Open Calls

Horizon Europe Health Cluster 2025

Horizon Europe Health Cluster 2025 Work Programme has just been published and you can find it here.

Single stage calls opened on 22 May and will close on 16 September 2025. They include:

Destination 3

  • HORIZON-HLTH-2025-01-DISEASE-01: Testing safety and efficacy of phage therapy for the treatment of antibiotic-resistant bacterial infections
  • HORIZON-HLTH-2025-01-DISEASE-03: Development of antibodies and antibody-derived proteins for the prevention and treatment of infectious diseases with epidemic potential
  • HORIZON-HLTH-2025-01-DISEASE-04: Leveraging artificial intelligence for pandemic preparedness and response
  • HORIZON-HLTH-2025-01-DISEASE-05: Support for the functioning of the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)
  • HORIZON-HLTH-2025-01-DISEASE-06: Implementation research addressing strategies to strengthen health systems for equitable high-quality care and health outcomes in the context of non-communicable diseases (GACD)
  • HORIZON-HLTH-2025-01-DISEASE-07: Tackling high-burden for patients and under-researched medical conditions

Destination 4

  • HORIZON-HLTH-2025-01-CARE-01: End user-driven application of Generative Artificial Intelligence models in healthcare (GenAI4EU)

Destination 5

  • HORIZON-HLTH-2025-01-TOOL-01: Enhancing cell therapies with genomic techniques
  • HORIZON-HLTH-2025-01-TOOL-02: Advancing cell secretome-based therapies
  • HORIZON-HLTH-2025-01-TOOL-03: Leveraging multimodal data to advance Generative Artificial Intelligence applicability in biomedical research (GenAI4EU)
  • HORIZON-HLTH-2025-01-TOOL-05: Boosting the translation of biotech research into innovative health therapies

Destination 6

  • HORIZON-HLTH-2025-01-IND-01: Optimising the manufacturing of Advanced Therapy Medicinal Products (ATMPs)
  • HORIZON-HLTH-2025-01-IND-02: Digitalisation of conformity assessment procedures of medical devices and in vitro diagnostic medical devices

Two-stage calls opened on 22 May. First stage deadline is on 16 September 2025. Successful proposals will go through to the 2nd stage with a deadline of 16 April 2026.

Destination 1

  • HORIZON-HLTH-2025-03-STAYHLTH-01-two-stage: Improving the quality of life of persons with intellectual disabilities and their families

Destination 2

  • HORIZON-HLTH-2025-03-ENVHLTH-01-two-stage: The impact of pollution on the development and progression of brain diseases and disorders
  • HORIZON-HLTH-2025-03-ENVHLTH-02-two-stage: Advancing knowledge on the impacts of micro and nanoplastics on human health

Destination 3

  • HORIZON-HLTH-2025-03-DISEASE-02-two-stage: Advancing innovative interventions for mental, behavioural and neurodevelopmental disorders

Destination 6

  • HORIZON-HLTH-2025-03-IND-03-two-stage: Facilitating the conduct of multinational clinical studies of orphan devices and/or of highly innovative (“breakthrough”) devices

An Information and Brokerage event for the health cluster and cancer mission will take place on 29 May 2025 in the Houston Lecture Theatre in RCSI. Register here.

Long term matchmaking is available through the Horizon Europe Brokerage Event on the 2025 Cluster 1 Health

2025 Health Cluster Info Day recordings are available here.

Cancer Mission 2025

The Cancer Mission 2025 Work Programme has just been published and you can find it here. Deadline for the Cancer Mission calls is 16 September 2025

Calls include:

  • HORIZON-MISS-2025-02-CANCER-01: Sustained collaboration of national and regional cancer funders to support the Cancer Mission through translational research
  • HORIZON-MISS-2025-02-CANCER-02: Understanding the effects of environmental exposure on the risk of paediatric, adolescent and young adult cancers
  • HORIZON-MISS-2025-02-CANCER-03: Innovative surgery as the cornerstone of affordable multi-modal therapeutic interventions benefitting cancer patients with locally advanced or metastatic disease
  • HORIZON-MISS-2025-02-CANCER-04: Investigator-initiated multinational early-stage innovative clinical trials for paediatric cancer
  • HORIZON-MISS-2025-02-CANCER-05: Pragmatic clinical trials to enhance the quality of life of older cancer patients (65 years and older) through nutrition
  • HORIZON-MISS-2025-02-CANCER-06: Support to the network of National Cancer Mission Hubs (NCMHs)

Cancer Mission 2025 Info Day recording is available here.

For more information on Horizon Europe Health Cluster or the Cancer Mission, please contact the Health NCP at icastellano@hrb.ie

Upcoming calls 

Innovative Health Initiative

Innovative Health Initiative – call 11

The following topics are under consideration for inclusion in IHI call 11, a two-stage call which is scheduled for launch in Q2 2025:

  • Understanding how infections foster and induce non-communicable diseases
  • Towards precision medicine: platform for transdiagnostic stratification of brain dysfunction
  • AI-powered signal detection in pharmacovigilance
  • Leveraging Europe’s expertise to accelerate cell therapy for type 1 diabetes
  • Establishing ortho and cardiology ambulatory surgical centres in Europe

EU4Health

The 2025 work programme for the EU4Health programme is due to be published in Q2 2025.

EU4health Calls for Tender 

Further calls for tenders are expected and will be published throughout the year. 

The tentative call calendar is published on HADEA’s webpage. 

See also the HRB website for general information on the Horizon Europe and EU4Health programmes.