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Funding Awarded

3 awards

  • Advanced, automated compound screening for the identification of therapeutic agents in Multiple Sulfatase Deficiency.

    Multiple Sulfatase Deficiency (MSD) is an extremely rare, fatal, yet untreatable condition. It is caused by the inherited deficiency of an enzyme (called FGE) that activates a whole family of 17 other cellular enzymes named sulfatases. Sulfatases are indispensable for the degradation of a subset of intracellular molecules. Thus,...

  • Plasma-based therapies for bone infection

    Orthopaedic infection is life-threatening and current treatments are only sparingly successful. Despite aggressive peri-operative antibiotic treatments, 1.5% of knee revisions, 0.7 to 11.9%, of spinal infections (depending on the complexity of the procedure) and up to 27% of open fractures become infected. Moreover, the complexity of...

  • Prediction of radiation toxicity in prostate cancer patients using Raman spectroscopy

    There are no tests currently available to predict an individual patient's response to radiotherapy. Some patients experience severe long term side effects months and even years after their treatment has finished and these effects can be permanent. For example, some prostate cancer patients develop life-changing bowel and urinary...