Resistant hypertension in general practice: prevalence, prognosis, description and development of platform cohort for future research

High blood pressure causes, or helps to cause, almost two-thirds of all strokes and half of all heart attacks. Most people with high blood pressure can be treated by changing what they eat, doing more exercise or taking medications. However, among people with high blood pressure are some whose blood pressure remains too high despite taking three drugs including a diuretic (resistant hypertension). Some may not be taking their drugs correctly. Others may simply have high blood pressure when they go to see their doctor, but it comes back to normal when they go about their daily business. However, it is hard to work out how important these two things are for individual patients.
Leading researchers have suggested that between 15% and 30% of treated patients with high blood pressure have resistant hypertension. Everyone agrees that there is a need for further research about how common resistant hypertension is, what happens to patients who have it, and how to treat them. With HRB funding, we showed that we could, using new software, remotely look at patient medical records and decide whether they had resistant hypertension or not.
The overall aim of the project is to
Look at all the global evidence describing how common resistant hypertension is (prevalence)
and using the software tool in 100 general practices to
(b) work out the prevalence of resistant hypertension
(c) see what happens to these patients over two years
And with ten general practices, and a hospital Resistant Hypertension Clinic,
(d) describe the characteristics of these patients looking at blood pressure readings taken over a whole day and how well patients are taking their medications, including examining their urine
(e) form a team of patients who definitely have resistant hypertension and who are ready for future research.

Award Date
19 June 2014
Award Value
Principal Investigator
Professor Andrew Murphy
Host Institution
National University of Ireland, Galway
Health Research Awards