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The early identification of individuals at high risk of type 2 diabetes: the relationship between circulating lipids and amino acid metabolites.

Type 2 diabetes has become a major public health issue. The increased prevalence is putting enormous pressure on clinical infrastructures, accounting for a substantial amount of health spending, and is not sustainable in the long term. One of major societal challenges is to identify individuals at risk of developing diabetes and to implement preventive strategies to decrease progression. DEXLIFE is an EU FP7 funded project that specifically addresses this issue and is working to identify biomarkers that better predict the onset of type 2 diabetes. At DCU a 12-week lifestyle intervention has been implemented to improve the health of individuals at high risk of developing type 2 diabetes. The purpose of the intervention is to determine if the biomarkers that predict progression also track with improvements in health and reduced risk. I will look at a novel aspect of this project by measuring circulating lipids and comparing those changes with the physiological outcomes and metabolite biomarkers.