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Atlantic Technological University DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Family Carers Ireland Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Katholieke Universiteit Leuven Limerick Institute of Technology Maynooth University Medical Research Charities Group Ltd National University of Ireland Galway National University of Ireland, Galway Our Lady's Hospice Queen’s University Belfast RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford UPMC Whitfield
Funding Awarded
8 awards
An investigation of the long-term impact of hypertensive disorders of pregnancy on maternal health, and exploration of optimal models of follow-up care for affected women in Ireland.
Hypertensive disorders of pregnancy (HDP) affect 18 million women annually. It is increasingly recognised that HDP are associated with increased risk of maternal cardiovascular and renal disease. Less is known about the risk of other chronic diseases, particularly those which emerge in older age, such as dementia, retinal vascular...
DEFINED: DEtermining Falls burden to INform carE Delivery
Background
Falls in later life are the most frequent reason for older people to present to acute care, and significantly increase the likelihood of adverse health outcomes. Many falls are potentially preventable however, with comprehensive falls care reducing the rate of further falls by 20%....
Cerebral Palsy – The Adolescent Growth Evaluation Study (CP-AGE)
Background: Cerebral Palsy (CP) is the most common cause of long-term childhood disability. In Ireland, ~110 children with CP are born annually with approximately 70% being able to walk with or without aids. Some children with CP will experience a decline in walking related function through adolescence...
Artificial Intelligence approach to improving blood pressure treatment
Hypertension is the leading cause of premature death worldwide, but the prevalence of hypertension control remains low. Physician capacity (number of physician clinic visits available for hypertension care) is a critical rate-limiting, determinant of hypertension control resulting in a major care-gap in hypertension management in all...
Expecting the unexpected: can viral metagenomics enhance optimised standard diagnostic pathways for detection of imported pathogens?
Background
Current testing practices for imported fever syndromes in Ireland are heterogenous and suboptimal, prolonging clinical care and limiting data capture for early warning surveillance systems. Identifying and diagnosing aetiological pathogens for imported fever syndromes with a standardised...
Personal formularies in general practice to support safe, effective and cost-effective prescribing.
The use of personal formularies of safe, effective medicines that a prescriber is readily familiar with may enhance the quality of prescribing. Additionally, there is evidence that audit and feedback can lead to improvements in prescribing. The Drug Utilisation 90% (DU90%), (the number of medicines making up 90% of a doctor’s...
Targeting immunometabolism to protect children from Tuberculosis infection
Introduction
Tuberculosis is the top global infectious killer in the last decade. The neonatal period is the most susceptible time to TB infection, with increased risk of active and disseminated disease. TB treatments require months of multiple drugs and resistance to first line agents is increasing...
Ex vivo autologous stem cell gene therapy for Multiple Sulfatase Deficiency
Multiple Sulfatase Deficiency (MSD) is an inherited lysosomal storage disorder (LSD) that predominately involves the brain, bones, and skin. The disease is due to mutations in SUMF1, a gene that provides the instructions for making an important enzyme called formylglycine generating enzyme (FGE). The FGE enzyme activates all the...