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Funding Awarded

106 awards

  • Communicating and promoting SAFE medicines use in Ireland

    The likelihood of side effects of medicines, drug interactions and potentially inappropriate prescribing increase with the increasing number of medicines people take. Taking multiple medicines at the same time is common in people age 65 year olds or older with six in every ten in this age group. Also, around one in ten of those aged 65...

  • Interact for Health: Increasing integrated knowledge translation capacity for impact

    Although the Health Behaviour Change Research Group (HBCRG) has engaged with the HSE Health and Wellbeing (H&W) Division as health partners on a number of activities to date, we believe there is significant potential for enhanced knowledge exchange between these two groups. Additionally, integrated Knowledge Translation (iKT)...

  • The biology of mood: What brain imaging and genetic studies tell us about Bipolar Disorder

    This project aims to translate the known biology of bipolar disorder, enhance the accessibility of the latest discoveries and interpret the meaning and relevance to individuals with bipolar disorder, their families, carers and health professionals that are not research active. To complement the current emphasis on clinical aspects of...

  • The youth mental health animation creation project

    This KEDS award will be used to create animations about young people's mental health that will be embedded into the youth mental health website, ReachOut.com.



    This project will involve crafting key messages from this study into short narratives using direct quotes from the research interviews conducted for...

  • Brain superheroes and villains

    We are a group of neuroscientists, funded by the HRB, who aim to test and develop novel drugs for brain related illnesses. We are excited about disseminating the value of work like ours and, in 2012, were delighted to be awarded our first HRB Knowledge Exchange and Dissemination Scheme (KEDS), which consisted of three activities...

  • Learning about trials - for children, by children

    This project will consist of the development of new resources for teaching primary school children (aged 10-12) about why we need trials and how trials work, with a view to being more widely used throughout the trial community. These resources will align with the START (Schools Teaching Awareness of Randomised Trials) Competition,...

  • Family carer knowledge exchange project

    We are interested in how family carers of people with dementia develop and maintain resilience in the care giving role and we are designing a project to help family carers to be more resilient and to better cope with the demands of care giving. As a team of researchers, we have reviewed studies of family carers'experiences in other...

  • Community exercise

    It is recognised that exercise benefits people living with chronic disease. The CRF at St James's Hospital exercise physiology suite is used by research studies examining the role of exercise training for patients with chronic disease. These exercise trials support patients to exercise during structured supervised exercise classes and...

  • Driving policy with data: A longterm sustainable specialist service for amyotrophic lateral sclerosis

    The JPND-funded project ALS-CarE is coordinated by the Irish partner, and has collected detailed information across 5 different countries about the Amyotrophic Lateral Sclerosis (ALS) patient and caregiver journey from ALS diagnosis through to end of life. In Ireland, we have collected extensive quantitiative and qualitative...

  • The StrokeCog partnership: effective intervention through collaboration

    Stroke is a leading cause of death and disability worldwide and will increase considerably in coming decades as people live for longer. Many people are aware of physical disabilities after stroke, but are less aware of cognitive problems. These include difficulties with memory, concentration and abstract thinking, often experienced as...

  • Non-motor symptoms in dystonia and musician's dystonia

    Our multidisciplinary Irish Dystonia Research Group, combining the expertise of Bioengineers in Trinity College Dublin and a network of Clinical Neurologists, has been working to determine the cause of a disabling movement disorder, adult onset dystonia, characterised by abnormal postures and excessive muscle activity. The causes of...

  • Evidence to Support Prevention Implementation and Translation - Knowledge Translation (ESPRIT-KT)

    This application adds to a larger HRB Research Leader Award about improving care for people with diabetes in Ireland. The goal of the KEDS project is to connect people who do research with people who make decisions about our national health policy so they can learn from each other and work together to improve the health of the...

  • Developing a website for public awareness about computer use in aphasia rehabilitation

    Aphasia is a language disorder which occurs in 1 in 3 people after stroke. It can impact on a person's ability to produce and understand spoken and written language. People with aphasia have had limited opportunities to have their voices heard within Irish stroke research.



    This research project has already...

  • The Art of Pregnancy

    The Art of Pregnancy is an exciting and ambitious public outreach exhibition and programme supported by the HRB Mother and Baby CTN togther with the Science Gallery Dublin as a key partner.

    For this project we want to commission (via an open call process) a group of artists to create works inspired by the wide ranging...

  • Speaking Up About Safety (SUAS)

    Speaking up about safety concerns is an important aspect of a healthcare professional's role. Our research has shown that in comparison to nurses, junior doctors are particularly poor at speaking up and tend not to report incidents and adverse events, in many cases because they believe it is not their responsibility to do so. Yet, a...

  • Our voices, our impact

    Wave 3 KEDS will build on previous success by recruiting actors with ID to develop DVD and on-line resources comprising scenes that illustrate key IDS-TILDA wave 3 findings. Feedback from wave 3 indicates that participants would like to receive the findings in DVD format and IDS-TILDA wishes to respond to the specific dissemination...

  • Brain, mind and psychosis: Engaging young people in learning about research

    Great progress has been made over the past few years in "destigmatising" mental illness and this has been particularly successful for conditions such as depression and anxiety. However there still remains a great lack of knowledge about psychosis. This lack of knowledge can lead to stigma and fear and can prevent young people...

  • The LinKT (Linking into Knowledge Translation) project: connecting, integrating and translating evidence to make a difference for families

    Increasing evidence highlights the effectiveness of early intervention and prevention parenting interventions for improving the mental health and wellbeing of parents and children in the earliest years. However, these are often complex, difficult to implement effectively and fail to reach the most vulnerable families. Accessible,...

  • Development of an online cancer genetics educational resource for undergraduate and postgraduate healthcare learners

    Genetic testing is becoming cheaper and easier to perform. As such, it is being performed more and more frequently; to help explain why people have developed cancer, or to try to identify genetic changes in their tumours to which novel drugs can be targeted. Genetic testing may also help identify individuals at risk of cancer,...

  • Pathfinder: Parental information on therapeutic hypothermia followIng neonatal encephalopathy

    Neonatal brain injury can have devastating outcomes for the baby and their family and may result in longterm disability. The only treatment available is whole body cooling started within a few hours of birth. Babies also require intensive care to support their lungs, heart and kidneys. We will develop an educational toolkit including...

  • Let's talk - and act - about adherence in multimorbidity - a teaching and learning resource for general practice

    More than half of those over the age of 65 live with more than one chronic condition. This is known as multimorbidity (MM). The prevalence of MM increases with age and is more common in less well off patients. Using muliple medications i.e. polypharmacy, is the norm in MM and many do not take their medications as prescribed i.e....

  • Cracking the mysteries of cancer immunotherapies - e.courses for oncology healthcare professionals

    The new therapies for cancer that target the immune system have revolutionised cancer care in recent times. The treatment of melanoma, leukaemia and other malignancies has been transformed by these immune modulating drugs. However, few oncology clinicians or oncology specialist nurses have backgrounds in immunology or immune...

  • The stressed brain & depression

    Understanding depression is challenging both for professionals and for the public. It is complex and poorly conceptualized. Clinical depression involves biological, psychological and social causes that all contribute to the expression of depression in each individual sufferer. Trauma, especially early in life when body systems are...

  • CERVIVA: The HPV educate project

    The goal of this CERVIVA HPV Educate Project is to provide accurate and reliable information relating to HPV and HPV associated diseases, to create awareness and educate the public, health care professionals and healthcare providers on public health issues related to HPV associated diseases and on the specific research programmes...

  • Overweight & obesity in Ireland: Translating policy into action

    The launch in 2016 of "A healthy weight for Ireland", the Government's National Obesity Policy and Action Plan, 2016-2025 represents an important milestone in Ireland's response to ongoing epidemic of overweight and obesity in children and adults. Researchers in the HRB Centre for Health & Diet (CHDR) generated key...

  • Listening to the newborn brain

    This outreach programme will provide dedicated public information and education resources on the neonatal brain stethoscope device, which aims to facilitate interrogation of the neonatal brain and improve the quality and accuracy of the diagnosis brain injuries, reduce the stress of parents with babies in the NICU and establish the...

  • Expert forum to advance the potential of IL-1 family members as novel therapeutics in IBD

    Current treatment strategies for Inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, are ineffective in a large number of patients. Although the reasons for this are not fully understood, it seems likely to reflect the complex nature of chronic intestinal inflammation. Recent advances in our understanding...

  • Supporting individuals and organisations involved in implementation of community water fluoridation

    The Fluoride And Caring for Children's Teeth (FACCT) study was initiated to determine the effect of the change in water fluoridation policy (2007) on dental caries (tooth decay) and enamel fluorosis (marks on tooth enamel which are associated with fluoride) in Irish children, while also considering the change in policy on the use of...

  • Psychosocial, psychiatric and work-related risk factors associated with suicide in Ireland: Enhancing dissemination and impact of research

    The SSIS-ACE study examines how psychosocial, psychiatric and work-related factors relate to suicide. The study involves liaising with family members bereaved by suicide, family members of those who survived a high-risk self-harm act, general practitioners (GPs), emergency department staff, mental health staff and coroners. During the...

  • Taking the stress out of dementia caregiving

    The existing award examines how the caring experience can impact the health of dementia spouse carers. Using this emerging research evidence we will develop two animated films and a dedicated online resource providing easy-to-understand practical advice to carers to improve their quality of life and reduce stress.
    FreeDem Films...

  • Synthesising and disseminating key lessons from the AIIHPC Palliative Care Research Network

    This application for KEDS funding proposes to further enhance knowledge transfer and exchange activities across the SRN/PCRN by conducting a higher level analysis of the dissemination products arising from each individual work project during the final year of the active grant. It is expected that dissemination products will include...

  • Capnography monitoring for conscious sedation in oral surgery

    Capnography has the potential to enhance patients safety in the dental setting. Procedural sedation techniques are specific to each area of medicine where sedation is practiced. Conscious sedation in an out of hospital setting by a non anaesthetist requires robust monitoring. The most important negative side effect of sedation is...

  • Doctor Emigration Knowledge Exchange Project (DEP-KEDS)

    The Doctor Emigration Project (DEP) aims to analyse doctor emigration from Ireland and to inform national health workforce policy about the factors influencing their emigration. The ultimate aim of the project is to assist national workforce planners to develop evidence-informed policies to promote the retention of doctors in, and the...

  • Creating awareness of research in caregiving (CARING)

    An increasing number of people in Ireland are providing care for a relative with dementia. This important unpaid work comes with an underappreciated cost to the health of the caregiver. Evidence suggests that dementia caregiving is associated with heightened psychological stress, as well as problems such as depression.
    Our...

  • Development of a national severe asthma registry and comprehensive care program

    There has been a drive to deliver new asthma treatments through new biological agents. However, age old issues including poor adherence and poor inhaler use still apply and mean that it is difficult to tell if a patient has difficult to manage asthma or therapy refractory asthma. The proposal is to build a registry for patients with...

  • Creation of a young adult colouring book illustrating biological research on mental illness

    We plan to create an innovative educational activity to promote our research on biological investigations in mental illness. Our idea is to publish a young adult colouring book that will introduce young people to the complex world of the human brain, how scientists perform neuroscience research and how the findings relate to...

  • Development and upgrading of the HMDB Schizophrenia Metabocard

    The Human Metabolome Database (HMDB) is a freely available database that contains detailed information about small molecules found in the human body. It is the first and foremost reference site for metabolite data worldwide. It provides scientists, clinicians, educators and the public with the most current and comprehensive coverage of...

  • Brain superheros return

    Making new drugs is long, costly and complex, and is often a mystery to many people. Our laboratory is involved in the development of new drugs for brain related illnesses, including illnesses such as Alzheimer's disease (AD) and Multiple Sclerosis. Alongside our research, we conduct a number of outreach projects in the hope of...

  • Priority setting in uncertainties in trial methodology

    Challenges in how clinical trials are designed and conducted are commonly experienced by researchers at different stages of the research process. For example, difficulty in recruiting people to a trial often results in a delay in completing the trial, or difficulty in using the trial results to make informed decisions about clinical...

  • Thinking outside the box: towards a novel approach to care delivery for young adults with type 1 diabetes

    Many young people living with type 1 diabetes struggle with the burden of day-to-day self-management. As a result they often have poor outcomes including the development of life-changing complications. We have formed a partnership between existing diabetes service providers (in Galway University Hospitals), academics in National...

  • Immunotherapy for the treatment of AMD: a preclinical evaluation

    Age-related Macular Degeneration (AMD) is the leading cause of central retinal vision loss worldwide. Estimated prevalence of AMD in Ireland is 7% with an annual cost

  • High quality pre-pregnancy care is essential for women with diabetes

    Women with diabetes have an increased risk of pregnancy complications. Many of these complications are due to high glucose levels in the first ten weeks of pregnancy. This means that pregnancy planning and tight glucose control is essential. Pre-pregnancy care is additional clinical care offered to women planning pregnancy. As part of...

  • Building a self-management programme for living well with and beyond head and neck cancer

    We propose to develop a new programme that empowers survivors of head and neck cancer (HNC) to better manage problems associated with their illness and live well with and beyond HNC. This is important because HNC survivors have many documented unmet care needs and can face significant challenges associated with their condition and its...

  • Behavioural changes in ALS : What families and healthcare professionals need to know

    Amyotrophic Lateral Sclerosis (ALS ) (or Motor Neuron Disease (MND)) is a rapidly progressive neurodegeneration associated with loss of muscle power. Until recently, thinking and behaviour were considered unaffected, but we have shown that up to 50% of people with ALS/MND experience changes in their ability to plan complex tasks, and...

  • Evidence based oral healthcare for older adults

    The World Health Organisation has highlighted the paucity of research into the oral health needs of older adults. The Health Research Board has recognised this and have funded a number of studies in recent years addressing this topic. Unfortunately there is a delay between the completion of studies and the publication of results in...

  • Cracking cancer with science; an educational outreach campaign for primary schoolchildren

    Breast cancer remains a significant disease in Ireland. Our laboratory is investigating novel therapies to target a sub-group of aggressive breast tumours. This work feeds into two larger efforts. The first is to help personalize cancer therapies for patients. The second is to provide new insight into how specific tumours develop, in...

  • SOLAS.net: Development and pilot implementation of an e-learning physiotherapist training programme for self-management of chronic musculoskeletal pain in primary care

    As part of the original award, an evidence-supported group treatment approach for clients with persistent musculoskeletal pain termed SOLAS: Self-management of Osteoarthritis and Low back pain through Activity and Skills was developed. Also, a two day face-to-face physiotherapist training programme was developed and delivered to HSE...

  • Applying health: Using healthcare technology to enhance the delivery of rehabilitation programmes in cancer survivors

    Recovery following oesophageal cancer (cancer of the food pipe) can be challenging. Cancer rehabilitation, which may involve exercise, advice from a dietitian, education or other therapeutic interventions, can help patients make an optimal recovery. The research team is currently investigating the effect of a 12 week rehabilitation...

  • Irish Dystonia Research Group: Innovation through collaboration

    Our research group of Irish consultant neurologists (with an interest in movement disorders) and laboratory based scientists (engineers in the Department of Neural Engineering in Trinity College Dublin) have been involved in finding the cause(s) of a movement disorder which affects about 600-800 individuals in Ireland. This movement...

  • Enhancing awareness of the socio-economic impact of inherited blindness

    In Ireland, many devastating diseases have an inherited cause and are passed onto further generations. Blindness due to inherited degeneration of the retina at the back of the eye is an excellent case-study with which to explain the basis of inherited disease, the socio-economic impact and the research required to generate new...

  • Enhancing awareness of blindness resulting from diabetes. Understanding treatments & preventative interventions

    In Ireland, Diabetic Retinopathy is a leading cause of blindness. The number of people becoming blind due to diabetes is set to rapidly increase as the "diabetes epidemic" unfolds. In general, there is a lack of awareness as to the social, economic and health impact of diabetic blindness.
    Here, we generate short...

  • Baby steps towards STRIDER: support, website, information, dissemination, exchange

    This outreach programme will provide a dedicated public information and education resources on intrauterine growth restriction (IUGR) and the STRIDER clinical trial, which aims to improve outcomes of pregnancies affected by IUGR with sildenafil citrate (Viagra). It will provide support to women and their partners experiencing IUGR by...

  • Promoting positive mental health messages for the older population: The Irish Longitudinal Study on Ageing (TILDA) films

    The Irish Longitudinal Study on Ageing (TILDA) offers unique data on the challenges associated with ageing and how these can affect mood as we age: grief, retirement, poorer physical health. We have demonstrated that mood may be affected by loss of support networks such as adult children moving abroad. Over 10% of the older Irish...

  • The Irish Longitudinal Study on Ageing (TILDA) hypertension seminars for health professionals in primary and community care practice

    In April 2015 the Irish Longitudinal Study on Ageing (TILDA) published research, funded through the active award, which indicates that approximately two thirds of older Irish adults have high blood pressure and close to half of them are unaware of their condition. High blood pressure is an important risk factor for heart disease and...

  • A web-based resource and community of practice (CoP) to transform practices around 'talking about epilepsy'

    This knowledge exchange and dissemination (KED) initiative proposes to develop a variety of educational and informative resources using different technological media (audio, video and e-authoring tools) which will be delivered online in a designated website to support the translation of research evidence on childhood epilepsy...

  • Healthy pregnancy in Ireland

    The HRB Ireland Perinatal CTN is an all-island of Ireland clinical trial network for mothers and babies representing a new and exciting collaboration between two established research groups; the Irish centre for Foetal and Neonatal Translational Research (INFANT) and Perinatal Ireland. The 'Healthy Pregnancy in Ireland' initiative is a...

  • Innovative dissemination of IDS-TILDA Wave 2 - Advancing years, different challenges

    The IDS-TILDA study is designed to better understand experiences and challenges for adults with an intellectual disability (ID) as they age. 753 persons aged 40+ started in the study. There have been two waves of data collection, with waves three years apart and 94% of people who answered at Wave one participated again at Wave two. We...

  • Development of The STOP-HF network for community based prevention of Heart Failure

    STOPHFnet will create a virtual community of practice which will utilize the results of research from our HRB funded Natural History of Diabetic Cardiomyopathy grant to allow rapid dissemination to general practitioners in the community. This is particularly timely as diabetes will for the first time be nationally managed by GPs under...

  • Understand my pain: Educational tools for chronic pain

    Based on the findings of the research during our HRB ICE award, we will develop two educational tools.
    Activity A will involve the creation of a free video that explains how chronic pain impacts on children and their families. This activity is vital based on our new understanding of the numbers of primary school children who...

  • Development and launch of Irish guidelines on the management of Helicobacter pylori Infection

    Helicobacter pylori infection is a public health issue. It remains one of the most common infections in adults in Ireland and is the primary cause of stomach ulcers and stomach cancers. Our recent findings have indicated that the eradication rate for standard first-line triple therapy for H. pylorihas fallen to unacceptable levels....

  • ICORG communications manager

    2016 will mark the 20th anniversary of ICORG's formation. There are a range of public engagement activities on the agenda but in order to co-ordinate them ICORG will need an in-house communications function.
    Activities will include;
    1. Short documentary-style videos on patient experience, innovative research activities and...

  • Development of an online training and accreditation resource for a novel outcome assessment tool in high risk infants: the Babyscreen app

    The HRB funded BiHiVE2 study has focused on predicting long term learning disability in children following birth related brain injury. Unfortunately there are, currently, no reliable methods of assessing learning ability in children at a young age. Current developmental assessments focus on developmental milestones. They are not true...

  • Thrombosis risk in pregnancy: what you need to know

    Venous thromboembolism (VTE; deep vein thrombosis and pulmonary embolism) remains a leading cause of death in pregnant and recently delivered women. Surviving mothers may have long-term disability. If VTE risk factors are identified, then preventative measures may be put in place . These interventions can be potentially life-saving....

  • Translating critical care research into clinical practice

    We are currently funded by the HRB to conduct clinical trials to determine which treatments may help patients who are critically ill. We have recently completed important research and the results will be published in a highly regarded medical journal in October. However it can take a long time between publication and improvements in...

  • Towards increased awareness and understanding of the risk of thrombosis in gynaecological cancers

    All cancers are associated with an increased risk of clots to the legs and lungs however gynaecological cancers have a particularly high risk. Clots can occur after surgery or during chemotherapy and can be life threatening if they are not treated in time. A recent survey of patients who suffered a clot during their cancer journey...

  • What is Alpha-1?

    Alpha-1 antitrypsin deficiency (Alpha-1) is a genetic disorder that affects the lungs. Typically people with Alpha-1 present with chronic obstructive pulmonary disease (COPD) or severe asthma. Ireland has one of the highest rates of AATD in the world. 1 in 25 Irish people are carriers for the condition and are at risk of lung disease,...

  • Cancer immunology research saves lives: Find Out

    The treatment of cancer is being revolutionised by cancer immunology. However cancer immunology is poorly understood by healthcare workers, patients and the general public. Here, in collaboration with the Irish Cancer Society (ICS), we aim to use the expertise and discoveries generated by HRB and ICS funded research projects to...

  • DEDIPAC Ireland: National one day symposium on determinants of diet and physical activity

    DEDIPAC (Determinants of Diet and Physical Activity; Knowledge Hub to integrate and develop infrastructure for research across Europe) is a collaborative European project, where Irish researchers play a major role in defining and understanding dietary and activity factors that influence health.
    The aim of this application is to...

  • Happy mothers...happy babies

    Pregnancy is the highest risk period in a woman's life for developing clinical depression. Depression and anxiety during pregnancy are common experiences. Women are usually anxious about the pregnancy and the delivery, about how they will cope with motherhood and the impact of the changes that having a baby will make on their lives. We...

  • CERVIVA: Making connections and creating impact

    The goal of CERVIVA's education and outreach programme is to create awareness, inform and effectively engage the public, health care professionals and healthcare providers on public health issues related to HPV associated diseases and on the specific research programmes underway within CERVIVA, which are addressing some of these...

  • Diet, health and sustainability - narrowing the gap between what we know and what we do

    Knowledge translation in the area of diet and health is challenging due to the range of vested interests in the food sector and the contested discourse on food, diet and health among policy makers, practitioners, media and the general public. There is considerable agreement on key food policy measures open to government with potential...

  • A user-friendly database of genetic dependencies in cancer

    A major challenge in cancer therapeutics is to kill tumour cells without harming other cells in the body. One means to achieve this is to exploit the genetic changes that distinguish cancer cells from normal cells and that may leave them vulnerable to targeted treatments.
    A promising approach to developing such targeted...

  • Together against HIV: raising awareness and knowledge through documented real-life experiences and research discovery

    There were approximately 2 million new HIV infections and 1.5 million HIV-related deaths worldwide in 2013, demonstrating the need for educational campaigns that raise awareness and prevent its spread. Current treatments suppress HIV, but do not totally clear it; however, a significant proportion of society believe these drugs cure...

  • Progressing universal health care: informing citizens by pooling and disseminating research and generating debate

    There is little informed public discussion and debate around Universal Healthcare (UHC) in Ireland. There is also much confusion in political discourse between UHC and universal health insurance notwithstanding a recent policy shift towards UHC. This KEDS project aims to build on the Pathways to UHC research by educating the public...

  • The Intellectual disability supplement to the Irish Longitudinal Study on Ageing (TILDA) Waves 3 and 4

    Similar to the general population, marked changes in the life expectancy of persons with intellectual disability (ID) have occurred among all age cohorts but in particular, among those aged 55 years and over. Almost half of people with a moderate, severe, or profound intellectual disability are aged 35 years or over. However, their...

  • Cancer Prevention Fellowship 2013

    Research Programme for mid-career researchers working in Republic of Ireland (RoI) to become NCI Cancer Prevention Fellows at the prestigious National Cancer Institute (NCI) in the USA.

    This programme provides training at post-doctorate level from the health professions, biomedical, and behavioural sciences to become...

  • Antiviral agents for infectious mononucleosis

    Review objective: To assess the effectiveness of antiviral therapy in improving outcomes for patients with Infectious Mononucleosis (IM). IM is a clinical syndrome that is usually associated with EBV infection. Although generally not considered a serious illness, IM can lead to significant loss of time from school or work due to...

  • Institutional smoking bans for reducing smoking prevalence and tobacco consumption

    Review objective: The objectives of this new review are twofold. The proposed new review will explore evidence specifically focusing on the impact of institutional smoking bans in workplaces, health care facilities and in other public places, so-called meso-level data. The update of the original review will assess the evidence since...

  • Aspirin and anti-inflammatory drugs for the prevention of dementia

    Review objective: To evaluate the effects of aspirin and other non-steroidal anti-inflammatory drugs in the prevention of dementia. In view of the perceived association between inflammation and Alzheimer's disease and stroke or multiple strokes arising from multiple infarcts in vascular dementia, research has focused on assessing...

  • Wound cleansing for treating venous leg ulcers

    Review objective: To explore the impact of wound cleansing on the healing rate of venous leg ulcers. Leg ulcers are a major health care problem, in terms of treatment, cost, recurrence and chronicity (Posnett and Franks, 2008). Indeed, for venous leg ulcers, with a prevalence of 49,000-1.3 million in the EU 27, the annual associated...

  • Interventions to improve end-of-life care in dementia

    Review objective: To determine the effectiveness of interventions to improve end-of-life care for people with dementia. For the purposes of this review, end-of-life care is defined as the care required when death is imminent for those with advanced dementia and for those with dementia of any severity who are in the terminal phase of an...

  • Interventions for breast cancer awareness amongst women of all ages

    Review objective: To assess the effects of interventions to develop breast cancer awareness amongst women. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females globally (Jemal et al., 2011). Early diagnosis of breast cancer is linked to more favourable outcomes and longer survival...

  • Patient Education for the prevention of venous leg ulceration

    Review objective: To determine the impact of patient educational interventions on the prevention of venous leg ulceration. The population for this review will include people over 18 years with a history of venous leg ulceration in any healthcare setting. Venous leg ulceration occurs as a result of impaired return of venous blood from...

  • Non-steroidal anti-inflammatory drugs (NSAIDS) for perineal pain in the early postpartum period

    Review objective: To determine the efficacy and safety of Non-steroidal anti-inflammatory drugs (NSAIDs) in relieving perineal pain in the early postpartum period. Perineal pain is commonly experienced by women after childbirth, particularly, although not exclusively, following episiotomy, spontaneous tears or bruising (Lawn and...

  • Irish Platform for Patients Organisations Science and Industry

    IPPOSI brings together patient groups, scientists, clinicians, industry and other key decision makers to discuss and build consensus on issues relevant to delivering treatments to people with unmet medical needs. On behalf of the DOH, the HRB has been co-funding IPPOSI with between 40-50% of their annual income since 2007. The...

  • ER stress induced microRNAs in insulin resistance

    The obesity epidemic has caused in a substantial increase in the incidence of type two diabetes mellitus (T2DM). Approximately 2.4 million people in Ireland are overweight/obese. Diabetes and its complications take a significant portion of the healthcare budget annually. T2DM results from the inability of the beta-cells of the pancreas...

  • The efficacy and effectiveness of capnogaphy monitoring during intravenous conscious sedation with midazolam for oral surgery

    Dentists use sedation to help patients accept difficult procedures and to relieve anxiety. During sedation, the well-being of the patient is monitored by the dental team. When carried out according to recognised guidelines, intravenous dental sedation is considered to be very safe. For some patients, dental sedation is a useful...

  • Direct acting antivirals in Hepatitis C: developing a personalised model of care

    Hepatitis C virus infection, which affects 170 million people worldwide, is a major global health problem, and is a leading cause of chronic liver disease, liver cancer and cirrhosis. The current treatment options for Hepatitis C infection fail to clear the virus in about 50% of patients. Two new antiviral drugs have just been licensed...

  • Multimodal characterisation of the benign prostate

    Benign Prostatic Hyperplasia (BPH) is a condition that will affect most men as they age, resulting in swelling of the prostate and causing problems when they try to pass urine. It is rare in men less than 40 but can be found in over 70% of men over the age of 70. Current treatment for BPH involves either tablet medication or surgery....

  • A randomised controlled trial to measure the effects of an augmented prescribed exercise program on mobility, quality of life and healthcare utilisation for frail hospilised older medical in-patients

    Older people can become less physically independent following a hospital stay. Up to one third become newly dependant on walking aids and others remain more dependent in the long-term, affecting physical and psychological health and increasing the burden on carers and healthcare. Although many factors can influence this deterioration,...

  • Concealed pregnancy in 21st century Ireland. Concealing and revealing by explaining: the care study

    There are many reasons why women choose to hide their pregnancy from friends and family and this study is trying to out why. Women who conceal a pregnancy are particularly vulnerable and may conceal right until, or even after, birth and as such represent an important issue for society. Risks of concealment are huge in terms of maternal...

  • Nervous system sensitisation in people with osteoarthritis of the knee: A prospective cohort study

    Osteoarthritis is a degenerative disease commoningly affecting the large joints such as the hip or knee. Ostheoarthritis is one of the ten most disabling diseases in developed countries according to the World Health Organisation. Pain and loss of function are the main symptoms. Current treatments including anti-inflammatory drugs,...

  • Maternal health And Maternal Morbidity in Ireland (MAMMI) - Sexual Health Strand

    The aim of this study is to identify if, and how women having their first baby in Ireland experience sexual health problems (SHPs) while pregnant and up to 12 months after childbirth. Within this aim are several objectives: a) To correctly estimate the number of women experiencing SHP while pregnant and up to 12 months after childbirth...

  • Functional capacity and thought disorder in first episode psychosis: an investigation of their clinical correlates and predictors over the first year of illness

    Psychosis is an illness that affects up to 3% of the population and it can often impact severely on an individual's mental health, quality of life and productivity. It is characterised by symptoms such as delusions and hallucinations in addition to lack of motivation and general withdrawal. If identified and treated at an early stage,...

  • The ability of urinary albumin excretion and estimated kidney function to predict short term all cause and cardiovascular mortality in community dwelling individuals

    Cardiovascular (CV) events such as stroke, heart attack and heart failure are the most common causes of death and adult disability. A priority in population-health is to accurately identify patients who are at increased risk of CV events, so that we can introduce effective preventative therapies in appropriate populations. Kidney...

  • Natural honey to eradicate nasal MRSA - a randomised control trial

    Staphylococcus aureus (S.aureus) is a frequent coloniser of normal skin and a common cause of blood stream infection "sepsis". The widespread use of antibiotics has led to the emergence of bacterial resistance to antibiotics. Meticillin-resistant staphylococcus aureus (MRSA) is the term used to describe S.aureus bacteria...

  • Does early detection and treatment of psychosis improve employment outcomes?

    A recent development within the mental health services is the focus on early detection and treatment, referred to as early intervention. This change in approach is most advanced in the treatment of psychotic conditions like schizophrenia. Evaluation of early intervention for psychosis services have shown that they are superior to...

  • Role of extra-oesophageal reflux in the development and severity of non-cystic fibrosis bronchiectasis

    Bronchiectasis is a chronic debilitating respiratory disease characterised by severe, recurrent chest infections with resultant high rates of morbidity and mortality, escalating public health costs and profound reductions in productivity and quality of life. In approximately 50% of cases, the cause of bronchiectasis is unknown...

  • Probing the metabolic response to vasculitic injury: towards a tool for non-invasive monitoring of immune activation in ANCA vasculitis

    A major unmet need in the care of patients with glomerulonephritis (GN) is a sensitive and specific means of identifying both the presence and absence of active vasculitic injury. I propose to undertake an in-depth PhD programme involving research that will incorporate pre-clinical and clinical tools to study the urinary metabolomic...

  • Structured Population and Health-services Research Education (SPHERE) Programme I

    The SPHeRE Programme was established to respond to an identified need to strengthen population health and health services research (PHHSR) capacity in Ireland in order to lessen the gap between research findings, health policy and health outcomes. The HRB-funded SPHeRE Programme is driven by three core institutions (RCSI, TCD and UCC)...

  • Designing and implementing effective behaviour change interventions to improve population health and health services in Ireland

    Priority issue: To improve population health by developing, using and advocating use of scientific methods for studying behaviour change.

    Key objectives of the proposal:

    1. To establish the Health Behaviour Change Research Cluster/Centre (HBCRC) at NUI Galway. 
    2. To establish expert working groups in 3...

    3. Economics of Personalised Heath

      Advances in science have increased the prospect of diagnosing, treating and preventing illness in a more personal way. Improved understanding of how individuals may benefit from tailored therapies will permit a better match and more informed choice by users and health care professionals. However, the discovery of personalised health...

    4. Improving care for people with diabetes: A population approach to prevention and control

      Diabetes is a common, disabling and deadly condition. In Ireland it is estimated that nearly 1 in 10 adults have diabetes, many of whom are undiagnosed. Currently diabetes costs the state approx. €580 million per annum and this will rise significantly in coming decades. Major changes are underway with a move to providing more care of...

    5. Psychological therapies for chronic pain and adjustment difficulties in multimorbid health conditions

      A significant number of people have chronic (long-term) health problems and some of these have so-called 'multimorbidities' this means a number of physical symptoms or diseases occurring at the same time, for example arthritis and depression or high blood pressure, diabetes and chronic pain. In the first part of this study, we will...

    6. Health Economics: the development and analysis of the health technology assessment infrastructure in Ireland and an analysis of the quality

      The overall vision is to create conditions that will allow for a sea change in the quantity and quality of health services research in Ireland, addressing specific needs articulated in the policy documents of various stakeholder and; secure NUI Galway's role as a national resource supporting the application of economic methods to...

    7. Development of a Bayesian Unit for Health Decision Sciences

      This proposal will develop a Bayesian unit for health decision making. A Bayesian approach formalises the bringing together of data from structured sources/trials with existing knowledge and uses formal decision criteria to identify optimal courses of action for a given health related problem/question. The centre will prioritise three...