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AIIHPC Structured Research Network APA Cycle 2 2019 Applied Partnership Awards Applying Research into Policy & Practice Postdoctoral Fellowships ARPP 2020 Cancer Prevention Fellowship Programme Cancer Prevention Fellowship Programme Reintegration Grant Capacity Building for Evidence Synthesis Clinical Research Facilities/Centres 2021 Cochrane Training Fellowships Collaborative Doctoral Awards Conference and Event Sponsorship Scheme COVID-19 2020 CSF 2020 DIFA - 2018 DIFA 2017 DIFA 2018 DIFA 2020 DIFA-2018 Doctoral Training Programme in Precision Medicine in Cancer Emerging Clinician Scientist Awards 2020 Emerging Investigator Awards Emerging Investigator Awards 2022 ERA-NET Cofund for Neuroscience Research (NEURON) ERA-NET Cofund for Personalised Medicine Framework for Safe Nurse Staffing and Skill Mix Fulbright-HRB Health Impact Awards Health Research Awards HRB Clinical Research Facilities HRB Collaboration in Ireland for Clinical Effectiveness Reviews HRB Postdoctoral Fellowships: ARPP 2023 HRB Postdoctoral Fellowships: CSF 2023 HRB Trials Methodology Research Network HRCI 2020 HRCI-HRB Joint Funding Scheme ICORG Statistics and Data Management Interdisciplinary Capacity Enhancement Awards Investigator Led Projects IPPOSI 2020 Irish Clinical Oncology Research Group Irish Platform for Patients Organisations Science and Industry Support Award Joint Programming Initiative Healthy Diet for a Healthy Life Joint Programming Initiative in Neurodegenerative Diseases Joint Programming Initiative on Antimicrobial Resistance Knowledge Exchange and Dissemination Scheme Knowledge Translation Awards Medical Research Charities Group Support Award MRCG-HRB Joint Funding Scheme National Children's Hospital Foundation Scheme National Clinical Trials Coordination Programme National integrated PhD programme for Medical Practitioners National Intellectual Disability Supplement to TILDA Patrick Quinn Awards for Parkinson's Research PPI Ignite Awards Project Development Grants Rare Diseases Research and Innovation Catalyst Awards (RDCat) 2023 RCQPS COVID-19 Research Collaborative for Quality and Patient Safety Research Collaborative in Quality and Patient Safety Research Training Fellowships for Healthcare Professionals RL FA 2020 RL PA 2020 Secondary Data Analysis Projects SFI-HRB-Wellcome Research Partnership Structured PhD Programme in Population Health and Health Services Research The Irish Longitudinal Study on Ageing Ulysses Research Visits US-Ireland R&D Partnership Awards WHO-SOLI-2020
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Host Institution
Atlantic Technological University DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Family Carers Ireland Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Katholieke Universiteit Leuven Limerick Institute of Technology Maynooth University Medical Research Charities Group Ltd National University of Ireland Galway National University of Ireland, Galway Our Lady's Hospice Queen’s University Belfast RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford UPMC Whitfield
Funding Awarded
56 awards
All-Island – US National Cancer Institute Joint Doctoral Training Programme in Precision - Cancer Medicine
Proposal: A unique Doctoral Training Programme (DTP) in Precision Cancer Medicine (PCM), involving tripartite collaboration between research-intensive institutions with a major focus on cancer in Northern Ireland (NI) and Republic of Ireland (RoI), in partnership with the US National Cancer Institute...
An investigation of the long-term impact of hypertensive disorders of pregnancy on maternal health, and exploration of optimal models of follow-up care for affected women in Ireland.
Hypertensive disorders of pregnancy (HDP) affect 18 million women annually. It is increasingly recognised that HDP are associated with increased risk of maternal cardiovascular and renal disease. Less is known about the risk of other chronic diseases, particularly those which emerge in older age, such as dementia, retinal vascular...
DEFINED: DEtermining Falls burden to INform carE Delivery
Background
Falls in later life are the most frequent reason for older people to present to acute care, and significantly increase the likelihood of adverse health outcomes. Many falls are potentially preventable however, with comprehensive falls care reducing the rate of further falls by 20%....
Improving public health through better implementation of alcohol policy: A multi-method study examining and addressing the factors influencing successful implementation
Background: Alcohol consumption places an enormous burden on society, causing over 200 disease and injury conditions globally. In Ireland, at least four deaths every day are caused by alcohol, which is key a target area of the Healthy Ireland Framework. The
Rare Disease Research Catalyst Consortium
Rare diseases each affect less than 5 in 10000 people, with about 300,000 Irish people estimated to be living with rare disease. Under the Cross Border Directive for access to healthcare, the European Union established 24 European Reference Networks (ERNs) for rare disease to enable equity of access to healthcare across...
RESTRICT - REducing intentional overdose: a mixed methods STudy of means RestrICTion interventions
Suicide and self-harm are serious public health problems, impacting significantly on individuals, families, communities, and health systems. Intentional drug overdose is the most common form of hospital-presenting self-harm and is a frequent method of suicide. Means restriction is an evidence informed measure to prevent suicide and...
Cerebral Palsy – The Adolescent Growth Evaluation Study (CP-AGE)
Background: Cerebral Palsy (CP) is the most common cause of long-term childhood disability. In Ireland, ~110 children with CP are born annually with approximately 70% being able to walk with or without aids. Some children with CP will experience a decline in walking related function through adolescence...
Artificial Intelligence approach to improving blood pressure treatment
Hypertension is the leading cause of premature death worldwide, but the prevalence of hypertension control remains low. Physician capacity (number of physician clinic visits available for hypertension care) is a critical rate-limiting, determinant of hypertension control resulting in a major care-gap in hypertension management in all...
Expecting the unexpected: can viral metagenomics enhance optimised standard diagnostic pathways for detection of imported pathogens?
Background
Current testing practices for imported fever syndromes in Ireland are heterogenous and suboptimal, prolonging clinical care and limiting data capture for early warning surveillance systems. Identifying and diagnosing aetiological pathogens for imported fever syndromes with a standardised...
Personal formularies in general practice to support safe, effective and cost-effective prescribing.
The use of personal formularies of safe, effective medicines that a prescriber is readily familiar with may enhance the quality of prescribing. Additionally, there is evidence that audit and feedback can lead to improvements in prescribing. The Drug Utilisation 90% (DU90%), (the number of medicines making up 90% of a doctor’s...
The HipCog Study: evaluating the impact of cognitive impairment on outcomes for older adults with hip fracture
Background: Over 3800 older people in Ireland experience hip fracture annually. These serious events have a one-year mortality rate of 20%. Since 2012, the Irish Hip Fracture Database (IHFD) has driven national clinical improvement and reduced variability of care across hospitals. While hospital-level care variation has decreased, it...
Targeting immunometabolism to protect children from Tuberculosis infection
Introduction
Tuberculosis is the top global infectious killer in the last decade. The neonatal period is the most susceptible time to TB infection, with increased risk of active and disseminated disease. TB treatments require months of multiple drugs and resistance to first line agents is increasing...
Identifying social determinants and mapping organisational and personal networks to enhance community support for people living with multimorbidity
Socially and economically deprived populations experience greater risk and earlier onset of multimorbidity. Healthcare services are one part of complex networks supporting people with chronic conditions. but knowledge of people’s social networks has not been used to inform and tailor chronic disease policy and programmes. Intersectoral...
Optimising the dissemination of health research in Ireland
Scientific publications have grown exponentially in recent years, contributing to an ‘infodemic’ widely seen during the Covid-19 pandemic. Public communication of scientific research can occur through individual researchers directly connecting with the public via social media or outreach events, however, many researchers struggle...
Revisiting suicide prevention in later life: human-centred approaches in an ageing Ireland
Globally, suicide is more prevalent in older adults when compared to any other age group. This is partly due to the fact that self-harm is more lethal among older adults, and this cohort has complex health conditions which influence recovery. Over the last six years, I have conducted research examining self-harm and suicidality in...
UCD’s 2nd Annual One Health Conference: Tackling Major Public Health Threats in a Post-Covid-19 World.
One health is a philosophy that acknowledges the interconnectedness of human, animal and environmental health. It recognises that to solve major challenges locally or globally, individuals or even groups of experts in one discipline can not solve them alone. It is recognized by the Irish Government, the European Union, the World Health...
Conference Event: Evidence-based approaches for innovation in patient centred care models in Ireland
The conference will focus on evidence-based approaches for embedding innovation into new models of care that are patient-centred in Ireland. Patient-centred models of care mean the patients and their carers are involved in the process planning, implementation and audit of how their illness is managed. These types of models give...
Priorities for future research on tapering psychiatric medicines: A collaborative workshop involving people with lived experience, family members, and healthcare professionals
A growing number of people with experience of mental health problems want to reduce and stop their use of psychiatric medicines, such as antidepressants and anti-anxiety tablets. There are many reasons for this ranging from side-effects to people feeling that the medicine is no longer needed. Tapering is the recommended process for...
Digital Surgery- Building a National Ecosystem
Digital surgery represents a significant step into the 21st century for surgical practice by combining technological advances in smart instruments, computer vision, artificial intelligence and cloud computing together with surgical expertise to improve patient outcomes and deliver enhanced healthcare value and outcomes. Despite still...
Measuring Outcomes of Social Prescribing
Social Prescribing (SP) is a non-medical community-based service that links people with health-promoting activities and support services in their local community. SP is usually delivered by link workers who meet with individuals to identify their activity and/or support needs. Following this, the link worker either provides information...
Creating Connections : A Dravet Syndrome Ireland - FutureNeuro Alliance
This event is being hosted on June 10th 2023, by Dravet Syndrome Ireland and the SFI FutureNeuro Research Centre for chronic and rare neurological diseases, with the support of Dublin Sports Partnership, Sports Inclusion Disability Officer (SIDO). The purpose of the event is to bring families and caregivers affected by...
Partnerships in Practice: Family Carers Ireland’s Annual Research Conference 2023
This half day event is a knowledge-exchange seminar that facilitates the exchange of learning amongst stakeholders with an interest in the caring sector. In particular, through a focus on research that Family Carers Ireland (FCI) has supported, the event demonstrates the value of partnership in practice. It will be hosted by FCI with...
Connecting Molecular Networks of Cancer to Other Diseases
In 2019, the Quantitative Biosciences Institute (QBI) at the University of California, San Francisco (UCSF) and University College Dublin (UCD) signed a 5-year agreement to i) reinforce the links between scientists in San Francisco and Ireland and ii) broaden their collaborative ability to strengthen scientific research and innovation....
European Radiation Protection Week (ERPW) 2023
European Radiation Protection Week (ERPW) is an annual, multidisciplinary, event which brings together experts and addresses current and emerging topics related to radiation protection. Under the Consortium of European Radiation Research Platforms (MEENAS Group), ERPW aims to: promote the integration and the efficiency of European...
Digital Mental Health: A shared vision for research, policy and practice
This event will bring together leading researchers, policy makers, mental health professionals, and experts-by-experience, to create a shared vision of digital mental health in Ireland. The number of digital mental health solutions is increasing, as the need for accessible mental health services becomes more urgent. It is important in...
The Science of Dementia for the Non-Scientist - An exploration of dementia and the brain
The focus of this event is to present the science of dementia to non-scientists, in order to build the understanding of the basic science of dementia. The event will be hosted by Dementia Research Network Ireland (DRNI) together with the Alzheimer Society of Ireland (ASI).
Dementia is an umbrella term for diseases of the brain...
Orthopaedics and Sports Medicine-From Research to Practice
Increased opportunity for sporting involvement in the population is a welcome development and will lead to a multitude of long term health benefits across the country. In tandem with greater participation in sport however, is an increased potential for injury.
The area of orthopedic and sports medicine is rapidly advancing, yet...
Building Connections workshop series
Building Connections workshop series
Dates: Workshops series in Autumn 2023 and a main event, An Meitheal, 21 October 2023
Venues: Venues at 3 community organisations (Dublin & Galway), An Meitheal at community venue,...Inaugral conference in Adult Safeguarding
Adult safeguarding in Ireland has been an increasing public health issue since undercover filming (Leas Cross, 2005; Aras Attracta, 2014) exposed poor care practices in residential care settings. Similar to other countries, abuse of adults in any setting continues to be recognised as a human rights issue and has both immediate and long...
8th Annual Public & Patient Involvement Summer School
Enhancing Public, Patient and Carer involvement (PPI) in health research was identified as a priority area within the HRB's Strategy 2016-2020 and reiterated in the Strategy 2021-2025. This includes a defined commitment to develop and promote PPI within the HRB and HRB-supported projects and programmes, as well as within the community...
Equity For People Living With A Rare Disease: An International Rare Disease Research Symposium
Rare disease’ (RD), refers to a collection of conditions whose signs and symptoms are heterogeneous but are grouped together due to individual low incidence rates. While individually rare, RDs are collective in society and are a significant global public health and policy priority. 80% of RDs are genetic and present at birth, affecting...
Staphylococcus Great Britain and Ireland 2023
This biannual event, which has been running for over 20 years, brings together the research community in Ireland, Northern Ireland and the UK working on all aspects of Staphylococcal Diseases. Staphylococci, including MRSA, are leading causes of bacterial infection in both hospitals and the community. New antibiotic development has not...
iPASTAR Conference - Achieving better outcomes from integrated pathways of care for acute stroke and rehabilitation
What is iPASTAR?
iPASTAR (Improving Pathways for Acute STroke And Rehabilitation) is a Structured Doctoral Training Programme funded by the HRB with four PhD scholars. The focus is to develop better care pathways from acute hospital care to rehabilitation in the community and living well after...
A functional genomics pipeline for genetic discovery in diabetic kidney disease
Diabetes is responsible for a large proportion of chronic kidney disease (CKD), end-stage kidney disease (ESKD), blindness, amputation, heart disease and stroke. Tight glycemic control in type 1 diabetes (T1D) or type 2 diabetes (T2D) can delay or arrest the progression of microvascular complications. How hyperglycemia...
HRCI Support Award
Award supporting HRCI activities.
Defining the consequences of innate immune training on protective versus pathogenic T cell responses in patients with tuberculosis.
Tuberculosis (TB) ranks alongside HIV as the world's most deadly infectious disease, killing 1.5 million people every year. It is caused by the bacteria Mycobacterium tuberculosis (Mtb), which primarily infects people's lungs. Treating this disease is becoming more difficult due to antibiotic-resistant Mtb, therefore, scientists are...
Evidence synthesis and translation of findings for national clinical guideline development: addressing the needs and preferences of guideline development groups
National clinical guidelines aim to help healthcare providers and patients' make decisions about appropriate healthcare. These guidelines use the best available evidence, gathered from national and international research, to develop recommendations on a wide range of topics. These include preventing and managing specific conditions to...
The impact of mutations in PI3K/AKT pathway gene loci on response to PI3K inhibitors
Despite advances in the treatment of breast cancer, the National Cancer Registry of Ireland reported in 2014 that it accounted for 30% of all diagnosed female cancers and 16% of all female cancer deaths. The application of modern technologies to the study of breast cancer has demonstrated that a group of cancer pathways acquire changes...
PRoviding Improved care for Self-harM: a mixed-methods study of intervention, economic and implementation outcomes from a national clinical programme
Suicide is a societal concern in Ireland and is associated with both personal and economic costs. People who self-harm are at particular risk of suicide, and so developing services and interventions for this population can help prevent deaths. Under Ireland's national strategy to reduce suicide, a programme to help people who present...
Engineering RNA-based therapeutics for treatment of sepsis and sepsis induced multiple organ dysfunction syndrome
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Worldwide it affects over 30 million people of all ages and results in 5.3 million deaths annually. In Ireland sepsis contributes to 25% of in-hospital deaths and one in five patients diagnosed with sepsis will die from this disease. To...
Comparison of staphylococcal species from the oro-nasal cavity, periodontal pockets and foot ulcers of patients with type II diabetes: a potential microbial reservoir for diabetic foot ulcer infection
The Research Collaborative in Quality and Patient Safety (RCQPS) is a collaborative initiative between the Health Research Board, the Health Service Executive, National Quality Improvement Team and the Royal College of Physicians of Ireland. It was established in 2013 to advance nationally relevant research in the area of quality and...
Investigating breast cancer risk factors to understand breast cancer epidemiological outcomes
This proposal aims to expand cancer prevention research in Ireland through the assessment of breast cancer risk factors and their influence on clinically relevant characteristics of aggressive breast cancers.Prior research has identified factors associated with increased risk of breast cancer development. One such known factor includes...
Harnessing the power of the Gut-Lung Axis: How Dietary Short-Chain Fatty Acids Balance Inflammatory Outcomes in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is an incurable lung condition triggered by smoking, or other air pollutants, that leads to long-term lung damage and serious trouble breathing. While COPD is an illness of the lungs, maintaining a healthy gut and a balanced diet can prevent COPD and reduce COPD attacks or flare-ups. But how...
SCaRLeT: Sex differences in Cardiovascular Risk across Life course Transitions
Heart disease is still the leading cause of death around the world. Preventing heart disease, by focusing on risk factors like smoking is essential for improving population health. Females and males do not experience heart disease equally. In adults, research suggests risk factors that can be changed like smoking do not have the same...
Developing a new approach to stroke rehabilitation for the upper limb based on TMS neurofeedback
Today in Ireland, most people who experience a stroke survive, but more than half are left with long-term disabilities due to paralysis of one arm. In the proposed research, we aim to push the boundaries of standard stroke rehabilitation, by introducing a technique that promises to boost the brain's recovery mechanisms, stimulating...
IMPlementation of osteoArthritis Clinical guidelines Together
Osteoarthritis is a disease of the joints, affecting 1 in 8 Irish people as they get older. Due to the growth of our ageing population amongst other reasons, this figure is expected to double within one generation. Most people with the disease in their hips or knees are likely to experience some level of pain as well as difficulty...
Development and validation of diagnostic biomarkers for neurodegenerative conditions based on MRI measures of pathognomonic brain regions
Amyotrophic Lateral Sclerosis (ALS) is a devastating, relentlessly progressive neurodegenerative condition with no effective disease-modifying therapies and no validated biomarkers. Three main themes exist in ALS biomarker research; (1) development of diagnostic indicators, (2) identification of accurate prognostic markers and (3)...
Biomarker discovery and validation in autism spectrum disorder: A study of neonatal cord blood in international birth cohorts
What is Autism? Autism spectrum disorder (ASD) is a complex disorder of brain development. ASD is characterized by difficulties in social interaction, verbal and nonverbal communication and repetitive behaviours. ASD begins in infancy and persists into adolescence and adulthood. ASD imposes significant emotional and economic burdens on...
Using Bayesian network models to predict the impact of public health interventions on disease-prevalence in population health research
Population Health Research studies determinants of health and disease with the goal of identifying interventions that promote health and reduce the burden of disease. Deciding on an appropriate intervention mandates a prior forecast of the intervention's effect on disease. For example, for an intervention targeting smoking, we might...
The Hospital Doctor Retention and Motivation (HDRM) project
Ireland is losing almost as many doctors to emigration as it trains each year. This rate of doctor emigration is a threat to the future of the health system, which may run short of doctors to staff its hospitals. So far, Ireland's solution has been to recruit doctors from other countries. One in three doctors in Ireland is from...
Targeting metabolism for individualised rectal cancer treatment: Development of an omics-led predictive signature of chemoradiation therapy response and novel neoadjuvant therapeutic strategy
Cancer of the rectum is one of the most common cancers in Ireland and worldwide. Patients with rectal cancer are commonly treated with chemoradiation therapy (CRT), which is a combination of chemotherapy and radiation therapy, to shrink the tumour before undergoing surgery to remove the tumour. CRT has been shown to improve survival...
Investigating mitochondrial dysfunction and meta-inflammation as a shared pathogenic network in pre-eclampsia and gestational diabetes mellitus
Pre-eclampsia (PE) and gestational diabetes (GDM) are two common complications of pregnancy. PE is characterised by high blood pressure and increased protein in the urine. GDM develops because the mother's body is not able to produce the extra insulin needed for pregnancy. Together, these pregnancy complications affect 15% of first...
An allostatic load framework for understanding social differences in health and mortality
A consistent finding in the epidemiological literature is that health is socially patterned. On average, individuals from more disadvantaged social backgrounds will develop diseases earlier and will die earlier compared with their more advantaged peers. So ubiquitous is the association between health and wealth that it has been...
Enhancing the evidence base for cost-effectiveness analysis in Ireland: Building improvements from the intervention-specific to system-wide levels
The objective of this research is to increase the relevance and reliability of health economic evidence in Ireland. The aim is to improve the methods for prioritising scarce health funding to the most beneficial uses. This research will translate valuable lessons learnt from cervical cancer prevention to screening for other cancers,...
The liver neighbourhood watch: regulatory tissue-resident natural killer (NK) cells protect against liver decompensation in patients with chronic liver disease
Liver cirrhosis occurs when normal liver tissue is replaced by scar tissue, leading to the eventual failure of normal liver functions. Cirrhosis develops as a result of chronic liver disease, and it accounts for 170,000 deaths annually in Europe and more than 3,000 deaths annually in Ireland. Presently the only treatment is liver...
Targeting adipose tissue inflammation by intermittent hypoxia: towards personalised medicine in obstructive sleep apnoea
Obstructive sleep apnoea (OSA) is a very frequent condition, which is strongly linked with obesity and associated with the development of various heart conditions, such as high blood pressure, heart attack or stroke. It also leads to diseases which are associated with abnormalities in blood glucose levels, such as type 2 diabetes...