As our population continues to age and our lifestyles grow more sedentary, the issue of ageing and brain degeneration is becoming an increasing global burden. Research has demonstrated the link between inflammation and the aged brain and how chronic inflammation in the brain can lead to both structural and functional impairment. The importance of exercise in maintaining brain health and its role in downregulating detrimental inflammatory activation in the brain has previously been demonstrated. However, the precise mechanism behind this finding has yet to be elucidated. My aim is to investigate and understand the role that lactate, a product of cellular metabolism, plays in mediating the protective elements of exercise in the brain. To do this, I will carry out a series of cellular analyses on isolated brain tissue and blood samples from a mouse model of neuroinflammation. By further understanding the link between exercise and it’s role in protecting the brain from inflammation, this may shed light on the potential therapeutic interventions for neurodegenerative diseases such as Alzheimer’s Disease and Parkinson’s disease, for which there is of yet no cure.