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Alpha One Foundation Athlone Institute of Technology Beaumont Hospital Cystinosis Foundation Ireland DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Fighting Blindness Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - Letterkenny General Hospital HSE - Midland Regional Hospital at Tullamore HSE - St. Luke's Hospital (Rathgar) Irish Blood Transfusion Service, National Blood Centre Irish Cancer Society Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Irish Thoracic Society Katholieke Universiteit Leuven Limerick Institute of Technology Mary Immaculate College Limerick Maynooth University Medical Research Charities Group Ltd Molecular Medicine Ireland National Rehabilitation Hospital National Suicide Research Foundation National University of Ireland Galway National University of Ireland, Galway National University of Ireland, Maynooth Our Lady's Hospice RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland Royal Victoria Eye and Ear Hospital Research Foundation Ltd St John of God's Research Foundation Limited St. James's Hospital TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia The Children's Medical and Research Foundation Trinity College Dublin University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford
Funding Awarded
26 awards
Perspectives of partners of women who experience mental health issues in the postnatal period
For most families having a baby is a happy occasion. A small number of women, however, suffer from mental health issues following the birth of their baby. Often the womans partner can play an important role in seeking help and supporting the woman and the baby. However, we have very little information on how the partners of women who...
The ExACT Trial
Exercise therapy is a well established, effective treatment for individuals with chronic pain and Acceptance and Commitment Therapy (ACT) is a promising new approach in the management of chronic pain. ACT helps people with chronic pain to focus on awareness of personal values and promotes activity that will enhance their quality of...
SDHB and its role in epigenetic alteration in malignant phaeochromocytoma
A phaeochromocytoma (PC) refers to a tumour located on the adrenal gland, which releases adrenaline and similar hormones and causes high blood pressure (in severe cases this may be fatal). When a similar tumour occurs outside of the adrenal gland it is called a paraganglioma (PGL) and can be located anywhere from skull to pelvis....
The Irish kidney gene project - identification and characterisation of novel genetic causes of familial kidney disease
Certain kidney diseases tend to run in families, suggesting that particular genes are inherited from one generation to the next, causing kidney disease. By undertaking a joint training programme between with Trinity College Dublin and Harvard Medical School Boston, I plan to study these families and seek to identify specific genes that...
Use of software and computer technology in aphasia rehabilitation; investigating issues of efficacy, usability and cost effectiveness
Technology can provide an answer for over-stretched health care provision but will service users, particular older adults, actively engage with it? This research will investigate the benefits of a computer programme on language comprehension abilities (i.e. ability to understand spoken sentences) and explore the user experience of...
Development and validation of metric-based training to proficiency for dental implant placement
Common dental diseases such as dental decay (caries) and gum (periodontal) disease can lead to the loss of teeth, which has detrimental effects on patients chewing ability, speech and smile. While retaining teeth for patients is a primary goal for the dental profession, the replacement of teeth when they are lost is an important role...
Characterisation of polyclonal IgG and paraprotein glycosylation in multiple myeloma to investigate structural and functional insights into stage-specific pathologies
Multiple myeloma is a type of blood cancer characterized by abnormal antibody called paraprotein, produced by the cancerous plasma cells in the bone marrow. Patients develop anaemia (due to bone marrow infiltration by cancerous cells), high calcium, bone destruction, kidney failure and death. Survival has improved since the approval of...
Unwrapping the layers of complexity of clinical performance assessment of physiotherapy students and identifying key stakeholders' preferences towards enhancing the process
Clinical performance assessment of health professional students is imperative as it provides a measure of a students readiness to practice within their profession. However, it is widely acknowledged as being inherently problematic. Difficulties reported by clinicians in medicine, nursing, psychology and social work include the...
Caesarean section in nulliparous women: factors influencing decision-making process and outcomes for women- The MAMMI study caesarean section strand
This study will find out the factors, or combination of several factors, that influence the decision to perform a caesarean section (CS) in first-time mothers in Ireland, the health problems women experience in the first year after the birth and what women, midwives and obstetricians believe are the reasons behind the decision to...
Towards personalised therapy in stricturing crohn's disease- exploring and exploiting the role of NADPH oxidase in intestinal fibrosis
Crohn's disease, a member of the family of inflammatory bowel diseases, causes inflammation throughout the digestive tract and frequently results in fibrosis (scarring) of the intestine, which will cause narrowing and ultimately bowel obstruction. Available treatments can dampen the inflammation, but do not prevent fibrosis. It is...
An investigation into early adverse life events and psychotic-like experiences in Irish youth
At some time in their life, up to one in six adolescents is likely to have experienced some form of hallucinations or delusions, also known as psychotic-like experiences. These experiences include things like hearing voices, seeing things that are not there and having fixed false beliefs about yourself or the world around you. Most...
Attenuation of exaggerated post-prandial gut hormone response: A novel therapeutic strategy for the treatment of excessive weight loss among disease-free post-oesophagectomy patients
There is increasing incidence of cancer of the oesophagus (the gullet or swallowing tube). Improvements to treatment strategies for oesophageal cancer have produced an increasing population of patients who remain free from the disease recurrence in the long-term. Optimising long-term outcomes for these patients after treatment...
The clinical application of immunometabolism to the TB Patient
Recent studies have shown that cells of the immune system change the way that they break down sugars (their metabolism) after they are stimulated, and that this change in metabolism is needed in order to produce specific chemicals (cytokines) that fight infection.
We will study what metabolism changes happen in immune cells from...Investigating the impact of body composition and nutritional intervention strategies in pancreatic cancer
Pancreatic cancer is the 9th most common cancer in Ireland, and the 5th most common cause of cancer related death. Because of its location deep within the abdomen, patients often present with advanced cancer at the time of diagnosis. The options for treatment are limited as surgery is only suitable for patients who don't have spread of...
Overcoming survival signalling in Multiple Myeloma
Multiple Myeloma (MM) is a blood cancer affecting plasma cells, a type of white blood cell located in the bone marrow. It affects the bones, kidneys and causes patients to have frequent infections. There are approximately 250 new cases diagnosed in Ireland annually. MM is not curable and although the treatment for this condition...
Living with Motor Neurone Disease (MND) and Dysphagia -the personal experiences of individuals with MND and their caregivers
Motor Neurone Disease (MND) is one of the most progressive diseases of the nervous system, for which there is no cure. It often leads to weakness in the arms, hands and legs, posing difficulties with daily life activities. Throat muscles can also be affected leading to speech and swallowing problems (dysphagia). Dysphagia can be life...
Development of a core set of clinical care provision indicators for non-specialist palliative care in the acute care hospital setting
Palliative care encompasses the support structure around people facing problems associated with life-limiting illness and includes the support of their families, but this is more than end-of-life care, and is viewed as central component of care for people living with limiting illnesses. Palliative care policies in Ireland draw on these...
The OPTIMAL study: A randomized controlled trial and process evaluation of an OccuPaTIonal therapy led self MAnagement support programme for patients with muLtimorbidity in primary care
Many people with chronic disease tend to have more than one chronic condition, referred to as multimorbidity. It is predicted that the number of individuals with multimorbidity is set to increase substantially in the future due to the growing elderly population. Those with multimorbidity experience poor physical function and find it...
Determining the breadth and burden of chronic kidney disease in Ireland: Associations with cognitive impairment, functional decline and quality of life
Chronic kidney disease (CKD) is a major health problem all over the world. At least one in 10 adults are estimated to have kidney disease. Some of these people will progress to end-stage kidney disease which requires dialysis treatment or a kidney transplant for survival. However the majority of people with CKD do not survive long...
The cost of survival: Understanding colorectal cancer survivors' quality of life
The lives of people who have completed treatment for colorectal cancer may be affected by physical and psychological disabilities, caused by surgery, chemotherapy and radiotherapy. For those who are cured, their quality of life may be adversely affected by side-effects such as fatigue, pain, sensory neuropathy, sexual dysfunction,...
Overcoming mechanism of treatment resistance in castration-resistant prostate cancer: Defining a new treatment paradigm
Prostate cancer is the second leading cause of male cancer mortality in Ireland: in 2012, 533 men died from this disease.Prostate cancer growth is stimulated by male sex hormones (androgens) e.g. testosterone. The mainstay of initial treatment is to block gonadal production of these hormones. However, with time, cancers develop other...
The use of eccentric exercises and topical glyceryl trinitrate (GTN) in the treatment of midportion Achilles tendinopathy: A randomised placebo controlled trial
Pain in the Achilles tendon is a common condition seen by physiotherapist and doctors. It affects people involved in sports and those who are not. For those who suffer with this condition, it can limit their ability to walk, hop, jump and run. If the pain persists for longer than three months it can become extremely difficult to...
A geographic model for improving out-of-hospital cardiac arrest survival in Ireland
Out-of-hospital cardiac arrest (OHCA) affects approximately 2,500 people every year in Ireland. Even when resuscitation is attempted, approximately one in fifteen people survive.
Evaluation of next generation sequencing to investigate the epidemiology of Clostridium difficile infection
Clostridium difficile('C. diff') is a common cause of infectious diarrhoea following antibiotic treatment, sometimes with serious consequences. Although most cases occur in hospital in-patients, they are increasingly seen in the community, without known sources of exposure. 'C diff' can colonise the intestine prior to developing...
The progression of crouch gait in diplegic cerebral palsy
Cerebral palsy (CP) is a neurological condition caused by a lesion to the brain at or near the time of birth. This leads to muscle tightness or weakness as well as general co-ordination difficulties. This commonly results in difficulties with walking and mobility. A common pattern of walking in CP is crouch gait or excessive flexion of...
Environmental and genetic epidemiology of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rare condition that is thought to be; caused by a combination of genetic and environmental influences. The lifetime risk of the condition is 1 in 300, and approximately 250 people in Ireland suffer from the condition. Ireland has a population based registers of ALS that has captured all new...