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AIIHPC Structured Research Network APA Cycle 2 2019 Applied Partnership Awards Applied Research Projects in Dementia Applying Research into Policy & Practice Postdoctoral Fellowships ARPP 2020 Cancer Prevention Fellowship Programme Cancer Prevention Fellowship Programme Reintegration Grant Capacity Building for Evidence Synthesis Clinical Research Facilities/Centres 2021 Cochrane Training Fellowships Collaborative Doctoral Awards Conference and Event Sponsorship Scheme COVID-19 2020 CSF 2020 DIFA - 2018 DIFA 2017 DIFA 2018 DIFA 2020 DIFA-2018 Emerging Clinician Scientist Awards 2020 Emerging Investigator Awards Emerging Investigator Awards 2022 ERA-NET Cofund for Neuroscience Research (NEURON) ERA-NET Cofund for Personalised Medicine EU Joint Programming Initiative Framework for Safe Nurse Staffing and Skill Mix Fulbright-HRB Health Impact Awards Health Research Awards Health Research Awards - Definitive Intervention Health Research Awards - Definitive Interventions Health Research Centre HRB Clinical Research Coordination Ireland HRB Clinical Research Facilities HRB Collaboration in Ireland for Clinical Effectiveness Reviews HRB Trials Methodology Research Network HRCI 2020 HRCI-HRB Joint Funding Scheme ICORG Statistics and Data Management Interdisciplinary Capacity Enhancement Awards Investigator Led Projects IPPOSI 2020 Irish Clinical Oncology Research Group Irish Network for Research in Dementia and Neurodegeneration Irish Platform for Patients Organisations Science and Industry Support Award Irish Platform for Patients' Organisations, Science and Industry Joint Programming Initiative Healthy Diet for a Healthy Life Joint Programming Initiative in Neurodegenerative Diseases Joint Programming Initiative on Antimicrobial Resistance Knowledge Exchange and Dissemination Scheme Knowledge Translation Awards Medical Education Research Grant Medical Research Charities Group Support Award MRCG-HRB Joint Funding Scheme National Children's Hospital Foundation Scheme National Clinical Trials Coordination Programme National integrated PhD programme for Medical Practitioners National Intellectual Disability Supplement to TILDA National SpR Academic Fellowship Programme/HRB Joint Funding Scheme National SpR/SR Academic Fellowship Programme Patrick Quinn Awards for Parkinson's Research PPI Ignite Awards Project Development Grants Project Development Grants in Cancer Nursing Research RCQPS COVID-19 Research Collaborative for Quality and Patient Safety Research Collaborative in Quality and Patient Safety Research Leader Awards Research Training Fellowships for Health Professionals Research Training Fellowships for Healthcare Professionals RL FA 2020 RL PA 2020 Secondary Data Analysis Projects SFI-HRB-Wellcome Biomedical Partnership SFI-HRB-Wellcome Research Partnership Structured PhD Programme in Population and Health-Services Research Education Structured PhD Programme in Population Health and Health Services Research The Irish Longitudinal Study on Ageing Trials Methodology Research Network Ulysses Research Visits US-Ireland R&D Partnership Awards WHO-SOLI-2020
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Alpha One Foundation Athlone Institute of Technology Beaumont Hospital Cystinosis Foundation Ireland DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Fighting Blindness Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - Letterkenny General Hospital HSE - Midland Regional Hospital at Tullamore HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Cancer Society Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Irish Thoracic Society Katholieke Universiteit Leuven Limerick Institute of Technology Mary Immaculate College Limerick Maynooth University Medical Research Charities Group Ltd Molecular Medicine Ireland National Rehabilitation Hospital National Suicide Research Foundation National University of Ireland Galway National University of Ireland, Galway National University of Ireland, Maynooth Our Lady's Hospice RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland Royal Victoria Eye and Ear Hospital Research Foundation Ltd St John of God's Research Foundation Limited St. James's Hospital TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia The Children's Medical and Research Foundation Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford
Funding Awarded
169 awards
Vaccination: Knowledge is power
Over 3 million global deaths are avoided annually due to the existence of vaccines. In Ireland the state funded immunization program protects against 14 infectious diseases including HPV. However, we face a number of challenges with immunization. Alarmingly, in recent years uptake of vaccines has been waning. Perhaps due to complacency...
Health and social inequalities in the Mid-West
As there are many disadvantaged areas in the Mid-West, health and social inequalities are important issues locally. This is because deprivation is linked with poor health and poor access to healthcare. Under the Healthy Ireland Framework, taking actions to address health inequalities is a key priority. In the Mid-West, many...
Self-Harm and Suicide AwaREness ? SHARE
SHARE is based on outcomes of the HRB funded research programme: Improving Prediction and Risk Assessment of Suicide and Self-Harm (IMPRESS). The IMPRESS study aims to improve the knowledge base on predictive risk factors associated with repeated self-harm and suicide among high-risk groups of self-harm patients in Ireland. During the...
Postnatal Mental Health PARTNERship
It is estimated that 10-25% of mothers will experience a mental health problem following the birth of their baby. With approximately 63,900 births in Ireland each year (6), conservative figures would suggest that over 6390 mothers will experience a mental health problem in the postnatal period. For many mothers, their partner plays a...
Towards Recovery After Childbirth, through Knowledge: (ON TRACK)
The Maternal health And Maternal Morbidity in Ireland (MAMMI) study identified problems women had postpartum. We have provided information for women on physical problems, such as incontinence, and will now address other important issues. For example, 15% of women have anxiety during pregnancy, and 44% have pain during sex at 3 months...
Developing an on-line course for first-time mothers: ?Pathway to Birth?
Concern has been expressed globally at rising caesarean section (CS) rates with no evidence of any decrease in associated health problems for mothers and babies, indicating that many CSs are unnecessary, and can be harmful. We are at present running a pilot trial called "REDUCE"to see if a new intervention, based on research evidence,...
The Breakfast Club
The Breakfast Club is the story of diabetes in pregnancy in Ireland. In a weekly, serialized, online graphic novel, we will follow the lives of women attending a Breakfast Club for women who have received a diagnosis of diabetes during their pregnancy. We will explore their experiences, from having a Glucose Tolerance Test, to meeting...
Medtrack KEDS
"Health professionals are the lifeblood of the health system"(President M Robinson), yet our junior doctors (NCHD-trainees) continue to report that responses for improving their working conditions have had "little tangible change or impact on their day-to-day working lives and training experience?. The RCSI research team has...
Development of a Teaching Programme for the Junior Cycle Mental health and Mental Ill-Health Module
Great progress has been made nationally on destigmatising mental health but it has not yet become a topic that people are universally comfortable with. A major change in the Junior Cycle in 2018 is the introduction of Wellbeing which directly addresses youth mental health through Strand 4 in the new Social Personal and Health Education...
Development of Book About Mental Health Problems For Children and Adolescents
There has been steady improvements in the quality of information available to people about mental health issues but a challenge remains to communicate this fully to children and adolescents. Much of the existing information is text heavy and can be off-putting for this age group. Presenting this information so that it is accessible...
Citizen Science: The People's Trial
Randomised trials are instrumental in providing reliable and robust evidence on the benefits, harms and costs of health care, so that people can make informed choices. However, the general public?s understanding of randomised trials can be limited and ensuring public support for and participation in trials remains challenging. The...
Delivering a Reduction in the Development of Maternal Prenatal Stress: DIRECTMAPS
Pregnancy can be a stressful time during which many expectant mothers experience understandable worries and concerns. High levels of prenatal maternal stress are linked to several unfavourable conditions which can affect the health of the child at birth. Normal development of the central nervous system is also at risk during the early...
Piloting the Community Engaged Scholars Program in Ireland
Public and patient involvement in health research is not embedded in Irish Universities. As part of the PPI Ignite Awards scheme the HRB have funded 5 Irish Universities to demonstrate the value of PPI and champion this approach in Ireland. PPI involves public/patients working in partnership with researchers in setting research...
Promoting Education and Research Knowledge (PERK)
THE PROBLEM Cancer of the oesophagus (food pipe) is an aggressive type of cancer, and has a low survival rate. It is usually diagnosed at a late stage, often due to a lack of knowledge of underlying symptoms which can be mild, including heartburn, bloating and problems swallowing. Oesophageal cancer is not as well known as some other...
Rheumatoid Arthritis Patient Awareness INitiative (RA-PAIN)
Rheumatoid Arthritis (RA) is a common autoimmune condition that causes disability for patient's day-to-day tasks. New medications that target bad molecules or cells improve outcomes, however responses may be limited or side effects may occur. Who will develop RA, get severe disease or respond to current treatments is not known. Studies...
Using photovoice to enhance knowledge exchange and dissemination
The EOLAS programmes are information and learning programmes for people with experience of psychosis and their family members. The programmes have been co-produced and are co-delivered by peer and clinician facilitators in partnership with mental health clinicians. Such service user and family member involvement in the design and...
CHErIsH- KEDS
This CHErIsH-KEDS application has two aims: to increase capacity in translation of research into practice in Ireland and to develop a knowledge exchange strategy for the future roll out of CHErIsH across different settings in primary care. This application builds on the existing study, the CHErIsH study. The CHErIsH study is funded...
How to Use TILDA Data - Webinar, Seminar and Workshop Series
The Irish Longitudinal Study on Ageing (TILDA) was established in 2006 with baseline data collection commencing in 2009. TILDA collects data in a series of data collection waves. The data is collected through a computer-assisted personal interview and a self-completion questionnaire once every two years with a comprehensive health...
Co-Designing, Pre-Testing and Refining an Intervention Programme to Support Parent-Adolescent Communication about Shared Self-Management Responsibilities in Type I Diabetes
This knowledge exchange activity aims to work together with young people with Type 1 Diabetes (TID), parents of young people with TID, professionals (from a range of disciplines e.g. diabetes nurse specialists, psychologists, consultant paediatric endocrinologists) and community advocates (e.g. Diabetes Ireland) to codesign, pre-test...
Collecting and using data about ethnicity in healthcare -a drama
Ireland has a long history of emigration. More recently, we have inward migration. Census 2016 found that 17% of the population were born outside Ireland. This means that there are different minority ethnic groups in our country, in addition the Irish Travellers. The Health Service Executive wants to gather information on the ethnic...
The APART Study Public Participation Initiative for Knowledge Exchange
The APART Study is exploring an important, low-cost intervention that may limit bone loss associated with initiation of antiretroviral therapy to treat HIV. Results from this trial may have significant implications for how HIV is managed both in Ireland and internationally. We will use this KEDS award to develop a research partnership...
Real Talk with Real Mums
?Real Talk with Real Mums? is a 10-episode podcast series looking at the issues of everyday pregnancy with medical professionals and the real women who have gone through the pregnancy journey. Each episode of c.30 minutes will tackle a different topic, from exercise in pregnancy (with a Physiotherapist), to mental health issues in...
TeamTalk: Interactive Resource Hub for Healthcare Teams
Healthcare teams who are interested in improving how they work together to deliver better patient care often struggle to find the time to learn and implement new practices. Teams rarely have the opportunity to attend training courses or other learning events together. This makes it difficult to transfer their newly acquired knowledge...
Working with the Research Community: Training and a Toolkit for Patients & Members of the Public
The PPI Ignite Programme at Trinity College Dublin is focused on building capacity for public and patient involvement in health research, with a particular emphasis on improving the quality of approaches. One of 10 Ignite Partners, the Medical Research Charities Group (MRCG), hosts a Public Patient Involvement (PPI) Shared Learning...
Disseminating, Engaging, and Sharing Knowledge (DESK):patient informed resource for understanding our research
Based on the findings of the research conducted during our HRB Research Leader's Award, the aim of the proposed KEDS project is to effectively disseminate the finding of our research to chronic pain patients and the general public. Sharing research findings with the general public is very important but can be difficult to get right; we...
A Patient Education Programme in Health Research & Innovation
Well informed patients and carers have a key role to play in the design and implementation of person-centered healthcare and research. Whilst patients are eager to have better and safer health products and innovations, they are often unaware of the complex nature of how new health innovations are researched, developed and made...
The patient is part of the answer - don't leave us out in the cold!
This application aims to produce a documentary that explains public and patient involvement in health research to the general public and encourages more people to become involved with researchers. Known as PPI, public and patient involvement means that people who are likely to be affected by research results are directly involved in...
Promoting National Awareness of Thrombosis in Pregnancy.
Women who are pregnant have a higher chance of developing blood clots (thrombosis) that can cause serious ill-health and can be fatal. Therefore, it is incredibly important that women who are pregnant, women of childbearing age and their families are aware of their risk factors for thrombosis in pregnancy. In the HRB-funded "HIGHLOW"...
Maximising collaboration to expedite positive change in the assessment process that determines physiotherapy students' readiness for independent practice
Assessment of student physiotherapists in the clinical environment is a critical part of their education which determines their readiness for independent clinical practice once qualified. Therefore it has significant implications for patient safety and quality of service delivery. Yet, research and experience highlight many challenges...
LoVIC-Kids: Improving public awareness of abnormal bleeding symptoms
Congenital bleeding disorders (CBD) may result in increased bleeding at times of injury, surgery, childbirth or with periods (menstrual bleeding). Although an estimated 1-2% of the population are affected by CBD, most people are unaware that their bleeding symptoms are abnormal. In addition, there is limited awareness amongst many...
"Let's Talk About" Series
Researchers in dementia at NUI Galway are producing important research insights into many aspects of dementia care in Ireland, specifically: resource allocation decision-making; support structures for family carers; and how people with dementia are treated within the care system. The focus is now turning to sharing the results...
Using visual media to communicate complex information
Services in Ireland for people with dementia are poorly developed. The main partnership award aims to (i) describe current dementia services across all sectors and (ii) ask people with dementia, carers, health workers and managers about the ideal level and type of service provision for people with dementia who have different needs and...
Factors influencing decision-making for caesarean section
The rising rate of caesarean section (CS) has become a growing concern worldwide, with limited justification of the rising trend. Understanding the factors that influence the rise in CS is important because obstetricians and midwives are directly involved in the decision to perform a CS and are the key drivers to achieving the remedial...
Enhancing ?The Model for Dementia Palliative Care Project? by targeting potential model users with innovative Knowledge, Transfer and Exchange activities.
This KEDS application will further enhance Knowledge, Transfer and Exchange (KTE) activities arising from 'The Model for Dementia Palliative Care Project', by supporting new connections with key groups, through novel activities and outputs. The active project will develop a new service delivery model for palliative care for people...
What the Researcher and the Dentist want to share, supporting knowledge dissemination
Research is ongoing to monitor the oral health of the Irish population, the uptake of dental services, and targeting of services to specific groups most in need. Results of such research inform policy makers in the Department of Health with respect to issues such as community water fluoridation and recommendations on the use of...
Communicating and promoting SAFE medicines use in Ireland
The likelihood of side effects of medicines, drug interactions and potentially inappropriate prescribing increase with the increasing number of medicines people take. Taking multiple medicines at the same time is common in people age 65 year olds or older with six in every ten in this age group. Also, around one in ten of those aged 65...
Interact for Health: Increasing integrated knowledge translation capacity for impact
Although the Health Behaviour Change Research Group (HBCRG) has engaged with the HSE Health and Wellbeing (H&W) Division as health partners on a number of activities to date, we believe there is significant potential for enhanced knowledge exchange between these two groups. Additionally, integrated Knowledge Translation (iKT)...
The biology of mood: What brain imaging and genetic studies tell us about Bipolar Disorder
This project aims to translate the known biology of bipolar disorder, enhance the accessibility of the latest discoveries and interpret the meaning and relevance to individuals with bipolar disorder, their families, carers and health professionals that are not research active. To complement the current emphasis on clinical aspects of...
The youth mental health animation creation project
This KEDS award will be used to create animations about young people's mental health that will be embedded into the youth mental health website, ReachOut.com.
This project will involve crafting key messages from this study into short narratives using direct quotes from the research interviews conducted for this...Brain superheroes and villains
We are a group of neuroscientists, funded by the HRB, who aim to test and develop novel drugs for brain related illnesses. We are excited about disseminating the value of work like ours and, in 2012, were delighted to be awarded our first HRB Knowledge Exchange and Dissemination Scheme (KEDS), which consisted of three activities...
Learning about trials - for children, by children
This project will consist of the development of new resources for teaching primary school children (aged 10-12) about why we need trials and how trials work, with a view to being more widely used throughout the trial community. These resources will align with the START (Schools Teaching Awareness of Randomised Trials) Competition,...
Family carer knowledge exchange project
We are interested in how family carers of people with dementia develop and maintain resilience in the care giving role and we are designing a project to help family carers to be more resilient and to better cope with the demands of care giving. As a team of researchers, we have reviewed studies of family carers'experiences in other...
Community exercise
It is recognised that exercise benefits people living with chronic disease. The CRF at St James's Hospital exercise physiology suite is used by research studies examining the role of exercise training for patients with chronic disease. These exercise trials support patients to exercise during structured supervised exercise classes and...
Driving policy with data: A longterm sustainable specialist service for amyotrophic lateral sclerosis
The JPND-funded project ALS-CarE is coordinated by the Irish partner, and has collected detailed information across 5 different countries about the Amyotrophic Lateral Sclerosis (ALS) patient and caregiver journey from ALS diagnosis through to end of life. In Ireland, we have collected extensive quantitiative and qualitative...
The StrokeCog partnership: effective intervention through collaboration
Stroke is a leading cause of death and disability worldwide and will increase considerably in coming decades as people live for longer. Many people are aware of physical disabilities after stroke, but are less aware of cognitive problems. These include difficulties with memory, concentration and abstract thinking, often experienced as...
Non-motor symptoms in dystonia and musician's dystonia
Our multidisciplinary Irish Dystonia Research Group, combining the expertise of Bioengineers in Trinity College Dublin and a network of Clinical Neurologists, has been working to determine the cause of a disabling movement disorder, adult onset dystonia, characterised by abnormal postures and excessive muscle activity. The causes of...
Evidence to Support Prevention Implementation and Translation - Knowledge Translation (ESPRIT-KT)
This application adds to a larger HRB Research Leader Award about improving care for people with diabetes in Ireland. The goal of the KEDS project is to connect people who do research with people who make decisions about our national health policy so they can learn from each other and work together to improve the health of the...
Developing a website for public awareness about computer use in aphasia rehabilitation
Aphasia is a language disorder which occurs in 1 in 3 people after stroke. It can impact on a person's ability to produce and understand spoken and written language. People with aphasia have had limited opportunities to have their voices heard within Irish stroke research.
This research project has already engaged...The Art of Pregnancy
The Art of Pregnancy is an exciting and ambitious public outreach exhibition and programme supported by the HRB Mother and Baby CTN togther with the Science Gallery Dublin as a key partner.
For this project we want to commission (via an open call process) a group of artists to create works inspired by the wide ranging areas of...Speaking Up About Safety (SUAS)
Speaking up about safety concerns is an important aspect of a healthcare professional's role. Our research has shown that in comparison to nurses, junior doctors are particularly poor at speaking up and tend not to report incidents and adverse events, in many cases because they believe it is not their responsibility to do so. Yet, a...
Our voices, our impact
Wave 3 KEDS will build on previous success by recruiting actors with ID to develop DVD and on-line resources comprising scenes that illustrate key IDS-TILDA wave 3 findings. Feedback from wave 3 indicates that participants would like to receive the findings in DVD format and IDS-TILDA wishes to respond to the specific dissemination...
Brain, mind and psychosis: Engaging young people in learning about research
Great progress has been made over the past few years in "destigmatising" mental illness and this has been particularly successful for conditions such as depression and anxiety. However there still remains a great lack of knowledge about psychosis. This lack of knowledge can lead to stigma and fear and can prevent young people coming...
The LinKT (Linking into Knowledge Translation) project: connecting, integrating and translating evidence to make a difference for families
Increasing evidence highlights the effectiveness of early intervention and prevention parenting interventions for improving the mental health and wellbeing of parents and children in the earliest years. However, these are often complex, difficult to implement effectively and fail to reach the most vulnerable families. Accessible,...
Development of an online cancer genetics educational resource for undergraduate and postgraduate healthcare learners
Genetic testing is becoming cheaper and easier to perform. As such, it is being performed more and more frequently; to help explain why people have developed cancer, or to try to identify genetic changes in their tumours to which novel drugs can be targeted. Genetic testing may also help identify individuals at risk of cancer,...
Pathfinder: Parental information on therapeutic hypothermia followIng neonatal encephalopathy
Neonatal brain injury can have devastating outcomes for the baby and their family and may result in longterm disability. The only treatment available is whole body cooling started within a few hours of birth. Babies also require intensive care to support their lungs, heart and kidneys. We will develop an educational toolkit including...
Let's talk - and act - about adherence in multimorbidity - a teaching and learning resource for general practice
More than half of those over the age of 65 live with more than one chronic condition. This is known as multimorbidity (MM). The prevalence of MM increases with age and is more common in less well off patients. Using muliple medications i.e. polypharmacy, is the norm in MM and many do not take their medications as prescribed i.e....
Cracking the mysteries of cancer immunotherapies - e.courses for oncology healthcare professionals
The new therapies for cancer that target the immune system have revolutionised cancer care in recent times. The treatment of melanoma, leukaemia and other malignancies has been transformed by these immune modulating drugs. However, few oncology clinicians or oncology specialist nurses have backgrounds in immunology or immune...
The stressed brain & depression
Understanding depression is challenging both for professionals and for the public. It is complex and poorly conceptualized. Clinical depression involves biological, psychological and social causes that all contribute to the expression of depression in each individual sufferer. Trauma, especially early in life when body systems are...
CERVIVA: The HPV educate project
The goal of this CERVIVA HPV Educate Project is to provide accurate and reliable information relating to HPV and HPV associated diseases, to create awareness and educate the public, health care professionals and healthcare providers on public health issues related to HPV associated diseases and on the specific research programmes...
Overweight & obesity in Ireland: Translating policy into action
The launch in 2016 of "A healthy weight for Ireland", the Government's National Obesity Policy and Action Plan, 2016-2025 represents an important milestone in Ireland's response to ongoing epidemic of overweight and obesity in children and adults. Researchers in the HRB Centre for Health & Diet (CHDR) generated key evidence which...
Listening to the newborn brain
This outreach programme will provide dedicated public information and education resources on the neonatal brain stethoscope device, which aims to facilitate interrogation of the neonatal brain and improve the quality and accuracy of the diagnosis brain injuries, reduce the stress of parents with babies in the NICU and establish the...
Expert forum to advance the potential of IL-1 family members as novel therapeutics in IBD
Current treatment strategies for Inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, are ineffective in a large number of patients. Although the reasons for this are not fully understood, it seems likely to reflect the complex nature of chronic intestinal inflammation. Recent advances in our understanding...
Supporting individuals and organisations involved in implementation of community water fluoridation
The Fluoride And Caring for Children's Teeth (FACCT) study was initiated to determine the effect of the change in water fluoridation policy (2007) on dental caries (tooth decay) and enamel fluorosis (marks on tooth enamel which are associated with fluoride) in Irish children, while also considering the change in policy on the use of...
Psychosocial, psychiatric and work-related risk factors associated with suicide in Ireland: Enhancing dissemination and impact of research
The SSIS-ACE study examines how psychosocial, psychiatric and work-related factors relate to suicide. The study involves liaising with family members bereaved by suicide, family members of those who survived a high-risk self-harm act, general practitioners (GPs), emergency department staff, mental health staff and coroners. During the...
Taking the stress out of dementia caregiving
The existing award examines how the caring experience can impact the health of dementia spouse carers. Using this emerging research evidence we will develop two animated films and a dedicated online resource providing easy-to-understand practical advice to carers to improve their quality of life and reduce stress.
FreeDem Films are...Synthesising and disseminating key lessons from the AIIHPC Palliative Care Research Network
This application for KEDS funding proposes to further enhance knowledge transfer and exchange activities across the SRN/PCRN by conducting a higher level analysis of the dissemination products arising from each individual work project during the final year of the active grant. It is expected that dissemination products will include...
Capnography monitoring for conscious sedation in oral surgery
Capnography has the potential to enhance patients safety in the dental setting. Procedural sedation techniques are specific to each area of medicine where sedation is practiced. Conscious sedation in an out of hospital setting by a non anaesthetist requires robust monitoring. The most important negative side effect of sedation is...
Doctor Emigration Knowledge Exchange Project (DEP-KEDS)
The Doctor Emigration Project (DEP) aims to analyse doctor emigration from Ireland and to inform national health workforce policy about the factors influencing their emigration. The ultimate aim of the project is to assist national workforce planners to develop evidence-informed policies to promote the retention of doctors in, and the...
Creating awareness of research in caregiving (CARING)
An increasing number of people in Ireland are providing care for a relative with dementia. This important unpaid work comes with an underappreciated cost to the health of the caregiver. Evidence suggests that dementia caregiving is associated with heightened psychological stress, as well as problems such as depression.
Our...Development of a national severe asthma registry and comprehensive care program
There has been a drive to deliver new asthma treatments through new biological agents. However, age old issues including poor adherence and poor inhaler use still apply and mean that it is difficult to tell if a patient has difficult to manage asthma or therapy refractory asthma. The proposal is to build a registry for patients with...
Creation of a young adult colouring book illustrating biological research on mental illness
We plan to create an innovative educational activity to promote our research on biological investigations in mental illness. Our idea is to publish a young adult colouring book that will introduce young people to the complex world of the human brain, how scientists perform neuroscience research and how the findings relate to...
Development and upgrading of the HMDB Schizophrenia Metabocard
The Human Metabolome Database (HMDB) is a freely available database that contains detailed information about small molecules found in the human body. It is the first and foremost reference site for metabolite data worldwide. It provides scientists, clinicians, educators and the public with the most current and comprehensive coverage of...
Brain superheros return
Making new drugs is long, costly and complex, and is often a mystery to many people. Our laboratory is involved in the development of new drugs for brain related illnesses, including illnesses such as Alzheimer's disease (AD) and Multiple Sclerosis. Alongside our research, we conduct a number of outreach projects in the hope of...
Priority setting in uncertainties in trial methodology
Challenges in how clinical trials are designed and conducted are commonly experienced by researchers at different stages of the research process. For example, difficulty in recruiting people to a trial often results in a delay in completing the trial, or difficulty in using the trial results to make informed decisions about clinical...
Thinking outside the box: towards a novel approach to care delivery for young adults with type 1 diabetes
Many young people living with type 1 diabetes struggle with the burden of day-to-day self-management. As a result they often have poor outcomes including the development of life-changing complications. We have formed a partnership between existing diabetes service providers (in Galway University Hospitals), academics in National...
Immunotherapy for the treatment of AMD: a preclinical evaluation
Age-related Macular Degeneration (AMD) is the leading cause of central retinal vision loss worldwide. Estimated prevalence of AMD in Ireland is 7% with an annual cost
High quality pre-pregnancy care is essential for women with diabetes
Women with diabetes have an increased risk of pregnancy complications. Many of these complications are due to high glucose levels in the first ten weeks of pregnancy. This means that pregnancy planning and tight glucose control is essential. Pre-pregnancy care is additional clinical care offered to women planning pregnancy. As part of...
Building a self-management programme for living well with and beyond head and neck cancer
We propose to develop a new programme that empowers survivors of head and neck cancer (HNC) to better manage problems associated with their illness and live well with and beyond HNC. This is important because HNC survivors have many documented unmet care needs and can face significant challenges associated with their condition and its...
Behavioural changes in ALS : What families and healthcare professionals need to know
Amyotrophic Lateral Sclerosis (ALS ) (or Motor Neuron Disease (MND)) is a rapidly progressive neurodegeneration associated with loss of muscle power. Until recently, thinking and behaviour were considered unaffected, but we have shown that up to 50% of people with ALS/MND experience changes in their ability to plan complex tasks, and...
Evidence based oral healthcare for older adults
The World Health Organisation has highlighted the paucity of research into the oral health needs of older adults. The Health Research Board has recognised this and have funded a number of studies in recent years addressing this topic. Unfortunately there is a delay between the completion of studies and the publication of results in...
Cracking cancer with science; an educational outreach campaign for primary schoolchildren
Breast cancer remains a significant disease in Ireland. Our laboratory is investigating novel therapies to target a sub-group of aggressive breast tumours. This work feeds into two larger efforts. The first is to help personalize cancer therapies for patients. The second is to provide new insight into how specific tumours develop, in...
SOLAS.net: Development and pilot implementation of an e-learning physiotherapist training programme for self-management of chronic musculoskeletal pain in primary care
As part of the original award, an evidence-supported group treatment approach for clients with persistent musculoskeletal pain termed SOLAS: Self-management of Osteoarthritis and Low back pain through Activity and Skills was developed. Also, a two day face-to-face physiotherapist training programme was developed and delivered to HSE...
Applying health: Using healthcare technology to enhance the delivery of rehabilitation programmes in cancer survivors
Recovery following oesophageal cancer (cancer of the food pipe) can be challenging. Cancer rehabilitation, which may involve exercise, advice from a dietitian, education or other therapeutic interventions, can help patients make an optimal recovery. The research team is currently investigating the effect of a 12 week rehabilitation...
Irish Dystonia Research Group: Innovation through collaboration
Our research group of Irish consultant neurologists (with an interest in movement disorders) and laboratory based scientists (engineers in the Department of Neural Engineering in Trinity College Dublin) have been involved in finding the cause(s) of a movement disorder which affects about 600-800 individuals in Ireland. This...
Enhancing awareness of the socio-economic impact of inherited blindness
In Ireland, many devastating diseases have an inherited cause and are passed onto further generations. Blindness due to inherited degeneration of the retina at the back of the eye is an excellent case-study with which to explain the basis of inherited disease, the socio-economic impact and the research required to generate new...
Enhancing awareness of blindness resulting from diabetes. Understanding treatments & preventative interventions
In Ireland, Diabetic Retinopathy is a leading cause of blindness. The number of people becoming blind due to diabetes is set to rapidly increase as the "diabetes epidemic" unfolds. In general, there is a lack of awareness as to the social, economic and health impact of diabetic blindness.
Here, we generate short 3D-animations that...Baby steps towards STRIDER: support, website, information, dissemination, exchange
This outreach programme will provide a dedicated public information and education resources on intrauterine growth restriction (IUGR) and the STRIDER clinical trial, which aims to improve outcomes of pregnancies affected by IUGR with sildenafil citrate (Viagra). It will provide support to women and their partners experiencing IUGR by...
Promoting positive mental health messages for the older population: The Irish Longitudinal Study on Ageing (TILDA) films
The Irish Longitudinal Study on Ageing (TILDA) offers unique data on the challenges associated with ageing and how these can affect mood as we age: grief, retirement, poorer physical health. We have demonstrated that mood may be affected by loss of support networks such as adult children moving abroad. Over 10% of the older Irish...
The Irish Longitudinal Study on Ageing (TILDA) hypertension seminars for health professionals in primary and community care practice
In April 2015 the Irish Longitudinal Study on Ageing (TILDA) published research, funded through the active award, which indicates that approximately two thirds of older Irish adults have high blood pressure and close to half of them are unaware of their condition. High blood pressure is an important risk factor for heart disease and...
A web-based resource and community of practice (CoP) to transform practices around 'talking about epilepsy'
This knowledge exchange and dissemination (KED) initiative proposes to develop a variety of educational and informative resources using different technological media (audio, video and e-authoring tools) which will be delivered online in a designated website to support the translation of research evidence on childhood epilepsy...
Healthy pregnancy in Ireland
The HRB Ireland Perinatal CTN is an all-island of Ireland clinical trial network for mothers and babies representing a new and exciting collaboration between two established research groups; the Irish centre for Foetal and Neonatal Translational Research (INFANT) and Perinatal Ireland. The 'Healthy Pregnancy in Ireland' initiative is a...
Innovative dissemination of IDS-TILDA Wave 2 - Advancing years, different challenges
The IDS-TILDA study is designed to better understand experiences and challenges for adults with an intellectual disability (ID) as they age. 753 persons aged 40+ started in the study. There have been two waves of data collection, with waves three years apart and 94% of people who answered at Wave one participated again at Wave two. We...
Development of The STOP-HF network for community based prevention of Heart Failure
STOPHFnet will create a virtual community of practice which will utilize the results of research from our HRB funded Natural History of Diabetic Cardiomyopathy grant to allow rapid dissemination to general practitioners in the community. This is particularly timely as diabetes will for the first time be nationally managed by GPs under...
Understand my pain: Educational tools for chronic pain
Based on the findings of the research during our HRB ICE award, we will develop two educational tools.
Activity A will involve the creation of a free video that explains how chronic pain impacts on children and their families. This activity is vital based on our new understanding of the numbers of primary school children who live...Development and launch of Irish guidelines on the management of Helicobacter pylori Infection
Helicobacter pylori infection is a public health issue. It remains one of the most common infections in adults in Ireland and is the primary cause of stomach ulcers and stomach cancers. Our recent findings have indicated that the eradication rate for standard first-line triple therapy for H. pylorihas fallen to unacceptable levels....
ICORG communications manager
2016 will mark the 20th anniversary of ICORG's formation. There are a range of public engagement activities on the agenda but in order to co-ordinate them ICORG will need an in-house communications function.
Activities will include;
1. Short documentary-style videos on patient experience, innovative research activities and new...Development of an online training and accreditation resource for a novel outcome assessment tool in high risk infants: the Babyscreen app
The HRB funded BiHiVE2 study has focused on predicting long term learning disability in children following birth related brain injury. Unfortunately there are, currently, no reliable methods of assessing learning ability in children at a young age. Current developmental assessments focus on developmental milestones. They are not true...
Thrombosis risk in pregnancy: what you need to know
Venous thromboembolism (VTE; deep vein thrombosis and pulmonary embolism) remains a leading cause of death in pregnant and recently delivered women. Surviving mothers may have long-term disability. If VTE risk factors are identified, then preventative measures may be put in place . These interventions can be potentially life-saving....
Translating critical care research into clinical practice
We are currently funded by the HRB to conduct clinical trials to determine which treatments may help patients who are critically ill. We have recently completed important research and the results will be published in a highly regarded medical journal in October. However it can take a long time between publication and improvements in...
Towards increased awareness and understanding of the risk of thrombosis in gynaecological cancers
All cancers are associated with an increased risk of clots to the legs and lungs however gynaecological cancers have a particularly high risk. Clots can occur after surgery or during chemotherapy and can be life threatening if they are not treated in time. A recent survey of patients who suffered a clot during their cancer journey...
What is Alpha-1?
Alpha-1 antitrypsin deficiency (Alpha-1) is a genetic disorder that affects the lungs. Typically people with Alpha-1 present with chronic obstructive pulmonary disease (COPD) or severe asthma. Ireland has one of the highest rates of AATD in the world. 1 in 25 Irish people are carriers for the condition and are at risk of lung disease,...
Cancer immunology research saves lives: Find Out
The treatment of cancer is being revolutionised by cancer immunology. However cancer immunology is poorly understood by healthcare workers, patients and the general public. Here, in collaboration with the Irish Cancer Society (ICS), we aim to use the expertise and discoveries generated by HRB and ICS funded research projects to...
DEDIPAC Ireland: National one day symposium on determinants of diet and physical activity
DEDIPAC (Determinants of Diet and Physical Activity; Knowledge Hub to integrate and develop infrastructure for research across Europe) is a collaborative European project, where Irish researchers play a major role in defining and understanding dietary and activity factors that influence health.
The aim of this application is to...Happy mothers...happy babies
Pregnancy is the highest risk period in a woman's life for developing clinical depression. Depression and anxiety during pregnancy are common experiences. Women are usually anxious about the pregnancy and the delivery, about how they will cope with motherhood and the impact of the changes that having a baby will make on their lives. We...
CERVIVA: Making connections and creating impact
The goal of CERVIVA's education and outreach programme is to create awareness, inform and effectively engage the public, health care professionals and healthcare providers on public health issues related to HPV associated diseases and on the specific research programmes underway within CERVIVA, which are addressing some of these...
Diet, health and sustainability - narrowing the gap between what we know and what we do
Knowledge translation in the area of diet and health is challenging due to the range of vested interests in the food sector and the contested discourse on food, diet and health among policy makers, practitioners, media and the general public. There is considerable agreement on key food policy measures open to government with potential...
A user-friendly database of genetic dependencies in cancer
A major challenge in cancer therapeutics is to kill tumour cells without harming other cells in the body. One means to achieve this is to exploit the genetic changes that distinguish cancer cells from normal cells and that may leave them vulnerable to targeted treatments.
A promising approach to developing such targeted treatments...Together against HIV: raising awareness and knowledge through documented real-life experiences and research discovery
There were approximately 2 million new HIV infections and 1.5 million HIV-related deaths worldwide in 2013, demonstrating the need for educational campaigns that raise awareness and prevent its spread. Current treatments suppress HIV, but do not totally clear it; however, a significant proportion of society believe these drugs cure...
Progressing universal health care: informing citizens by pooling and disseminating research and generating debate
There is little informed public discussion and debate around Universal Healthcare (UHC) in Ireland. There is also much confusion in political discourse between UHC and universal health insurance notwithstanding a recent policy shift towards UHC. This KEDS project aims to build on the Pathways to UHC research by educating the public...
Exploring clinical learning environments for postgraduate medical education and training
After graduation from medical school, doctors continue to train under the supervision, for several years, until they are ready to practice independently. These trainee doctors learn while they work, providing care to patients. Their working environments, therefore, need to support learning. It is difficult for those charged with the...
Neuroexercise: The effects of an extensive exercise program on the progression of mild cognitive impairment (MCI)
Joint Programme on Neurodegenerative Disease (JPND)
A lack of physical exercise plays a major role in the pathophysiology of vascular, metabolic, and metastatic diseases. Regular physical exercise has been successfully proven to counteract this deconditioning. Human and animal studies have demonstrated that regular...Neuroexercise: The effects of an extensive exercise program on the progression of mild cognitive impairment (MCI)
Joint Programme on Neurodegenerative Disease (JPND)
A lack of physical exercise plays a major role in the pathophysiology of vascular, metabolic, and metastatic diseases. Regular physical exercise has been successfully proven to counteract this deconditioning. Human and animal studies have demonstrated that...Imbuing Medical Professionalism (IMP)
This project aims to encourage and support medical graduates to become good doctors. Medical professionalism is essentially a set of values, enacted through behaviours and relationships, which underpin the public's trust in doctors. Employers and healthcare organisations govern the settings where doctors train and work and they have a...
Can implementation of an emergency department monitoring and escalation protocol of adult patients in a large teaching hospital reduce the number of critical incidents and improve timely intervention in patients requiring a high level of care and improve
The HIQA Report on the investigation into the quality, safety and governance of the care provided by Tallaght Hospital for patients requiring acute admission has recommended that an Emergency Department-specific system of physiological monitoring and triggered responses comparable to the National Early Warning Score (NEWS) should be...
Supporting work participation through early intervention in patients with regional MSK pain
Background: Patients with regional musculoskeletal pain (RMSKP) are at risk for work disability and instability and associated social and financial deprivation. Early intervention targeting prevention of work disability has potential to enhance patient outcomes and the effectiveness of care, with positive spill over effects for...
Irish cancer survivors' knowledge and perceptions of their lifestyle risk factors for cancer
The cancer landscape is changing and the picture emerging is a complex one that recognizes that some types of cancer are preventable. Empiric research has identified a number of lifestyle risk factors for cancer. Previous international and Irish research has explored the public's knowledge of cancer lifestyle risk, but to our knowledge...
The cognitive thalamus: more than a relay.
WT Scheme: Investigator Award in Science.
How do brain circuits support different but complementary aspects of event memory? The answer lies in distributed networks across the medial temporal lobe, prefrontal cortex and parietal cortex. Via their widespread connectivity, nuclei within the rostral thalamus support these memory...The impact of genetic heterogeneity on synthetic lethality in cancer
WT Scheme: Sir Henry Wellcome Postdoctoral Fellowship
Synthetic lethal interaction occurs when the function of one gene only becomes essential for viability in the presence of a mutation in another gene. In cancer treatment this phenomenon can be exploited to selectively kill tumour cells that have specific genetic mutations....Inequalities in access to GP care in Ireland: An analysis using longitudinal data
The principle of equal treatment for equal need is a key component of health policy. However, Irish and international evidence shows that factors other than health need are important in determining healthcare use. For example, there is extensive evidence that those who must pay for general practitioner (GP) care have fewer visits than...
Genetic basis of reflux nephropathy-related hypertension and renal failure in children
Vesicoureteric reflux (VUR) is the backflow of urine from the bladder towards the kidneys. It is a common disorder in children, but is often not diagnosed because it may have no symptoms. In some children, it stops happening as they grow, and they suffer no ill effects. However, it can be associated with kidney damage, and is a major...
The CHARMS Intervention to improve sexual assessment and counselling in hospital cardiac rehabilitation: A pilot study
Sexual problems are particularly common among people with cardiovascular disease, and have been shown to negatively impact quality of life, psychological wellbeing (anxiety and depression) and relationship satisfaction.
A prospective assessment of the biological burden of stress in caregivers: Impact on cognitive performance, mood and the benefits of mindfulness
The age structure of the population in Ireland is changing rapidly and the HSE predicts that the 65+ year old age group will contribute 20% of the population by the year 2036. Already, nearly 5% of the population are engaged as caregivers for ill elderly relatives and this is particularly stressful for those whose spouses or parents...
INCA SUn: A prospective randomised multicentre study to optimise the management of symptomatically uncontrolled asthma.
Inhalers are used in the treatment of patients with severe asthma. About 10% of people with asthma fail to achieve control of their asthma symptoms with inhalers. These patients with severe asthma, are often treated with extra medications or have severe attacks. One reason why these patients may not achieve control of their asthma is...
Examining the effects of S1P receptor drugs in Alzheimer's disease
Alzheimers disease (AD) represents one of the major brain illnesses that we now face. Treatments against this disease are limited and offer little in terms of cure. With the global population age now rising, AD is suggested to affect 1 in every 3 people. If left untreated, AD has potential to bring about collapse in healthcare,...
The heme oxygenase system as a therapeutic intervention for psoriasis
Psoriasis is a chronic inflammatory skin disease that causes cells to build up rapidly on the surface of the skin, forming thick silvery scales that become itchy, dry and sometimes painful. Current treatments for psoriasis depend on disease severity and include topical ointments, light therapy and systemic medications which are...
HRB Centre for Primary Care Research
The HRB Centre for Primary Care Research (CPCR- www.hrbcentreprimarycare.ie) is focussing on improving the quality and safety of medicines to vulnerable patient groups in Ireland, building upon observational epidemiology completed and published during the first phase of funding. Information and Communication Technology (ICT)...
Single blind randomised trial of supportive text messages for patients with alcohol use disorder and a comorbid depression
Most patients who present with problem drinking also present with mood problems. Problem drinking and mood problems co-occurring together in individuals lead them to have more severe symptoms, greater disability and poorer quality of life than individuals with only problem drinking, and they pose a greater economic burden to society...
Functional as well as structural brain connectivity and epigenetic changes in major depressive disorder associated with remission and persistence of symptoms over a 5 year course
Still less than one third of patients with MDD achieve remission with an adequate trial of a standard antidepressant after 10 - 14 weeks of treatment. This project will provide a crucial part of the research required for the development of more effective therapy strategies and for understanding the backgrounds for achieving remission...
Unlocking HIV-1 latency with metabolic cues
With 35 million people currently leaving with HIV and 1.6 million people worldwide who died from HIV in 2012, the AIDS pandemic is a major health crisis. In Ireland, the HSE and the HSPC have made HIV/AIDS a notifiable disease and a major public health importance. 30 years of intense HIV/AIDS research have provided efficient...
A multi-pronged translational approach towards testing a novel JAM-A inhibitor to reduce aggressive HER2-dependent breast cancer progression
Although breast cancer surgery and treatment have greatly improved in recent years, certain types of tumours are much more aggressive than others and therefore represent a greater risk to the patient. One such type of breast tumour is identified by the fact that it has high levels of a specific tumour marker called HER2. Therapies...
Rehabilitation following oesophageal cancer: Idenfitying rehabilitative needs and strategies
The treatments used to cure cancer of the oesophagus (food pipe) are usually twofold. Patients may first receive chemotherapy (drug treatment) to shrink the cancer followed by surgery to remove the oesophagus from the body. Patients who undergo this treatment for oesophageal cancer experience a number of weakening side-effects which...
The STRIDER Trial: A randomised controlled trial of sildenafil therapy In dismal prognosis early-onset intrauterine growth restriction
Severe early-onset in utero growth restriction (IUGR) affects babies in womb and is caused by reduced blood flow through the placenta. There is no treatment or cure for IUGR and the current clinical management involves intensive fetal surveillance with elective delivery performed when there is evidence of fetal distress and before the...
Hypotension, vasoreactivity and white matter intensities in the ageing brain: The Irish Longitudinal Study on Ageing (TILDA).
High blood pressure (hypertension) is known to cause brain ageing, from memory problems through to frank dementia, and is common in older age, affecting 70% of people over 70 years of age. Low blood pressure (hypotension) may be an even greater risk factor for cognitive decline and dementia; as it is an easily treatable condition this...
Proof of concept studies to validate clinical microsensors for the real-time detection of oxygen and pH
Currently there is no efficient method of continuously measuring oxygen or pH in real-time in hospitals. Existing techniques suffer from slow, indirect recordings and require the undesirable removal of a blood sample from patients. Doctors are extremely interested in measuring both of these parameters since they provide important...
Alendronate for Prevention of AntiRetroviral Therapy-associated bone loss (APART study)
Over six thousand people have been diagnosed with HIV infection in Ireland. People living with HIV are now living longer because of effective therapy. However, therapy is life-long and is associated with significant side effects. In addition, immune damage induced by HIV persists even with effective therapy. As a result, people with...
Investigate the impact of bile aspiration on chronic respiratory infection - bile paradigm
This study proposes to investigate the unexplained link between gastro-oesophageal reflux (GOR) and severe respiratory disease. During GOR, bile, normally found in the duodenum and stomach, is refluxed to the throat and subsequently aspirated into the airways and lungs of patients. A high prevalence of this phenomenon is seen in...
Ketamine for depression relapse prevention following electroconvulsive therapy: A randomised pilot trial with blood neuroplasticity biomarker evaluation
Depression affects up to 20% of people in their lifetime and can be a severe debilitating illness. Indeed, the World Health Organisation has estimated that depression will soon be the second leading contributor to the burden of disease worldwide. One of the big problems for patients and doctors is that currently available...
An antimicrobial susceptibility testing-based approach for Helicobacter pylori eradication: will tailored therapy overcome the increasing failure of standard empirical therapy?
Helicobacter pylori infection is a public health issue. It remains one of the most common infections in adults in Ireland (22%) and is associated with significant morbidity and mortality as the primary cause of stomach ulcers and stomach cancers. Infection is more common in lower socioeconomic groups and increases with age. Despite...
Identification of drugs that can safely and effectively maintain visual function in models of inherited retinal degeneration
Inherited Retinal Degenerations (IRD) are a diverse group of conditions resulting in blindness. This is often traumatic to the affected patient and families, and can cause significant socio-economic impact. Gene or stem-cell therapy show promise as treatments for IRD. However, these approaches are hampered by high costs and treatment...
Inherited retinal degenerations: All Ireland Retinal Degenerations Partnership (AIRDP)
Retinitis Pigmentosa (RP) is the most common inherited disorder of the retina affecting approximately one in 4000 people. The symptoms of RP are night blindness, tunnel vision and reduction of central vision. Although the symptoms of RP are broadly similar in most people, the genetic causes are complex with over 50 genes being...
Evaluating the impact of the systematic implementation of advance care directives and palliative care education on quality of care at end of life in long term care settings
It is essential that nursing home staff are equipped to provide high-quality end-of-life care, while it is also essential that the wishes of the older person about their care are taken into account. Many nursing home residents develop dementia, which can interfere with their ability to make healthcare decisions and to communicate...
Disease modification in rheumatoid arthritis using AMPK directed therapies: Resoring metabolic balance to innate immune pathways
Rheumatoid Arthritis (RA) is a chronic inflammatory disease affecting 1-2% of the population. Over time, RA causes joint destruction, chronic pain and lifelong disability. In addition to these effects, increased resistance to the effects of insulin and alterations in glucose handling mimicking effects seen in type II diabetes occur in...
Resistant hypertension in general practice: prevalence, prognosis, description and development of platform cohort for future research
High blood pressure causes, or helps to cause, almost two-thirds of all strokes and half of all heart attacks. Most people with high blood pressure can be treated by changing what they eat, doing more exercise or taking medications. However, among people with high blood pressure are some whose blood pressure remains too high despite...
Preventing chemotherapy resistance in triple negative breast cancer
Background: Breast cancers that lack the three molecules used to classify breast cancers; the oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), are described as triple negative breast cancers. Approximately 15 per cent of all breast cancers are triple negative. Triple negative...
STandaRd Issue TrANsfusion versuS Fresher red blood cell Use in intenSive carE (TRANSFUSE) - a randomised controlled trial.
Red blood cell (RBC) transfusion is required to treat a number of life threatening conditions within the general hospital setting and Intensive Care Units (ICU). Red blood cell units represent a very limited but essential resource. Given the value and relative scarcity of RBC, it is important to ensure its use in the optimal way. A...
Development of bioactive therapeutics harnessing stem cell mechanobiology
Tissue engineering is an emerging field of medicine that aims to treat diseased or damaged tissue through regeneration, rather than replacement. In order to achieve this, implantable scaffolds, that act as templates for tissue formation, are designed so that they not only provide structural support but also provide signals to cells...
Splintcost - Sensor providing longitudinal information on nocturnal toothgrinding and compliance of splint therapy
Many people grind their teeth at night, and may not be aware of it. Tooth grinding can cause headaches, facial pain or severe damage to the teeth. To prevent these problems, dentists often prescribe a mouthguard to use at night. Mouthguards are effective but few patients use them enough. Patients often wrongly believe that their...
Altered lipid raft cholesterol content contributes to the dysregulated activity of neutrophils in alpha-1 antitrypsin deficiency
Alpha-1-antitrypsin (AAT) deficiency (AATD) is largely unrecognized and under diagnosed. This hereditary disorder results in the rapid progression of lung disease, especially in smokers. Specific treatment for this disorder is available in the form of weekly intravenous injections of AAT. This is referred to as augmentation therapy...
Alpha-1 antitrypsin deficiency: Which is important phenotype, level, activity or all three?
Alpha-1 antitrypsin (AAT) deficiency (AATD) is generally regarded as a rare condition but more recently, evidence points towards it being a condition that is relatively common but rarely diagnosed. The most severe form of this genetic disorder, where people carry two bad AAT genes (Z) is known as ZZ-AATD and this affects around 2000...
The Low Von Willebrand factor Ireland Cohort (LoVIC) study.
Von Willebrand factor (VWF) is a large plasma protein that plays an essential role in normal blood coagulation. Inherited VWF deficiency is responsible for the commonest inherited bleeding disorder (von Willebrand disease or VWD) that affects up to 1% of the general population. Although substantial progress has been achieved in...
Sodium inTake In Chronic Kidney disease (STICK): A randomised controlled trial
Chronic kidney disease, which affects an estimated 300,000 people in Ireland and over 50 million people in the developed world, is responsible for a considerable burden of premature mortality and morbidity. All patients with chronic kidney disease are recommended low salt diets, i.e. less than a teaspoon of salt per day (which is 5-6g...
Modelling cystinosis with human stem cells and the therapeutic potential of aspartate
Cystinosis is a rare genetic disease that causes the amino acid cystine to accumulate in the body due to mutations in the CTNS gene. In its severest form, cystinosis causes kidney failure before the age of 10. Treatment is limited to cysteamine, a cystine-depleting drug, but this only slows the progression of the disease. The toxic...
Drug eluting contact lenses for cystinosis therapy
Cystinosis is a metabolic disease characterized by accumulation of cysteine crystals in various tissues including cornea. Cystinosis patients begin showing ocular symptoms at the age of 16 months and without appropriate treatment, the entire peripheral stroma and endothelium can be packed with crystals. Eventually complications such...
Effect of glucagon like peptide-1 therapy on obesity driven inflammation and co-morbid inflammatory conditions.
Obesity has been shown to cause and worsen diseases such as diabetes, psoriasis, arthritis, asthma and cancer. Increased inflammation is the basic process, which causes obesity related diseases. Inflammation is the body's normal way of dealing with an infection or injury, but is usually specific and short lived. However, in obese...
HRB Centre for Health and Diet Research
The vision for the Centre for the next five years:
The overall vision for the CHDR over the next five years is to contribute to the promotion of the health and wellbeing of the population through the development of a sustainable and internationally competitive National Research Centre for Public Health Nutrition which will:
...A systems-based patient stratification tool of Bcl-2 family protein interactions to evaluate acute treatment responses in rectal cancer patients
Cancers of the rectum (the lower part of the large intestine where the body stores stool) are a common cause of cancer-related death in Ireland and cause a significant burden to the quality of life of affected patients. Surgery is the mainstay for the treatment of rectal cancer, but surgeons often prefer to 'downstage' or 'shrink' the...
Enhancing the antimicrobial efficacy of mesenchymal stem cells (MSCs) for eliminating sepsis induced acute lung injury (ALI) using a novel combination of immune-stimulants
Despite advances in medicine, pneumonia is still a common disease accounting for 5% of deaths in Ireland and is the most common cause of acute lung injury and acute respiratory distress syndrome where there currently remains no specific therapy. Studies carried out by this and other research groups have recently shown that bone-marrow...
The natural history of cystic fibrosis liver disease - refining the phenotype
The incidence of Cystic Fibrosis (CF) is very high in Ireland. Survival has improved greatly over the past 30 years. However as longevity has increased so has the development of complications including liver disease. The diagnosis and treatment of liver disease in CF is particularly challenging. We do not understand the cause of liver...
Inhibiting XBP1s production as a novel therapeutic strategy in sepsis
Sepsis accounts for over 18 million deaths annually and is characterised by a severe/hyper activation of the immune system, also referred to as a cytokine storm, which is triggered by infection. In its most severe form sepsis manifests as septic shock and can lead to hypotension and multi-organ failure leading to death. The incidence...
An inter-sectoral analysis by geographic area of the need for and the supply and utilisation of health services in Ireland
The objective of this study is to provide an understanding of the supply of and interaction between health and social care services delivered in different sectors (acute hospitals: primary and community care; long-term care; informal care at home) in Ireland to inform the Governments policy of transferring activity and resources from...
Acute kidney injury (AKI) in the Irish health system; Incidence, severity and clinical consequences
Acute Kidney Injury (AKI), previously called acute renal failure, occurs when kidney function deteriorates rapidly over hours or days and elevated levels of waste products accumulate in the blood. AKI is most common in people who are hospitalized, particularly in critically ill people who need intensive care. AKI may occur in multiple...
Mapping the pathway to universal health care in Ireland
The current Irish Government has committed itself to achieving universal access to health care, free at the point of delivery, by 2016. Yet, at the moment, timely access to essential healthcare in Ireland is often determined by ability to pay, such as with private insurance. Further, those without medical cards or GP visit cards face...
Galactosaemia, translating novel monitoring approaches into improved clinical practice
Galactosaemia is an inherited condition caused by a lack of an enzyme (catalyst) which normally breaks down galactose (the sugar found in milk products). This affects on in 16,000 births annually in Ireland (the highest incidence worldwide), and is screened for by the National Newborn Screening Programme.
When an affected infant is...Restoring immune balance in patients with patients with primary Sjogrens Syndrome (pSS) by modulating microRNA expression
Sjogren's Syndrome (SS) is an autoimmune disease which affects 0.3-0.5% of people in the developed world. SS can occur at any age but is most common between the ages of 40 and 60. Women are 9 times more likely to suffer from SS than men. Specialised secretory glands that produce saliva, tears, and bowel secretions are targeted for...
HRB Trials Methodology Research Network
These are exciting and challenging times for clinical trials. The number and variety of treatments continues to grow, increasing pressures on researchers to determine how these compare to current treatments, while rising costs and regulation can make trials expensive and complex. However, as pressure on resources grows, there is more...
The role of angiopoietins and their mediators in symptomatic gastrointestinal angiodyslasia; novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding
Background: Approximately 5% of patients with gastrointestinal bleeding have no source identified on standard endoscopy and are classified as having obscure gastrointestinal bleeding, of which Small Bowel Angiodysplasia (SBA) accounts for more than 50% of cases. Due to limited understanding of the pathophysiology behind SBA no specific...
Overcoming mechanism of treatment resistance in castration-resistant prostate cancer: Defining a new treatment paradigm
Prostate cancer is the second leading cause of male cancer mortality in Ireland: in 2012, 533 men died from this disease.Prostate cancer growth is stimulated by male sex hormones (androgens) e.g. testosterone. The mainstay of initial treatment is to block gonadal production of these hormones. However, with time, cancers develop other...
An analysis of genetic and environmental modifiers of breast cancers risk
Breast Cancer Susceptibility Genes (BRCA) 1 and 2 are tumour suppressor genes that maintain genomic stability by repairing damaged DNA. Pathogenic mutations in these genes disrupt their role as tumour suppressors and can predispose to various malignancies, in particular those of the breast or ovary. Single gene mutations in BRCA 1 or...
Irish Platform for Patients' Organisations, Science and Industry
The purpose of this award is to enable IPPOSI to undertake a work programme providing a forum for patient organisations, scientists and industry to inform and support the advancement of health research for the development of therapies and cures for unmet medical needs specifically but not limited to:
- Providing information for...