The overall aim of HRB-CICER is to deliver a high quality evidence base with regard to systematic reviews of clinical effectiveness, systematic reviews of cost-effectiveness and budget impact analyses to support the development of National Clinical Guidelines/Audits. CICER will support Guideline Developers in developing evidence based recommendations. In addition, the collaboration will advise NCEC on improvements in methodological developments in evidence generation and on research gaps with regard to the evidence base and how best they may be addressed. CICER will publish the evidence generated in academic and other fora to raise the profile of CICER and NCEC.