Inappropriate opioid use has been identified as a growing problem in Ireland. Several successful opioid stewardship strategies (OSS) have been developed and implemented in Kentucky. This project aims to explore OSS in Kentucky, describe their impact, and assess transferability of these strategies to Ireland. A convergent parallel mixed-method approach will be used. Semi structured interviews with stakeholders will explore OSS in Kentucky and quantitative data on opioid prescribing will be analysed to describe the impact of these strategies. Findings will be presented to Irish stakeholders to co-develop OSS suitable for the Irish healthcare context.