Funding Awarded

Co-design and co-adaptation of a trustworthy online resource for healthcare professionals and people with chronic hip and knee pain in Ireland

Long-term, painful conditions of the hip and knee joint are common in Ireland. Yet, many patients sit on waiting lists for months or years, even when specialist opinions are not needed. In the meantime, pain gets worse, affecting ability to live, work and be fully active. Expert knowledge on how to exercise with these conditions and...

Combining HDAC6 inhibitors with KRAS inhibitors for the treatment of Non-Small Cell Lung Cancer (NSCLC)

In Europe lung cancer is the second most common cancer in men and the third most common cancer in women. Globally, lung cancer contributes to more cancer deaths than any other type of cancer. While we have witnessed some improvements for lung cancer patients, the outcomes and treatment options for the majority remains poor. One...

The design and psychometric evaluation of a health-related quality-of-life outcome measure (QoLTEN) for adults with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are devastating conditions with a sudden onset. Patients are catapulted into a rapid and unexpected form of acute skin failure with a significant risk to their life. They become critically ill within a short period of time and are treated as a medical emergency with the...

Development of a Core Outcome Set for research studies with older adults in the Emergency Department

The number of people over the age of 65 is increasing. This change in the population will continue to put pressure on healthcare services including Emergency Services into the coming decades as older adults are most frequent Emergency Department (ED) attendees.

Older adults are at risk of health decline and functional decline...

The Past, Present and Future of our Emergency Medical Services: Consultation on the Implementation of a National Research Strategy for Paramedicine in Ireland

Context:

Pre-hospital care traditionally refers to emergency medical care administered to ill or injured patients by paramedics, prior to transportation by ambulance to a medical facility. Internationally, Emergency Medical Services (EMS) have evolved to treat and referral models and paramedicine is moving towards a future of...

Migrant health research networking and knowledge exchange seminar: An arts based event

People have always migrated for a variety of reasons, to seek work, education and to seek protection from conflict, natural disasters and persecution. While Ireland has a long history of emigration, since the early 2000s the trend has changed and there are more migrants coming into Ireland than before. Therefore gaining greater...

7th Annual Public & Patient Involvement Summer School

Enhancing Public, Patient and Carer involvement (PPI) in health research was identified as a priority area within the HRB's Strategy 2016-2020 and reiterated in the Strategy 2021-2025. This includes a defined commitment to develop and promote PPI within the HRB and HRB-supported projects and programmes, as well as within the community...

Moving policy evaluation forward: A workshop on how to identify the ‘best buys’ in public policy for the promotion of physical activity and healthy nutrition.

Over the last 3 years, researchers and policy-makers in food and physical activity have been working together to establish the Policy Evaluation Network (PEN). PEN aims to evaluate policy measures to promote a healthy diet and physical activity of the population in terms of their content, implementation and effectiveness.

By...

Early Identification of Suicide and Self-Harm Risk and Comorbid Mental and PHysical Disorders: An INterdisciplinary TrAining, Research and InterventioN Programme (MHAINTAIN)

MHAINTAIN will create a research-through-training network addressing the need for doctoral training and career paths, to improving early identification and intervention of suicide and self-harm risk. The aim of this interdisciplinary consortium is to improve capacity building in the assessment of risk of suicide and self-harm...

PSychosis Ireland Structured Training and Research programme (PSI-STAR)

Psychotic disorders, such as schizophrenia and bipolar disorder,  occur in about 3 in a hundred people and usually start in adolescence or young adulthood, greatly disrupting a young person's life in terms of education, social relationships and career outcomes. Because of the early age of onset and...

MIRANDA- Multidisciplinary Innovation and Research Advancing Neurological care in a Digital Age

Amyotrophic Lateral Sclerosis (ALS) or Motor Neurone Disease (MND) is a degenerative disease of the nervous system, which affects one in 300 people in Ireland. Those affected lose their ability to use their arms, legs and voice, and eventually their ability to breathe. Some people also experience changes in thinking.

There...

Advancing clinical research on ageing in Ireland

As the population of the world ages, there is a critical need to integrate research on aging into the medical training of clinicians. The goal of this program is to provide research development, training, and mentoring to physician-scientists in the newly established Master's of Medical Gerontology program at Trinity College...

Using single-cell RNA-sequencing to rationally model inflammatory skin disease

Rapidly advancing single-cell genomic methodology can give biologists unprecedented resolution in the study of cell types and states in tissues, such as the different epithelial cells (EC) of the skin. I wish to employ it to address an unmet clinical need in the chronic inflammatory skin condition hidradenitis suppurativa (HS) where EC...

Exploring the factors and mechanisms involved in the delivery of healthcare and support programs to people with dementia from diverse cultural and linguistic backgrounds

The management of dementia among immigrant populations is considered a global public health priority. Dementia interferes with the brain and older age is the strongest risk factor. The migration experience has been associated with specific stressors that can lead to poor health outcomes. In the United States dementia affects an...

HRB Trials Methodology Research Network (HRB-TMRN) 2021 - 2026

No summary available

Clinical Trial Feasibility Award - University of Limerick

No summary available

Clinical Trial Feasibility Award - Royal College of Surgeons in Ireland

No summary available

UCD Clinical Research Centre

No summary available

HRB Clinical Research Facility - UCC (HRB CRF-UCC)

No summary available

Wellcome HRB Clinical Research Facility at St. James's Hospital

No summary available

Children's Health Ireland

No summary available

HRB Clinical Research Facility Galway

No summary available

National Clinical Trials Office 2021 - 2024

No summary available

Social Circumstances and Epigenomics: Promoting Health in Three Countries

This project proposes an integrated set of aims and analyses of existing social and epigenetic data from three national studies of aging in the family of Health and Retirement studies (the US Health and Retirement Study (HRS), the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), and the Irish Longitudinal Study of...

Uncovering the neural architecture underlying decisions abstracted from movements

Decision making is a core component of normal and abnormal cognitive function. Understanding the neural mechanisms of decision-making will lead to advances in the diagnosis, classification and future treatments of disorders affecting thought and control. Mathematical models of the decision process, based on bounded evidence...

MinDful: Music aNd Dance For Older adULts: The Feasibility of an Arts-Based Health Intervention for Health and Wellbeing

Ireland has an ageing population. Many older adults in Ireland have a chronic condition, low levels of physical activity and experience loneliness and social isolation. Additionally, approximately a third of adults over 65 years of age fall each year. Additionally, the unprecedented consequences of the coronavirus (COVID-19) pandemic,...

Exercise therapy for degenerative meniscal tears in the primary care - a feasibility cluster randomised controlled trial

Knee pain due to a degenerative meniscal tear is a common joint condition seen in Irish orthopaedic clinics. Changes to the knee joint and meniscus (cartilage within the knee that helps cushion the joint) occur normally with age but can become painful in some middle-aged adults. Exercise is recommended as the main treatment to aid...

Towards an integrated model of care for older adults transitioning from the Emergency Department to the community

Worldwide increases in life expectancy are leading to the rapid ageing of populations. By 2031, it is forecasted that there will be more than one million older adults in Ireland, representing 20% of our overall population. It is widely accepted that older adults frequently avail of health services in the community and in the hospital...

Using lessons learned from statutory notifications to improve quality and safety in social care settings

In Ireland, providers of designated centres for older people and people with disabilities are required to inform the Chief Inspector of Social Services in the Health Information and Quality Authority (HIQA) about certain events that occur. For example: serious injuries to residents and allegations of abuse. These are known as statutory...

Disparities in Heath Outcomes of Chronic Kidney Disease between Men and Women in the Irish Health System

It is increasingly recognised that there are differences between men and women in regard to chronic kidney disease (CKD). It appears to be more common in women and they have a shorter survival compared to women in the general population. It is unclear 1) whether these differences are due to biological factors like hormones or due to...

Transitions of Care in Advanced Chronic Kidney Disease

Patients who suffer from advanced chronic kidney disease (CKD) are at risk of progressing to kidney failure which is associated with a shortened life span and significant disability. The transition from advanced CKD to kidney failure requiring renal replacement therapy (RRT) [dialysis, kidney transplantation or conservative therapy] is...

IMPlementation of osteoArthritis Clinical guidelines Together

Osteoarthritis is a disease of the joints, affecting 1 in 8 Irish people as they get older. Due to the growth of our ageing population amongst other reasons, this figure is expected to double within one generation. Most people with the disease in their hips or knees are likely to experience some level of pain as well as difficulty...

Development and evaluation of an adaptive mobile health physical activity intervention post-stroke: a Sequential Multiple Assignment Randomised Trial

Despite recent advances in acute stroke intervention, strategies to prevent recurrent stroke are lacking. This is of urgent importance for people with stroke who are at risk of having another stroke. Physical activity (PA) is the second-largest predictor of stroke and the cornerstone of secondary prevention therapies. Interventions...

A Physiotherapist led intervention to Promote Physical Activity in Rheumatoid Arthritis- a pilot study

As a long-term chronic condition, Rheumatoid arthritis (RA) can have a significant long-term impact. Typically presenting as a disease that causes joint pain and swelling, excessive tiredness and difficulty doing everyday activities RA occurs usually in people over 40 and is three times more likely in women than men. There has been...

Health and social inequalities in the Mid-West

As there are many disadvantaged areas in the Mid-West, health and social inequalities are important issues locally. This is because deprivation is linked with poor health and poor access to healthcare. Under the Healthy Ireland Framework, taking actions to address health inequalities is a key priority. In the Mid-West, many...

Collecting and using data about ethnicity in healthcare -a drama

Ireland has a long history of emigration. More recently, we have inward migration. Census 2016 found that 17% of the population were born outside Ireland. This means that there are different minority ethnic groups in our country, in addition the Irish Travellers. The Health Service Executive wants to gather information on the ethnic...

Maximising collaboration to expedite positive change in the assessment process that determines physiotherapy students' readiness for independent practice

Assessment of student physiotherapists in the clinical environment is a critical part of their education which determines their readiness for independent clinical practice once qualified. Therefore it has significant implications for patient safety and quality of service delivery. Yet, research and experience highlight many challenges...

I-PARC (Ireland’s Physical Activity Research Collaboration): Bridging the research to action gap to support the implementation of the National Physical Activity Plan

The purpose of this research is to develop a bespoke research collaboration ‘I-PARC’ (Irish – Physical Activity Research Collaboration) to support Get Ireland Active! the National Physical Activity Plan (NPAP)1. I-PARC will bring together researchers, policy makers and practitioners from physical activity (PA) to establish how best to...

Implementing evidence based guidance for dementia palliative care through participatory action research

Dementia is a progressive illness and as the condition progresses into the later stages, the person will have difficulty communicating their needs particularly in relation to thirst, hunger, pain or discomfort.  In Ireland persons with dementia are often cared for in Long Term Care (LTC) settings. Carers of persons with dementia...

Implementing evidence based guidance for dementia palliative care through participatory action research

Dementia is a progressive illness and as the condition progresses into the later stages, the person will have difficulty communicating their needs particularly in relation to thirst, hunger, pain or discomfort. In Ireland persons with dementia are often cared for in Long Term Care (LTC) settings. Carers of persons with dementia can...

OPTI-MEND: Optimising early assessment and intervention by health and social care professionals in the emergency department (ED)

Emergency Departments (ED) face significant challenges in delivering high quality and timely patient care against a background of increasing patient numbers and limited hospital resources. A mismatch between patient demand and the hospital's capacity often leads to poor patient flow and ED crowding, resulting in a reduction in the...

PPI Ignite Award - University of Limerick

PPI Ignite at the University of Limerick will serve as a rallying point within the university and the wider community it serves, to build capacity for research conducted  "with" or "by" patients and members of the public rather than "to", "about" or "for" them. PPI Ignite UL will accomplish this among a coalition of academic,...

Cancer Prevention Fellowship 2017

Research Programme for mid-career researchers working in Republic of Ireland (RoI) to become NCI Cancer Prevention Fellows at the prestigious National Cancer Institute (NCI) in the USA.

This programme provides training at post-doctorate level from the health professions, biomedical, and behavioural sciences to become...

The utility of high-tech drug analysis to the decision maker

The Health (Pricing and Supply) Act 2013 stipulates that the payer must consider the cost-effectiveness (the likelihood that the drug will offer value for money) and the likely cost impact of a new drug prior to deciding if it should be reimbursed. It also states that, after a 3-5 year period, continued reimbursement must be reviewed....

HRB Collaboration in Ireland for Clinical Effectiveness Reviews (HRB-CICER)

Through the National Clinical Effectiveness Committee (NCEC), the Minister for Health mandates clinical guidelines as National Clinical Guidelines for use in public healthcare in Ireland. The goal of the guidelines is to promote healthcare that is current, effective and consistent, ensuring best outcomes for patients and service users....

Unwrapping the layers of complexity of clinical performance assessment of physiotherapy students and identifying key stakeholders' preferences towards enhancing the process

Clinical performance assessment of health professional students is imperative as it provides a measure of a students readiness to practice within their profession. However, it is widely acknowledged as being inherently problematic. Difficulties reported by clinicians in medicine, nursing, psychology and social work include the...

Ethnic Minority Health in Ireland - Building the evidence base to address health inequities

International evidence shows that minority ethnic groups have poorer health and more difficulties accessing healthcare than majority ethnic groups. Analysis of existing health datasets and the use of ethnic identifiers in health care systems are promoted internationally as valuable ways to address these differences. It is not possible...

Interventions for preventing falls in Multiple Sclerosis

Multiple Sclerosis (MS) is one of the most prevalent diseases of the central nervous system (CNS) and directly affects an estimated 2.5 million people worldwide (MS International Federation 2013) including approximately 8,000 people in Ireland (MS Ireland 2014). It is the most common disabling neurological disorder among young people...

Left atrial appendage closure for the prevention of stroke in patients with atrial fibrillation

The review will assess the effectiveness of left atrial appendage closure (LAAC) for the prevention of stroke in patients with atrial fibrillation (AFib) compared to oral anticoagulation. The review question was chosen because AFib is a common and serious condition. It is the most common arrhythmia seen in clinical practice and is...

Acute kidney injury (AKI) in the Irish health system; Incidence, severity and clinical consequences

Acute Kidney Injury (AKI), previously called acute renal failure, occurs when kidney function deteriorates rapidly over hours or days and elevated levels of waste products accumulate in the blood. AKI is most common in people who are hospitalized, particularly in critically ill people who need intensive care. AKI may occur in multiple...

Multimodal characterisation of the benign prostate

Benign Prostatic Hyperplasia (BPH) is a condition that will affect most men as they age, resulting in swelling of the prostate and causing problems when they try to pass urine. It is rare in men less than 40 but can be found in over 70% of men over the age of 70. Current treatment for BPH involves either tablet medication or surgery....

Economics of Personalised Heath

Advances in science have increased the prospect of diagnosing, treating and preventing illness in a more personal way. Improved understanding of how individuals may benefit from tailored therapies will permit a better match and more informed choice by users and health care professionals. However, the discovery of personalised health...

Development of a Bayesian Unit for Health Decision Sciences

This proposal will develop a Bayesian unit for health decision making. A Bayesian approach formalises the bringing together of data from structured sources/trials with existing knowledge and uses formal decision criteria to identify optimal courses of action for a given health related problem/question. The centre will prioritise three...