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Funding Awarded

3 awards

  • Advanced, automated compound screening for the identification of therapeutic agents in Multiple Sulfatase Deficiency.

    Multiple Sulfatase Deficiency (MSD) is an extremely rare, fatal, yet untreatable condition. It is caused by the inherited deficiency of an enzyme (called FGE) that activates a whole family of 17 other cellular enzymes named sulfatases. Sulfatases are indispensable for the degradation of a subset of intracellular molecules. Thus,...

  • The cognitive thalamus: more than a relay.

    WT Scheme: Investigator Award in Science.

    How do brain circuits support different but complementary aspects of event memory? The answer lies in distributed networks across the medial temporal lobe, prefrontal cortex and parietal cortex. Via their widespread connectivity, nuclei within the rostral thalamus support these memory...

  • The impact of genetic heterogeneity on synthetic lethality in cancer

    WT Scheme: Sir Henry Wellcome Postdoctoral Fellowship

    Synthetic lethal interaction occurs when the function of one gene only becomes essential for viability in the presence of a mutation in another gene. In cancer treatment this phenomenon can be exploited to selectively kill tumour cells that have specific genetic mutations....