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Funding Awarded

138 awards

  • Vaccination: Knowledge is power

    Over 3 million global deaths are avoided annually due to the existence of vaccines. In Ireland the state funded immunization program protects against 14 infectious diseases including HPV. However, we face a number of challenges with immunization. Alarmingly, in recent years uptake of vaccines has been waning. Perhaps due to complacency...

  • Health and social inequalities in the Mid-West

    As there are many disadvantaged areas in the Mid-West, health and social inequalities are important issues locally. This is because deprivation is linked with poor health and poor access to healthcare. Under the Healthy Ireland Framework, taking actions to address health inequalities is a key priority. In the Mid-West, many...

  • Self-Harm and Suicide AwaREness ? SHARE

    SHARE is based on outcomes of the HRB funded research programme: Improving Prediction and Risk Assessment of Suicide and Self-Harm (IMPRESS). The IMPRESS study aims to improve the knowledge base on predictive risk factors associated with repeated self-harm and suicide among high-risk groups of self-harm patients in Ireland. During the...

  • Postnatal Mental Health PARTNERship

    It is estimated that 10-25% of mothers will experience a mental health problem following the birth of their baby. With approximately 63,900 births in Ireland each year (6), conservative figures would suggest that over 6390 mothers will experience a mental health problem in the postnatal period. For many mothers, their partner plays a...

  • Towards Recovery After Childbirth, through Knowledge: (ON TRACK)

    The Maternal health And Maternal Morbidity in Ireland (MAMMI) study identified problems women had postpartum. We have provided information for women on physical problems, such as incontinence, and will now address other important issues. For example, 15% of women have anxiety during pregnancy, and 44% have pain during sex at 3 months...

  • Developing an on-line course for first-time mothers: ?Pathway to Birth?

    Concern has been expressed globally at rising caesarean section (CS) rates with no evidence of any decrease in associated health problems for mothers and babies, indicating that many CSs are unnecessary, and can be harmful. We are at present running a pilot trial called "REDUCE"to see if a new intervention, based on research evidence,...

  • The Breakfast Club

    The Breakfast Club is the story of diabetes in pregnancy in Ireland. In a weekly, serialized, online graphic novel, we will follow the lives of women attending a Breakfast Club for women who have received a diagnosis of diabetes during their pregnancy. We will explore their experiences, from having a Glucose Tolerance Test, to meeting...

  • Medtrack KEDS

    "Health professionals are the lifeblood of the health system"(President M Robinson), yet our junior doctors (NCHD-trainees) continue to report that responses for improving their working conditions have had "little tangible change or impact on their day-to-day working lives and training experience?. The RCSI research team has...

  • Development of a Teaching Programme for the Junior Cycle Mental health and Mental Ill-Health Module

    Great progress has been made nationally on destigmatising mental health but it has not yet become a topic that people are universally comfortable with. A major change in the Junior Cycle in 2018 is the introduction of Wellbeing which directly addresses youth mental health through Strand 4 in the new Social Personal and Health Education...

  • Development of Book About Mental Health Problems For Children and Adolescents

    There has been steady improvements in the quality of information available to people about mental health issues but a challenge remains to communicate this fully to children and adolescents. Much of the existing information is text heavy and can be off-putting for this age group. Presenting this information so that it is accessible...

  • Citizen Science: The People's Trial

    Randomised trials are instrumental in providing reliable and robust evidence on the benefits, harms and costs of health care, so that people can make informed choices. However, the general public?s understanding of randomised trials can be limited and ensuring public support for and participation in trials remains challenging. The...

  • Delivering a Reduction in the Development of Maternal Prenatal Stress: DIRECTMAPS

    Pregnancy can be a stressful time during which many expectant mothers experience understandable worries and concerns. High levels of prenatal maternal stress are linked to several unfavourable conditions which can affect the health of the child at birth. Normal development of the central nervous system is also at risk during the early...

  • Piloting the Community Engaged Scholars Program in Ireland

    Public and patient involvement in health research is not embedded in Irish Universities. As part of the PPI Ignite Awards scheme the HRB have funded 5 Irish Universities to demonstrate the value of PPI and champion this approach in Ireland. PPI involves public/patients working in partnership with researchers in setting research...

  • Promoting Education and Research Knowledge (PERK)

    THE PROBLEM Cancer of the oesophagus (food pipe) is an aggressive type of cancer, and has a low survival rate. It is usually diagnosed at a late stage, often due to a lack of knowledge of underlying symptoms which can be mild, including heartburn, bloating and problems swallowing. Oesophageal cancer is not as well known as some other...

  • Rheumatoid Arthritis Patient Awareness INitiative (RA-PAIN)

    Rheumatoid Arthritis (RA) is a common autoimmune condition that causes disability for patient's day-to-day tasks. New medications that target bad molecules or cells improve outcomes, however responses may be limited or side effects may occur. Who will develop RA, get severe disease or respond to current treatments is not known. Studies...

  • Using photovoice to enhance knowledge exchange and dissemination

    The EOLAS programmes are information and learning programmes for people with experience of psychosis and their family members. The programmes have been co-produced and are co-delivered by peer and clinician facilitators in partnership with mental health clinicians. Such service user and family member involvement in the design and...

  • CHErIsH- KEDS

    This CHErIsH-KEDS application has two aims: to increase capacity in translation of research into practice in Ireland and to develop a knowledge exchange strategy for the future roll out of CHErIsH across different settings in primary care. This application builds on the existing study, the CHErIsH study. The CHErIsH study is funded...

  • How to Use TILDA Data - Webinar, Seminar and Workshop Series

    The Irish Longitudinal Study on Ageing (TILDA) was established in 2006 with baseline data collection commencing in 2009. TILDA collects data in a series of data collection waves. The data is collected through a computer-assisted personal interview and a self-completion questionnaire once every two years with a comprehensive health...

  • Co-Designing, Pre-Testing and Refining an Intervention Programme to Support Parent-Adolescent Communication about Shared Self-Management Responsibilities in Type I Diabetes

    This knowledge exchange activity aims to work together with young people with Type 1 Diabetes (TID), parents of young people with TID, professionals (from a range of disciplines e.g. diabetes nurse specialists, psychologists, consultant paediatric endocrinologists) and community advocates (e.g. Diabetes Ireland) to codesign, pre-test...

  • Collecting and using data about ethnicity in healthcare -a drama

    Ireland has a long history of emigration. More recently, we have inward migration. Census 2016 found that 17% of the population were born outside Ireland. This means that there are different minority ethnic groups in our country, in addition the Irish Travellers. The Health Service Executive wants to gather information on the ethnic...

  • The APART Study Public Participation Initiative for Knowledge Exchange

    The APART Study is exploring an important, low-cost intervention that may limit bone loss associated with initiation of antiretroviral therapy to treat HIV. Results from this trial may have significant implications for how HIV is managed both in Ireland and internationally. We will use this KEDS award to develop a research partnership...

  • Real Talk with Real Mums

    ?Real Talk with Real Mums? is a 10-episode podcast series looking at the issues of everyday pregnancy with medical professionals and the real women who have gone through the pregnancy journey. Each episode of c.30 minutes will tackle a different topic, from exercise in pregnancy (with a Physiotherapist), to mental health issues in...

  • TeamTalk: Interactive Resource Hub for Healthcare Teams

    Healthcare teams who are interested in improving how they work together to deliver better patient care often struggle to find the time to learn and implement new practices. Teams rarely have the opportunity to attend training courses or other learning events together. This makes it difficult to transfer their newly acquired knowledge...

  • Working with the Research Community: Training and a Toolkit for Patients & Members of the Public

    The PPI Ignite Programme at Trinity College Dublin is focused on building capacity for public and patient involvement in health research, with a particular emphasis on improving the quality of approaches. One of 10 Ignite Partners, the Medical Research Charities Group (MRCG), hosts a Public Patient Involvement (PPI) Shared Learning...

  • Disseminating, Engaging, and Sharing Knowledge (DESK):patient informed resource for understanding our research

    Based on the findings of the research conducted during our HRB Research Leader's Award, the aim of the proposed KEDS project is to effectively disseminate the finding of our research to chronic pain patients and the general public. Sharing research findings with the general public is very important but can be difficult to get right; we...

  • A Patient Education Programme in Health Research & Innovation

    Well informed patients and carers have a key role to play in the design and implementation of person-centered healthcare and research. Whilst patients are eager to have better and safer health products and innovations, they are often unaware of the complex nature of how new health innovations are researched, developed and made...

  • The patient is part of the answer - don't leave us out in the cold!

    This application aims to produce a documentary that explains public and patient involvement in health research to the general public and encourages more people to become involved with researchers. Known as PPI, public and patient involvement means that people who are likely to be affected by research results are directly involved in...

  • Promoting National Awareness of Thrombosis in Pregnancy.

    Women who are pregnant have a higher chance of developing blood clots (thrombosis) that can cause serious ill-health and can be fatal. Therefore, it is incredibly important that women who are pregnant, women of childbearing age and their families are aware of their risk factors for thrombosis in pregnancy. In the HRB-funded "HIGHLOW"...

  • Maximising collaboration to expedite positive change in the assessment process that determines physiotherapy students' readiness for independent practice

    Assessment of student physiotherapists in the clinical environment is a critical part of their education which determines their readiness for independent clinical practice once qualified. Therefore it has significant implications for patient safety and quality of service delivery. Yet, research and experience highlight many challenges...

  • LoVIC-Kids: Improving public awareness of abnormal bleeding symptoms

    Congenital bleeding disorders (CBD) may result in increased bleeding at times of injury, surgery, childbirth or with periods (menstrual bleeding). Although an estimated 1-2% of the population are affected by CBD, most people are unaware that their bleeding symptoms are abnormal. In addition, there is limited awareness amongst many...

  • "Let's Talk About" Series

    Researchers in dementia at NUI Galway are producing important research insights into many aspects of dementia care in Ireland, specifically: resource allocation decision-making; support structures for family carers; and how people with dementia are treated within the care system. The focus is now turning to sharing the results...

  • Using visual media to communicate complex information

    Services in Ireland for people with dementia are poorly developed. The main partnership award aims to (i) describe current dementia services across all sectors and (ii) ask people with dementia, carers, health workers and managers about the ideal level and type of service provision for people with dementia who have different needs and...

  • Factors influencing decision-making for caesarean section

    The rising rate of caesarean section (CS) has become a growing concern worldwide, with limited justification of the rising trend. Understanding the factors that influence the rise in CS is important because obstetricians and midwives are directly involved in the decision to perform a CS and are the key drivers to achieving the remedial...

  • Enhancing ?The Model for Dementia Palliative Care Project? by targeting potential model users with innovative Knowledge, Transfer and Exchange activities.

    This KEDS application will further enhance Knowledge, Transfer and Exchange (KTE) activities arising from 'The Model for Dementia Palliative Care Project', by supporting new connections with key groups, through novel activities and outputs. The active project will develop a new service delivery model for palliative care for people...

  • What the Researcher and the Dentist want to share, supporting knowledge dissemination

    Research is ongoing to monitor the oral health of the Irish population, the uptake of dental services, and targeting of services to specific groups most in need. Results of such research inform policy makers in the Department of Health with respect to issues such as community water fluoridation and recommendations on the use of...

  • Communicating and promoting SAFE medicines use in Ireland

    The likelihood of side effects of medicines, drug interactions and potentially inappropriate prescribing increase with the increasing number of medicines people take. Taking multiple medicines at the same time is common in people age 65 year olds or older with six in every ten in this age group. Also, around one in ten of those aged 65...

  • Interact for Health: Increasing integrated knowledge translation capacity for impact

    Although the Health Behaviour Change Research Group (HBCRG) has engaged with the HSE Health and Wellbeing (H&W) Division as health partners on a number of activities to date, we believe there is significant potential for enhanced knowledge exchange between these two groups. Additionally, integrated Knowledge Translation (iKT)...

  • The biology of mood: What brain imaging and genetic studies tell us about Bipolar Disorder

    This project aims to translate the known biology of bipolar disorder, enhance the accessibility of the latest discoveries and interpret the meaning and relevance to individuals with bipolar disorder, their families, carers and health professionals that are not research active. To complement the current emphasis on clinical aspects of...

  • The youth mental health animation creation project

    This KEDS award will be used to create animations about young people's mental health that will be embedded into the youth mental health website, ReachOut.com.



    This project will involve crafting key messages from this study into short narratives using direct quotes from the research interviews conducted for this...

  • Brain superheroes and villains

    We are a group of neuroscientists, funded by the HRB, who aim to test and develop novel drugs for brain related illnesses. We are excited about disseminating the value of work like ours and, in 2012, were delighted to be awarded our first HRB Knowledge Exchange and Dissemination Scheme (KEDS), which consisted of three activities...

  • Learning about trials - for children, by children

    This project will consist of the development of new resources for teaching primary school children (aged 10-12) about why we need trials and how trials work, with a view to being more widely used throughout the trial community. These resources will align with the START (Schools Teaching Awareness of Randomised Trials) Competition,...

  • Family carer knowledge exchange project

    We are interested in how family carers of people with dementia develop and maintain resilience in the care giving role and we are designing a project to help family carers to be more resilient and to better cope with the demands of care giving. As a team of researchers, we have reviewed studies of family carers'experiences in other...

  • Community exercise

    It is recognised that exercise benefits people living with chronic disease. The CRF at St James's Hospital exercise physiology suite is used by research studies examining the role of exercise training for patients with chronic disease. These exercise trials support patients to exercise during structured supervised exercise classes and...

  • Driving policy with data: A longterm sustainable specialist service for amyotrophic lateral sclerosis

    The JPND-funded project ALS-CarE is coordinated by the Irish partner, and has collected detailed information across 5 different countries about the Amyotrophic Lateral Sclerosis (ALS) patient and caregiver journey from ALS diagnosis through to end of life. In Ireland, we have collected extensive quantitiative and qualitative...

  • The StrokeCog partnership: effective intervention through collaboration

    Stroke is a leading cause of death and disability worldwide and will increase considerably in coming decades as people live for longer. Many people are aware of physical disabilities after stroke, but are less aware of cognitive problems. These include difficulties with memory, concentration and abstract thinking, often experienced as...

  • Non-motor symptoms in dystonia and musician's dystonia

    Our multidisciplinary Irish Dystonia Research Group, combining the expertise of Bioengineers in Trinity College Dublin and a network of Clinical Neurologists, has been working to determine the cause of a disabling movement disorder, adult onset dystonia, characterised by abnormal postures and excessive muscle activity. The causes of...

  • Evidence to Support Prevention Implementation and Translation - Knowledge Translation (ESPRIT-KT)

    This application adds to a larger HRB Research Leader Award about improving care for people with diabetes in Ireland. The goal of the KEDS project is to connect people who do research with people who make decisions about our national health policy so they can learn from each other and work together to improve the health of the...

  • Developing a website for public awareness about computer use in aphasia rehabilitation

    Aphasia is a language disorder which occurs in 1 in 3 people after stroke. It can impact on a person's ability to produce and understand spoken and written language. People with aphasia have had limited opportunities to have their voices heard within Irish stroke research.



    This research project has already engaged...

  • The Art of Pregnancy

    The Art of Pregnancy is an exciting and ambitious public outreach exhibition and programme supported by the HRB Mother and Baby CTN togther with the Science Gallery Dublin as a key partner.

    For this project we want to commission (via an open call process) a group of artists to create works inspired by the wide ranging areas of...

  • Speaking Up About Safety (SUAS)

    Speaking up about safety concerns is an important aspect of a healthcare professional's role. Our research has shown that in comparison to nurses, junior doctors are particularly poor at speaking up and tend not to report incidents and adverse events, in many cases because they believe it is not their responsibility to do so. Yet, a...

  • Our voices, our impact

    Wave 3 KEDS will build on previous success by recruiting actors with ID to develop DVD and on-line resources comprising scenes that illustrate key IDS-TILDA wave 3 findings. Feedback from wave 3 indicates that participants would like to receive the findings in DVD format and IDS-TILDA wishes to respond to the specific dissemination...

  • Brain, mind and psychosis: Engaging young people in learning about research

    Great progress has been made over the past few years in "destigmatising" mental illness and this has been particularly successful for conditions such as depression and anxiety. However there still remains a great lack of knowledge about psychosis. This lack of knowledge can lead to stigma and fear and can prevent young people coming...

  • The LinKT (Linking into Knowledge Translation) project: connecting, integrating and translating evidence to make a difference for families

    Increasing evidence highlights the effectiveness of early intervention and prevention parenting interventions for improving the mental health and wellbeing of parents and children in the earliest years. However, these are often complex, difficult to implement effectively and fail to reach the most vulnerable families. Accessible,...

  • Development of an online cancer genetics educational resource for undergraduate and postgraduate healthcare learners

    Genetic testing is becoming cheaper and easier to perform. As such, it is being performed more and more frequently; to help explain why people have developed cancer, or to try to identify genetic changes in their tumours to which novel drugs can be targeted. Genetic testing may also help identify individuals at risk of cancer,...

  • Pathfinder: Parental information on therapeutic hypothermia followIng neonatal encephalopathy

    Neonatal brain injury can have devastating outcomes for the baby and their family and may result in longterm disability. The only treatment available is whole body cooling started within a few hours of birth. Babies also require intensive care to support their lungs, heart and kidneys. We will develop an educational toolkit including...

  • Let's talk - and act - about adherence in multimorbidity - a teaching and learning resource for general practice

    More than half of those over the age of 65 live with more than one chronic condition. This is known as multimorbidity (MM). The prevalence of MM increases with age and is more common in less well off patients. Using muliple medications i.e. polypharmacy, is the norm in MM and many do not take their medications as prescribed i.e....

  • Cracking the mysteries of cancer immunotherapies - e.courses for oncology healthcare professionals

    The new therapies for cancer that target the immune system have revolutionised cancer care in recent times. The treatment of melanoma, leukaemia and other malignancies has been transformed by these immune modulating drugs. However, few oncology clinicians or oncology specialist nurses have backgrounds in immunology or immune...

  • The stressed brain & depression

    Understanding depression is challenging both for professionals and for the public. It is complex and poorly conceptualized. Clinical depression involves biological, psychological and social causes that all contribute to the expression of depression in each individual sufferer. Trauma, especially early in life when body systems are...

  • CERVIVA: The HPV educate project

    The goal of this CERVIVA HPV Educate Project is to provide accurate and reliable information relating to HPV and HPV associated diseases, to create awareness and educate the public, health care professionals and healthcare providers on public health issues related to HPV associated diseases and on the specific research programmes...

  • Overweight & obesity in Ireland: Translating policy into action

    The launch in 2016 of "A healthy weight for Ireland", the Government's National Obesity Policy and Action Plan, 2016-2025 represents an important milestone in Ireland's response to ongoing epidemic of overweight and obesity in children and adults. Researchers in the HRB Centre for Health & Diet (CHDR) generated key evidence which...

  • Listening to the newborn brain

    This outreach programme will provide dedicated public information and education resources on the neonatal brain stethoscope device, which aims to facilitate interrogation of the neonatal brain and improve the quality and accuracy of the diagnosis brain injuries, reduce the stress of parents with babies in the NICU and establish the...

  • Expert forum to advance the potential of IL-1 family members as novel therapeutics in IBD

    Current treatment strategies for Inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, are ineffective in a large number of patients. Although the reasons for this are not fully understood, it seems likely to reflect the complex nature of chronic intestinal inflammation. Recent advances in our understanding...

  • Supporting individuals and organisations involved in implementation of community water fluoridation

    The Fluoride And Caring for Children's Teeth (FACCT) study was initiated to determine the effect of the change in water fluoridation policy (2007) on dental caries (tooth decay) and enamel fluorosis (marks on tooth enamel which are associated with fluoride) in Irish children, while also considering the change in policy on the use of...

  • MRCG support award

    The Medical Research Charities Group (MRCG) is the national organization of 35 patient groups and foundations which promote an improved environment for medical research in general and for charities in particular, obtain funding for research projects, bring together organizations working in the field and disseminate the outcomes. Its...

  • MRCG interim support award

    The Medical Research Charities Group (MRCG) is the national organization of 35 medical research patient-led charities formed to promote dynamic medical research in Ireland. The MRCG works in partnership with key stakeholders, such as the Health Research Board (HRB), to bring added value to the health research landscape. The MRCG is...

  • Perspectives of partners of women who experience mental health issues in the postnatal period

    For most families having a baby is a happy occasion. A small number of women, however, suffer from mental health issues following the birth of their baby. Often the womans partner can play an important role in seeking help and supporting the woman and the baby. However, we have very little information on how the partners of women who...

  • The ExACT Trial

    Exercise therapy is a well established, effective treatment for individuals with chronic pain and Acceptance and Commitment Therapy (ACT) is a promising new approach in the management of chronic pain. ACT helps people with chronic pain to focus on awareness of personal values and promotes activity that will enhance their quality of...

  • SDHB and its role in epigenetic alteration in malignant phaeochromocytoma

    A phaeochromocytoma (PC) refers to a tumour located on the adrenal gland, which releases adrenaline and similar hormones and causes high blood pressure (in severe cases this may be fatal). When a similar tumour occurs outside of the adrenal gland it is called a paraganglioma (PGL) and can be located anywhere from skull to pelvis....

  • The Irish kidney gene project - identification and characterisation of novel genetic causes of familial kidney disease

    Certain kidney diseases tend to run in families, suggesting that particular genes are inherited from one generation to the next, causing kidney disease. By undertaking a joint training programme between with Trinity College Dublin and Harvard Medical School Boston, I plan to study these families and seek to identify specific genes that...

  • Use of software and computer technology in aphasia rehabilitation; investigating issues of efficacy, usability and cost effectiveness

    Technology can provide an answer for over-stretched health care provision but will service users, particular older adults, actively engage with it? This research will investigate the benefits of a computer programme on language comprehension abilities (i.e. ability to understand spoken sentences) and explore the user experience of...

  • Development and validation of metric-based training to proficiency for dental implant placement

    Common dental diseases such as dental decay (caries) and gum (periodontal) disease can lead to the loss of teeth, which has detrimental effects on patients chewing ability, speech and smile. While retaining teeth for patients is a primary goal for the dental profession, the replacement of teeth when they are lost is an important role...

  • Characterisation of polyclonal IgG and paraprotein glycosylation in multiple myeloma to investigate structural and functional insights into stage-specific pathologies

    Multiple myeloma is a type of blood cancer characterized by abnormal antibody called paraprotein, produced by the cancerous plasma cells in the bone marrow. Patients develop anaemia (due to bone marrow infiltration by cancerous cells), high calcium, bone destruction, kidney failure and death. Survival has improved since the approval of...

  • Unwrapping the layers of complexity of clinical performance assessment of physiotherapy students and identifying key stakeholders' preferences towards enhancing the process

    Clinical performance assessment of health professional students is imperative as it provides a measure of a students readiness to practice within their profession. However, it is widely acknowledged as being inherently problematic. Difficulties reported by clinicians in medicine, nursing, psychology and social work include the...

  • Caesarean section in nulliparous women: factors influencing decision-making process and outcomes for women- The MAMMI study caesarean section strand

    This study will find out the factors, or combination of several factors, that influence the decision to perform a caesarean section (CS) in first-time mothers in Ireland, the health problems women experience in the first year after the birth and what women, midwives and obstetricians believe are the reasons behind the decision to...

  • Towards personalised therapy in stricturing crohn's disease- exploring and exploiting the role of NADPH oxidase in intestinal fibrosis

    Crohn's disease, a member of the family of inflammatory bowel diseases, causes inflammation throughout the digestive tract and frequently results in fibrosis (scarring) of the intestine, which will cause narrowing and ultimately bowel obstruction. Available treatments can dampen the inflammation, but do not prevent fibrosis. It is...

  • An investigation into early adverse life events and psychotic-like experiences in Irish youth

    At some time in their life, up to one in six adolescents is likely to have experienced some form of hallucinations or delusions, also known as psychotic-like experiences. These experiences include things like hearing voices, seeing things that are not there and having fixed false beliefs about yourself or the world around you. Most...

  • Attenuation of exaggerated post-prandial gut hormone response: A novel therapeutic strategy for the treatment of excessive weight loss among disease-free post-oesophagectomy patients

    There is increasing incidence of cancer of the oesophagus (the gullet or swallowing tube). Improvements to treatment strategies for oesophageal cancer have produced an increasing population of patients who remain free from the disease recurrence in the long-term. Optimising long-term outcomes for these patients after treatment...

  • The clinical application of immunometabolism to the TB Patient

    Recent studies have shown that cells of the immune system change the way that they break down sugars (their metabolism) after they are stimulated, and that this change in metabolism is needed in order to produce specific chemicals (cytokines) that fight infection.
    We will study what metabolism changes happen in immune cells from...

  • Investigating the impact of body composition and nutritional intervention strategies in pancreatic cancer

    Pancreatic cancer is the 9th most common cancer in Ireland, and the 5th most common cause of cancer related death. Because of its location deep within the abdomen, patients often present with advanced cancer at the time of diagnosis. The options for treatment are limited as surgery is only suitable for patients who don't have spread of...

  • Overcoming survival signalling in Multiple Myeloma

    Multiple Myeloma (MM) is a blood cancer affecting plasma cells, a type of white blood cell located in the bone marrow. It affects the bones, kidneys and causes patients to have frequent infections. There are approximately 250 new cases diagnosed in Ireland annually. MM is not curable and although the treatment for this condition...

  • Living with Motor Neurone Disease (MND) and Dysphagia -the personal experiences of individuals with MND and their caregivers

    Motor Neurone Disease (MND) is one of the most progressive diseases of the nervous system, for which there is no cure. It often leads to weakness in the arms, hands and legs, posing difficulties with daily life activities. Throat muscles can also be affected leading to speech and swallowing problems (dysphagia). Dysphagia can be life...

  • Development of a core set of clinical care provision indicators for non-specialist palliative care in the acute care hospital setting

    Palliative care encompasses the support structure around people facing problems associated with life-limiting illness and includes the support of their families, but this is more than end-of-life care, and is viewed as central component of care for people living with limiting illnesses. Palliative care policies in Ireland draw on these...

  • The OPTIMAL study: A randomized controlled trial and process evaluation of an OccuPaTIonal therapy led self MAnagement support programme for patients with muLtimorbidity in primary care

    Many people with chronic disease tend to have more than one chronic condition, referred to as multimorbidity. It is predicted that the number of individuals with multimorbidity is set to increase substantially in the future due to the growing elderly population. Those with multimorbidity experience poor physical function and find it...

  • Psychosocial, psychiatric and work-related risk factors associated with suicide in Ireland: Enhancing dissemination and impact of research

    The SSIS-ACE study examines how psychosocial, psychiatric and work-related factors relate to suicide. The study involves liaising with family members bereaved by suicide, family members of those who survived a high-risk self-harm act, general practitioners (GPs), emergency department staff, mental health staff and coroners. During the...

  • Taking the stress out of dementia caregiving

    The existing award examines how the caring experience can impact the health of dementia spouse carers. Using this emerging research evidence we will develop two animated films and a dedicated online resource providing easy-to-understand practical advice to carers to improve their quality of life and reduce stress.
    FreeDem Films are...

  • Synthesising and disseminating key lessons from the AIIHPC Palliative Care Research Network

    This application for KEDS funding proposes to further enhance knowledge transfer and exchange activities across the SRN/PCRN by conducting a higher level analysis of the dissemination products arising from each individual work project during the final year of the active grant. It is expected that dissemination products will include...

  • Capnography monitoring for conscious sedation in oral surgery

    Capnography has the potential to enhance patients safety in the dental setting. Procedural sedation techniques are specific to each area of medicine where sedation is practiced. Conscious sedation in an out of hospital setting by a non anaesthetist requires robust monitoring. The most important negative side effect of sedation is...

  • Doctor Emigration Knowledge Exchange Project (DEP-KEDS)

    The Doctor Emigration Project (DEP) aims to analyse doctor emigration from Ireland and to inform national health workforce policy about the factors influencing their emigration. The ultimate aim of the project is to assist national workforce planners to develop evidence-informed policies to promote the retention of doctors in, and the...

  • Creating awareness of research in caregiving (CARING)

    An increasing number of people in Ireland are providing care for a relative with dementia. This important unpaid work comes with an underappreciated cost to the health of the caregiver. Evidence suggests that dementia caregiving is associated with heightened psychological stress, as well as problems such as depression.
    Our...

  • Development of a national severe asthma registry and comprehensive care program

    There has been a drive to deliver new asthma treatments through new biological agents. However, age old issues including poor adherence and poor inhaler use still apply and mean that it is difficult to tell if a patient has difficult to manage asthma or therapy refractory asthma. The proposal is to build a registry for patients with...

  • Creation of a young adult colouring book illustrating biological research on mental illness

    We plan to create an innovative educational activity to promote our research on biological investigations in mental illness. Our idea is to publish a young adult colouring book that will introduce young people to the complex world of the human brain, how scientists perform neuroscience research and how the findings relate to...

  • Development and upgrading of the HMDB Schizophrenia Metabocard

    The Human Metabolome Database (HMDB) is a freely available database that contains detailed information about small molecules found in the human body. It is the first and foremost reference site for metabolite data worldwide. It provides scientists, clinicians, educators and the public with the most current and comprehensive coverage of...

  • Brain superheros return

    Making new drugs is long, costly and complex, and is often a mystery to many people. Our laboratory is involved in the development of new drugs for brain related illnesses, including illnesses such as Alzheimer's disease (AD) and Multiple Sclerosis. Alongside our research, we conduct a number of outreach projects in the hope of...

  • Priority setting in uncertainties in trial methodology

    Challenges in how clinical trials are designed and conducted are commonly experienced by researchers at different stages of the research process. For example, difficulty in recruiting people to a trial often results in a delay in completing the trial, or difficulty in using the trial results to make informed decisions about clinical...

  • Thinking outside the box: towards a novel approach to care delivery for young adults with type 1 diabetes

    Many young people living with type 1 diabetes struggle with the burden of day-to-day self-management. As a result they often have poor outcomes including the development of life-changing complications. We have formed a partnership between existing diabetes service providers (in Galway University Hospitals), academics in National...

  • Immunotherapy for the treatment of AMD: a preclinical evaluation

    Age-related Macular Degeneration (AMD) is the leading cause of central retinal vision loss worldwide. Estimated prevalence of AMD in Ireland is 7% with an annual cost

  • High quality pre-pregnancy care is essential for women with diabetes

    Women with diabetes have an increased risk of pregnancy complications. Many of these complications are due to high glucose levels in the first ten weeks of pregnancy. This means that pregnancy planning and tight glucose control is essential. Pre-pregnancy care is additional clinical care offered to women planning pregnancy. As part of...

  • Building a self-management programme for living well with and beyond head and neck cancer

    We propose to develop a new programme that empowers survivors of head and neck cancer (HNC) to better manage problems associated with their illness and live well with and beyond HNC. This is important because HNC survivors have many documented unmet care needs and can face significant challenges associated with their condition and its...

  • Behavioural changes in ALS : What families and healthcare professionals need to know

    Amyotrophic Lateral Sclerosis (ALS ) (or Motor Neuron Disease (MND)) is a rapidly progressive neurodegeneration associated with loss of muscle power. Until recently, thinking and behaviour were considered unaffected, but we have shown that up to 50% of people with ALS/MND experience changes in their ability to plan complex tasks, and...

  • Evidence based oral healthcare for older adults

    The World Health Organisation has highlighted the paucity of research into the oral health needs of older adults. The Health Research Board has recognised this and have funded a number of studies in recent years addressing this topic. Unfortunately there is a delay between the completion of studies and the publication of results in...

  • Cracking cancer with science; an educational outreach campaign for primary schoolchildren

    Breast cancer remains a significant disease in Ireland. Our laboratory is investigating novel therapies to target a sub-group of aggressive breast tumours. This work feeds into two larger efforts. The first is to help personalize cancer therapies for patients. The second is to provide new insight into how specific tumours develop, in...

  • SOLAS.net: Development and pilot implementation of an e-learning physiotherapist training programme for self-management of chronic musculoskeletal pain in primary care

    As part of the original award, an evidence-supported group treatment approach for clients with persistent musculoskeletal pain termed SOLAS: Self-management of Osteoarthritis and Low back pain through Activity and Skills was developed. Also, a two day face-to-face physiotherapist training programme was developed and delivered to HSE...

  • Applying health: Using healthcare technology to enhance the delivery of rehabilitation programmes in cancer survivors

    Recovery following oesophageal cancer (cancer of the food pipe) can be challenging. Cancer rehabilitation, which may involve exercise, advice from a dietitian, education or other therapeutic interventions, can help patients make an optimal recovery. The research team is currently investigating the effect of a 12 week rehabilitation...

  • Irish Dystonia Research Group: Innovation through collaboration

    Our research group of Irish consultant neurologists (with an interest in movement disorders) and laboratory based scientists (engineers in the Department of Neural Engineering in Trinity College Dublin) have been involved in finding the cause(s) of a movement disorder which affects about 600-800 individuals in Ireland. This...

  • Enhancing awareness of the socio-economic impact of inherited blindness

    In Ireland, many devastating diseases have an inherited cause and are passed onto further generations. Blindness due to inherited degeneration of the retina at the back of the eye is an excellent case-study with which to explain the basis of inherited disease, the socio-economic impact and the research required to generate new...

  • Enhancing awareness of blindness resulting from diabetes. Understanding treatments & preventative interventions

    In Ireland, Diabetic Retinopathy is a leading cause of blindness. The number of people becoming blind due to diabetes is set to rapidly increase as the "diabetes epidemic" unfolds. In general, there is a lack of awareness as to the social, economic and health impact of diabetic blindness.
    Here, we generate short 3D-animations that...

  • Baby steps towards STRIDER: support, website, information, dissemination, exchange

    This outreach programme will provide a dedicated public information and education resources on intrauterine growth restriction (IUGR) and the STRIDER clinical trial, which aims to improve outcomes of pregnancies affected by IUGR with sildenafil citrate (Viagra). It will provide support to women and their partners experiencing IUGR by...

  • Promoting positive mental health messages for the older population: The Irish Longitudinal Study on Ageing (TILDA) films

    The Irish Longitudinal Study on Ageing (TILDA) offers unique data on the challenges associated with ageing and how these can affect mood as we age: grief, retirement, poorer physical health. We have demonstrated that mood may be affected by loss of support networks such as adult children moving abroad. Over 10% of the older Irish...

  • The Irish Longitudinal Study on Ageing (TILDA) hypertension seminars for health professionals in primary and community care practice

    In April 2015 the Irish Longitudinal Study on Ageing (TILDA) published research, funded through the active award, which indicates that approximately two thirds of older Irish adults have high blood pressure and close to half of them are unaware of their condition. High blood pressure is an important risk factor for heart disease and...

  • A web-based resource and community of practice (CoP) to transform practices around 'talking about epilepsy'

    This knowledge exchange and dissemination (KED) initiative proposes to develop a variety of educational and informative resources using different technological media (audio, video and e-authoring tools) which will be delivered online in a designated website to support the translation of research evidence on childhood epilepsy...

  • Healthy pregnancy in Ireland

    The HRB Ireland Perinatal CTN is an all-island of Ireland clinical trial network for mothers and babies representing a new and exciting collaboration between two established research groups; the Irish centre for Foetal and Neonatal Translational Research (INFANT) and Perinatal Ireland. The 'Healthy Pregnancy in Ireland' initiative is a...

  • Innovative dissemination of IDS-TILDA Wave 2 - Advancing years, different challenges

    The IDS-TILDA study is designed to better understand experiences and challenges for adults with an intellectual disability (ID) as they age. 753 persons aged 40+ started in the study. There have been two waves of data collection, with waves three years apart and 94% of people who answered at Wave one participated again at Wave two. We...

  • Development of The STOP-HF network for community based prevention of Heart Failure

    STOPHFnet will create a virtual community of practice which will utilize the results of research from our HRB funded Natural History of Diabetic Cardiomyopathy grant to allow rapid dissemination to general practitioners in the community. This is particularly timely as diabetes will for the first time be nationally managed by GPs under...

  • Understand my pain: Educational tools for chronic pain

    Based on the findings of the research during our HRB ICE award, we will develop two educational tools.
    Activity A will involve the creation of a free video that explains how chronic pain impacts on children and their families. This activity is vital based on our new understanding of the numbers of primary school children who live...

  • Development and launch of Irish guidelines on the management of Helicobacter pylori Infection

    Helicobacter pylori infection is a public health issue. It remains one of the most common infections in adults in Ireland and is the primary cause of stomach ulcers and stomach cancers. Our recent findings have indicated that the eradication rate for standard first-line triple therapy for H. pylorihas fallen to unacceptable levels....

  • ICORG communications manager

    2016 will mark the 20th anniversary of ICORG's formation. There are a range of public engagement activities on the agenda but in order to co-ordinate them ICORG will need an in-house communications function.
    Activities will include;
    1. Short documentary-style videos on patient experience, innovative research activities and new...

  • Development of an online training and accreditation resource for a novel outcome assessment tool in high risk infants: the Babyscreen app

    The HRB funded BiHiVE2 study has focused on predicting long term learning disability in children following birth related brain injury. Unfortunately there are, currently, no reliable methods of assessing learning ability in children at a young age. Current developmental assessments focus on developmental milestones. They are not true...

  • Thrombosis risk in pregnancy: what you need to know

    Venous thromboembolism (VTE; deep vein thrombosis and pulmonary embolism) remains a leading cause of death in pregnant and recently delivered women. Surviving mothers may have long-term disability. If VTE risk factors are identified, then preventative measures may be put in place . These interventions can be potentially life-saving....

  • Translating critical care research into clinical practice

    We are currently funded by the HRB to conduct clinical trials to determine which treatments may help patients who are critically ill. We have recently completed important research and the results will be published in a highly regarded medical journal in October. However it can take a long time between publication and improvements in...

  • Towards increased awareness and understanding of the risk of thrombosis in gynaecological cancers

    All cancers are associated with an increased risk of clots to the legs and lungs however gynaecological cancers have a particularly high risk. Clots can occur after surgery or during chemotherapy and can be life threatening if they are not treated in time. A recent survey of patients who suffered a clot during their cancer journey...

  • What is Alpha-1?

    Alpha-1 antitrypsin deficiency (Alpha-1) is a genetic disorder that affects the lungs. Typically people with Alpha-1 present with chronic obstructive pulmonary disease (COPD) or severe asthma. Ireland has one of the highest rates of AATD in the world. 1 in 25 Irish people are carriers for the condition and are at risk of lung disease,...

  • Cancer immunology research saves lives: Find Out

    The treatment of cancer is being revolutionised by cancer immunology. However cancer immunology is poorly understood by healthcare workers, patients and the general public. Here, in collaboration with the Irish Cancer Society (ICS), we aim to use the expertise and discoveries generated by HRB and ICS funded research projects to...

  • DEDIPAC Ireland: National one day symposium on determinants of diet and physical activity

    DEDIPAC (Determinants of Diet and Physical Activity; Knowledge Hub to integrate and develop infrastructure for research across Europe) is a collaborative European project, where Irish researchers play a major role in defining and understanding dietary and activity factors that influence health.
    The aim of this application is to...

  • Happy mothers...happy babies

    Pregnancy is the highest risk period in a woman's life for developing clinical depression. Depression and anxiety during pregnancy are common experiences. Women are usually anxious about the pregnancy and the delivery, about how they will cope with motherhood and the impact of the changes that having a baby will make on their lives. We...

  • CERVIVA: Making connections and creating impact

    The goal of CERVIVA's education and outreach programme is to create awareness, inform and effectively engage the public, health care professionals and healthcare providers on public health issues related to HPV associated diseases and on the specific research programmes underway within CERVIVA, which are addressing some of these...

  • Diet, health and sustainability - narrowing the gap between what we know and what we do

    Knowledge translation in the area of diet and health is challenging due to the range of vested interests in the food sector and the contested discourse on food, diet and health among policy makers, practitioners, media and the general public. There is considerable agreement on key food policy measures open to government with potential...

  • A user-friendly database of genetic dependencies in cancer

    A major challenge in cancer therapeutics is to kill tumour cells without harming other cells in the body. One means to achieve this is to exploit the genetic changes that distinguish cancer cells from normal cells and that may leave them vulnerable to targeted treatments.
    A promising approach to developing such targeted treatments...

  • Together against HIV: raising awareness and knowledge through documented real-life experiences and research discovery

    There were approximately 2 million new HIV infections and 1.5 million HIV-related deaths worldwide in 2013, demonstrating the need for educational campaigns that raise awareness and prevent its spread. Current treatments suppress HIV, but do not totally clear it; however, a significant proportion of society believe these drugs cure...

  • Progressing universal health care: informing citizens by pooling and disseminating research and generating debate

    There is little informed public discussion and debate around Universal Healthcare (UHC) in Ireland. There is also much confusion in political discourse between UHC and universal health insurance notwithstanding a recent policy shift towards UHC. This KEDS project aims to build on the Pathways to UHC research by educating the public...

  • HRB Clinical Research Coordination Ireland

    Clinical Research Facilities and Centres (CRF/Cs) have been developed in each of the five applicant universities, providing the infrastructure and specialist staff to facilitate collaborative research but they lack an overarching support structure with which to coordinate multicentre clinical trial activities. One key exception is...

  • Determining the breadth and burden of chronic kidney disease in Ireland: Associations with cognitive impairment, functional decline and quality of life

    Chronic kidney disease (CKD) is a major health problem all over the world. At least one in 10 adults are estimated to have kidney disease. Some of these people will progress to end-stage kidney disease which requires dialysis treatment or a kidney transplant for survival. However the majority of people with CKD do not survive long...

  • The cost of survival: Understanding colorectal cancer survivors' quality of life

    The lives of people who have completed treatment for colorectal cancer may be affected by physical and psychological disabilities, caused by surgery, chemotherapy and radiotherapy. For those who are cured, their quality of life may be adversely affected by side-effects such as fatigue, pain, sensory neuropathy, sexual dysfunction,...

  • Overcoming mechanism of treatment resistance in castration-resistant prostate cancer: Defining a new treatment paradigm

    Prostate cancer is the second leading cause of male cancer mortality in Ireland: in 2012, 533 men died from this disease.Prostate cancer growth is stimulated by male sex hormones (androgens) e.g. testosterone. The mainstay of initial treatment is to block gonadal production of these hormones. However, with time, cancers develop other...

  • The use of eccentric exercises and topical glyceryl trinitrate (GTN) in the treatment of midportion Achilles tendinopathy: A randomised placebo controlled trial

    Pain in the Achilles tendon is a common condition seen by physiotherapist and doctors. It affects people involved in sports and those who are not. For those who suffer with this condition, it can limit their ability to walk, hop, jump and run. If the pain persists for longer than three months it can become extremely difficult to...

  • A geographic model for improving out-of-hospital cardiac arrest survival in Ireland

    Out-of-hospital cardiac arrest (OHCA) affects approximately 2,500 people every year in Ireland. Even when resuscitation is attempted, approximately one in fifteen people survive.

  • Evaluation of next generation sequencing to investigate the epidemiology of Clostridium difficile infection

    Clostridium difficile('C. diff') is a common cause of infectious diarrhoea following antibiotic treatment, sometimes with serious consequences. Although most cases occur in hospital in-patients, they are increasingly seen in the community, without known sources of exposure. 'C diff' can colonise the intestine prior to developing...

  • The progression of crouch gait in diplegic cerebral palsy

    Cerebral palsy (CP) is a neurological condition caused by a lesion to the brain at or near the time of birth. This leads to muscle tightness or weakness as well as general co-ordination difficulties. This commonly results in difficulties with walking and mobility. A common pattern of walking in CP is crouch gait or excessive flexion of...

  • Environmental and genetic epidemiology of amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is a rare condition that is thought to be; caused by a combination of genetic and environmental influences. The lifetime risk of the condition is 1 in 300, and approximately 250 people in Ireland suffer from the condition. Ireland has a population based registers of ALS that has captured all new...