Funding Awarded

Early Identification of Suicide and Self-Harm Risk and Comorbid Mental and PHysical Disorders: An INterdisciplinary TrAining, Research and InterventioN Programme (MHAINTAIN)

MHAINTAIN will create a research-through-training network addressing the need for doctoral training and career paths, to improving early identification and intervention of suicide and self-harm risk. The aim of this interdisciplinary consortium is to improve capacity building in the assessment of risk of suicide and self-harm...

PSychosis Ireland Structured Training and Research programme (PSI-STAR)

Psychotic disorders, such as schizophrenia and bipolar disorder,  occur in about 3 in a hundred people and usually start in adolescence or young adulthood, greatly disrupting a young person's life in terms of education, social relationships and career outcomes. Because of the early age of onset and...

MIRANDA- Multidisciplinary Innovation and Research Advancing Neurological care in a Digital Age

Amyotrophic Lateral Sclerosis (ALS) or Motor Neurone Disease (MND) is a degenerative disease of the nervous system, which affects one in 300 people in Ireland. Those affected lose their ability to use their arms, legs and voice, and eventually their ability to breathe. Some people also experience changes in thinking.

There...

Advancing clinical research on ageing in Ireland

As the population of the world ages, there is a critical need to integrate research on aging into the medical training of clinicians. The goal of this program is to provide research development, training, and mentoring to physician-scientists in the newly established Master's of Medical Gerontology program at Trinity College...

Using single-cell RNA-sequencing to rationally model inflammatory skin disease

Rapidly advancing single-cell genomic methodology can give biologists unprecedented resolution in the study of cell types and states in tissues, such as the different epithelial cells (EC) of the skin. I wish to employ it to address an unmet clinical need in the chronic inflammatory skin condition hidradenitis suppurativa (HS) where EC...

Exploring the factors and mechanisms involved in the delivery of healthcare and support programs to people with dementia from diverse cultural and linguistic backgrounds

The management of dementia among immigrant populations is considered a global public health priority. Dementia interferes with the brain and older age is the strongest risk factor. The migration experience has been associated with specific stressors that can lead to poor health outcomes. In the United States dementia affects an...

HRB Trials Methodology Research Network (HRB-TMRN) 2021 - 2026

No summary available

Clinical Trial Feasibility Award - University of Limerick

No summary available

Clinical Trial Feasibility Award - Royal College of Surgeons in Ireland

No summary available

UCD Clinical Research Centre

No summary available

HRB Clinical Research Facility - UCC (HRB CRF-UCC)

No summary available

Wellcome HRB Clinical Research Facility at St. James's Hospital

No summary available

Children's Health Ireland

No summary available

HRB Clinical Research Facility Galway

No summary available

National Clinical Trials Office 2021 - 2024

No summary available

Social Circumstances and Epigenomics: Promoting Health in Three Countries

This project proposes an integrated set of aims and analyses of existing social and epigenetic data from three national studies of aging in the family of Health and Retirement studies (the US Health and Retirement Study (HRS), the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), and the Irish Longitudinal Study of...

Uncovering the neural architecture underlying decisions abstracted from movements

Decision making is a core component of normal and abnormal cognitive function. Understanding the neural mechanisms of decision-making will lead to advances in the diagnosis, classification and future treatments of disorders affecting thought and control. Mathematical models of the decision process, based on bounded evidence...

Autophagy induction as a novel therapeutic strategy for MSD

The lysosomal degradation pathway of autophagy has a crucial role in different pathophysiological conditions, such as infection, neurodegenerative disorders, cancer and ageing. In particular, autophagy plays an important role in the pathophysiology of a family of inborn errors of metabolism due to defect in the activity of lysosomal...

The microbiome as an environmental trigger for autoimmune epilepsy (MICA)

Autoimmune epilepsy is a rare form of drug-resistant epilepsy characterised by frequent seizures in later life. Patients may respond to immune therapy, but causation of disease is poorly understood, and more targeted treatments are required. This gap in knowledge is the major priority for epilepsy specialists, and the area of greatest...

Elucidation of the role of SARM1 in retinal homeostasis and oxidative stress induced retinal degeneration

Photoreceptor cells found in the back of our eyes convert light into signals that allow us to see. Death of these cells and the cells that nourish them, called RPE cells, is termed retinal degeneration and is characteristic of blinding diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa. Millions of people...

Towards novel anti-infective with enhanced wound-healing for diabetic foot infections : Co2 releasing star shaped micro biocidal polymers

It is estimated that 422 million people worldwide are living with diabetes and among them, a common and serious problem is the development of diabetic foot infection. One in five patients with diabetes are hospitalised with a diabetic foot wound (DFW) at least once in their lives. Infected DFWs are treated by removal of infected tissue...

Combining Electrochemotherapy with a Toll Like receptor agonist for the treatment of lung cancer

Successful cancer treatment aims to totally eliminate the entire tumour and the risk of recurrence. Treatment currently relies on removal of the primary tumour by surgery or radiotherapy followed by control of the remaining dispersed cancer cells in the whole body usually by chemotherapy. At the Cork Cancer Research Centre (CCRC) we...

Preoperative Exercise to Improve Fitness in Patients Undergoing Complex Surgery for Cancer of the Lung or Oesophagus

Treatment for people with cancer of the lung or the oesophagus (food-pipe) often involves surgery. This surgery is complex and there is a high risk that patients will develop severe complications afterwards, mainly lung or heart problems, leading to a longer hospital stay and higher hospital costs, and impacting greatly on recovery and...

Evaluation of the role of MxA and ISGylation in chemosensitivity in oesophageal cancer

Many oesophageal cancers develop resistance to the drugs currently used to treat this disease. This allows the cancer cells to survive and the cancer can come back again at variable times after the initial treatment. Research already performed by this group has identified genetic differences between cancer cells that respond well to...

Incorporation of sensor technology to provide clinical meaningfulness for existing standardised measurement scales in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) also known as Motor Neurone Disease (MND) is a progressive and ultimately fatal neurodegenerative disease for which there is no cure. People with ALS experience loss of mobility and arm function, breathlessness and chest infections, loss of speech and swallow and in 30-50%, cognitive and behavioural...

Novel Neurophysical Biomarkers of Heterogeneous Network Degeneration in Motor Neuron Disease for Quantifying the Progression and Outcome in Clinical Trials

Motor Neurone Disease (MND)/Amyotrophic Lateral Sclerosis (ALS) is a terminal neurological condition in which the neurones (neural cells) that control movement degenerate. Despite encouraging results from studies in animals, translation of new treatments to humans has been disappointing. The aim of this study is to provide scientific...

Evaluating a novel macrolide based early intervention in the clinical management of chronic infections and inflammation in Cystic Fibrosis

Chronic persistent respiratory disease is a leading cause of death worldwide. Despite years of global research, the clinical management of respiratory disease, including the life-limiting genetic disease cystic fibrosis (CF), remains a significant challenge. Treatment options are extremely limited, due in part to the increased pathogen...

Gold-drug: Targeting a novel dual inhibitor drug with gold nanoparticles for improving radiation response in oesophageal cancer

Oesophageal cancer (cancer of the food pipe) has low survival rates and a very poor response to treatment. Sadly, this cancer type is on the rise in Ireland and is linked with increasing obesity rates. Unlike many other cancer types, we are still only using treatments that have existed for decades - chemotherapy drugs with radiation...

The role of sialylated-alpha-1 antitrypsin in resolution of acute and chronic inflammation

Alpha-1-antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that results in the rapid progression of lung disease, especially in smokers. Specific treatment for this disorder is available in the form of weekly intravenous injections of AAT. This is referred to as augmentation therapy and studies have shown that augmentation...

Compound library screening in a zebrafish model of MSD to identify novel therapeutic compounds

Multiple Sulfatase Deficiency (MSD) is currently an untreatable disease and while we know some of the processes inside cells that cause or influence the disease, there is still much to be understood. While progress has been made from studying simple cell culture systems, this does not tell us about how different disease changes may...