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AIIHPC Structured Research Network APA Cycle 2 2019 Applied Partnership Awards Applying Research into Policy & Practice Postdoctoral Fellowships ARPP 2020 Cancer Prevention Fellowship Programme Cancer Prevention Fellowship Programme Reintegration Grant Capacity Building for Evidence Synthesis Clinical Research Facilities/Centres 2021 Cochrane Training Fellowships Collaborative Doctoral Awards Conference and Event Sponsorship Scheme COVID-19 2020 CSF 2020 DIFA - 2018 DIFA 2017 DIFA 2018 DIFA 2020 DIFA-2018 Doctoral Training Programme in Precision Medicine in Cancer Emerging Clinician Scientist Awards 2020 Emerging Investigator Awards Emerging Investigator Awards 2022 ERA-NET Cofund for Neuroscience Research (NEURON) ERA-NET Cofund for Personalised Medicine Framework for Safe Nurse Staffing and Skill Mix Fulbright-HRB Health Impact Awards Health Research Awards HRB Clinical Research Facilities HRB Collaboration in Ireland for Clinical Effectiveness Reviews HRB Postdoctoral Fellowships: ARPP 2023 HRB Postdoctoral Fellowships: CSF 2023 HRB Trials Methodology Research Network HRCI 2020 HRCI-HRB Joint Funding Scheme ICORG Statistics and Data Management Interdisciplinary Capacity Enhancement Awards Investigator Led Projects IPPOSI 2020 Irish Clinical Oncology Research Group Irish Platform for Patients Organisations Science and Industry Support Award Joint Programming Initiative Healthy Diet for a Healthy Life Joint Programming Initiative in Neurodegenerative Diseases Joint Programming Initiative on Antimicrobial Resistance Knowledge Exchange and Dissemination Scheme Knowledge Translation Awards Medical Research Charities Group Support Award MRCG-HRB Joint Funding Scheme National Children's Hospital Foundation Scheme National Clinical Trials Coordination Programme National integrated PhD programme for Medical Practitioners National Intellectual Disability Supplement to TILDA Patrick Quinn Awards for Parkinson's Research PPI Ignite Awards Project Development Grants Rare Diseases Research and Innovation Catalyst Awards (RDCat) 2023 RCQPS COVID-19 Research Collaborative for Quality and Patient Safety Research Collaborative in Quality and Patient Safety Research Training Fellowships for Healthcare Professionals RL FA 2020 RL PA 2020 Secondary Data Analysis Projects SFI-HRB-Wellcome Research Partnership Structured PhD Programme in Population Health and Health Services Research The Irish Longitudinal Study on Ageing Ulysses Research Visits US-Ireland R&D Partnership Awards WHO-SOLI-2020
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Host Institution
Atlantic Technological University DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Family Carers Ireland Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Katholieke Universiteit Leuven Limerick Institute of Technology Maynooth University Medical Research Charities Group Ltd National University of Ireland Galway National University of Ireland, Galway Our Lady's Hospice Queen’s University Belfast RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford UPMC Whitfield
Funding Awarded
48 awards
Digital Mental Health: A shared vision for research, policy and practice
This event will bring together leading researchers, policy makers, mental health professionals, and experts-by-experience, to create a shared vision of digital mental health in Ireland. The number of digital mental health solutions is increasing, as the need for accessible mental health services becomes more urgent. It is important in...
8th Annual Public & Patient Involvement Summer School
Enhancing Public, Patient and Carer involvement (PPI) in health research was identified as a priority area within the HRB's Strategy 2016-2020 and reiterated in the Strategy 2021-2025. This includes a defined commitment to develop and promote PPI within the HRB and HRB-supported projects and programmes, as well as within the community...
Cystic Fibrosis Liver Disease (CFLD); predicting and prescribing in the era of CFTR modulators
Life expectancy for people with Cystic Fibrosis (PWCF) has improved dramatically over the last 2 decades. This improved survival has not been observed in those with CF liver disease (CFLD). In the Irish Longitudinal Study of CFLD (ILSCFLD), we found that those with CFLD had a mortality rate difference of 6.6 versus those with no liver...
Developing an innovative patient-centred xenograft model of multiple myeloma and its use in testing novel antagonists of JAM-A signalling
Multiple myeloma (MM) is an incurable cancer in which uncontrolled plasma cell proliferation disrupts the bone marrow environment and impairs immune function. With poor 5-year patient survival (<50%), better clinical models and pipelines for targeted therapies are urgently required. This proposal will focus on both. Firstly, an MSc...
Development of mRNA Vaccines for Children with High-Risk Neuroblastoma
Neuroblastoma is one of the most aggressive childhood cancers contributing to 15% of cancer related childhood deaths. At diagnosis half of the patients have a metastatic tumour and recurrence is very common. Despite advances in available therapies, children with drug-resistant and relapsed neuroblastoma have a dismal outlook with...
A pain and wound management approach for RDEB patients via a functionalized collagen-based hydrogel dressing with controlled release of painkillers
Patients with Epidermolysis Bullosa (EB) have a broad spectrum of need for pain and wound treatment, varying with the type of EB, the severity within that type, and the particular physical, emotional, and psychological milieu of each individual. EB research has advanced considerably in the past decade and wound and pain management have...
Co-design and co-adaptation of a trustworthy online resource for healthcare professionals and people with chronic hip and knee pain in Ireland
Long-term, painful conditions of the hip and knee joint are common in Ireland. Yet, many patients sit on waiting lists for months or years, even when specialist opinions are not needed. In the meantime, pain gets worse, affecting ability to live, work and be fully active. Expert knowledge on how to exercise with these conditions and...
Ex vivo autologous stem cell gene therapy for Multiple Sulfatase Deficiency
Multiple Sulfatase Deficiency (MSD) is an inherited lysosomal storage disorder (LSD) that predominately involves the brain, bones, and skin. The disease is due to mutations in SUMF1, a gene that provides the instructions for making an important enzyme called formylglycine generating enzyme (FGE). The FGE enzyme activates all the...
Surgery, radiotherapy, chemotherapy, but now what? Exploring the rehabilitation needs of people with brain tumours in Ireland
In Ireland, about 480 people are diagnosed with primary brain tumours every year. Many more people develop secondary brain tumours arising from other cancers. Brain tumours can shorten life span and cause many problems including muscle weakness, speech difficulties, loss of mobility and independence, difficulties thinking and...
Retinal Dystrophy in Ciliopathies (RDCilia): modelling patient mutations to decipher disease mechanisms, interpret Variants of Uncertain Significance, and uncover therapeutics
Retinal dystrophies (RD) are inherited disorders characterised by degeneration of light sensing retinal cells (photoreceptors). Affecting approximately 2 million people worldwide, RD causes chronic and gradual sight loss. A major research issue is that RD is rarely investigated in the context of the gene mutations found in patients....
Long non-coding RNAs: regulators of epileptogenesis and potential targets for therapy
Temporal lobe epilepsy is the most common type of epilepsy in adults, with seizures being the major symptom although individuals with this disease may also have anxiety, depression and/or memory disturbances as a result of their condition. Temporal lobe epilepsy is very difficult to treat and about 30% of individuals with this type of...
Predicting and monitoring outcomes in Autoimmune Encephalitis (POTA)
Epilepsy is a disorder of the brain in which people have repeated seizures.
Autoimmune encephalitis (AE) is a rare cause of epilepsy. It is an inflammatory disease of the brain. This means that the body’s own immune system attacks healthy brain tissue, just like it would if it were infected by a virus or a bacteria, by...
Combining HDAC6 inhibitors with KRAS inhibitors for the treatment of Non-Small Cell Lung Cancer (NSCLC)
In Europe lung cancer is the second most common cancer in men and the third most common cancer in women. Globally, lung cancer contributes to more cancer deaths than any other type of cancer. While we have witnessed some improvements for lung cancer patients, the outcomes and treatment options for the majority remains poor. One...
Pathways to Improving Transition to Adult Services & Enhancing Self-Management in Adolescents with Cystic Fibrosis: A New Era of Treatments
The teenage years are a time of change. Being an adolescent with Cystic Fibrosis (CF) can bring additional challenges due to complex and demanding treatments. A key task for teenagers with CF is to learn the skills to manage their health, as they prepare to transition into adult-based care. In Ireland, many adolescents transition to...
Evaluation of a novel drug combination treatment for nephropathic cystinosis in a new cystinotic rat model.
Cystinosis is a rare disease that results in the build-up of cystine in all cells of the body. Cystine is a protein building block and normally the excess is moved out of cells. In cystinosis the transporter for cystine does not work and cystine builds up inside the cells and forms crystals which cause damage to all organs and...
Investigating the potential of CTNS-mRNA loaded nanoparticles as a new therapeutic strategy for nephropathic cystinosis.
Cystinosis is a rare disease that results in the build-up of cystine in all cells of the body. Cystine is a building block of proteins and normally the excess is moved out of cells. In cystinosis, the transporter for cystine is deficient and cystine builds up inside cells. It forms crystals which cause damage and eventually...
Participation in physical activity: what really matters to adolescents with physical disability?
Being physically active is hugely important for health. It improves physical and mental wellbeing and reduces the risk of health problems in adulthood. Young people with physical disability, especially adolescents, do less physical activity than their peers. We want to learn more about how we can support adolescents with physical...
Sustaining activity with arthritis (SAWA) following an Arthritis Ireland Be active with arthritis (BAWA) exercise programme
Best practice guidelines across the world always recommend those living with arthritis to be physically active. Research shows that being active can help people living with arthritis to do the things that they want to do for longer, reduce pain, improve quality of life and protect against getting other health conditions such as heart...
Counting the cost: The contribution of older carers in Ireland and impact of caring on mental health and wellbeing of carers
Family caring plays an essential role in Ireland’s health system, but it does place social, financial, physical, and emotional demands on carers. Caring by older people has been shown to have benefits for health and longevity when providing lower numbers of hours of care. Less is known about why some carers seem to manage better than...
The design and psychometric evaluation of a health-related quality-of-life outcome measure (QoLTEN) for adults with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are devastating conditions with a sudden onset. Patients are catapulted into a rapid and unexpected form of acute skin failure with a significant risk to their life. They become critically ill within a short period of time and are treated as a medical emergency with the...
Patient-led development of a “Patient Reported Outcomes” instrument to improve health-related quality of life in patients with Glomerular Disease – PRO-GD
Glomerular diseases (GDs) are rare kidney diseases that damage kidney filters (glomeruli) and can result in kidney failure, hospitalisation, and death. Glomerular diseases also affect health-related quality of life (HRQOL), including reduced ability to participate in normal life, fear or anxiety about the future, low mood, or eroded...
Development of a Core Outcome Set for research studies with older adults in the Emergency Department
The number of people over the age of 65 is increasing. This change in the population will continue to put pressure on healthcare services including Emergency Services into the coming decades as older adults are most frequent Emergency Department (ED) attendees.
Older adults are at risk of health decline and functional decline...
An investigation into the prevalence and experience of psychopathology and mental disorders among children and adolescents with cerebral palsy
Cerebral palsy (CP) is the most common cause of physical disability in childhood. Most people with CP live well into adulthood. Although CP primarily affects a person’s ability to sit or move, many people with CP report experiencing mental health problems. Children and adolescents with CP who experience mental health problems are more...
Advanced, automated compound screening for the identification of therapeutic agents in Multiple Sulfatase Deficiency.
Multiple Sulfatase Deficiency (MSD) is an extremely rare, fatal, yet untreatable condition. It is caused by the inherited deficiency of an enzyme (called FGE) that activates a whole family of 17 other cellular enzymes named sulfatases. Sulfatases are indispensable for the degradation of a subset of intracellular molecules. Thus,...
The Past, Present and Future of our Emergency Medical Services: Consultation on the Implementation of a National Research Strategy for Paramedicine in Ireland
Context:
Pre-hospital care traditionally refers to emergency medical care administered to ill or injured patients by paramedics, prior to transportation by ambulance to a medical facility. Internationally, Emergency Medical Services (EMS) have evolved to treat and referral models and paramedicine is moving towards a future of...
Migrant health research networking and knowledge exchange seminar: An arts based event
People have always migrated for a variety of reasons, to seek work, education and to seek protection from conflict, natural disasters and persecution. While Ireland has a long history of emigration, since the early 2000s the trend has changed and there are more migrants coming into Ireland than before. Therefore gaining greater...
7th Annual Public & Patient Involvement Summer School
Enhancing Public, Patient and Carer involvement (PPI) in health research was identified as a priority area within the HRB's Strategy 2016-2020 and reiterated in the Strategy 2021-2025. This includes a defined commitment to develop and promote PPI within the HRB and HRB-supported projects and programmes, as well as within the community...
Moving policy evaluation forward: A workshop on how to identify the ‘best buys’ in public policy for the promotion of physical activity and healthy nutrition.
Over the last 3 years, researchers and policy-makers in food and physical activity have been working together to establish the Policy Evaluation Network (PEN). PEN aims to evaluate policy measures to promote a healthy diet and physical activity of the population in terms of their content, implementation and effectiveness.
By...
Clinical Trial Feasibility Award - University of Limerick
No summary available
MinDful: Music aNd Dance For Older adULts: The Feasibility of an Arts-Based Health Intervention for Health and Wellbeing
Ireland has an ageing population. Many older adults in Ireland have a chronic condition, low levels of physical activity and experience loneliness and social isolation. Additionally, approximately a third of adults over 65 years of age fall each year. Additionally, the unprecedented consequences of the coronavirus (COVID-19) pandemic,...
Exercise therapy for degenerative meniscal tears in the primary care - a feasibility cluster randomised controlled trial
Knee pain due to a degenerative meniscal tear is a common joint condition seen in Irish orthopaedic clinics. Changes to the knee joint and meniscus (cartilage within the knee that helps cushion the joint) occur normally with age but can become painful in some middle-aged adults. Exercise is recommended as the main treatment to aid...
Towards an integrated model of care for older adults transitioning from the Emergency Department to the community
Worldwide increases in life expectancy are leading to the rapid ageing of populations. By 2031, it is forecasted that there will be more than one million older adults in Ireland, representing 20% of our overall population. It is widely accepted that older adults frequently avail of health services in the community and in the hospital...
Disparities in Heath Outcomes of Chronic Kidney Disease between Men and Women in the Irish Health System
It is increasingly recognised that there are differences between men and women in regard to chronic kidney disease (CKD). It appears to be more common in women and they have a shorter survival compared to women in the general population. It is unclear 1) whether these differences are due to biological factors like hormones or due to...
Transitions of Care in Advanced Chronic Kidney Disease
Patients who suffer from advanced chronic kidney disease (CKD) are at risk of progressing to kidney failure which is associated with a shortened life span and significant disability. The transition from advanced CKD to kidney failure requiring renal replacement therapy (RRT) [dialysis, kidney transplantation or conservative therapy] is...
IMPlementation of osteoArthritis Clinical guidelines Together
Osteoarthritis is a disease of the joints, affecting 1 in 8 Irish people as they get older. Due to the growth of our ageing population amongst other reasons, this figure is expected to double within one generation. Most people with the disease in their hips or knees are likely to experience some level of pain as well as difficulty...
Development and evaluation of an adaptive mobile health physical activity intervention post-stroke: a Sequential Multiple Assignment Randomised Trial
Despite recent advances in acute stroke intervention, strategies to prevent recurrent stroke are lacking. This is of urgent importance for people with stroke who are at risk of having another stroke. Physical activity (PA) is the second-largest predictor of stroke and the cornerstone of secondary prevention therapies. Interventions...
A Physiotherapist led intervention to Promote Physical Activity in Rheumatoid Arthritis- a pilot study
As a long-term chronic condition, Rheumatoid arthritis (RA) can have a significant long-term impact. Typically presenting as a disease that causes joint pain and swelling, excessive tiredness and difficulty doing everyday activities RA occurs usually in people over 40 and is three times more likely in women than men. There has been...
Health and social inequalities in the Mid-West
As there are many disadvantaged areas in the Mid-West, health and social inequalities are important issues locally. This is because deprivation is linked with poor health and poor access to healthcare. Under the Healthy Ireland Framework, taking actions to address health inequalities is a key priority. In the Mid-West, many...
Collecting and using data about ethnicity in healthcare -a drama
Ireland has a long history of emigration. More recently, we have inward migration. Census 2016 found that 17% of the population were born outside Ireland. This means that there are different minority ethnic groups in our country, in addition the Irish Travellers. The Health Service Executive wants to gather information on the ethnic...
Maximising collaboration to expedite positive change in the assessment process that determines physiotherapy students' readiness for independent practice
Assessment of student physiotherapists in the clinical environment is a critical part of their education which determines their readiness for independent clinical practice once qualified. Therefore it has significant implications for patient safety and quality of service delivery. Yet, research and experience highlight many challenges...
Autophagy induction as a novel therapeutic strategy for MSD
The lysosomal degradation pathway of autophagy has a crucial role in different pathophysiological conditions, such as infection, neurodegenerative disorders, cancer and ageing. In particular, autophagy plays an important role in the pathophysiology of a family of inborn errors of metabolism due to defect in the activity of lysosomal...
I-PARC (Ireland’s Physical Activity Research Collaboration): Bridging the research to action gap to support the implementation of the National Physical Activity Plan
The purpose of this research is to develop a bespoke research collaboration ‘I-PARC’ (Irish – Physical Activity Research Collaboration) to support Get Ireland Active! the National Physical Activity Plan (NPAP)1. I-PARC will bring together researchers, policy makers and practitioners from physical activity (PA) to establish how best to...
Implementing evidence based guidance for dementia palliative care through participatory action research
Dementia is a progressive illness and as the condition progresses into the later stages, the person will have difficulty communicating their needs particularly in relation to thirst, hunger, pain or discomfort. In Ireland persons with dementia are often cared for in Long Term Care (LTC) settings. Carers of persons with dementia...
Implementing evidence based guidance for dementia palliative care through participatory action research
Dementia is a progressive illness and as the condition progresses into the later stages, the person will have difficulty communicating their needs particularly in relation to thirst, hunger, pain or discomfort. In Ireland persons with dementia are often cared for in Long Term Care (LTC) settings. Carers of persons with dementia can...
OPTI-MEND: Optimising early assessment and intervention by health and social care professionals in the emergency department (ED)
Emergency Departments (ED) face significant challenges in delivering high quality and timely patient care against a background of increasing patient numbers and limited hospital resources. A mismatch between patient demand and the hospital's capacity often leads to poor patient flow and ED crowding, resulting in a reduction in the...
PPI Ignite Award - University of Limerick
PPI Ignite at the University of Limerick will serve as a rallying point within the university and the wider community it serves, to build capacity for research conducted "with" or "by" patients and members of the public rather than "to", "about" or "for" them. PPI Ignite UL will accomplish this among a coalition of academic,...
Cancer Prevention Fellowship 2017
Research Programme for mid-career researchers working in Republic of Ireland (RoI) to become NCI Cancer Prevention Fellows at the prestigious National Cancer Institute (NCI) in the USA.
This programme provides training at post-doctorate level from the health professions, biomedical, and behavioural sciences to become...
The utility of high-tech drug analysis to the decision maker
The Health (Pricing and Supply) Act 2013 stipulates that the payer must consider the cost-effectiveness (the likelihood that the drug will offer value for money) and the likely cost impact of a new drug prior to deciding if it should be reimbursed. It also states that, after a 3-5 year period, continued reimbursement must be reviewed....