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Translation aspects of the Shamrock study: a single arm phase 2 trial of neoadjuvant trastuzumab deruxtecan in early-stage HER2-positive breast cancer

Background: Low physical fitness and psychological stress are risk factors for post-surgery cancer complications. The PANO Trial is funded by the Irish Research Council and is a single-centre feasibility randomised controlled trial comparing a prehabilitation programme vs. usual care in cancer patients.The prehabilitation programme includes physical activity and nutrition optimisation. Prehabilitation shows promise as a preventative strategy by increasing psychological resilience against anxiety and depression pre- surgery, and to restore patients to baseline levels of fitness. Aims & Objectives: The PANO Trial aims to assess the feasibility of incorporating prehabilitation as part of a treatment pathway for patients. A further aim is to understand the effects of this prehabilitation program on psychological well being, physical fitness and clinical outcomes. The student project is in line with these aims as it will assist in the preliminary analysis and coding of ActivPal (Exercise) and Foodbook24 (Nutrition) data. This student project will help to establish whether bi-modal prehabilitation is feasible and whether activity levels and nutritional status may be positively impacted by the programme.