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Atlantic Technological University DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Family Carers Ireland Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Katholieke Universiteit Leuven Limerick Institute of Technology Maynooth University Medical Research Charities Group Ltd National University of Ireland Galway National University of Ireland, Galway Our Lady's Hospice Queen’s University Belfast RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford UPMC Whitfield
Funding Awarded
33 awards
Cystic Fibrosis Liver Disease (CFLD); predicting and prescribing in the era of CFTR modulators
Life expectancy for people with Cystic Fibrosis (PWCF) has improved dramatically over the last 2 decades. This improved survival has not been observed in those with CF liver disease (CFLD). In the Irish Longitudinal Study of CFLD (ILSCFLD), we found that those with CFLD had a mortality rate difference of 6.6 versus those with no liver...
Developing an innovative patient-centred xenograft model of multiple myeloma and its use in testing novel antagonists of JAM-A signalling
Multiple myeloma (MM) is an incurable cancer in which uncontrolled plasma cell proliferation disrupts the bone marrow environment and impairs immune function. With poor 5-year patient survival (<50%), better clinical models and pipelines for targeted therapies are urgently required. This proposal will focus on both. Firstly, an MSc...
Development of mRNA Vaccines for Children with High-Risk Neuroblastoma
Neuroblastoma is one of the most aggressive childhood cancers contributing to 15% of cancer related childhood deaths. At diagnosis half of the patients have a metastatic tumour and recurrence is very common. Despite advances in available therapies, children with drug-resistant and relapsed neuroblastoma have a dismal outlook with...
A pain and wound management approach for RDEB patients via a functionalized collagen-based hydrogel dressing with controlled release of painkillers
Patients with Epidermolysis Bullosa (EB) have a broad spectrum of need for pain and wound treatment, varying with the type of EB, the severity within that type, and the particular physical, emotional, and psychological milieu of each individual. EB research has advanced considerably in the past decade and wound and pain management have...
Ex vivo autologous stem cell gene therapy for Multiple Sulfatase Deficiency
Multiple Sulfatase Deficiency (MSD) is an inherited lysosomal storage disorder (LSD) that predominately involves the brain, bones, and skin. The disease is due to mutations in SUMF1, a gene that provides the instructions for making an important enzyme called formylglycine generating enzyme (FGE). The FGE enzyme activates all the...
Surgery, radiotherapy, chemotherapy, but now what? Exploring the rehabilitation needs of people with brain tumours in Ireland
In Ireland, about 480 people are diagnosed with primary brain tumours every year. Many more people develop secondary brain tumours arising from other cancers. Brain tumours can shorten life span and cause many problems including muscle weakness, speech difficulties, loss of mobility and independence, difficulties thinking and...
Retinal Dystrophy in Ciliopathies (RDCilia): modelling patient mutations to decipher disease mechanisms, interpret Variants of Uncertain Significance, and uncover therapeutics
Retinal dystrophies (RD) are inherited disorders characterised by degeneration of light sensing retinal cells (photoreceptors). Affecting approximately 2 million people worldwide, RD causes chronic and gradual sight loss. A major research issue is that RD is rarely investigated in the context of the gene mutations found in patients....
Long non-coding RNAs: regulators of epileptogenesis and potential targets for therapy
Temporal lobe epilepsy is the most common type of epilepsy in adults, with seizures being the major symptom although individuals with this disease may also have anxiety, depression and/or memory disturbances as a result of their condition. Temporal lobe epilepsy is very difficult to treat and about 30% of individuals with this type of...
Predicting and monitoring outcomes in Autoimmune Encephalitis (POTA)
Epilepsy is a disorder of the brain in which people have repeated seizures.
Autoimmune encephalitis (AE) is a rare cause of epilepsy. It is an inflammatory disease of the brain. This means that the body’s own immune system attacks healthy brain tissue, just like it would if it were infected by a virus or a bacteria, by...
Combining HDAC6 inhibitors with KRAS inhibitors for the treatment of Non-Small Cell Lung Cancer (NSCLC)
In Europe lung cancer is the second most common cancer in men and the third most common cancer in women. Globally, lung cancer contributes to more cancer deaths than any other type of cancer. While we have witnessed some improvements for lung cancer patients, the outcomes and treatment options for the majority remains poor. One...
Pathways to Improving Transition to Adult Services & Enhancing Self-Management in Adolescents with Cystic Fibrosis: A New Era of Treatments
The teenage years are a time of change. Being an adolescent with Cystic Fibrosis (CF) can bring additional challenges due to complex and demanding treatments. A key task for teenagers with CF is to learn the skills to manage their health, as they prepare to transition into adult-based care. In Ireland, many adolescents transition to...
Evaluation of a novel drug combination treatment for nephropathic cystinosis in a new cystinotic rat model.
Cystinosis is a rare disease that results in the build-up of cystine in all cells of the body. Cystine is a protein building block and normally the excess is moved out of cells. In cystinosis the transporter for cystine does not work and cystine builds up inside the cells and forms crystals which cause damage to all organs and...
Investigating the potential of CTNS-mRNA loaded nanoparticles as a new therapeutic strategy for nephropathic cystinosis.
Cystinosis is a rare disease that results in the build-up of cystine in all cells of the body. Cystine is a building block of proteins and normally the excess is moved out of cells. In cystinosis, the transporter for cystine is deficient and cystine builds up inside cells. It forms crystals which cause damage and eventually...
Participation in physical activity: what really matters to adolescents with physical disability?
Being physically active is hugely important for health. It improves physical and mental wellbeing and reduces the risk of health problems in adulthood. Young people with physical disability, especially adolescents, do less physical activity than their peers. We want to learn more about how we can support adolescents with physical...
Sustaining activity with arthritis (SAWA) following an Arthritis Ireland Be active with arthritis (BAWA) exercise programme
Best practice guidelines across the world always recommend those living with arthritis to be physically active. Research shows that being active can help people living with arthritis to do the things that they want to do for longer, reduce pain, improve quality of life and protect against getting other health conditions such as heart...
Counting the cost: The contribution of older carers in Ireland and impact of caring on mental health and wellbeing of carers
Family caring plays an essential role in Ireland’s health system, but it does place social, financial, physical, and emotional demands on carers. Caring by older people has been shown to have benefits for health and longevity when providing lower numbers of hours of care. Less is known about why some carers seem to manage better than...
Patient-led development of a “Patient Reported Outcomes” instrument to improve health-related quality of life in patients with Glomerular Disease – PRO-GD
Glomerular diseases (GDs) are rare kidney diseases that damage kidney filters (glomeruli) and can result in kidney failure, hospitalisation, and death. Glomerular diseases also affect health-related quality of life (HRQOL), including reduced ability to participate in normal life, fear or anxiety about the future, low mood, or eroded...
An investigation into the prevalence and experience of psychopathology and mental disorders among children and adolescents with cerebral palsy
Cerebral palsy (CP) is the most common cause of physical disability in childhood. Most people with CP live well into adulthood. Although CP primarily affects a person’s ability to sit or move, many people with CP report experiencing mental health problems. Children and adolescents with CP who experience mental health problems are more...
Advanced, automated compound screening for the identification of therapeutic agents in Multiple Sulfatase Deficiency.
Multiple Sulfatase Deficiency (MSD) is an extremely rare, fatal, yet untreatable condition. It is caused by the inherited deficiency of an enzyme (called FGE) that activates a whole family of 17 other cellular enzymes named sulfatases. Sulfatases are indispensable for the degradation of a subset of intracellular molecules. Thus,...
Computational evaluation of morphologic tumour tissue features as diagnostic and prognostic predictors of lung cancer
Co-funded with Irish Cancer Society
Autophagy induction as a novel therapeutic strategy for MSD
The lysosomal degradation pathway of autophagy has a crucial role in different pathophysiological conditions, such as infection, neurodegenerative disorders, cancer and ageing. In particular, autophagy plays an important role in the pathophysiology of a family of inborn errors of metabolism due to defect in the activity of lysosomal...
The microbiome as an environmental trigger for autoimmune epilepsy (MICA)
Autoimmune epilepsy is a rare form of drug-resistant epilepsy characterised by frequent seizures in later life. Patients may respond to immune therapy, but causation of disease is poorly understood, and more targeted treatments are required. This gap in knowledge is the major priority for epilepsy specialists, and the area of greatest...
Elucidation of the role of SARM1 in retinal homeostasis and oxidative stress induced retinal degeneration
Photoreceptor cells found in the back of our eyes convert light into signals that allow us to see. Death of these cells and the cells that nourish them, called RPE cells, is termed retinal degeneration and is characteristic of blinding diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa. Millions of people...
Towards novel anti-infective with enhanced wound-healing for diabetic foot infections : Co2 releasing star shaped micro biocidal polymers
It is estimated that 422 million people worldwide are living with diabetes and among them, a common and serious problem is the development of diabetic foot infection. One in five patients with diabetes are hospitalised with a diabetic foot wound (DFW) at least once in their lives. Infected DFWs are treated by removal of infected tissue...
Combining Electrochemotherapy with a Toll Like receptor agonist for the treatment of lung cancer
Successful cancer treatment aims to totally eliminate the entire tumour and the risk of recurrence. Treatment currently relies on removal of the primary tumour by surgery or radiotherapy followed by control of the remaining dispersed cancer cells in the whole body usually by chemotherapy. At the Cork Cancer Research Centre (CCRC) we...
Preoperative Exercise to Improve Fitness in Patients Undergoing Complex Surgery for Cancer of the Lung or Oesophagus
Treatment for people with cancer of the lung or the oesophagus (food-pipe) often involves surgery. This surgery is complex and there is a high risk that patients will develop severe complications afterwards, mainly lung or heart problems, leading to a longer hospital stay and higher hospital costs, and impacting greatly on recovery and...
Evaluation of the role of MxA and ISGylation in chemosensitivity in oesophageal cancer
Many oesophageal cancers develop resistance to the drugs currently used to treat this disease. This allows the cancer cells to survive and the cancer can come back again at variable times after the initial treatment. Research already performed by this group has identified genetic differences between cancer cells that respond well to...
Incorporation of sensor technology to provide clinical meaningfulness for existing standardised measurement scales in Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) also known as Motor Neurone Disease (MND) is a progressive and ultimately fatal neurodegenerative disease for which there is no cure. People with ALS experience loss of mobility and arm function, breathlessness and chest infections, loss of speech and swallow and in 30-50%, cognitive and behavioural...
Novel Neurophysical Biomarkers of Heterogeneous Network Degeneration in Motor Neuron Disease for Quantifying the Progression and Outcome in Clinical Trials
Motor Neurone Disease (MND)/Amyotrophic Lateral Sclerosis (ALS) is a terminal neurological condition in which the neurones (neural cells) that control movement degenerate. Despite encouraging results from studies in animals, translation of new treatments to humans has been disappointing. The aim of this study is to provide scientific...
Evaluating a novel macrolide based early intervention in the clinical management of chronic infections and inflammation in Cystic Fibrosis
Chronic persistent respiratory disease is a leading cause of death worldwide. Despite years of global research, the clinical management of respiratory disease, including the life-limiting genetic disease cystic fibrosis (CF), remains a significant challenge. Treatment options are extremely limited, due in part to the increased pathogen...
Gold-drug: Targeting a novel dual inhibitor drug with gold nanoparticles for improving radiation response in oesophageal cancer
Oesophageal cancer (cancer of the food pipe) has low survival rates and a very poor response to treatment. Sadly, this cancer type is on the rise in Ireland and is linked with increasing obesity rates. Unlike many other cancer types, we are still only using treatments that have existed for decades - chemotherapy drugs with radiation...
The role of sialylated-alpha-1 antitrypsin in resolution of acute and chronic inflammation
Alpha-1-antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that results in the rapid progression of lung disease, especially in smokers. Specific treatment for this disorder is available in the form of weekly intravenous injections of AAT. This is referred to as augmentation therapy and studies have shown that augmentation...
Compound library screening in a zebrafish model of MSD to identify novel therapeutic compounds
Multiple Sulfatase Deficiency (MSD) is currently an untreatable disease and while we know some of the processes inside cells that cause or influence the disease, there is still much to be understood. While progress has been made from studying simple cell culture systems, this does not tell us about how different disease changes may...