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Funding Awarded

3 awards

  • Investigate the impact of bile aspiration on chronic respiratory infection - bile paradigm

    This study proposes to investigate the unexplained link between gastro-oesophageal reflux (GOR) and severe respiratory disease. During GOR, bile, normally found in the duodenum and stomach, is refluxed to the throat and subsequently aspirated into the airways and lungs of patients. A high prevalence of this phenomenon is seen in...

  • Modelling cystinosis with human stem cells and the therapeutic potential of aspartate

    Cystinosis is a rare genetic disease that causes the amino acid cystine to accumulate in the body due to mutations in the CTNS gene. In its severest form, cystinosis causes kidney failure before the age of 10. Treatment is limited to cysteamine, a cystine-depleting drug, but this only slows the progression of the disease. The toxic...

  • Drug eluting contact lenses for cystinosis therapy

    Cystinosis is a metabolic disease characterized by accumulation of cysteine crystals in various tissues including cornea. Cystinosis patients begin showing ocular symptoms at the age of 16 months and without appropriate treatment, the entire peripheral stroma and endothelium can be packed with crystals. Eventually complications such as...