The HRB Clinical Research Facility Galway (HRB-CRFG) is essential to help local and national researchers in generating ideas for clinical trials. HRB-CRFG is particularly important in the design, execution and completion of these clinical trials that aim to improve the health of patients and the general public, as we provide key knowledge, experience, physical space, systems and equipment to ensure that all trials are completed in the best way possible. HRB-CRFG developed through essential partnership between NUI Galway, Saolta University Health Care Group and the Health Research Board. HRB-CRFG staff have extensive experience in conducting a large range and variety of clinical trials (e.g. medications or devices for diagnosing, preventing or treating health problems), within Ireland and across the world (e.g. collaborators, other Irish Universities, companies). Since HRB-CRFG was established in 2008, we led the growth of clinical trials, including trials where researchers at NUI Galway planned, designed and executed all stages. From a small team in 2008, HRB-CRFG grew into a central core team that supports seven groups of researchers in conducting a large number of trials across a wide range of clinical areas. Key to the success of HRB-CRFG is that we provide all systems and departments (e.g. clinical experience, trial design, regulations, business and handling of data) needed to safely and effectively complete clinical trials, based on laws and standards. We provide these services to researchers in Galway, but also provide services to researchers across the country, including particular strengths in the handling of clinical trial data, where we work with researchers in Galway, Cancer Trials Ireland, University College Dublin and Trinity College Dublin. HRB-CRFG will allow patients and researchers across Ireland to be involved in and/or design clinical trials that will improve the health of the local, national and international population.