarily concentrate on maximising health gain. However, with more integrated social care, there is growing recognition that this perspective is too narrow. Health maximisation is unlikely to be a relevant objective, particularly where demand for social care is high (e.g. in chronic diseases,...
Food industry corporate political activity and its potential influence on public health policy, research and practice in Ireland
In Ireland, non-communicable diseases (NCD), which include diabetes, cardio-vascular diseases and cancers, contribute to premature death and increased suffering and disability. Unhealthy diets, particularly those high in ultra-processed food products, and obesity, are one of the primary risks factors for NCD. Internationally...
COVID-19 and the role and impact of the built environment on resident, family, and staff experiences in residential long-term care settings: Key findings and recommendations for building adaptation and retrofit.
Supporting the Sustainability of Long-Term Residential Care in a COVID-19 Environment and in the Future.
Long-term residential care (LTRC) homes have been at the centre of the COVID-19 pandemic, with high infection rates among staff and residents. A significant proportion of COVID-19 deaths have occurred in LTRC residents....
National Helicobacter pylori antibiotic resistance surveillance to guide clinical practice
Helicobacter pylori infection is a public health issue. It remains one of the most common infections in adults in Ireland and is associated with significant disease as the main cause of stomach ulcers and stomach cancers. Infection is more common in lower socioeconomic groups and increases with age.
Despite significant work...
Identifying children at risk of schizophrenia
Five of the ten leading causes of disability in young people are mental illnesses, of which psychotic disorders, such as schizophrenia, are the most severe and disabling.
The Health Service Executive recently launched a National Clinical Programme for Early Intervention in Psychosis, which emphasizes the importance of...
Towards dynamic resilience in health system performance and reform
Worldwide increases in life expectancy are leading to the rapid ageing of populations. By 2031, it is forecasted that there will be more than one million older adults in Ireland, representing 20% of our overall population. It is widely accepted that older adults frequently avail of health services in the community and in the hospital...
TeenPath: Social Environment, Health and Well-Being Among Adolescents in Ireland
A person's physical growth, psychological development and personal behaviours in adolescence are the foundation upon which the life course is built. Health behaviours established in adolescence will likely continue into adulthood with long-term implications for health and life-expectancy. For example, 80% of teenagers measured as obese...
Study of queuosine salvage and function in eukaryotes; a forgotten micronutrient
Queuine is a largely forgotten bacterial-derived micronutrient that is obtained exclusively from the gut; a preeminent small-molecule of the gut-brain axis. Our contention is that queuine is important in metabolism and development—mammals are born sterile and queuine free—and induces long-lasting effects into adulthood, particularly in...
Health system foundations for effective Regional Integrated Care Organisations (RICOs) - co-producing evidence to inform the design of regional organisations to support integrated care in Ireland
Health systems all over the world are struggling to provide equitable access to integrated, patient centred services that better meets the needs of individuals and populations. In Ireland, the way our health system is funded and structured creates particular barriers for people trying to access effective, responsive, quality...
Implementation of Making Every Contact Count (MECC): developing a collaborative strategy to optimise and scale-up MECC.
Importance of the study:
Many chronic illnesses can be prevented if people adopt healthier behaviours. The Making Every Contact Count (MECC) programme, developed by the Irish Health Service Executive (HSE), aims to train all healthcare professionals to support patients to make healthier lifestyle choices during...Examining the interplay of the immune system with brain cells in Parkinson's disease.
Parkinson's disease occurs when nerve cells that produce the chemical dopamine are lost from the brain. This causes a person to have many symptoms including a tremor of their hands and slowness of movement. There have been a lot of studies trying to determine why these dopamine nerve cells die.
There is growing evidence that the...
Implementation of a Frailty Care Bundle for older adults in acute care
During hospital admission, older patients often reduce their walking activity and nutrition intake due to illness. However, research suggests that inflexible hospital routines, lack of patient awareness and limited nursing attention are also factors. Long periods of inactivity combined with suboptimal nutrition cause leg muscle...
Embedding collective leadership to foster collaborative inter-professional working in the care of older people (Eclectic)
Recent government policy in Ireland has emphasised the importance of supporting older people to live well in their homes and communities. This would mean fewer older people will have to go to hospitals to receive health care. In order to do this it is necessary for healthcare professionals to work as a team to manage the care of...
Improving transition from child to adult health services for young people with cerebral palsy living in Ireland.
In Ireland, people with cerebral palsy (CP) receive healthcare from children's services up to the age of 18, after which they transfer to adult services. Poor management of the transition from child to adult health services can lead to poor health and increased hospital admissions. While there are practices that health professionals...
Evidence-based guidance in general practice: exploring general practitioner preferences, content prioritisation and dissemination
General practitioners (GPs) need resources to support their use of the most up to date information in their clinical practice. This is to make sure that patients are receiving the best care possible from their GP.Th e Irish College of General Practitioners (ICGP) produces research update guides for GPs to support their management of...
To identify molecular signatures that can predict disease onset in 'at-risk ACPA+' individuals and disease progression in RA patients
Inflammation is a critical process in fighting infection. However, if uncontrolled, it can contribute to the development of autoimmune disease, including inflammatory forms of arthritis such as rheumatoid arthritis (RA), which causes joint destruction and disability. Targeted therapies have advanced the treatment of RA, however a...
Immunometabolic manipulation of pulmonary immunity - towards TB host directed therapy
Tuberculosis (TB) is a major global health emergency, with over one and a half million people dying per year, despite being a curable disease. Drug-resistant TB is a new aspect of the epidemic meaning this disease has now become more difficult to treat with antibiotics. Consequently there is urgent need to generate better treatments,...
FIREFLY: Followup of Inflammatory Responses and multiorgan outcomes FoLlowing neonatal brain injurY
Babies who have brain injury also frequently have involvement of their kideys, lung and heart. Although clinical care in the neonatal period is well defined there are few guidelines and evidence for developmental, heart and kidney followup in childhood. We aim to develop and implement guidelines for health care workers and families on...
Optimizing 40 Hz sensory stimulation protocols for Alzheimer's disease treatment
Clinical dementia, the majority of cases being caused by Alzheimer's disease, seriously impairs the lives of over 50 million people worldwide currently. There are approximately 55,000 people with dementia and as many dementia carers in Ireland. At present the lifetime risk of developing dementia is about 10% but this is increasing...
Defining the consequences of innate immune training on protective versus pathogenic T cell responses in patients with tuberculosis.
Tuberculosis (TB) ranks alongside HIV as the world's most deadly infectious disease, killing 1.5 million people every year. It is caused by the bacteria Mycobacterium tuberculosis (Mtb), which primarily infects people's lungs. Treating this disease is becoming more difficult due to antibiotic-resistant Mtb, therefore, scientists are...
Harnessing the power of the Gut-Lung Axis: How Dietary Short-Chain Fatty Acids Balance Inflammatory Outcomes in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is an incurable lung condition triggered by smoking, or other air pollutants, that leads to long-term lung damage and serious trouble breathing. While COPD is an illness of the lungs, maintaining a healthy gut and a balanced diet can prevent COPD and reduce COPD attacks or flare-ups. But how...
Developing a new approach to stroke rehabilitation for the upper limb based on TMS neurofeedback
Today in Ireland, most people who experience a stroke survive, but more than half are left with long-term disabilities due to paralysis of one arm. In the proposed research, we aim to push the boundaries of standard stroke rehabilitation, by introducing a technique that promises to boost the brain's recovery mechanisms, stimulating...
Rehabilitation Strategies following Oesophagogastric and Hepatopancreaticobiliary Cancer
In our bodies, the oesophagus, stomach, pancreas and liver help us digest food. Together, they form the “upper digestive system”. The treatment used to cure cancer in the upper digestive system is surgery to remove that part of the body. Some patients also receive chemotherapy (drug treatment) before and/or after...
Ketamine as an adjunctive therapy for major depression- a randomised controlled trial
According to the World Health Organisation, depression is now the leading cause of disability worldwide. Depression can be a chronic disorder, with 5-9 episodes per lifetime, and 30% of sufferers don’t respond to adequate trials of antidepressant drugs and/or talking therapies. This creates a great societal as well as...
Digital Fetal Scalp Stimulation (dFSS) versus Fetal Blood Sampling (FBS) to assess fetal wellbeing in labour- a multi-centre randomised controlled trial.
Despite recent advances in acute stroke intervention, strategies to prevent recurrent stroke are lacking. This is of urgent importance for people with stroke who are at risk of having another stroke. Physical activity (PA) is the second-largest predictor of stroke and the cornerstone of secondary prevention therapies. Interventions...
Computational evaluation of morphologic tumour tissue features as diagnostic and prognostic predictors of lung cancer
Co-funded with Irish Cancer Society
Intensive Care Airway and Lung Microbiome Network ICALM Network
Hospital acquired pneumonia (HAP) is the most frequent infection acquired in the Intensive Care Unit (ICU). ICU-related respiratory infections arise as a consequence of the processes of ICU care. Mechanical ventilation (MV) is potentially lifesaving, but also carries microorganisms into the lower airways, changing the native flora, and...
National intellectual Disability Supplement to The Irish Longitudinal Study of Ageing-Wave 4
IDS-TILDA is a longitudinal study researching ageing in Ireland among people with an intellectual disability (ID) aged 40 and over. This study is the first of its kind in Europe, and the only study able to directly compare the ageing of people with intellectual disability with the general ageing population through its linkage to The...
Vaccination: Knowledge is power
Over 3 million global deaths are avoided annually due to the existence of vaccines. In Ireland the state funded immunization program protects against 14 infectious diseases including HPV. However, we face a number of challenges with immunization. Alarmingly, in recent years uptake of vaccines has been waning. Perhaps due to complacency...
Health and social inequalities in the Mid-West
As there are many disadvantaged areas in the Mid-West, health and social inequalities are important issues locally. This is because deprivation is linked with poor health and poor access to healthcare. Under the Healthy Ireland Framework, taking actions to address health inequalities is a key priority. In the Mid-West, many...
Self-Harm and Suicide AwaREness ? SHARE
SHARE is based on outcomes of the HRB funded research programme: Improving Prediction and Risk Assessment of Suicide and Self-Harm (IMPRESS). The IMPRESS study aims to improve the knowledge base on predictive risk factors associated with repeated self-harm and suicide among high-risk groups of self-harm patients in Ireland. During the...
Postnatal Mental Health PARTNERship
It is estimated that 10-25% of mothers will experience a mental health problem following the birth of their baby. With approximately 63,900 births in Ireland each year (6), conservative figures would suggest that over 6390 mothers will experience a mental health problem in the postnatal period. For many mothers, their partner plays a...
Towards Recovery After Childbirth, through Knowledge: (ON TRACK)
The Maternal health And Maternal Morbidity in Ireland (MAMMI) study identified problems women had postpartum. We have provided information for women on physical problems, such as incontinence, and will now address other important issues. For example, 15% of women have anxiety during pregnancy, and 44% have pain during sex at 3 months...
Developing an on-line course for first-time mothers: ?Pathway to Birth?
Concern has been expressed globally at rising caesarean section (CS) rates with no evidence of any decrease in associated health problems for mothers and babies, indicating that many CSs are unnecessary, and can be harmful. We are at present running a pilot trial called "REDUCE"to see if a new intervention, based on research evidence,...
The Breakfast Club
The Breakfast Club is the story of diabetes in pregnancy in Ireland. In a weekly, serialized, online graphic novel, we will follow the lives of women attending a Breakfast Club for women who have received a diagnosis of diabetes during their pregnancy. We will explore their experiences, from having a Glucose Tolerance Test, to meeting...
Medtrack KEDS
"Health professionals are the lifeblood of the health system"(President M Robinson), yet our junior doctors (NCHD-trainees) continue to report that responses for improving their working conditions have had "little tangible change or impact on their day-to-day working lives and training experience?. The RCSI research team has...
Development of a Teaching Programme for the Junior Cycle Mental health and Mental Ill-Health Module
Great progress has been made nationally on destigmatising mental health but it has not yet become a topic that people are universally comfortable with. A major change in the Junior Cycle in 2018 is the introduction of Wellbeing which directly addresses youth mental health through Strand 4 in the new Social Personal and Health Education...
Development of Book About Mental Health Problems For Children and Adolescents
There has been steady improvements in the quality of information available to people about mental health issues but a challenge remains to communicate this fully to children and adolescents. Much of the existing information is text heavy and can be off-putting for this age group. Presenting this information so that it is accessible...
Citizen Science: The People's Trial
Randomised trials are instrumental in providing reliable and robust evidence on the benefits, harms and costs of health care, so that people can make informed choices. However, the general public?s understanding of randomised trials can be limited and ensuring public support for and participation in trials remains challenging. The...
Delivering a Reduction in the Development of Maternal Prenatal Stress: DIRECTMAPS
Pregnancy can be a stressful time during which many expectant mothers experience understandable worries and concerns. High levels of prenatal maternal stress are linked to several unfavourable conditions which can affect the health of the child at birth. Normal development of the central nervous system is also at risk during the early...
Piloting the Community Engaged Scholars Program in Ireland
Public and patient involvement in health research is not embedded in Irish Universities. As part of the PPI Ignite Awards scheme the HRB have funded 5 Irish Universities to demonstrate the value of PPI and champion this approach in Ireland. PPI involves public/patients working in partnership with researchers in setting research...
The GENIE fellowship: Gauging the Effectiveness of Novel computer-support technologies for Implementing Evidence in healthcare
Healthcare professionals must keep pace with a rapidly growing knowledge base. By 2020, the quantity of medical evidence is expected to double every 73 days. Typically, healthcare professionals leverage 'systematic review' articles to tackle this issue. A systematic review is a consolidated summary of evidence that healthcare...
Exploring the immunome of oesophageal adenocarcinoma using bioinformatics to assess and predict responses to neoadjuvant therapy (Immune-AEGIS)
The immune system is made up of cells that are designed to protect the body from infection and disease, like cancer. However, in patients with cancer, the immune system often does not do this well. Recently, a new treatment for cancer has been tested - called immunotherapy, which uses the patient?s own immune system to fight the...
Promoting Education and Research Knowledge (PERK)
THE PROBLEM Cancer of the oesophagus (food pipe) is an aggressive type of cancer, and has a low survival rate. It is usually diagnosed at a late stage, often due to a lack of knowledge of underlying symptoms which can be mild, including heartburn, bloating and problems swallowing. Oesophageal cancer is not as well known as some other...
Rheumatoid Arthritis Patient Awareness INitiative (RA-PAIN)
Rheumatoid Arthritis (RA) is a common autoimmune condition that causes disability for patient's day-to-day tasks. New medications that target bad molecules or cells improve outcomes, however responses may be limited or side effects may occur. Who will develop RA, get severe disease or respond to current treatments is not known. Studies...
Using photovoice to enhance knowledge exchange and dissemination
The EOLAS programmes are information and learning programmes for people with experience of psychosis and their family members. The programmes have been co-produced and are co-delivered by peer and clinician facilitators in partnership with mental health clinicians. Such service user and family member involvement in the design and...
CHErIsH- KEDS
This CHErIsH-KEDS application has two aims: to increase capacity in translation of research into practice in Ireland and to develop a knowledge exchange strategy for the future roll out of CHErIsH across different settings in primary care. This application builds on the existing study, the CHErIsH study. The CHErIsH study is funded...
How to Use TILDA Data - Webinar, Seminar and Workshop Series
The Irish Longitudinal Study on Ageing (TILDA) was established in 2006 with baseline data collection commencing in 2009. TILDA collects data in a series of data collection waves. The data is collected through a computer-assisted personal interview and a self-completion questionnaire once every two years with a comprehensive health...
Co-Designing, Pre-Testing and Refining an Intervention Programme to Support Parent-Adolescent Communication about Shared Self-Management Responsibilities in Type I Diabetes
This knowledge exchange activity aims to work together with young people with Type 1 Diabetes (TID), parents of young people with TID, professionals (from a range of disciplines e.g. diabetes nurse specialists, psychologists, consultant paediatric endocrinologists) and community advocates (e.g. Diabetes Ireland) to codesign, pre-test...
Collecting and using data about ethnicity in healthcare -a drama
Ireland has a long history of emigration. More recently, we have inward migration. Census 2016 found that 17% of the population were born outside Ireland. This means that there are different minority ethnic groups in our country, in addition the Irish Travellers. The Health Service Executive wants to gather information on the ethnic...
The APART Study Public Participation Initiative for Knowledge Exchange
The APART Study is exploring an important, low-cost intervention that may limit bone loss associated with initiation of antiretroviral therapy to treat HIV. Results from this trial may have significant implications for how HIV is managed both in Ireland and internationally. We will use this KEDS award to develop a research partnership...
Real Talk with Real Mums
?Real Talk with Real Mums? is a 10-episode podcast series looking at the issues of everyday pregnancy with medical professionals and the real women who have gone through the pregnancy journey. Each episode of c.30 minutes will tackle a different topic, from exercise in pregnancy (with a Physiotherapist), to mental health issues in...
Reducing Maternal Stress in Ireland
Stress experienced by women during pregnancy and up to two years after the baby is born can have negative consequences for the mother and the child. Strategies and guidelines to reduce stress experienced during pregnancy and early parenthood is lacking in Ireland. In this project the research team will develop an intervention...
Economics of palliative care: from international evidence to Irish policy
Palliative care is specialised care for people with serious and complex illness. Its goal is to improve quality of life for patients and families, and studies show that it generally achieves this goal. Palliative care access is strong in Ireland by international standards but there are still significant gaps in services and...
Investigating the iceberg model of self-harm and suicide in children, adolescents and young adults: a multi-methods study of predictors of onset, escalation and premature mortality
Rates of self-harm among children, adolescents and young adults in Ireland have increased sharply in the past decade and rates of youth suicide remain high. Self-harm and suicide have been described as an "iceberg", with the rare event of suicide as the tip of the iceberg. Beneath this are higher rates of self-harm resulting in...
TeamTalk: Interactive Resource Hub for Healthcare Teams
Healthcare teams who are interested in improving how they work together to deliver better patient care often struggle to find the time to learn and implement new practices. Teams rarely have the opportunity to attend training courses or other learning events together. This makes it difficult to transfer their newly acquired knowledge...
Working with the Research Community: Training and a Toolkit for Patients & Members of the Public
The PPI Ignite Programme at Trinity College Dublin is focused on building capacity for public and patient involvement in health research, with a particular emphasis on improving the quality of approaches. One of 10 Ignite Partners, the Medical Research Charities Group (MRCG), hosts a Public Patient Involvement (PPI) Shared Learning...
Disseminating, Engaging, and Sharing Knowledge (DESK):patient informed resource for understanding our research
Based on the findings of the research conducted during our HRB Research Leader's Award, the aim of the proposed KEDS project is to effectively disseminate the finding of our research to chronic pain patients and the general public. Sharing research findings with the general public is very important but can be difficult to get right; we...
A Patient Education Programme in Health Research & Innovation
Well informed patients and carers have a key role to play in the design and implementation of person-centered healthcare and research. Whilst patients are eager to have better and safer health products and innovations, they are often unaware of the complex nature of how new health innovations are researched, developed and made...
The patient is part of the answer - don't leave us out in the cold!
This application aims to produce a documentary that explains public and patient involvement in health research to the general public and encourages more people to become involved with researchers. Known as PPI, public and patient involvement means that people who are likely to be affected by research results are directly involved in...
Promoting National Awareness of Thrombosis in Pregnancy.
Women who are pregnant have a higher chance of developing blood clots (thrombosis) that can cause serious ill-health and can be fatal. Therefore, it is incredibly important that women who are pregnant, women of childbearing age and their families are aware of their risk factors for thrombosis in pregnancy. In the HRB-funded "HIGHLOW"...
Access to primary and emergency care for children with intellectual disabilities: utilisation, decision making, parental preferences and disparities
The aim of this research is to learn about the inequalities faced by children with intellectual disabilities (ID) in Ireland in relation to healthcare and to find out the reasons why these inequalities occur. In many other countries around the world, children with ID do not receive the same standard of healthcare as children without...
Maximising collaboration to expedite positive change in the assessment process that determines physiotherapy students' readiness for independent practice
Assessment of student physiotherapists in the clinical environment is a critical part of their education which determines their readiness for independent clinical practice once qualified. Therefore it has significant implications for patient safety and quality of service delivery. Yet, research and experience highlight many challenges...
LoVIC-Kids: Improving public awareness of abnormal bleeding symptoms
Congenital bleeding disorders (CBD) may result in increased bleeding at times of injury, surgery, childbirth or with periods (menstrual bleeding). Although an estimated 1-2% of the population are affected by CBD, most people are unaware that their bleeding symptoms are abnormal. In addition, there is limited awareness amongst many...
"Let's Talk About" Series
Researchers in dementia at NUI Galway are producing important research insights into many aspects of dementia care in Ireland, specifically: resource allocation decision-making; support structures for family carers; and how people with dementia are treated within the care system. The focus is now turning to sharing the results...
Using visual media to communicate complex information
Services in Ireland for people with dementia are poorly developed. The main partnership award aims to (i) describe current dementia services across all sectors and (ii) ask people with dementia, carers, health workers and managers about the ideal level and type of service provision for people with dementia who have different needs and...
Factors influencing decision-making for caesarean section
The rising rate of caesarean section (CS) has become a growing concern worldwide, with limited justification of the rising trend. Understanding the factors that influence the rise in CS is important because obstetricians and midwives are directly involved in the decision to perform a CS and are the key drivers to achieving the remedial...
The Frail Brain and the Frail Body: Impact of FRAILty and COGnitive impairment on trajectories, patterns and costs in care in old age
Informing Chronic Kidney Disease health policy in Ireland: Linkage of large datasets to study the interaction between ageing and kidney
The Irish Longitudinal Study on Ageing (TILDA) is a remarkable study undertaken in Ireland, which invited over 8,500 people aged 50 and over to participate at wave 1 between 2009 and 2011. Individuals who agreed to take part were subsequently invited to present for a comprehensive health assessment. This study is invaluable to the...
Enhancing ?The Model for Dementia Palliative Care Project? by targeting potential model users with innovative Knowledge, Transfer and Exchange activities.
This KEDS application will further enhance Knowledge, Transfer and Exchange (KTE) activities arising from 'The Model for Dementia Palliative Care Project', by supporting new connections with key groups, through novel activities and outputs. The active project will develop a new service delivery model for palliative care for people...
What the Researcher and the Dentist want to share, supporting knowledge dissemination
Research is ongoing to monitor the oral health of the Irish population, the uptake of dental services, and targeting of services to specific groups most in need. Results of such research inform policy makers in the Department of Health with respect to issues such as community water fluoridation and recommendations on the use of...
HPV associated disease: shaping the future prevention and management pathway
Infection with HPV is the most important cause of cervical cancer. As such, HPV testing is now being introduced as part of cervical cancer screening. HPV is also involved in the development of other anogenital cancers, which include: vulvar, vaginal, anal and penile cancers. HPV vaccination will help reduce the burden of HPV-associated...
Scaling up the Family Carer Decision Support Intervention: A transnational effectiveness-implementation evaluation
The Family Carer Decision Support (FCDS) intervention has been designed to inform family carers about end of life care options available to a person living with advanced dementia. The effect of the FCDS was demonstrated through a study that employed a cluster randomized control trial involving 24 care homes located in the United...
European eHealth care model for rare neurodegenerative diseases
Rare neurodegenerative disorders (RND) like Huntington?s Disease (HD) require multidisciplinary care teams which are in short supply. Given the devastating consequences of RNDs for the individual patient and their families there is an urgent need to develop innovative ways to ensure access to best practices and established care...
Multi-Domain Lifestyle Targets for Improving ProgNOsis in Huntington?s Disease
Huntington?s Disease (HD) is a progressive, life-limiting neurodegenerative disease. It has devastating consequences for the individual and their families. No current treatment to modify the course of the disease exists. Improved evidence-based symptom assessment is crucial to optimising disease management. This project aims to...
Control of neuronal proteostasis by stress-induced transfer RNA fragments (?tiRNA?) as a common stress pathway across neurodegenerative disorders.
This application is for supplemental funding through PA-18-591 for the recently funded grant (1R01AG058476-01), entitled ?Dysfunction of the autophagy-lysosomal pathway as a common mechanism of neurodegeneration,? and the JPND project to support collaborative studies between Dr. Finkbeiner?s lab (Gladstone) and the JPND RNA NEURO...
Autophagy induction as a novel therapeutic strategy for MSD
The lysosomal degradation pathway of autophagy has a crucial role in different pathophysiological conditions, such as infection, neurodegenerative disorders, cancer and ageing. In particular, autophagy plays an important role in the pathophysiology of a family of inborn errors of metabolism due to defect in the activity of lysosomal...
The microbiome as an environmental trigger for autoimmune epilepsy (MICA)
Autoimmune epilepsy is a rare form of drug-resistant epilepsy characterised by frequent seizures in later life. Patients may respond to immune therapy, but causation of disease is poorly understood, and more targeted treatments are required. This gap in knowledge is the major priority for epilepsy specialists, and the area of greatest...
Elucidation of the role of SARM1 in retinal homeostasis and oxidative stress induced retinal degeneration
Photoreceptor cells found in the back of our eyes convert light into signals that allow us to see. Death of these cells and the cells that nourish them, called RPE cells, is termed retinal degeneration and is characteristic of blinding diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa. Millions of people...
Towards novel anti-infective with enhanced wound-healing for diabetic foot infections : Co2 releasing star shaped micro biocidal polymers
It is estimated that 422 million people worldwide are living with diabetes and among them, a common and serious problem is the development of diabetic foot infection. One in five patients with diabetes are hospitalised with a diabetic foot wound (DFW) at least once in their lives. Infected DFWs are treated by removal of infected tissue...
Combining Electrochemotherapy with a Toll Like receptor agonist for the treatment of lung cancer
Successful cancer treatment aims to totally eliminate the entire tumour and the risk of recurrence. Treatment currently relies on removal of the primary tumour by surgery or radiotherapy followed by control of the remaining dispersed cancer cells in the whole body usually by chemotherapy. At the Cork Cancer Research Centre (CCRC) we...
Preoperative Exercise to Improve Fitness in Patients Undergoing Complex Surgery for Cancer of the Lung or Oesophagus
Treatment for people with cancer of the lung or the oesophagus (food-pipe) often involves surgery. This surgery is complex and there is a high risk that patients will develop severe complications afterwards, mainly lung or heart problems, leading to a longer hospital stay and higher hospital costs, and impacting greatly on recovery and...
Evaluation of the role of MxA and ISGylation in chemosensitivity in oesophageal cancer
Many oesophageal cancers develop resistance to the drugs currently used to treat this disease. This allows the cancer cells to survive and the cancer can come back again at variable times after the initial treatment. Research already performed by this group has identified genetic differences between cancer cells that respond well to...
Incorporation of sensor technology to provide clinical meaningfulness for existing standardised measurement scales in Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) also known as Motor Neurone Disease (MND) is a progressive and ultimately fatal neurodegenerative disease for which there is no cure. People with ALS experience loss of mobility and arm function, breathlessness and chest infections, loss of speech and swallow and in 30-50%, cognitive and behavioural...
Novel Neurophysical Biomarkers of Heterogeneous Network Degeneration in Motor Neuron Disease for Quantifying the Progression and Outcome in Clinical Trials
Motor Neurone Disease (MND)/Amyotrophic Lateral Sclerosis (ALS) is a terminal neurological condition in which the neurones (neural cells) that control movement degenerate. Despite encouraging results from studies in animals, translation of new treatments to humans has been disappointing. The aim of this study is to provide scientific...
Evaluating a novel macrolide based early intervention in the clinical management of chronic infections and inflammation in Cystic Fibrosis
Chronic persistent respiratory disease is a leading cause of death worldwide. Despite years of global research, the clinical management of respiratory disease, including the life-limiting genetic disease cystic fibrosis (CF), remains a significant challenge. Treatment options are extremely limited, due in part to the increased pathogen...
Gold-drug: Targeting a novel dual inhibitor drug with gold nanoparticles for improving radiation response in oesophageal cancer
Oesophageal cancer (cancer of the food pipe) has low survival rates and a very poor response to treatment. Sadly, this cancer type is on the rise in Ireland and is linked with increasing obesity rates. Unlike many other cancer types, we are still only using treatments that have existed for decades - chemotherapy drugs with radiation...
The role of sialylated-alpha-1 antitrypsin in resolution of acute and chronic inflammation
Alpha-1-antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that results in the rapid progression of lung disease, especially in smokers. Specific treatment for this disorder is available in the form of weekly intravenous injections of AAT. This is referred to as augmentation therapy and studies have shown that augmentation...
Compound library screening in a zebrafish model of MSD to identify novel therapeutic compounds
Multiple Sulfatase Deficiency (MSD) is currently an untreatable disease and while we know some of the processes inside cells that cause or influence the disease, there is still much to be understood. While progress has been made from studying simple cell culture systems, this does not tell us about how different disease changes may...
Evidence Synthesis Ireland
Health care decisions should be based on the combination of the full amount of information that is available rather than relying on the convenient selection of one or more individual pieces of information, or studies. Evidence synthesis methods seek to establish the overall balance of information on a given topic, and are based on...
Good vigilance practice in pregnancy: A multistakeholder approach to optimising the effectiveness of risk minimisation measures to prevent harms from teratogenic medicines
When new medicines are approved for use in the general population the drug company responsible for the medicine has to make sure that certain measures are in place to avoid unnecessary harm. These are known as risk minimisation measures (RMMs). This is particularly important when the medicine may cause harmful effects to an unborn...
Co-producing health and well-being in partnership with patients, families and communities: the role of the epilepsy patient portal
Claire a 35 year old teacher with a 10 year history of epilepsy attends the Galway University Hospital (GUH) where an electronic patient record (EPR) is used by the epilepsy service. Recently on a weekend trip to Waterford, Claire had a seizure resulting in a fall in the street and a minor injury. She was taken to the emergency...
Enhancing existing formal home support to improve and maintain functional status in older adults: A feasibility study on the implementation of the Care to Move (CTM) programme
Ireland has an increasing ageing population and this has created the need for better and more integrated health and social care services. The benefits of physical activity for all ages are widely known. Physical activity programmes have been shown to improve older adults’ health and well-being and reduce falls, enabling the older adult...
Loneliness and health: the moderating role of befriending services.
Befriending services deliver companionship to older adults through regular volunteer visits. ALONE is a charitable organisation providing befriending services to older adults in Ireland. It is the mission statement of ALONE to use befriending to reduce the negative impact loneliness has on health, but evidence for this use of...
Premature Ageing in long-Term Homeless adults (PATH)
The number of homeless adults in Ireland is rising. Homeless people have more chronic illnesses and a shorter
life-expectancy than people who have somewhere secure to live. We have carried out a pilot study showing that
homeless people have dementia, frailty and other diseases associated with ageing at a much younger age...Unlocking the potential of healthcare complaints to improve hospital care (UP-CIC)
Most assessments of quality of care in Irish healthcare services are focused on healthcare workers’ opinions, statistics (e.g., how many patients got infections), or investigating large errors. However, these assessments fail to consider patients’ unique insights into quality of care and support improvement in services. For example,...
I-PARC (Ireland’s Physical Activity Research Collaboration): Bridging the research to action gap to support the implementation of the National Physical Activity Plan
The purpose of this research is to develop a bespoke research collaboration ‘I-PARC’ (Irish – Physical Activity Research Collaboration) to support Get Ireland Active! the National Physical Activity Plan (NPAP)1. I-PARC will bring together researchers, policy makers and practitioners from physical activity (PA) to establish how best to...
How can a multi-disciplinary prescribing strategy support appropriate prescribing of oral nutritional supplements (ONS) by Irish general practitioners (GPs)?
Malnutrition is a major burden to the Irish health service as malnourished patients have poorer health and are more expensive to treat than patients who are well-nourished. The annual cost of healthcare associated with malnutrition is approximately €1.4 billion in Ireland (10% of our total healthcare budget). Oral nutritional...
Doctoral program in youth mental health leadership (The YouLead Program)
This doctoral training program focuses on youth mental health research. Mental health difficulties (including depression, bipolar disorder, and schizophrenia) account for approximately half of all causes of disability in individuals under the age of 35. Despite the fact that access to treatment is strongly associated with reduced risk...
"Right Care": a programme of research to enhance safe and appropriate care for older patients in Ireland
We propose a structured PhD training programme for multi-disciplinary health researchers on the topic of “Right Care” for older people. This research programme will examine how right care can be given at the right time and in the right setting, so that older people get the greatest benefit and the lowest harm from health interventions....
Neonatal Brain Injury Consortium Ireland
Neonatal brain injury has serious consequences including problems with development and cerebral palsy. Cooling or Hypothermia therapy is the only treatment available but half of all babies still have brain injury. All babies have detailed tests of their brain function using brain imaging and brainwave monitoring. They also have...
Managing complex multimorbidity in primary care: a multidisciplnary doctoral training programme
This application outlines a Structured Doctoral Training Programme for four PhD students with clinical and research backgrounds. The focus is on primary care delivery for patients who are referred to as having complex multimorbidity, which means that they have multiple long term conditions and are often on ten or more regular...
Cancer Prevention Fellowship 2018
Research Programme for mid-career researchers working in Republic of Ireland (RoI) to become NCI Cancer Prevention Fellows at the prestigious National Cancer Institute (NCI) in the USA.
This programme provides training at post-doctorate level from the health professions, biomedical, and behavioural sciences to become leaders in the...Manganese enhanced MRI as an early technique for lung cancer
The objective of the project is to prove that the manganese enhanced MRI (MEMRI) technique could help to detect early-stage cancers and metastases in lungs which could be treated rapidly with a good prognosis. This patient friendly and inexpensive diagnostic technique will be tested in preclinical models and presented to clinicians to...
Label free monitoring of fibrinogen levels in human blood plasma using asymmetric imides
The project aims to develop new methodologies for analysis of blood plasma samples using vibration spectroscopy (infrared and Raman spectroscopy) as alternative to the time consuming, costly and poorly reliable Clauss assay, commonly used in hospitals. Two different aspects will be addressed, (i) requirement for optimisation of...
Implementing evidence based guidance for dementia palliative care through participatory action research
Dementia is a progressive illness and as the condition progresses into the later stages, the person will have difficulty communicating their needs particularly in relation to thirst, hunger, pain or discomfort. In Ireland persons with dementia are often cared for in Long Term Care (LTC) settings. Carers of persons with dementia...
Implementing evidence based guidance for dementia palliative care through participatory action research
Dementia is a progressive illness and as the condition progresses into the later stages, the person will have difficulty communicating their needs particularly in relation to thirst, hunger, pain or discomfort. In Ireland persons with dementia are often cared for in Long Term Care (LTC) settings. Carers of persons with dementia can...
Brain superheroes and villains
We are a group of neuroscientists, funded by the HRB, who aim to test and develop novel drugs for brain related illnesses. We are excited about disseminating the value of work like ours and, in 2012, were delighted to be awarded our first HRB Knowledge Exchange and Dissemination Scheme (KEDS), which consisted of three activities...
Community exercise
It is recognised that exercise benefits people living with chronic disease. The CRF at St James's Hospital exercise physiology suite is used by research studies examining the role of exercise training for patients with chronic disease. These exercise trials support patients to exercise during structured supervised exercise classes and...
Biological Resource Analysis to Identify New Mechanisms and phenotypes in Neurodegenerative Diseases "BRAINMEND"
Joint Programme on Neurodegenerative Disease (JPND)
No summary available.Driving policy with data: A longterm sustainable specialist service for amyotrophic lateral sclerosis
The JPND-funded project ALS-CarE is coordinated by the Irish partner, and has collected detailed information across 5 different countries about the Amyotrophic Lateral Sclerosis (ALS) patient and caregiver journey from ALS diagnosis through to end of life. In Ireland, we have collected extensive quantitiative and qualitative...
The implementation of National Clinical Effectiveness Committee clinical guidelines relating to health care associated infections in Irish healthcare organisations: multiple perspectives
Background: Healthcare associated infections (HCAI) create a major burden on individuals, their families, and the health services. They lead to longer stays in hospital, higher risk of death, and increased frequency of other health problems such as heart failure, and pneumonia. All of this also contributes to greatly increased...
Our voices, our impact
Wave 3 KEDS will build on previous success by recruiting actors with ID to develop DVD and on-line resources comprising scenes that illustrate key IDS-TILDA wave 3 findings. Feedback from wave 3 indicates that participants would like to receive the findings in DVD format and IDS-TILDA wishes to respond to the specific dissemination...
Pathfinder: Parental information on therapeutic hypothermia followIng neonatal encephalopathy
Neonatal brain injury can have devastating outcomes for the baby and their family and may result in longterm disability. The only treatment available is whole body cooling started within a few hours of birth. Babies also require intensive care to support their lungs, heart and kidneys. We will develop an educational toolkit including...
Cracking the mysteries of cancer immunotherapies - e.courses for oncology healthcare professionals
The new therapies for cancer that target the immune system have revolutionised cancer care in recent times. The treatment of melanoma, leukaemia and other malignancies has been transformed by these immune modulating drugs. However, few oncology clinicians or oncology specialist nurses have backgrounds in immunology or immune...
The stressed brain & depression
Understanding depression is challenging both for professionals and for the public. It is complex and poorly conceptualized. Clinical depression involves biological, psychological and social causes that all contribute to the expression of depression in each individual sufferer. Trauma, especially early in life when body systems are...
CERVIVA: The HPV educate project
The goal of this CERVIVA HPV Educate Project is to provide accurate and reliable information relating to HPV and HPV associated diseases, to create awareness and educate the public, health care professionals and healthcare providers on public health issues related to HPV associated diseases and on the specific research programmes...
Expert forum to advance the potential of IL-1 family members as novel therapeutics in IBD
Current treatment strategies for Inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, are ineffective in a large number of patients. Although the reasons for this are not fully understood, it seems likely to reflect the complex nature of chronic intestinal inflammation. Recent advances in our understanding...
Development and validation of diagnostic biomarkers for neurodegenerative conditions based on MRI measures of pathognomonic brain regions
Amyotrophic Lateral Sclerosis (ALS) is a devastating, relentlessly progressive neurodegenerative condition with no effective disease-modifying therapies and no validated biomarkers. Three main themes exist in ALS biomarker research; (1) development of diagnostic indicators, (2) identification of accurate prognostic markers and (3)...
Targeting metabolism for individualised rectal cancer treatment: Development of an omics-led predictive signature of chemoradiation therapy response and novel neoadjuvant therapeutic strategy
Cancer of the rectum is one of the most common cancers in Ireland and worldwide. Patients with rectal cancer are commonly treated with chemoradiation therapy (CRT), which is a combination of chemotherapy and radiation therapy, to shrink the tumour before undergoing surgery to remove the tumour. CRT has been shown to improve survival...
An allostatic load framework for understanding social differences in health and mortality
A consistent finding in the epidemiological literature is that health is socially patterned. On average, individuals from more disadvantaged social backgrounds will develop diseases earlier and will die earlier compared with their more advantaged peers. So ubiquitous is the association between health and wealth that it has been...
Enhancing the evidence base for cost-effectiveness analysis in Ireland: Building improvements from the intervention-specific to system-wide levels
The objective of this research is to increase the relevance and reliability of health economic evidence in Ireland. The aim is to improve the methods for prioritising scarce health funding to the most beneficial uses. This research will translate valuable lessons learnt from cervical cancer prevention to screening for other cancers,...
The liver neighbourhood watch: regulatory tissue-resident natural killer (NK) cells protect against liver decompensation in patients with chronic liver disease
Liver cirrhosis occurs when normal liver tissue is replaced by scar tissue, leading to the eventual failure of normal liver functions. Cirrhosis develops as a result of chronic liver disease, and it accounts for 170,000 deaths annually in Europe and more than 3,000 deaths annually in Ireland. Presently the only treatment is liver...
Using genetics and CRISPR to personalise new targeted treatments for patients with familial breast cancer
This research project is focused on the genetics of breast cancer. We know that cancer can be caused by errors in certain genes, called mutations. We also know that these mutations run in some families, and therefore some women unfortunately inherit a risk of developing breast cancer. Landmark studies on these families led to the...
The heme oxygenase system as a therapeutic intervention for inflammatory bowel disease
Ulcerative colitis (UC) and Crohn disease (CD) are major chronic inflammatory bowel diseases affecting approximately 20,000 people in Ireland and an estimated 2.2 million individuals in Europe. Treatment with infliximab, corticosteroids and aminosalicylate-based compounds has been shown to suppress the generation of pathogenic immune...
Assessment of the predictive value of immune and histological parameters in oesophageal adenocarcinoma using digital pathology
Cancer of the oesophagus, or food pipe, is an aggressive type of cancer, with poor survival rates. The number of people affected is increasing and is set to double in Ireland within the next 20 years. Chemotherapy and radiotherapy are used to treat patients with oesophageal cancer, but these therapies only work for a small number of...
Phenotypic and functional characterisation of immune cell populations in ACPA+ vs ACPA- RA patients: Implications for treatment strategies
Rheumatoid arthritis (RA) is the most common inflammatory arthritis affecting 1-2% of the population, with potentially debilitating effects impacting on quality of life and function. Targeted therapies inhibiting TNF have advanced RA treatment, however these treatments are expensive, placing further strain on an already overstretched...
IRISH-1: A retrospective cohort study of PD-L1 by RNA ISH (RISH) as a potentially superior companion biomarker for immune checkpoint inhibitors in NSCLC
The role of the immune system to fight illness is well known, but it can in fact also fight cancer. Indeed, most potential cancer causing cells are detected and removed from our bodies by our immune system in process called "immune surveillance". However, at some point, tumors manage to evade our immune system by producing molecules...
Wellcome-HRB Clinical Research Facility at St James'Hospital 2018-2021
No summary available
Do we die as we live? Age, socioeconomic status, healthcare utilisation and pathways to death in Ireland
It has long been understood that illness and healthcare needs increase as a person approaches the end of life, and that much of what appears to be higher costs with ageing is mainly the costs of dying. Age at death is closely linked to socioeconomic status, but little is known about how patterns of illness and use of services vary...
Prospective validation of the complement system as a novel treatment stratification tool in oesophageal adenocarcinoma patients
Cancer of the oesophagus (food-pipe) is rapidly increasing in incidence in Ireland and worldwide and has one of the worst survival rates of all cancers. In Ireland, oesophageal cancer patients are currently treated with chemoradiation therapy (CRT), which is a combination of drugs (chemotherapy) and radiation (radiation therapy),...
Elucidating the pathological role of obesity, inflammation and immunity in cancer related sarcopenia in upper gastrointestinal cancers
Cancer is a devastating disease affecting the majority of us at some point in our lives. Cachexia is a common debilitating consequence of cancer, which is responsible for the deaths of nearly 20% of all cancer patients. It is thought to be driven by inflammation and leads to an involuntary loss of muscle (sarcopenia) and fat. This has...
CERVIVA-Vax: Monitoring the impact of HPV vaccination in Ireland
Infection with Human Papillomavirus (HPV) can lead to development of cervical cancer. For this reason HPV now plays an important role in cervical cancer prevention. For example, HPV vaccination programmes are established in several countries worldwide, including Ireland, where a national school based HPV vaccination programme began in...
A population-based, longitudinal investigation of changes in multisensory integration with ageing and its causal role in the incidence of falls and cognitive decline in older adults
Our sensory systems are constantly bombarded by information, yet we are able to maintain a coherent perception that allows us to efficiently interact with our world. Recent research in neuroscience has led to important breakthroughs in our understanding of how multisensory interactions occur in the brain. However, the ageing process...
Multimodal cardiovascular modelling for predicting and preventing disability in TILDA
Increasing proportions of older adults will lead to an increased prevalence of age-related health problems, and long-term care systems. The issues are numerous and complex. In response to these challenges, 'ageing' has become a research priority both nationally and internationally. TILDA aims to improve population health by providing...
PPI Ignite Award - Trinity College Dublin
Research is considered "engaged" when it is developed in collaboration with patients, community members and partnering organisations rather than for or about them. Such public and patient involvement improves the relevancy of the research question, the quality of the approach, and the likelihood that what is discovered through the...
Ancient genomics and the Atlantic burden
WT Scheme: Investigator Award in Science.
Massive human genome resequencing projects are in train to further the understanding of the genetic contributions to disease. However these offer a limited view of genome genealogies, variant history and past selection, all of which are instrument to the models underpinning genomic...Reducing caesarean section rates in Ireland: a feasibility study and pilot randomised trial of an evidence-based intervention designed to reduce unnecessary caesarean section
Concern has been expressed globally at the rising caesarean section (CS) rate with a lack of evidence of any associated decrease in health problems for mothers and babies, indicating that many CSs are unnecessary. Maternal death and severe maternal health problems are trebled following CS compared with vaginal birth, and newborn babies...
Enhancing doctors' engagement with regulation of professional competence
In the field of medicine, information about how best to care for patients is constantly changing. Since 2011, medical doctors in Ireland are required by law to demonstrate that they are taking part in educational activities to keep them up to date. The aim of this requirement is to reassure the public that their doctors are competent...
We Can Quit2: A cluster randomised pilot trial of a community-based smoking cessation intervention for women in disadvantaged areas of Ireland
Smoking rates remain high in Ireland despite considerable progress being made to reduce them in recent years. Ireland ranks second highest for smoking-related causes of death in the EU. Lung cancer, which is strongly linked to smoking, is now the most common cause of death for women in Ireland particularly those living in more...
EOLAS: Building capacity for collaborative education between service users, family members and practitioners within mental health services
Background: Service users and families need information so they can take charge of their own recovery and relationship with the mental health system. To support this, we developed and delivered 2 mental health information programmes (the EOLAS Programmes), to over 800 service users and family members. The programmes were on recovery...
Promoting Assisted Decision Making in Acute Care Settings (PADMACS) for care planning purposes
This project aims to produce an educational interactive game which will support health and social care professionals working in acute hospitals to include their patients in decisions about treatment and care plans. Decision-making capacity is the ability to make decisions for one-self. In some cases an older person may experience...
Out of hospital cardiac arrest and community first response: International best practice, national consultation and prospective evaluation
Cardiac arrest occurs when the heart suddenly ceases to pump blood around the body. The term 'Out-of-Hospital Cardiac Arrest' (OHCA) is used to describe incidents where cardiac arrest occurs unexpectedly and is responded to by statutory emergency medical services (EMS). OHCA causes approximately 1,900 unexpected deaths in Ireland every...
Lifetime exposure to community water fluoridation and associations with key indicators of health in community-dwelling adults aged 50 years and over in Ireland
The main aim of this project is to provide evidence that informs future policy about water fluoridation in Ireland. Community water fluoridation has existed in Ireland since 1964, so it is important to examine any association between long term exposure to water fluoridation and general health status. Such an assessment is a requirement...
What influences cervical screening uptake in older women and how can screening programmes translate this knowledge into behaviour changing strategies? A CERVIVA-CervicalCheck co-production project
Most cervical cancers can be prevented by detecting early changes in the cervix which, if not found, could progress to cancer. This is done by testing cells from the cervix in a smear test. CervicalCheck, the Irish National Cervical Screening programme, started in 2008 and offers free tests to women aged 25-60. For the programme to be...
Resource allocation, priority-setting and consensus in dementia care in Ireland
A key action under the National Dementia Strategy (2014) is the delivery of appropriate supports and services for people with dementia that can be accessed in people's own homes and local communities. There is also an emphasis in the Strategy to address the individual needs of people with dementia and their carers in a manner that is...
Traumatic brain injury: epidemiology and rehabilitation in Ireland
Traumatic brain injury (TBI, informally known as head injury) is a leading cause of death and disability worldwide1. Neither the number of people affected by TBI, nor the severity of the disability caused, in Ireland, is known. This makes it hard to plan the specialised neuro-rehabilitation services, which are under-developed and...
The utility of high-tech drug analysis to the decision maker
The Health (Pricing and Supply) Act 2013 stipulates that the payer must consider the cost-effectiveness (the likelihood that the drug will offer value for money) and the likely cost impact of a new drug prior to deciding if it should be reimbursed. It also states that, after a 3-5 year period, continued reimbursement must be reviewed....
Longitudinal profiling of adverse events in Irish hospitals and provision of a standardised assessment tool to the Irish healthcare system: the INAES-2 study
Adverse events (AEs) are unintended injuries or complications that are caused by healthcare management, rather than a patient's underlying disease, which lead to death, disability at the time of hospital discharge, prolonged hospital stay or subsequent hospitalisation. The first Irish National Adverse Events Study (INAES) determined...
Staphylococcus aureus induced immunosuppressive memory: Consequences for bug and for host
WT Scheme: Investigator Award in Science.
Antimicrobial resistance by Staphylococcus aureus is a global epidemic. New approaches based on induction of immune responses that control/prevent S. aureus infection, are required. This necessitates a thorough understanding of the unique relationship cultivated by S. aureus with the...