Filter By:
- Year
-
Scheme
AIIHPC Structured Research Network APA Cycle 2 2019 Applied Partnership Awards Applying Research into Policy & Practice Postdoctoral Fellowships ARPP 2020 Cancer Prevention Fellowship Programme Cancer Prevention Fellowship Programme Reintegration Grant Capacity Building for Evidence Synthesis Clinical Research Facilities/Centres 2021 Cochrane Training Fellowships Collaborative Doctoral Awards Conference and Event Sponsorship Scheme COVID-19 2020 CSF 2020 DIFA - 2018 DIFA 2017 DIFA 2018 DIFA 2020 DIFA-2018 Doctoral Training Programme in Precision Medicine in Cancer Emerging Clinician Scientist Awards 2020 Emerging Investigator Awards Emerging Investigator Awards 2022 ERA-NET Cofund for Neuroscience Research (NEURON) ERA-NET Cofund for Personalised Medicine Framework for Safe Nurse Staffing and Skill Mix Fulbright-HRB Health Impact Awards Health Research Awards HRB Clinical Research Facilities HRB Collaboration in Ireland for Clinical Effectiveness Reviews HRB Postdoctoral Fellowships: ARPP 2023 HRB Postdoctoral Fellowships: CSF 2023 HRB Trials Methodology Research Network HRCI 2020 HRCI-HRB Joint Funding Scheme ICORG Statistics and Data Management Interdisciplinary Capacity Enhancement Awards Investigator Led Projects IPPOSI 2020 Irish Clinical Oncology Research Group Irish Platform for Patients Organisations Science and Industry Support Award Joint Programming Initiative Healthy Diet for a Healthy Life Joint Programming Initiative in Neurodegenerative Diseases Joint Programming Initiative on Antimicrobial Resistance Knowledge Exchange and Dissemination Scheme Knowledge Translation Awards Medical Research Charities Group Support Award MRCG-HRB Joint Funding Scheme National Children's Hospital Foundation Scheme National Clinical Trials Coordination Programme National integrated PhD programme for Medical Practitioners National Intellectual Disability Supplement to TILDA Patrick Quinn Awards for Parkinson's Research PPI Ignite Awards Project Development Grants Rare Diseases Research and Innovation Catalyst Awards (RDCat) 2023 RCQPS COVID-19 Research Collaborative for Quality and Patient Safety Research Collaborative in Quality and Patient Safety Research Training Fellowships for Healthcare Professionals RL FA 2020 RL PA 2020 Secondary Data Analysis Projects SFI-HRB-Wellcome Research Partnership Structured PhD Programme in Population Health and Health Services Research The Irish Longitudinal Study on Ageing Ulysses Research Visits US-Ireland R&D Partnership Awards WHO-SOLI-2020
-
Host Institution
Atlantic Technological University DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Family Carers Ireland Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Katholieke Universiteit Leuven Limerick Institute of Technology Maynooth University Medical Research Charities Group Ltd National University of Ireland Galway National University of Ireland, Galway Our Lady's Hospice Queen’s University Belfast RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford UPMC Whitfield
Funding Awarded
22 awards
Ongoing examination of the PD-1:PD-L1 pathway throughout the evolution of Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic autoimmune disease which causes joint destruction, disability, and increased mortality. While treatment has improved, only 1:4 patients achieve full remission and predicting who will develop severe disease or who will respond to treatment is difficult. This research will examine an immune pathway...
Polyfunctional-T "" stromal cell crosstalk in the joint of patients with inflammatory arthritis
Over a million people in Ireland alone, with inflammatory arthritis and other autoimmune diseases know only too well the frustration of the trial-and-error approach in finding the right treatment. In many cases this entails enduring chronic pain over several years, before a successful drug is stumbled upon. Therefore, there are areas...
Development of a gene activated construct targeting proinflammatory signalling to promote zonal regeneration of osteoarthritic cartilage
Cartilage is a specialised, layered tissue that coats the end of bones, facilitating low friction movement of the joints and providing cushioning from impacts. When cartilage is injured or degenerates, due to diseases such as osteoarthritis, these functions are impaired, causing inflammation, pain and significantly impacting quality of...
Identifying gut microbiome-responsive brain biomarkers of cognitive impairments relevant to schizophrenia: A next-generation functional CNS circuit mapping approach
Ireland has among the highest rates of mental illness in Europe. Schizophrenia is the leading psychiatric diagnosis nationally. Schizophrenia patients have problems remembering their past, are unable for social interactions and cannot hold on to information long enough to use it. Scientists have found that gut microbes can affect our...
A Standardised Approach to Measuring Infant Feeding Outcomes to Prevent Childhood Obesity
Approximately one in five children currently experience obesity worldwide, making it a major public health challenge. What, how and when children are fed in the first year of life ("infant-feeding") contributes to childhood obesity risk. However, strategies, including interventions to prevent childhood obesity by targeting...
Cortical and Spinal Connectivity of Motor Units as a novel biomarker of Amyotrophic Lateral Sclerosis pathology
One in every 400 in Ireland is at risk of developing Motor Neurone Disease during their lifetime, with Ireland having the highest overall incidence of Amyotrophic lateral sclerosis (ALS) in Europe. ALS is a nervous system disease that causes a gradual loss of muscle control. It is characterised by the death of motor neurons, which are...
Co-producing actionable knowledge to strengthen cultural humility in Irish mental health services
Research tells us that ethnic minority populations experience mental health difficulties at an unequal rate compared to the general population and experience great difficulties getting their mental healthcare needs met. Human rights law and mental health policy state that everyone must get their mental healthcare needs met. People have...
Development of a Health Impact Assessment (HIA) Implementation Model: Enhancing Intersectoral Approaches in Tackling Health Inequalities
Public health research has shown that our health and wellbeing are affected by the circumstances into which we are born, grow, live, work and age. These circumstances are generally described as the social determinants of health. We know that incorporating a health focus drawing on the social determinants of health across all publicly...
Interrogating the role of miRNA in predicting responses to novel modulator therapies in children with Cystic Fibrosis
Cystic Fibrosis (CF) is a hereditary condition effecting over 80.000 people worldwide with the highest incidence occurring amongst the Irish population. There is no cure for CF however the arrival of a new era of medication that can correct Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) mutations, the basic defect that...
Autophagy induction as a novel therapeutic strategy for MSD
The lysosomal degradation pathway of autophagy has a crucial role in different pathophysiological conditions, such as infection, neurodegenerative disorders, cancer and ageing. In particular, autophagy plays an important role in the pathophysiology of a family of inborn errors of metabolism due to defect in the activity of lysosomal...
The microbiome as an environmental trigger for autoimmune epilepsy (MICA)
Autoimmune epilepsy is a rare form of drug-resistant epilepsy characterised by frequent seizures in later life. Patients may respond to immune therapy, but causation of disease is poorly understood, and more targeted treatments are required. This gap in knowledge is the major priority for epilepsy specialists, and the area of greatest...
Elucidation of the role of SARM1 in retinal homeostasis and oxidative stress induced retinal degeneration
Photoreceptor cells found in the back of our eyes convert light into signals that allow us to see. Death of these cells and the cells that nourish them, called RPE cells, is termed retinal degeneration and is characteristic of blinding diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa. Millions of people...
Towards novel anti-infective with enhanced wound-healing for diabetic foot infections : Co2 releasing star shaped micro biocidal polymers
It is estimated that 422 million people worldwide are living with diabetes and among them, a common and serious problem is the development of diabetic foot infection. One in five patients with diabetes are hospitalised with a diabetic foot wound (DFW) at least once in their lives. Infected DFWs are treated by removal of infected tissue...
Combining Electrochemotherapy with a Toll Like receptor agonist for the treatment of lung cancer
Successful cancer treatment aims to totally eliminate the entire tumour and the risk of recurrence. Treatment currently relies on removal of the primary tumour by surgery or radiotherapy followed by control of the remaining dispersed cancer cells in the whole body usually by chemotherapy. At the Cork Cancer Research Centre (CCRC) we...
Preoperative Exercise to Improve Fitness in Patients Undergoing Complex Surgery for Cancer of the Lung or Oesophagus
Treatment for people with cancer of the lung or the oesophagus (food-pipe) often involves surgery. This surgery is complex and there is a high risk that patients will develop severe complications afterwards, mainly lung or heart problems, leading to a longer hospital stay and higher hospital costs, and impacting greatly on recovery and...
Evaluation of the role of MxA and ISGylation in chemosensitivity in oesophageal cancer
Many oesophageal cancers develop resistance to the drugs currently used to treat this disease. This allows the cancer cells to survive and the cancer can come back again at variable times after the initial treatment. Research already performed by this group has identified genetic differences between cancer cells that respond well to...
Incorporation of sensor technology to provide clinical meaningfulness for existing standardised measurement scales in Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) also known as Motor Neurone Disease (MND) is a progressive and ultimately fatal neurodegenerative disease for which there is no cure. People with ALS experience loss of mobility and arm function, breathlessness and chest infections, loss of speech and swallow and in 30-50%, cognitive and behavioural...
Novel Neurophysical Biomarkers of Heterogeneous Network Degeneration in Motor Neuron Disease for Quantifying the Progression and Outcome in Clinical Trials
Motor Neurone Disease (MND)/Amyotrophic Lateral Sclerosis (ALS) is a terminal neurological condition in which the neurones (neural cells) that control movement degenerate. Despite encouraging results from studies in animals, translation of new treatments to humans has been disappointing. The aim of this study is to provide scientific...
Evaluating a novel macrolide based early intervention in the clinical management of chronic infections and inflammation in Cystic Fibrosis
Chronic persistent respiratory disease is a leading cause of death worldwide. Despite years of global research, the clinical management of respiratory disease, including the life-limiting genetic disease cystic fibrosis (CF), remains a significant challenge. Treatment options are extremely limited, due in part to the increased pathogen...
Gold-drug: Targeting a novel dual inhibitor drug with gold nanoparticles for improving radiation response in oesophageal cancer
Oesophageal cancer (cancer of the food pipe) has low survival rates and a very poor response to treatment. Sadly, this cancer type is on the rise in Ireland and is linked with increasing obesity rates. Unlike many other cancer types, we are still only using treatments that have existed for decades - chemotherapy drugs with radiation...
The role of sialylated-alpha-1 antitrypsin in resolution of acute and chronic inflammation
Alpha-1-antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that results in the rapid progression of lung disease, especially in smokers. Specific treatment for this disorder is available in the form of weekly intravenous injections of AAT. This is referred to as augmentation therapy and studies have shown that augmentation...
Compound library screening in a zebrafish model of MSD to identify novel therapeutic compounds
Multiple Sulfatase Deficiency (MSD) is currently an untreatable disease and while we know some of the processes inside cells that cause or influence the disease, there is still much to be understood. While progress has been made from studying simple cell culture systems, this does not tell us about how different disease changes may...