Huntington’s disease is an inherited, progressive currently incurable brain disease. Patients present with a triad of impairments which include dementia, psychiatric symptoms and a progressive movement disorder. In Ireland there are approximately 700 patients living with HD with an incidence of 10-12/100,000. Beaumont Hospital and Trinity College Dublin manage the only ENROLL-HD research programme in Ireland. ENROLL-HD is an international, longitudinal observational trial that has created a platform to evaluate patients over many years. At present internationally there are almost 17,000 patients in the ENROLL-HD study. In Ireland there are currently 48 patients many seen over 4 annual visits. There are currently 90 waiting for inclusion. The patients undergo detailed cognitive testing, genetic analysis, psychiatric review and neurological examination. These data are available for interrogation by the candidate student.
