Development of temporal lobe epilepsy (TLE) is associated with significant epigenetic changes, particularly in long non-coding RNAs (lncRNAs), yet their functional role in epilepsy remains largely unexplored. This project aims to characterize lncRNA dysregulation in human TLE, examining abundance, differential expression, and cellular patterns. Utilizing qPCR analysis and in situ hybridization on human hippocampal tissue, the study seeks insights into the extent of lncRNA dysregulation. The project aligns with the HRB remit for patient-oriented research, addressing the urgent need for novel drug targets in epilepsy. Anticipated outcomes include identifying dysregulated lncRNAs in human TLE, potentially informing the development of targeted therapeutic interventions.
