Diabetic foot disease is one of the most common complications in diabetic patients throughout the world. There is a higher incidence of diabetic foot disease in patients with concurrent renal disease and the outcomes for these patients are generally poorer. Dialysis therapy was reported as one of the risk factors associated with frequent foot diseases in diabetic patients with renal disease. We would like to characterise diabetic foot disease in patients with different stages of chronic kidney disease and assess the impact of disease on quality of life in these patients. The results from this study may be a guide for physicians in planning service requirements for patients. Several blood proteins such as osteoprotegerin, prolactin, testosterone and sex hormone binding globulins have been reported as strong disease outcome predictors in diabetic patients with chronic kidney disease. The level of each of these proteins is not well characterised in different stages of chronic kidney disease. The risk therefore is that studies that show correlation are simply identifying an association of CKD severity with Diabetic Foot Disease. There are very few studies that investigate the clinical utility of these proteins.We would like to investigate whether blood proteins may be clinically useful by assessing their levels in relation to stages of chronic kidney disease and thereafter in patients with CKD and diabetic foot disease.
