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Funding Awarded

17 awards

  • Ancient genomics and the Atlantic burden

    WT Scheme: Investigator Award in Science.

    Massive human genome resequencing projects are in train to further the understanding of the genetic contributions to disease. However these offer a limited view of genome genealogies, variant history and past selection, all of which are instrument to the models underpinning genomic...

  • Staphylococcus aureus induced immunosuppressive memory: Consequences for bug and for host

    WT Scheme: Investigator Award in Science.

    Antimicrobial resistance by Staphylococcus aureus is a global epidemic. New approaches based on induction of immune responses that control/prevent S. aureus infection, are required. This necessitates a thorough understanding of the unique relationship cultivated by S. aureus with...

  • Irish clinical academic training (ICAT) Programme

    WT Scheme: PhD Programme for Clinicians

    Ireland's ongoing economic recovery represents a unique opportunity to effect fundamental change in academic medicine that can have lasting societal benefits. We have designed a comprehensive National Programme for Clinician Scientists based at six major Irish universities. Our...

  • Institutional Strategic Support Fund (ISSF)

    These funds will be used to grow and enhance a connected programme of health-related Research, Teaching and Public Engagement in Trinity College. Specific activities will include: (a) seed research support to early stage academics; (b) a programme to stimulate strategic international collaboration and: (c) the creation of a truly...

  • Institutional Strategic Support Fund (ISSF)

    The Wellcome Trust ISSF scheme will help UCD's researchers to overcome systemic barriers to career and network development that will unlock future research potential within the University and beyond. The fund will support outstanding research in biomedical sciences, clinical sciences and the medical humanities that will enable UCD to...

  • Uncovering the role of ER-shaping proteins in neurodegenerative disease

    WT Scheme: Seed Award in Science

    Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders characterised by degeneration of the longest motor neurons which leads to muscle weakness and spasticity in the lower limbs. There are currently no treatments to cure or even to slow the course ofthese...

  • Identifying Interventions to prevent and manage chronic kidney disease

    WT Scheme: Postdoctoral Training Fellowships for Clinicians

    Chronic kidney disease (CKD) affects almost 500million people worldwide is increasingly prevalent,associated with morbidity and mortality, and interventions (dialysis or transplant) are expensive and unavailable in some regions. Developing programs to reduce CKD...

  • Determining the mechanism of action of a novel histone deacetylase 6 specific inhibitor that kills chemoresistant breast cancer

    WT Scheme: Seed Award in Science

    The majority of cytotoxic agents used to treat patients kill tumour cells via the mitochondrial pathway of cell death. Previously, the applicant found that primary tumours that are chemoresistant in vivo usually contain mitochondria that are resistant to apoptotic signalling. Therefore, we...

  • Modelling of pharmacokinetics into ischemic heart tissue from an implantable, replenishable therapy reservoir

    WT Scheme: Seed Award in Science

    Precisely controlled delivery of drugs, bioagents and cells directly to the heart has the potential to dramatically improve regenerative cardiac therapy for ischemic heart failure. Likewise, localized therapy delivery to ischemic tissue can increase retention at the target site and reduce...

  • Artificial neural networks, genomic data and case-control classification

    WT Scheme: Seed Award in Science

    Genome wide association studies have now reached the scale where one can hope to extract information relevant to clinical applications and public health. The large and complex nature of current datasets will benefit from new and more powerful methods of analysis. We propose to investigate...

  • Sound-based observation of neonatal brain growth and status

    WT Scheme: Seed Award in Science

    Neurological problems are more likely to happen in the early neonatal period than at any other time of life. 85% of neonatal deaths worldwide occurred in developing countries with neonatal encephalopathy due to the birth asphyxia being one of the major causes of high child mortality. The...

  • Metabolic reprogramming in innate immunity

    WT Scheme: Investigator Award in Science.

    Immune cells undergo metabolic reprogramming during activation which directly impacts on their phenotype (1,2). Glycolysis is a key feature of M1 macrophages and Th17 cells, whilst oxidative phosphorylation is more apparent in M2 macrophages and Treg cells. Signals regulated by the...

  • Validation of FcgRlla as a potential drug target in sepsis

    WT Scheme: Seed Award in Science.

    Sepsis is characterised by a severe coagulopathy which is responsible for the high mortality in this disease. This coagulopathy is due to extensive platelet activation and consumption which leads to bleeding due to the subsequent thrombocytopenia and thrombosis due to the platelet...

  • Electrophysiological investigations on the molecular mechanisms underlying gut-to-brain signalling evoked by colonic microbiota

    WT Scheme: Seed Award in Science.

    The concept of the 'microbiota-gut-brain' signalling axis has been proposed recently, with headline-grabbing studies demonstrating how altering the intestinal microbiome with commensal probiotics has beneficial effects both on gut function but more intriguingly, on central nervous system...

  • The genomic architecture of human nucleolar organizer regions and its role in nucleolar biology

    WT Scheme: Investigator Award in Science.


    The nucleolus is the largest functional domain in the nucleus of all human cells. Its primary role is the biogenesis of ribosomes, the complex machines that translate the language of nucleic acids (DNA and RNA) in to proteins. Nucleoli form around arrays of genes that encode the...

  • The cognitive thalamus: more than a relay

    WT Scheme: Investigator Award in Science.

    How do brain circuits support different but complementary aspects of event memory? The answer lies in distributed networks across the medial temporal lobe, prefrontal cortex and parietal cortex. Via their widespread connectivity, nuclei within the rostral thalamus support these...

  • The impact of genetic heterogeneity on synthetic lethality in cancer

    WT Scheme: Sir Henry Wellcome Postdoctoral Fellowship

    Synthetic lethal interaction occurs when the function of one gene only becomes essential for viability in the presence of a mutation in another gene. In cancer treatment this phenomenon can be exploited to selectively kill tumour cells that have specific genetic...