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Funding Awarded

11 awards

  • A functional genomics pipeline for genetic discovery in diabetic kidney disease

    Diabetes is responsible for a large proportion of chronic kidney disease (CKD), end-stage kidney disease (ESKD), blindness, amputation, heart disease and stroke. Tight glycemic control in type 1 diabetes (T1D) or type 2 diabetes (T2D) can delay or arrest the progression of microvascular complications. How hyperglycemia...

  • Social Circumstances and Epigenomics: Promoting Health in Three Countries

    This project proposes an integrated set of aims and analyses of existing social and epigenetic data from three national studies of aging in the family of Health and Retirement studies (the US Health and Retirement Study (HRS), the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), and the Irish Longitudinal Study of...

  • Uncovering the neural architecture underlying decisions abstracted from movements

    Decision making is a core component of normal and abnormal cognitive function. Understanding the neural mechanisms of decision-making will lead to advances in the diagnosis, classification and future treatments of disorders affecting thought and control. Mathematical models of the decision process, based on bounded evidence...

  • Plasma-based therapies for bone infection

    Orthopaedic infection is life-threatening and current treatments are only sparingly successful. Despite aggressive peri-operative antibiotic treatments, 1.5% of knee revisions, 0.7 to 11.9%, of spinal infections (depending on the complexity of the procedure) and up to 27% of open fractures become infected. Moreover, the complexity of...

  • Treating Primary aldosteronism-induced hypertension via microwave thermal therapy

    In this tripartite US-Ireland R&D partnership program R01 research plan, we propose the development, optimization, and evaluation of a minimally-invasive microwave thermal therapy (MWT) system for definitive treatment of primary aldosteronism. Primary aldosteronism (PA) accounts for 5 - 12% of all hypertension and confers a higher...

  • Targeting the compromised brain endothelial barrier function during cerebral malaria with AT2 receptor agonists.

    Strengthening of inter-cellular junctions of endothelial cells would facilitate important translational applications for a variety of diseases where endothelial integrity is compromised. As a first model, we have chosen cerebral malaria (CM), which remains the deadliest manifestation of malaria. It is caused by Plasmodium falciparum...

  • Study of queuosine salvage and function in eukaryotes; a forgotten micronutrient

    Queuine is a largely forgotten bacterial-derived micronutrient that is obtained exclusively from the gut; a preeminent small-molecule of the gut-brain axis. Our contention is that queuine is important in metabolism and development—mammals are born sterile and queuine free—and induces long-lasting effects into adulthood, particularly in...

  • Food-based biomarkers, diet quality and cardiometabolic health

    Accurate assessment of human diet is the cornerstone of nutritional epidemiology. Biomarkers that are sensitive and specific to food intake can provide objective information that improves the characterization of diet. Advances in metabolomic profiling techniques now permit the discovery of novel food biomarkers, although, thus far,...

  • Systems modelling of tumor heterogeneity & therapy response in colorectal cancer

    Colorectal cancer (CRC) has one of the highest worldwide incidences (>1.3 million new cases) and mortality rates (~610,000 deaths per year). Genotoxic chemotherapy in stage II and III confers minimal treatment benefit (improved survival in 3-4% stage II and 15-20% of stage III patients), and predictive markers to select...

  • Ancient genomics and the Atlantic burden

    WT Scheme: Investigator Award in Science.

    Massive human genome resequencing projects are in train to further the understanding of the genetic contributions to disease. However these offer a limited view of genome genealogies, variant history and past selection, all of which are instrument to the models underpinning genomic...

  • Staphylococcus aureus induced immunosuppressive memory: Consequences for bug and for host

    WT Scheme: Investigator Award in Science.

    Antimicrobial resistance by Staphylococcus aureus is a global epidemic. New approaches based on induction of immune responses that control/prevent S. aureus infection, are required. This necessitates a thorough understanding of the unique relationship cultivated by S. aureus with the...