TAME-Translation: Translating the TAME cardiac arrest trial results to public, policy, clinicians and researchers.

People who survive sudden out-of-hospital cardiac arrest (OHCA) usually require intensive care unit (ICU) treatment. The ‘TAME’ cardiac arrest trial, co-led by the Irish Critical Care-Clinical Trials Network (ICC-CTN), has just completed, including 1700 ICU patients from Ireland and 17 countries worldwide. TAME looked at a novel intervention of facilitating slightly higher carbon dioxide levels (‘hypercapnia’) to reduce brain injury (due to lack of oxygen) which occurs after an OHCA. Right now, the trial data trial is being analysed and we are preparing to present the results (2022/2023). It is essential that these important results, which will significantly influence patient treatment (whether hypercapnia is beneficial or not), are properly translated to all stakeholders (patients, public, policymakers, bedside clinicians/healthcare providers, clinician-researchers). We propose ‘TAME-Translation’ a programme of knowledge translation activities aimed at widely disseminating TAME, enhancing ‘translation’ of results into clinical practice/healthcare policy, public/patient knowledge and future research directions.

TAME-Translation will incorporate a varied knowledge translation (KT) strategy. A major highlight will be the results presentation at Critical Care Reviews 2023- an in-person (500 delegates) and live-streamed (>50 countries, >2000 viewers) interactive global meeting with a diverse audience including research funders, healthcare policymakers, patients/public and bedside-clinicians. Alongside this, we will host an OHCA stakeholder session at our ICC-CTN Summer meeting to specifically inform/involve knowledge users including PPI, supporting the development of a European OHCA KT partnership to continue to inform optimal trial conduct and dissemination practice. Our KT strategy will include a multimedia platform to disseminate/translate results including public-facing documents, Department of Health policy brief, website/social media and press releases. As part of TAME we collected biological samples in collaboration with another large OHCA trial (‘TTM2’). We will develop data and sample access plans for dissemination, and to prime future knowledge translation. Our stakeholders will inform this strategy at all stages.

Award Date
12 September 2022
Award Value
Principal Investigator
Professor Alistair Nichol
Host Institution
University College Dublin
Knowledge Translation Awards