Cancer persists as one of the biggest concerns in modern life and is a huge strain on patients, families and health care systems. Inhibiting cancer spread is the most likely way to produce a rapid and positive impact in the fight against this disease. This remains one of the biggest challenges facing scientists today. This project proposal is designed to identify how cancer cells respond to changes in their local environment to make new proteins that give them an advantage, an ability to survive and spread. We will do this in a very specific way by culturing cells in 3-Dimensional growth so that we can monitor their behaviour in a way that is much closer to what occurs in the body. The proposal being put forward is very original and is designed to build my methodology and skill set to enhance my competitiveness for further funding programmes.