Label free monitoring of fibrinogen levels in human blood plasma using asymmetric imides

The project aims to develop new methodologies for analysis of blood plasma samples using vibration spectroscopy (infrared and Raman spectroscopy) as alternative to the time consuming, costly and poorly reliable Clauss assay, commonly used in hospitals. Two different aspects will be addressed, (i) requirement for optimisation of experimental conditions, including sample preparation protocols, (ii) development and evaluation of data-mining approaches (means of multivariate analysis) for the specific quantification of plasma fibrinogen. Reagent-free molecular spectroscopy techniques (infrared and Raman) could lead to the next generation of new diagnostic tools usable as a routine screening technique in the clinical environment.

Award Date
01 January 2018
Award Value
Principal Investigator
Dr Jennifer McIntyre
Host Institution
Dublin Institute of Technology
Ulysses Research Visits