Group A and B Streptococci both cause significant infections in humans. One common virulence factor produced by both organisms is the C5a peptidase. This enzyme hampers the body’s normal innate immune response to infection, thus promoting survival of the bacteria.
Dr Cooney’s group at the University of Limerick have determined the atomic structure of the Group A Streptococcal enzyme, ScpA. Others have determined the atomic structure of the Group B enzyme, ScpB. The mechanism of activity of the enzymes is very distinct despite very high sequence identity.
This project will determine how such similar enzymes have such distinct mechanisms for activity. Understanding how these critical bacterial enzymes contribute to the infective process will complement studies on their development as particulate vaccine candidates.
