AIIHPC Structured Research Network APA Cycle 2 2019 Applied Partnership Awards Applied Research Projects in Dementia Applying Research into Policy & Practice Postdoctoral Fellowships ARPP 2020 Cancer Prevention Fellowship Programme Cancer Prevention Fellowship Programme Reintegration Grant Capacity Building for Evidence Synthesis Clinical Research Facilities/Centres 2021 Cochrane Training Fellowships Collaborative Doctoral Awards Conference and Event Sponsorship Scheme COVID-19 2020 CSF 2020 DIFA - 2018 DIFA 2017 DIFA 2018 DIFA 2020 DIFA-2018 ECSA Full Application 2020 ECSA FA 2020 Emerging Investigator Awards Emerging Investigator Awards for Health (EIA) 2022 Emerging Investigator Awards Full ERA-NET Cofund for Neuroscience Research (NEURON) ERA-NET Cofund for Personalised Medicine EU Joint Programming Initiative Framework for Safe Nurse Staffing and Skill Mix Health Research Awards Health Research Awards - Definitive Intervention Health Research Awards - Definitive Interventions Health Research Centre HRB Clinical Research Coordination Ireland HRB Clinical Research Facilities HRB Collaboration in Ireland for Clinical Effectiveness Reviews HRB Trials Methodology Research Network HRCI 2020 HRCI-HRB Joint Funding Scheme ICORG Statistics and Data Management Interdisciplinary Capacity Enhancement Awards Investigator Led Projects IPPOSI 2020 Irish Clinical Oncology Research Group Irish Network for Research in Dementia and Neurodegeneration Irish Platform for Patients Organisations Science and Industry Support Award Irish Platform for Patients' Organisations, Science and Industry Joint Programming Initiative Healthy Diet for a Healthy Life Joint Programming Initiative in Neurodegenerative Diseases Joint Programming Initiative on Antimicrobial Resistance Knowledge Exchange and Dissemination Scheme Knowledge Translation Awards Medical Education Research Grant Medical Research Charities Group Support Award MRCG-HRB Joint Funding Scheme National Children's Hospital Foundation Scheme National Clinical Trials Coordination Programme National integrated PhD programme for Medical Practitioners National Intellectual Disability Supplement to TILDA National SpR Academic Fellowship Programme/HRB Joint Funding Scheme National SpR/SR Academic Fellowship Programme Patrick Quinn Awards for Parkinson's Research PPI Ignite Awards Project Development Grants Project Development Grants in Cancer Nursing Research RCQPS COVID-19 Research Collaborative for Quality and Patient Safety Research Collaborative in Quality and Patient Safety Research Leader Awards Research Training Fellowships for Health Professionals Research Training Fellowships for Healthcare Professionals RL FA 2020 RL PA 2020 Secondary Data Analysis Projects SFI-HRB-Wellcome Biomedical Partnership SFI-HRB-Wellcome Research Partnership Structured PhD Programme in Population and Health-Services Research Education Structured PhD Programme in Population Health and Health Services Research The Irish Longitudinal Study on Ageing Trials Methodology Research Network Ulysses Research Visits US-Ireland R&D Partnership Awards WHO-SOLI-2020
Alpha One Foundation Athlone Institute of Technology Beaumont Hospital Cystinosis Foundation Ireland DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Fighting Blindness Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - Letterkenny General Hospital HSE - Midland Regional Hospital at Tullamore HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Cancer Society Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Irish Thoracic Society Katholieke Universiteit Leuven Limerick Institute of Technology Mary Immaculate College Limerick Maynooth University Medical Research Charities Group Ltd Molecular Medicine Ireland National Rehabilitation Hospital National Suicide Research Foundation National University of Ireland Galway National University of Ireland, Galway National University of Ireland, Maynooth Our Lady's Hospice RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland Royal Victoria Eye and Ear Hospital Research Foundation Ltd St John of God's Research Foundation Limited St. James's Hospital TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia The Children's Medical and Research Foundation Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford
What is Alpha-1?
Alpha-1 antitrypsin deficiency (Alpha-1) is a genetic disorder that affects the lungs. Typically people with Alpha-1 present with chronic obstructive pulmonary disease (COPD) or severe asthma. Ireland has one of the highest rates of AATD in the world. 1 in 25 Irish people are carriers for the condition and are at risk of lung disease,...
Altered lipid raft cholesterol content contributes to the dysregulated activity of neutrophils in alpha-1 antitrypsin deficiency
Alpha-1-antitrypsin (AAT) deficiency (AATD) is largely unrecognized and under diagnosed. This hereditary disorder results in the rapid progression of lung disease, especially in smokers. Specific treatment for this disorder is available in the form of weekly intravenous injections of AAT. This is referred to as augmentation therapy...
Alpha-1 antitrypsin deficiency: Which is important phenotype, level, activity or all three?
Alpha-1 antitrypsin (AAT) deficiency (AATD) is generally regarded as a rare condition but more recently, evidence points towards it being a condition that is relatively common but rarely diagnosed. The most severe form of this genetic disorder, where people carry two bad AAT genes (Z) is known as ZZ-AATD and this affects around 2000...