Background: Older adults with poor appetite are at high risk of undernutrition due to the role of appetite as key driver of food intake. Dietary protein and fibre are critical nutrients in this population, and enhancing their intake is vital to preventing undernutrition and maintaining organ function and health. Objective and approach: In APPETITE a transdisciplinary consortium of experienced and well-connected experts from eight institutions in six European countries will collaborate to enhance protein and fibre consumption of community-dwelling older persons with poor appetite and overcome undernutrition through targeted nutrition and physical activity. In a translational approach – from development of innovative food products in cooperation with consumers, to testing of these products at experimental level to clinical application using harmonised methodologies in shared samples – we will combine high-level developmental, metabolic and clinical research. Workplan: Older persons with poor appetite will first be carefully characterized, and their nutritional and behavioral preferences evaluated in a mixed-methods approach. Innovative, affordable, easily and widely applicable food products will be developed for and together with older persons with poor appetite by combining several domestic plant proteins and dietary fibres. Mechanistic insights will be gained by examining the impact of selected products, physical activity and probiotic interventions on digestibility, amino acid bioavailability and whole-body protein metabolism. In a multi-country randomized controlled intervention trial, the impact of two new food products as part of a personalised optimized diet, a physical activity program, and their combination will be determined regarding appetite, dietary intake, nutritional status, anabolic response, metabolic parameters and physiological function. A wide range of dissemination activities will raise awareness, share knowledge, and improve dialogue between consumers, scientists, healthcare professionals, food industry and health policy. Impact: APPETITE will improve our understanding about plant-based protein and fibre products and their metabolic and clinical effects. It will create new knowledge how these products in a whole-diet approach together with physical activity and regular social contacts may contribute to overcome undernutrition. Results will be incorporated in recommendations and guidelines, strengthen European agri-food industry, and inform policy to finally contribute to a better quality of life of older Europeans.
