Adult safeguarding in Ireland has been an increasing public health issue since undercover filming (Leas Cross, 2005; Aras Attracta, 2014) exposed poor care practices in residential care settings. Similar to other countries, abuse of adults in any setting continues to be recognised as a human rights issue and has both immediate and long term negative effects on adults at risk. In 2021, there were 11,604 concerns disclosed to the HSE Adult Safeguarding services and these are only a proportion of what happens in reality as many are not reported. Consequently, there is an urgent need to ensure strong responses are in place to maximise protection for adults at risk. This international conference will be the first in Ireland and one of the few internationally to enable professionals, policy makers, non-governmental agencies, financial institutions and regulatory bodies to meet to consider best inter-sector practices and gaps in current abuse prevention and intervention approaches. The conference will facilitate a national and international platform for sharing innovative responses and evidenced-based research as well as providing opportunities for networking. This will include how other countries prevent and manage cases, how we can change cultures to make people aware of safeguarding issues, good practices in collaboration and engagement and how policy and legislation works/should work to safeguard adults at risk. To support the international conference and simulate further collaboration, engagement and rotation of biennial adult safeguarding conferences internationally, an international committee with inter-sectorial representatives from the US, Canada, United Kingdom has been convened. The conference will accommodate 230 people face to face with a capacity for 500 virtually. Conference material will be made freely available on the School of Nursing & Midwifery “Events” page to maximise impact.