Acute kidney injury (AKI) is a significant public health problem and it is associated with major adverse clinical outcomes and health care costs. Emerging evidence suggests that serum uric acid may be a potential risk factor for AKI.
This project will evaluate the available evidence using large observational data from the National Kidney Disease Surveillance System in Ireland to determine whether a relationship exists between elevated uric acid levels and future occurrence of AKI. This study will be the first to explore thresholds of risk for AKI associated with increasing uric acid concentrations in the Irish health system. This project is important as it will improve our understanding of the relationship between uric acid and AKI and will help determine whether hyperuricemia is a potential modifiable risk factor of AKI.
We anticipate that the results of this work will fuel further research into the potential benefits urate-lowering therapy in reducing AKI events and related adverse outcomes.
