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Evaluation of the effect of miR-379, Retinoic Acid Receptors and Thyroid Hormone Receptor overexpression in Breast Cancer Outcomes

miR-379, Retinoic Acid Receptors (α and β)and Thyroid Hormone Receptors (α and β) are three known markers for breast cancer. It has been postulated that overexpression of these markers act to suppress tumour growth. Unpublished data from this lab support this hypothesis based on in-vivo animal model studies of the miR-379 and published works on both the receptors mentioned. However, there is currently an unknown importance of these identified receptors relating to overall outcome in a clinical setting. Therefore the aim of this study is to find any correlation between overall outcomes such as tumour re-occurrence and mortality with the expressed levels of miR379, retinoic acid receptors or thyroid hormone receptors. If any significant association exists between any of the three markers and one of the specific subtypes associated with breast cancer, it is possible that they could be used as treatment targets for patients with said breast cancer subtype. This would allow for personalised treatment versus the current one treatment fits all that is currently in use.