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Examining The Role of Long Non-Coding RNAs in Regulating Microcalcification in Ductal Carcinoma In Situ

Breast screening involves an x-ray of the breast (mammogram) to look for signs of early breast cancer. If detected early, breast cancer is easier to treat and the woman has a greater chance of a good recovery. Microcalcifications, which are detected on a mammogram, are routinely used to help in the identification of potential breast cancer. Despite this, very little is known regarding why microcalcifications form, or the consequences of their formation in breast tissue. The proposed summer study will investigate if the genetic factors, in particular, the long non-coding RNAs, play a role in the process of microcalcification deposition by breast cancer cells and will help us understand the complexities of this significant marker of preinvasive breast cancer.