Study design for interventions
- “Defining Feasibility and Pilot Studies in Preparation for Randomised Controlled Trials: Development of a Conceptual Framework” by Eldridge S. et al.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150205 - “The PRECIS-2 tool: designing trials that are fit for purpose” by Louden et al.
http://dx.doi.org/10.1136/bmj.h2147 - “A process for Decision-making after Pilot and feasibility Trials (aDePT): development following a feasibility study of a complex intervention for pelvic organ prolapse” by Bugge C et al.
http://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-14-353 - “Developing and Evaluating Complex Interventions” by MRC, UK
www.mrc.ac.uk/complexinterventionsguidance - “Process evaluation of complex interventions: Medical Research Council guidance” by Moore GF. et al.
http://dx.doi.org/10.1136/bmj.h1258 - “Using natural experiments to evaluate population health interventions: Guidance for producers and users of research evidence” by MRC, UK
https://pubmed.ncbi.nlm.nih.gov/22577181/ - Consort 2010 Statement: updated guidelines for reporting parallel group randomised trials
www.consort-statement.org - SQUIRE Guidelines: provides a framework that authors can use when developing applications or writing research articles about quality improvement
www.squire-statement.org - HIQA Guidelines for the Economic Evaluation of Health Technologies in Ireland (2018)
https://www.hiqa.ie/reports-and-publications/health-technology-assessment/guidelines-economic-evaluation-health - HIQA Guidelines for the budget Impact Analysis of Health Technologies in Ireland (2015)
https://www.hiqa.ie/reports-and-publications/health-technology-assessment/guidance-budget-impact-analysis - HIQA Guidelines for Evaluating the Clinical Effectiveness of Health technologies in Ireland (2011)
https://www.hiqa.ie/sites/default/files/2019-01/Clinical-Effectiveness-Guidelines.pdf
Study registration
- International Clinical Trials Registration Platform (run by the WHO)
http://apps.who.int/trialsearch/Default.aspx - European Clinical Trials Database (EudraCT): database of all regulated clinical trials which commenced in the EU from 1 May 2004
https://eudract.ema.europa.eu/results-web/ - US National Library of Medicine database: database of privately and publicly funded clinical studies – regulated and unregulated – conducted around the world
https://www.clinicaltrials.gov/
Reporting
- COMET (Core Outcome Measures in Effectiveness Trials) Initiative: development and application of agreed standardised sets of outcomes, known as ‘core outcome sets’
http://www.comet-initiative.org/ - EQUATOR Network Library for health research reporting: an international initiative that seeks to improve reliability and value of health research literature by promoting transparent and accurate reporting of research studies
https://www.equator-network.org/library/ - Registry of Research Data Repositories
http://www.re3data.org/ - Zenodo Data Repository (OpenAIR)
https://zenodo.org/
Evidence synthesis
- Evidence Synthesis Ireland: aims to build evidence synthesis knowledge, awareness and capacity among the public, health care institutions and policymakers, clinicians, and researchers on the Island of Ireland.
https://evidencesynthesisireland.ie/ - The Cochrane Library: online collection of databases in medicine and other healthcare specialties which summarise and interpret the results of medical research.
www.thecochranelibrary.com - The Campbell Collaboration: promotes positive social and economic change through the production and use of systematic reviews and other evidence synthesis for evidence-based policy and practice.
https://www.campbellcollaboration.org/ - The Campbell Collaboration UK & Ireland: hub at Queens University Belfast.
https://www.qub.ac.uk/research-centres/CampbellUKIreland/ - EQUATOR Network Library for health research reporting: an international initiative that seeks to improve reliability and value of health research literature by promoting transparent and accurate reporting of research studies.
https://www.equator-network.org/library/
Clinical research infrastructures
- The Northern Ireland Hub for Trials Methodology Research
https://www.qub.ac.uk/sites/TheNorthernIrelandNetworkforTrialsMethodologyResearch/ - Centre for Support and training Analysis and Research (CSTAR)
http://www.cstar.ie - Children’s Clinical Research Unit
https://www.childrenshealthireland.ie/research-innovation-index/research-at-chi/ - Clinical Research Support Unit, Limerick
https://www.ul.ie/hri/clinical-research-support-unit - Clinical Research Centre, Royal College of Surgeons in Ireland
https://www.rcsi.com/dublin/research-and-innovation/research/resources-and-facilities/clinical-research-centre - Clinical Research Facility, University College Dublin
http://www.ucd.ie/medicine/ourresearch/researchenvironment/ucdclinicalresearchcentre/ - HRB Clinical Research Facility, Cork (HRB CRFC)
http://www.ucc.ie/en/crfc/ - HRB Clinical Research Facility, Galway (HRB CRFG)
http://www.nuigalway.ie/hrb_crfg/ - HRB Critical Care Clinical Trials Network (HRB Critical Care CTN)
ICC-CTN (iccctn.org) - HRB Irish Network for Children’s Clinical Trials (in4kinds)
In4kids - HRB Primary Care Clinical Trials Network (HRB Primary Care CTN)
Primary Care Clinical Trials Network Ireland – HRB PC CTNI (primarycaretrials.ie) - HRB Trials Methodology Research Network (TMRN)
http://www.hrb-tmrn.ie - The National Clinical Trials Office (NCTO)
https://ncto.ie/ - Wellcome Trust-Health Research Board Clinical Research Facility, St James’s Hospital (WT-HRB CRF SJH)
http://www.sjhcrf.ie/
Biobanking
- Council of Europe Recommendation of the Committee of Ministers to member States on research on biological materials of human origin (2016)
https://search.coe.int/cm/Pages/result_details.aspx?ObjectId=090000168064e8ff - BBMRI-ERIC is a European research infrastructure for biobanking
https://www.bbmri-eric.eu/ - OECD Guidelines on Human Biobanks and Genetic Research Databases
https://legalinstruments.oecd.org/en/instruments/OECD-LEGAL-0375 - ISBER Best Practices for Repositories
https://www.isber.org/page/BPR - Molecular Medicine Ireland Biobanking Guidelines
https://www.liebertpub.com/doi/10.1089/bio.2010.8101 - NCI Best Practices for Biospecimen Resources (2016 version)
https://biospecimens.cancer.gov/bestpractices/2016-NCIBestPractices.pdf
Public and Patient Involvement in research and research priorities
- The National PPI Ignite Network
https://ppinetwork.ie/ - NIHR PPI resources
https://www.nihr.ac.uk/research-funding/application-support/working-with-people-and-communities
https://www.learningforinvolvement.org.uk/ - How to involve the public in knowledge mobilisation:
https://evidence.nihr.ac.uk/collection/how-to-involve-the-public-in-knowledge-mobilisation/ - Patient-Centred Outcomes Research Institute (PCORI)
http://www.pcori.org - Public Involvement Impact Assessment Framework: Provides tools for successful involvement of members of the public in research projects and for assessment of impacts.
http://piiaf.org.uk/ - NIHR Payment guidance for researchers and professionals
https://www.nihr.ac.uk/documents/payment-guidance-for-researchers-and-professionals/27392 - European Patient Forum Value + Handbook: For Project Co-ordinators, Leaders and Promoters on Meaningful Patient Involvement.
http://www.eu-patient.eu/globalassets/projects/valueplus/doc_epf_handbook.pdf - The James Lind Alliance Priority Setting Partnerships: Research priorities in disease areas set jointly by patients, clinicians, and researchers.
http://www.jla.nihr.ac.uk/ - Campus Engage: Supporting Irish HEIs to embed civic engagement in their work. Includes resources, how-to-guides, and case studies for engaged research.
http://www.campusengage.ie/what-we-do/publications/ - UK Standards for Public Involvement: The six UK Standards for Public Involvement provide clear, concise statements of effective public involvement against which improvement can be assessed.
https://sites.google.com/nihr.ac.uk/pi-standards/home - The Involvement Matrix: A tool for researchers/project leaders to promote collaboration with patients in projects and research.
https://www.kcrutrecht.nl/involvement-matrix/ - The Evaluation Toolkit: is a resource designed for practitioners of the health sector, produced after the completion of a rigorous systematic review of patient and public engagement evaluation tools.
https://ceppp.ca/en/evaluation-toolkit/ - GRIPP2 reporting checklists: Tools to improve reporting of patient and public involvement in research
https://researchinvolvement.biomedcentral.com/articles/10.1186/s40900-017-0062-2#Tab1
Use of animals in research
- EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) (reviews of available non animal models)
https://joint-research-centre.ec.europa.eu/eu-reference-laboratory-alternatives-animal-testing-eurl-ecvam_en - Experimental Design Assistant (EDA) (online tool for design of animal experiments)
https://eda.nc3rs.org.uk/ - PREPARE (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence) guidelines
https://norecopa.no/prepare - ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines
https://arriveguidelines.org/ - SYRCLE (Guidance and training on systematic review of animal studies)
https://www.syrcle.network/ - PROSPERO (Register for systematic reviews including animal studies)
https://www.crd.york.ac.uk/PROSPERO/
Gender and/or sex dimensions in research
- Examples of case studies in Health & Medicine where gender/sex in research matters
http://genderedinnovations.stanford.edu/case-studies-medicine.html - Gender Toolkit in EU-funded research for examples and guidance
http://www.yellowwindow.be/genderinresearch/downloads/YW2009_GenderToolKit_Module1.pdf - How to integrate sex and gender into research
https://cihr-irsc.gc.ca/e/50836.html - Impacts of integrating sex and gender in research
https://cihr-irsc.gc.ca/e/50839.html - NIH Policy on Sex as a Biological Variable
https://orwh.od.nih.gov/sex-gender/nih-policy-sex-biological-variable
Data management and sharing and FAIR principles
- Digital Curation Centre: How to develop a data management and sharing plan and examples DMPs.
http://www.dcc.ac.uk/resources/data-management-plans/guidance-examples - FAIR data principles FORCE 11
https://www.force11.org/fairprinciples - UK Concordat on Open Research Data (July 2016)
https://www.ukri.org/wp-content/uploads/2020/10/UKRI-020920-ConcordatonOpenResearchData.pdf - Guidelines on FAIR data management plans in Horizon 2020
http://ec.europa.eu/research/participants/data/ref/h2020/grants_manual/hi/oa_pilot/h2020-hi-oa-data-mgt_en.pdf - FAIR at the Dutch centre for Life sciences
https://www.dtls.nl/fair-data/ - Registry of Research Data Repositories
http://www.re3data.org/
Research data management plans
- Data Stewardship Wizard created by ELIXIR CZ and NL
https://ds-wizard.org/ - DMPonline of the Digital Curation Centre (DCC), UK
https://dmponline.dcc.ac.uk/ - DMPTool of University of California Curation Center of the California Digital Library (CDL), USA
https://dmptool.org/ - RDMO Research Data Management Organiser of the German Research Foundation, Germany
https://rdmorganiser.github.io/en/ - Guidelines on FAIR data management plans in Horizon 2020
http://ec.europa.eu/research/participants/data/ref/h2020/grants_manual/hi/oa_pilot/h2020-hi-oa-data-mgt_en.pdf
Knowledge translation resources
- Health Service Executive Research & Development Main Page
https://hseresearch.ie/research-dissemination-and-translation/ - Health Service Executive Research & Development: Knowledge Translation, Dissemination, and Impact A Practical Guide for Researchers
https://hseresearch.ie/wp-content/uploads/2021/04/Tools-and-templates-.pdf - Integrated Knowledge Translation (iKT) NUI Galway
https://www.nuigalway.ie/hbcrg/ikt/ - The Canadian Institutes of Health Research: Guide to Knowledge Translation Planning
https://cihr-irsc.gc.ca/e/45321.html - Training Institute for Dissemination and Implementation Research in Health: Open Access Course
https://cancercontrol.cancer.gov/is/training-education/TIDIRC-open-access
Implementation science resources
- Centre for Effective Services
https://www.effectiveservices.org/resources/implementation - UCC Implementation Science Training Institute
https://www.ucc.ie/en/cpd/options/medhealth/cpd1778uccimplementationsciencetraininginstitute/ - European Implementation Collaborative
https://implementation.eu/resources/
Co-creation resources
- ACCOMPLISSH Guide to impact planning
https://www.ugent.be/psync/en/what/projects/impactplanning.pdf - Working together to co-create knowledge: A unique co-creation tool – Carnegie UK Trust
https://www.carnegieuktrust.org.uk/publications/working-together-to-co-create-knowledge-a-unique-co-creation-tool/
Information on persistent identifiers
- DOI: List of current DOI registration agencies provided by the International DOI Foundation
http://www.doi.org/registration_agencies.html - Handle: Assigning, managing and resolving persistent identifiers for digital objects and other Internet resources provided by the Corporation for National Research Initiatives (CNRI)
http://www.handle.net/ - URN: List of all registered namespaces provided by the Internet Assigned Numbers Authority (IANA)
https://www.iana.org/assignments/urn-namespaces/urn-namespaces.xml
Data repositories
- Registry of Research Data Repositories
http://www.re3data.org/ - Data centers accredited by the German Data forum according to uniform and transparent standards (Germany)
https://www.konsortswd.de/ueber-uns/ratswd/ - Zenodo Data Repository (OpenAIR)
https://zenodo.org/
Research ethics resources
- National Office for Research Ethics Committees
https://www.nrecoffice.ie/ethics-resources/ - HSE Research Ethics
https://hseresearch.ie/research-ethics/
Other useful links
- Tool that helps to select and apply a license to a resource, provided by Creative Commons
https://creativecommons.org/choose/