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AIIHPC Structured Research Network APA Cycle 2 2019 Applied Partnership Awards Applying Research into Policy & Practice Postdoctoral Fellowships ARPP 2020 Cancer Prevention Fellowship Programme Cancer Prevention Fellowship Programme Reintegration Grant Capacity Building for Evidence Synthesis Clinical Research Facilities/Centres 2021 Cochrane Training Fellowships Collaborative Doctoral Awards Conference and Event Sponsorship Scheme COVID-19 2020 CSF 2020 DIFA - 2018 DIFA 2017 DIFA 2018 DIFA 2020 DIFA-2018 Doctoral Training Programme in Precision Medicine in Cancer Emerging Clinician Scientist Awards 2020 Emerging Investigator Awards Emerging Investigator Awards 2022 ERA-NET Cofund for Neuroscience Research (NEURON) ERA-NET Cofund for Personalised Medicine Framework for Safe Nurse Staffing and Skill Mix Fulbright-HRB Health Impact Awards Health Research Awards HRB Clinical Research Facilities HRB Collaboration in Ireland for Clinical Effectiveness Reviews HRB Postdoctoral Fellowships: ARPP 2023 HRB Postdoctoral Fellowships: CSF 2023 HRB Trials Methodology Research Network HRCI 2020 HRCI-HRB Joint Funding Scheme ICORG Statistics and Data Management Interdisciplinary Capacity Enhancement Awards Investigator Led Projects IPPOSI 2020 Irish Clinical Oncology Research Group Irish Platform for Patients Organisations Science and Industry Support Award Joint Programming Initiative Healthy Diet for a Healthy Life Joint Programming Initiative in Neurodegenerative Diseases Joint Programming Initiative on Antimicrobial Resistance Knowledge Exchange and Dissemination Scheme Knowledge Translation Awards Medical Research Charities Group Support Award MRCG-HRB Joint Funding Scheme National Children's Hospital Foundation Scheme National Clinical Trials Coordination Programme National integrated PhD programme for Medical Practitioners National Intellectual Disability Supplement to TILDA Patrick Quinn Awards for Parkinson's Research PPI Ignite Awards Project Development Grants Rare Diseases Research and Innovation Catalyst Awards (RDCat) 2023 RCQPS COVID-19 Research Collaborative for Quality and Patient Safety Research Collaborative in Quality and Patient Safety Research Training Fellowships for Healthcare Professionals RL FA 2020 RL PA 2020 Secondary Data Analysis Projects SFI-HRB-Wellcome Research Partnership Structured PhD Programme in Population Health and Health Services Research The Irish Longitudinal Study on Ageing Ulysses Research Visits US-Ireland R&D Partnership Awards WHO-SOLI-2020
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Host Institution
Atlantic Technological University DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Family Carers Ireland Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Katholieke Universiteit Leuven Limerick Institute of Technology Maynooth University Medical Research Charities Group Ltd National University of Ireland Galway National University of Ireland, Galway Our Lady's Hospice Queen’s University Belfast RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford UPMC Whitfield
Funding Awarded
86 awards
Rare Disease Research Catalyst Consortium
Rare diseases each affect less than 5 in 10000 people, with about 300,000 Irish people estimated to be living with rare disease. Under the Cross Border Directive for access to healthcare, the European Union established 24 European Reference Networks (ERNs) for rare disease to enable equity of access to healthcare across...
Expecting the unexpected: can viral metagenomics enhance optimised standard diagnostic pathways for detection of imported pathogens?
Background
Current testing practices for imported fever syndromes in Ireland are heterogenous and suboptimal, prolonging clinical care and limiting data capture for early warning surveillance systems. Identifying and diagnosing aetiological pathogens for imported fever syndromes with a standardised...
The HipCog Study: evaluating the impact of cognitive impairment on outcomes for older adults with hip fracture
Background: Over 3800 older people in Ireland experience hip fracture annually. These serious events have a one-year mortality rate of 20%. Since 2012, the Irish Hip Fracture Database (IHFD) has driven national clinical improvement and reduced variability of care across hospitals. While hospital-level care variation has decreased, it...
UCD’s 2nd Annual One Health Conference: Tackling Major Public Health Threats in a Post-Covid-19 World.
One health is a philosophy that acknowledges the interconnectedness of human, animal and environmental health. It recognises that to solve major challenges locally or globally, individuals or even groups of experts in one discipline can not solve them alone. It is recognized by the Irish Government, the European Union, the World Health...
Digital Surgery- Building a National Ecosystem
Digital surgery represents a significant step into the 21st century for surgical practice by combining technological advances in smart instruments, computer vision, artificial intelligence and cloud computing together with surgical expertise to improve patient outcomes and deliver enhanced healthcare value and outcomes. Despite still...
Connecting Molecular Networks of Cancer to Other Diseases
In 2019, the Quantitative Biosciences Institute (QBI) at the University of California, San Francisco (UCSF) and University College Dublin (UCD) signed a 5-year agreement to i) reinforce the links between scientists in San Francisco and Ireland and ii) broaden their collaborative ability to strengthen scientific research and innovation....
European Radiation Protection Week (ERPW) 2023
European Radiation Protection Week (ERPW) is an annual, multidisciplinary, event which brings together experts and addresses current and emerging topics related to radiation protection. Under the Consortium of European Radiation Research Platforms (MEENAS Group), ERPW aims to: promote the integration and the efficiency of European...
Equity For People Living With A Rare Disease: An International Rare Disease Research Symposium
Rare disease’ (RD), refers to a collection of conditions whose signs and symptoms are heterogeneous but are grouped together due to individual low incidence rates. While individually rare, RDs are collective in society and are a significant global public health and policy priority. 80% of RDs are genetic and present at birth, affecting...
A functional genomics pipeline for genetic discovery in diabetic kidney disease
Diabetes is responsible for a large proportion of chronic kidney disease (CKD), end-stage kidney disease (ESKD), blindness, amputation, heart disease and stroke. Tight glycemic control in type 1 diabetes (T1D) or type 2 diabetes (T2D) can delay or arrest the progression of microvascular complications. How hyperglycemia...
Multi-markers risk assessment of kidney sensitivity to injury to personalize prevention of acute kidney injury "SpareKid"
Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). The cost of AKI is very high and...
Early Detection and Intervention for Cerebral Palsy (EDI4CP).
Public and Patient Involvement (PPI) in research is a key focus of our active award, the HRB Irish Network for Children’s Clinical Trials (In4kids). We are now seeking KTA funding for a 0.6FTE PPI coordinator dedicated to our Cerebral Palsy (CP) Research programme in the network. This is a new national programme that will be rolled out...
Co-creation of a cookery book - pathways to making changes in diet
Personalized nutrition is based on the idea that individualizing nutritional advice will be more effective than more generic approaches. Studies are showing successful outcomes by applying such methods. Our group has been involved in several human intervention studies where dietary advice is given to participants based on their...
Medication without harm: Building a network and knowledge exchange programme.
The World Health Organisation (WHO) has a Global Patient Safety Challenge: ‘Medication Without Harm’ which aims to reduce worldwide harm associated with medications by half over 5 years. Medication-related harm includes medication incidents, errors, adverse drug reactions (ADRs; harmful responses to medicine) and adverse drug events...
PARKIE: Parkinson's community Awareness of Research; emphasis on Knowledge and Information Exchange.
Our lab is studying the role of our immune system in the development of Parkinson's. Our immune system protects the body against attacks from viruses and bacteria but, when we look at blood samples of people with Parkinson's, we can see they have an increased amount of one immune cell type, namely a type of T-cell called Th17 cells. In...
Art4Knowledge – Art Therapy for Knowledge Exchange between UCC CTG patients with cancer, their families, and clinical trials teams.
Art4Knowledge expands on efforts of the HRB-funded UCC Cancer Trials Group (UCC CTG), which provides access via clinical trials to cutting edge treatments and supportive care for patients with cancer in the South of Ireland. UCC CTG connects UCC research teams with clinical trials units in Cork University Hospital, University Hospital...
Psychosis in the Theatre
This project is about enhancing our public patient involvement (PPI) activities within our Clinical Doctoral Award (CDA) programme by using the Arts to give voice to and tell the story of the collective of people who are affected by psychosis. Our CDA, PSI-STAR (Psychosis Ireland Structured Training and Research Programme) includes...
Taking a World Cafe approach to improving understanding of psychosis and establishing a psychosis research PPI network
The primary aim of this project is to establish a psychosis research PPI network in Ireland. This will be done via a process of meaningful engagement and dialogue with people with lived experience of psychosis and other individuals and organisations with an interest in psychosis.
Specifically, we propose to host a series of...
Clinical trials: what are they and why are they important.
Randomised trials are an important research design and can provide reliable and robust evidence on the benefits, harms and costs of health care. Substantial public and charitable funding is allocated to clinical trials every year. However, there are concerns that much of this is wasted.1 The reasons for such waste include inadequate...
National Patient Education and Research Engagement Programme.
Inflammation is a critical process in fighting infection. However, if uncontrolled, it can contribute to the development of autoimmune disease, including inflammatory forms of arthritis, which cause joint destruction and disability. Medicines available for patients with RA have improved a lot over the last 15-years, however a...
Better Osteoarthritis Care: Delivering education and training for primary care health professionals in Ireland.
Osteoarthritis is the most common form of arthritis in Ireland. It is a condition of the joints that can cause pain, reduce mobility and result in poorer quality of life. It is more common in people over the age of 50 and often affects the knee and hip joints. To ensure that people with osteoarthritis receive ideal care, it is...
Developing an online platform to promote oral health among the Cystic Fibrosis community.
This KTA will be used in order to disseminate findings from our research into the oral health of people with Cystic Fibrosis (PWCF). We seek to provide information and education to two groups of people: 1. PWCF and parents/guardians of PWCF, and 2. Oral Healthcare Professionals.
We will engage with patient advocates from...
Integrated Knowledge Translation for Advanced Therapies: From Bench to Bedside.
The value of clinical research is to improve treatment outcomes for patients and to inform health policy. However, the knowledge gained from research only translates into impact for patients when new therapies become used as part of routine practice.
Advanced therapy medicinal products (ATMPs) are...
HD-knowhow.
A rare disease is a health condition that affects a small number of people compared with other prevalent diseases in the general population. Empirical research shows that patients with severe illnesses prefer the physician to dominate decision processes and provide the information needed. However, in rare diseases, due to the low...
Translating knowledge into care to enhance sensory-cognitive health of people in longterm care in Ireland
This Knowledge Translation (KT) project will convert our research into practice to improve sensory-cognitive health in residents with dementia (RwD) in nursing homes in Ireland. We are currently conducting a pilot clinical trial (‘SENSE-Cog Residential Care’) to evaluate whether enhancing sensory health (i.e. hearing/vision) in...
FUTURE-VASC
This project, FUTURE-VASC, aims to share knowledge from a research study called FAIRVASC, so that more people can benefit beyond the life of the original award. FAIRVASC has united scientists, clinicians and patients across Europe in a common goal of linking together data from several vasculitis registries (databases) to create one...
Building Circles of Support for people with intellectual disabilities.
The overall aim of the project is to use research information to develop resources to enhance the Circles of Support (COS) for adults with intellectual disabilities that can be used in person-centred planning processes. Person-centred planning puts the individual with intellectual disability at the centre of the process, and builds...
Translating the tailoring process to improve the implementation of diabetes care.
Our application supports the CUSTOMISE project funded by a HRB Research Leader Award. Our project which is looking at how to implement effective programmes in the health service in a way that is acceptable and practical for health professionals and service users. One such programme is the DAFNE self-management programme for adults with...
Educating the Irish Public on Genomics
The exploration of the human genome is one of the defining medical ethical issues of our time. It has both the potential to improve and save countless human lives, but doesn’t come without risk. As genomics enters the Irish public's eye, there is a recognised need for efforts to educate the public here in Ireland about the...
Pandemic Resilience- translating knowledge for improved future pandemic preparedness.
Since 2015, the HRB-Irish Critical Care-Clinical Trials Network has established a research program in preparation for pandemics. As part of this, we assessed the barriers and developed solutions to conducting research during a future global pandemic. This work led to a coordinated Irish and global response to COVID-19 with a programme...
TAME-Translation: Translating the TAME cardiac arrest trial results to public, policy, clinicians and researchers.
People who survive sudden out-of-hospital cardiac arrest (OHCA) usually require intensive care unit (ICU) treatment. The ‘TAME’ cardiac arrest trial, co-led by the Irish Critical Care-Clinical Trials Network (ICC-CTN), has just completed, including 1700 ICU patients from Ireland and 17 countries worldwide. TAME looked at a novel...
CURRENT-KTA | Recurrent Miscarriage: evaluating CURRENT services-Knowledge Translation Acceleration.
Through this RE:CURRENT-KTA application we aim to work with knowledge users to raise awareness, share knowledge, and facilitate practice change to maximise the impact of the RE:CURRENT (Recurrent miscarriage: evaluating CURRENT services) Project and provide more effective healthcare services for people with recurrent miscarriage. We...
Tip of the iceberg: highlighting the long term health consequences of polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is a chronic health condition that affects up to 15% of all women. It is characterised by increased blood levels of hormones called androgens (such as testosterone), alongside irregular periods and multiple follicles on the ovaries on ultrasound. PCOS has traditionally been perceived as a purely...
The Ignition study: Sharing stories to improve the experience of transition for young people with cerebral palsy
Cerebral palsy (CP) is a common cause of disability among children. All people with CP have a physical impairment. About 30% use a wheelchair and some children also have difficulties hearing, seeing and speaking. Children with CP are transferred from children’s health services to adult services at age 18. This can be challenging as...
Enhancing Testicular Awareness and Self-Examination Among Gay Men: Campaign Co-Design and Delivery Using the World Café Methodology.
Purpose
To design and deliver a community-based campaign to promote testicular awareness and self-examination among gay men.
Importance
In comparison to straight men, gay men are more likely to report a cancer diagnosis including testicular cancer, the most common...
Co-design and co-adaptation of a trustworthy online resource for healthcare professionals and people with chronic hip and knee pain in Ireland
Long-term, painful conditions of the hip and knee joint are common in Ireland. Yet, many patients sit on waiting lists for months or years, even when specialist opinions are not needed. In the meantime, pain gets worse, affecting ability to live, work and be fully active. Expert knowledge on how to exercise with these conditions and...
Teaching & Learning Trauma Informed Care for Health Settings.
While most people have experienced some form of psychological trauma at some point in their life, severe psychological trauma is particularly common in people who are socially excluded (i.e., through homelessness, addiction, poverty, incarceration and/or belonging to minority ethnic groups). Accessing healthcare in hospitals for those...
Retinal Dystrophy in Ciliopathies (RDCilia): modelling patient mutations to decipher disease mechanisms, interpret Variants of Uncertain Significance, and uncover therapeutics
Retinal dystrophies (RD) are inherited disorders characterised by degeneration of light sensing retinal cells (photoreceptors). Affecting approximately 2 million people worldwide, RD causes chronic and gradual sight loss. A major research issue is that RD is rarely investigated in the context of the gene mutations found in patients....
Long non-coding RNAs: regulators of epileptogenesis and potential targets for therapy
Temporal lobe epilepsy is the most common type of epilepsy in adults, with seizures being the major symptom although individuals with this disease may also have anxiety, depression and/or memory disturbances as a result of their condition. Temporal lobe epilepsy is very difficult to treat and about 30% of individuals with this type of...
Hepato-Flame: Studying the interaction of diet, obesity, microbial translocation and inflammatory pathways in hepatobiliary cancer development: A European prospective cohort study
In many world regions including Ireland, the incidence of liver cancer and nearby cancers of the biliary tract (together termed hepatobiliary cancers) is rising steadily, and these deadly cancers have limited available treatments. Increasing rates may be linked to obesity and other components of unhealthy lifestyles which cause...
Neutrophil Plasticity in Infection and Inflammation
Neutrophils make up 40-60% of all white blood cells. They arrive as the first cell type wherever viral, bacterial, or fungal infections occur, or when tissue damage and injury happen. In severe and longer lasting incidents neutrophil numbers go up due to increased release from the bone marrow. Neutrophils detect, swallow up and destroy...
A realist process evaluation of an intervention to promote competencies in interprofessional collaboration among interdisciplinary integrated care teams for older people
Government policy in Ireland recognises the importance for older people to live well in their homes and their communities. This means that the right healthcare is available for older people and their family carers in their communities as and when they need it. The government have a plan to develop healthcare teams called Integrated...
PRedicting Onset, Variation and Effect of treatment in Rheumatoid Arthritis (PROVE-RA)
Rheumatoid arthritis (RA) is a common, autoimmune disease affecting synovial joints that may result in cartilage damage, joint destruction, and disability. Treatments available for patients with RA have improved a lot over the last two decades with the result that many patients will go into remission. However, a significant number of...
Discovering and modulating mechanisms by which Peptidylglycine alpha-Amidating Monooxygenase (PAM) influences the risk of genetically inherited tissue damage in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a disease in which the immune system attacks the body and affects around 50,000 people in Ireland. This results in swollen and painful joints, which can be severely debilitating. The underlying cause is a mixture of nature (genetics) and nurture (environment). The genetic site rs26232 has been found to be...
Exploring enablers & barriers to community-based & community-led LGBTQI+ Healthcare
While many aspects of life for Lesbian, Gay, Bisexual, Trans, Queer & Intersex individuals & communities have notably improved through shifting societal attitudes & legislative reform; significant health inequalities remain for these groups, & LGBTQI+ people are often invisible in healthcare research & service...
"Euro Public Health + Consortium: reaching the future through research partnerships"
"Dublin 2023: First joint Euro Public Health + Consortium research seminar: reaching the future through research partnerships":
The European Public Health Plus program is an intercultural, multidisciplinary master's degree in public health delivered by eight European universities (EHESP School of Public Health, Andalusian...
Neurodevelopmental ciliopathies: a multimodel approach from molecular mechanisms to patients variant interpretation and treatment strategies "NDCil"
Nervous system malformation and neurodevelopmental defects (ND) are common hallmark features of genetically inherited diseases called ciliopathies. All ciliopathies are caused by abnormalities in tiny hair-like extensions called primary cilia (Cil), which are found on the surface of most cell types, including neuronal and glial cells....
Using single-cell RNA-sequencing to rationally model inflammatory skin disease
Rapidly advancing single-cell genomic methodology can give biologists unprecedented resolution in the study of cell types and states in tissues, such as the different epithelial cells (EC) of the skin. I wish to employ it to address an unmet clinical need in the chronic inflammatory skin condition hidradenitis suppurativa (HS) where EC...
Exploring the factors and mechanisms involved in the delivery of healthcare and support programs to people with dementia from diverse cultural and linguistic backgrounds
The management of dementia among immigrant populations is considered a global public health priority. Dementia interferes with the brain and older age is the strongest risk factor. The migration experience has been associated with specific stressors that can lead to poor health outcomes. In the United States dementia affects an...
UCD Clinical Research Centre
No summary available
Uncovering the neural architecture underlying decisions abstracted from movements
Decision making is a core component of normal and abnormal cognitive function. Understanding the neural mechanisms of decision-making will lead to advances in the diagnosis, classification and future treatments of disorders affecting thought and control. Mathematical models of the decision process, based on bounded evidence...
Randomised controlled trial of reduced versus standard volume platelet transfusion in preterm babies with thrombocytopenia (with add-on studies to explore mechanisms of harm)
Platelets are cells which help blood clot but they also have other effects such as directing pathways of inflammation. Premature babies often have low platelets, particularly if they have an infection or bowel inflammation. Doctors give platelet transfusions because they think that this prevents bleeding but there is no evidence...
European Blood Pressure Intensive Control after Stroke-Pilot trial (EPICS-Pilot)
Stroke is the second leading cause of death, the leading cause of new disability and a major contributing cause of dementia and healthcare costs in the world. About one-third of recovered stroke survivors will have second stroke or heart attack by 5 years. High blood pressure (hypertension) is the leading treatable condition...
Randomised Placebo-Controlled Trial of Early Targeted Treatment of Patent Ductus Arteriosus with Paracetamol in Extremely Low Birth Weight Infants
Patent Ductus Arteriosus (PDA) is common in newborn infants, especially premature infants. During pregnancy, the Ductus Arteriosus is an open channel between the two main blood vessels coming from the baby's heart. After birth it usually closes during the first few days. For very premature babies it may take longer to close, or may not...
Building research capacity, harnessing data and strengthening health systems to improve outcomes in community emergency & unscheduled care in Ireland
This research project aims to improve systems of community emergency care by focusing on a condition called Out-of-Hospital Cardiac Arrest (OHCA). OHCA is an emergency where a person’s heart suddenly stops pumping blood around the body. It happens without warning, often because of an abnormal heart rhythm. In Ireland 2500 people suffer...
Hip fracture outcome recording and geographic equality
Hip fracture is a serious event in the lives of older people with around one in five individuals dying in the first year after their injury and many more losing their independence. Currently in Ireland, little is known about how people recover in the longer-term after hip fracture and many do not receive routine follow-up. In the last...
Plasma-based therapies for bone infection
Orthopaedic infection is life-threatening and current treatments are only sparingly successful. Despite aggressive peri-operative antibiotic treatments, 1.5% of knee revisions, 0.7 to 11.9%, of spinal infections (depending on the complexity of the procedure) and up to 27% of open fractures become infected. Moreover, the complexity of...
Food-based biomarkers, diet quality and cardiometabolic health
Accurate assessment of human diet is the cornerstone of nutritional epidemiology. Biomarkers that are sensitive and specific to food intake can provide objective information that improves the characterization of diet. Advances in metabolomic profiling techniques now permit the discovery of novel food biomarkers, although, thus far,...
Embedding collective leadership to foster collaborative inter-professional working in the care of older people (Eclectic)
Recent government policy in Ireland has emphasised the importance of supporting older people to live well in their homes and communities. This would mean fewer older people will have to go to hospitals to receive health care. In order to do this it is necessary for healthcare professionals to work as a team to manage the care of...
Evaluation of the clinical, psychological and economic effects of the Cystic Fibrosis Newborn Screening Programme: the Irish Comparative Outcomes Study of CF (ICOS) Part 2
This is a national programme of research which addresses key outcomes in the recently established Cystic Fibrosis (CF) Newborn Screening programme (NBS). Ireland has the highest prevalence of CF worldwide. NBS for CF was introduced in 2011. The Irish Comparative Outcome Study (ICOS) Part I was conducted in 2013-2017 and studied...
Switching on the light: Reprogramming T cell metabolism for novel HIV Cure interventions
With 37 millions people currently living with HIV and 2.6 million people newly infected worldwide, the AIDS pandemic is a global health crisis. In Ireland, the HSE and the HSPC have made HIV/AIDS "a notifiable disease and a major public health importance". 30 years of intense HIV/AIDS research have provided efficient antiretroviral...
Prediction of radiation toxicity in prostate cancer patients using Raman spectroscopy
There are no tests currently available to predict an individual patient's response to radiotherapy. Some patients experience severe long term side effects months and even years after their treatment has finished and these effects can be permanent. For example, some prostate cancer patients develop life-changing bowel and urinary...
NK cell RESTORE - Can GLP-1 therapy restore tumour immunity in severely obese patients?
Obesity has recently over taken smoking as the number one cause of preventable deaths worldwide. This is because obesity causes many serious diseases such as heart disease and cancer. Recent reports suggest that up to 50% of all cancers are now due to obesity. Obesity is linked to cancer through many avenues from inflammation, hormonal...
COIchine for prevention of Vascular Inflammation in Non-CardioEmbolic stoke- a randomised clinical trial of low-dose colchicine for secondary prevention of Stroke. European and Canadian extension
Inflammation of the lining of arteries is an important factor contributing to clots,leading to heart attacks and strokes.Current studies are testing medicines traditionally used for inflammation of joints (arthritis) to prevent strokes and heart attacks. One such clinical trial has shown that an anti-inflammatory drug used for...
A prospective, multicentre, randomised, double-blind placebo-controlled, phase III trial of EPOetin alfa vs, placebo in critically ill TRAUMA patients
Trauma-a major public health problem
Trauma is a global health problem with estimates of more than five million deaths per year (WHO). Trauma includes road traffic accidents, falls, assaults and crush injuries. Patients who suffer major trauma are often critically ill and require breathing support. Despite...
The GENIE fellowship: Gauging the Effectiveness of Novel computer-support technologies for Implementing Evidence in healthcare
Healthcare professionals must keep pace with a rapidly growing knowledge base. By 2020, the quantity of medical evidence is expected to double every 73 days. Typically, healthcare professionals leverage 'systematic review' articles to tackle this issue. A systematic review is a consolidated summary of evidence that healthcare...
The APART Study Public Participation Initiative for Knowledge Exchange
The APART Study is exploring an important, low-cost intervention that may limit bone loss associated with initiation of antiretroviral therapy to treat HIV. Results from this trial may have significant implications for how HIV is managed both in Ireland and internationally. We will use this KEDS award to develop a research partnership...
TeamTalk: Interactive Resource Hub for Healthcare Teams
Healthcare teams who are interested in improving how they work together to deliver better patient care often struggle to find the time to learn and implement new practices. Teams rarely have the opportunity to attend training courses or other learning events together. This makes it difficult to transfer their newly acquired knowledge...
Access to primary and emergency care for children with intellectual disabilities: utilisation, decision making, parental preferences and disparities
The aim of this research is to learn about the inequalities faced by children with intellectual disabilities (ID) in Ireland in relation to healthcare and to find out the reasons why these inequalities occur. In many other countries around the world, children with ID do not receive the same standard of healthcare as children without...
Multi-Domain Lifestyle Targets for Improving ProgNOsis in Huntington?s Disease
Huntington?s Disease (HD) is a progressive, life-limiting neurodegenerative disease. It has devastating consequences for the individual and their families. No current treatment to modify the course of the disease exists. Improved evidence-based symptom assessment is crucial to optimising disease management. This project aims to...
How can a multi-disciplinary prescribing strategy support appropriate prescribing of oral nutritional supplements (ONS) by Irish general practitioners (GPs)?
Malnutrition is a major burden to the Irish health service as malnourished patients have poorer health and are more expensive to treat than patients who are well-nourished. The annual cost of healthcare associated with malnutrition is approximately €1.4 billion in Ireland (10% of our total healthcare budget). Oral nutritional...
Cancer Prevention Fellowship 2018
Research Programme for mid-career researchers working in Republic of Ireland (RoI) to become NCI Cancer Prevention Fellows at the prestigious National Cancer Institute (NCI) in the USA.
This programme provides training at post-doctorate level from the health professions, biomedical, and behavioural sciences to become leaders in the...How can mental health services and primary care best collaborate to enhance physical health outcomes among patients presenting with first episode of psychosis? A mixed methods study
For people who experience a first episode psychosis, this is a critical event in their life. If they do not receive the appropriate treatment at an early stage of the illness, they will experience potentially serious health consequences - both physical and mental. Good collaboration between specialist mental health services and primary...
Family carer knowledge exchange project
We are interested in how family carers of people with dementia develop and maintain resilience in the care giving role and we are designing a project to help family carers to be more resilient and to better cope with the demands of care giving. As a team of researchers, we have reviewed studies of family carers'experiences in other...
Non-motor symptoms in dystonia and musician's dystonia
Our multidisciplinary Irish Dystonia Research Group, combining the expertise of Bioengineers in Trinity College Dublin and a network of Clinical Neurologists, has been working to determine the cause of a disabling movement disorder, adult onset dystonia, characterised by abnormal postures and excessive muscle activity. The causes of...
Speaking Up About Safety (SUAS)
Speaking up about safety concerns is an important aspect of a healthcare professional's role. Our research has shown that in comparison to nurses, junior doctors are particularly poor at speaking up and tend not to report incidents and adverse events, in many cases because they believe it is not their responsibility to do so. Yet, a...
Targeting adipose tissue inflammation by intermittent hypoxia: towards personalised medicine in obstructive sleep apnoea
Obstructive sleep apnoea (OSA) is a very frequent condition, which is strongly linked with obesity and associated with the development of various heart conditions, such as high blood pressure, heart attack or stroke. It also leads to diseases which are associated with abnormalities in blood glucose levels, such as type 2 diabetes...
Alpha melanocyte stimulatory hormone and improvements in glucose tolerance in humans: Role of enhanced skeletal muscle glucose uptake and utilisation
Patients with diabetes show significant impairements in the control of blood levels of nutrients such as sugars and fats after eating. This causes excessive levels of nutrient to circulate (e.g. high blood sugar-hyperglycaemia) and over time this phenomenon can injure cells and tissues of the body resulting in complications such as...
Targeting HIV persistent reservoirs: Evaluation of new classes of latency reversing agent as part of novel strategies for HIV cure approaches
With 37 millions people currently living with HIV and 2.6 million people newly infected worldwide, the AIDS pandemic is a global health crisis. In Ireland, the HSE and the HSPC have made HIV/AIDS "a notifiable disease and a major public health importance". 30 years of intense HIV/AIDS research have provided efficient antiretroviral...
Gastric cancer risk: The influence of selenium status and selenoprotein genetic variation
Dietary and lifestyle factors and infection with the bacterium Helicobacter pylori play important roles in the development of different types of stomach (gastric) cancer (GC), one of the top ten most serious cancers in Europe. Selenium is a micronutrient needed in small amounts for important proteins, called selenoproteins, countering...
Skin in Parkinson's disease - a potential biomarker?
Parkinsonism is characterized by slowness, stiffness, tremor and poor balance. Parkinson's disease (PD) is a progressive, incurable neurological disease and the most common cause of Parkinsonism. PD is caused by a reduced level of a chemical (dopamine) in an area of the brain responsible for automatic movement control. Current...
Epigenetics in the pathogenesis of pseudoexfoliation glaucoma
Glaucoma is a common cause of blindness, which affects approximately 60 million people worldwide. There are many causes and risk factors for developing this disease but pseudoexfoliation (PXF) syndrome is currently the single most important identifiable risk factor for developing glaucoma (PXFG). A build up of certain proteins...
PPI Ignite Award - University College Dublin
UCD in collaboration with 10 partner organisations will develop a PPI network and resource platform called UCD PPI Ignite Connect that will seek to firmly embed patient and public involvement in UCD's research,learning and teaching activities and in its academic processes. The partner organisations include the Ireland East Hospital...
Children's unscheduled primary and emergency care in Ireland: decision making, trends, outcomes and parental perspectives (CUPID)
The Irish healthcare system is partly publicly funded by government spending and partly privately funded by out-of-pocket payments and private health insurance. Universal healthcare coverage is a situation where all people who need health services receive them, without undue financial hardship, based on need, not income. In 2011 the...
Colchine for prevention of vascular inflammation in non-cardioembolic stroke (CONVINCE) - a randomised clinical trial of low-dose colchicine for secondary prevention of stroke. Northern Europe extension
Inflammation of the lining of arteries is an important factor contributing to clots, leading to heart attacks and strokes. Current studies are testing medicines traditionally used for inflammation of joints (arthritis) to prevent strokes and heart attacks. CONVINCE is a clinical trial, testing colchicine in low doses, a medicine used...
Promoting Assisted Decision Making in Acute Care Settings (PADMACS) for care planning purposes
This project aims to produce an educational interactive game which will support health and social care professionals working in acute hospitals to include their patients in decisions about treatment and care plans. Decision-making capacity is the ability to make decisions for one-self. In some cases an older person may experience...
Targeted therapeutic mild hypercapnia after resuscitated cardiac arrest: A phase III multi-centre randomised controlled trial
A cardiac arrest occurs when the heart stops pumping blood to the brain and other major organs. Approximately 10,000 people die from cardiovascular disease every year in Ireland. It is estimated that 5,000 of these deaths are from a sudden cardiac arrest. Early resuscitation (CPR) can get the heart pumping again but in many cases the...