Many studies suggest that changes in the number and types of bacteria and other microbes, called microbiota, in the gut can occur in a number of disease states, including various brain disorders. There are a number of ways in which microbiota have been shown to communicate with the brain including via immune pathways, via the HPA axis and via direct contact with the gut. As a result, the concept of targeting gut microbes as a potential therapy has emerged. This can be done directly by using probiotics, or indirectly by using prebiotic fibres. Prebiotics are substances that enable existing beneficial bacteria to thrive. This study aims to examine the effects a prebiotic substance on stress, mood, memory and cognition, in situations of stress. We will examine the effects of 4 weeks of supplementation with a prebiotic or a placebo on a group of 40 healthy female volunteers. We will focus on the effects on stress, cognition, memory and mood using a variety of tests. Blood and saliva samples will also be analysed for the presence of stress hormones and inflammation. Stool samples will be assessed for gut microbiota composition.
