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Insulin Resistance and Inflammation in Pre-eclampsia: Is Maternal BMI Involved?

Sleep disturbances are highly prevalent in children with autism. The origins of autism are considered largely genetic, however, the mechanisms that underlie sleep disruption, and their relationship to autism, are less well known. A statistically significant positive correlation in genetic effects has been observed for autism and self-reported tiredness and a statistically significant negative correlation in genetic effects has been observed for autism and a self-reported morningness chronotype. This means that there is a significant overlap in the genetic variation that contributes to both pairs of phenotypes. However, the post-GWAS results, which aim to identify the genes, biological pathways, and tissues impacted by genetic variation, have never been compared for these phenotypes. The aim of this project is to compare the post-GWAS results for autism, insomnia and chronotype. The results will be beneficial for understanding the molecular impact of the shared genetic effects between autism and sleep and inform future studies for our lab group.