Filter By:

Choose an area from the filter to limit results to that area and show available options for further filtering

Funding Awarded

48 awards

  • Ancient genomics and the Atlantic burden

    WT Scheme: Investigator Award in Science.

    Massive human genome resequencing projects are in train to further the understanding of the genetic contributions to disease. However these offer a limited view of genome genealogies, variant history and past selection, all of which are instrument to the models underpinning genomic...

  • Staphylococcus aureus induced immunosuppressive memory: Consequences for bug and for host

    WT Scheme: Investigator Award in Science.

    Antimicrobial resistance by Staphylococcus aureus is a global epidemic. New approaches based on induction of immune responses that control/prevent S. aureus infection, are required. This necessitates a thorough understanding of the unique relationship cultivated by S. aureus with...

  • Irish clinical academic training (ICAT) Programme

    WT Scheme: PhD Programme for Clinicians

    Ireland's ongoing economic recovery represents a unique opportunity to effect fundamental change in academic medicine that can have lasting societal benefits. We have designed a comprehensive National Programme for Clinician Scientists based at six major Irish universities. Our...

  • Institutional Strategic Support Fund (ISSF)

    These funds will be used to grow and enhance a connected programme of health-related Research, Teaching and Public Engagement in Trinity College. Specific activities will include: (a) seed research support to early stage academics; (b) a programme to stimulate strategic international collaboration and: (c) the creation of a truly...

  • Institutional Strategic Support Fund (ISSF)

    The Wellcome Trust ISSF scheme will help UCD's researchers to overcome systemic barriers to career and network development that will unlock future research potential within the University and beyond. The fund will support outstanding research in biomedical sciences, clinical sciences and the medical humanities that will enable UCD to...

  • Anti-inflammatory therapy for preventing stroke and other vascular events after ischaemic stroke or transient ischaemic attack

    To systematically review the randomised clinical trials evaluating anti-inflammatory medications plus standard medical therapy for the prevention of recurrent vascular events after ischaemic stroke / transient ischaemic attack compared with standard medical therapy.

  • Hybrid repair versus conventional open repair for thoracic aortic arch aneurysms

    To evaluate the effectiveness and safety of hybrid technique versus open arch repair in the management of thoracic aortic arch aneurysms.

  • Membrane sweeping for induction of labour

    The objective of this review is to evaluate the effectiveness of amniotic membrane sweep for induction of labour in women at term gestation.

  • Neoadjuvant treatments for malignant and metastatic melanoma

    The objective of this review is to assess the effects of neoadjuvant treatments for stage III and IV melanoma in adults. Historically stage III and IV melanoma have been associated with a very poor prognosis, and available treatments have had very little impact on the disease course.Various clinical options have been explored,...

  • Hospital design for supporting people with dementia and their carers

    The relationship between health and wellbeing and the design of the built environment is becoming an important area of research that is bringing together the medical/clinical community with design professionals such as architects and urban planners. Evidence based medicine already underpins good healthcare, however, evidence based...

  • Interventions for promoting participation in shared decision-making for children and adolescents with cystic fibrosis

    To determine the effectiveness of interventions that promote shared-decision making (SDM) for children and adolescents with cystic fibrosis aged 4 to 18 years of age.Shared decision-making (SDM) is defined as a patient centered, collaborative process that enables individuals and their healthcare providers to make decisions together...

  • Risk prediction models for familial breast cancer: a systematic review

    The majority of breast-cancers are sporadic, however, 20-30% are considered familial (occur in the context of a significant family-history of the disease). Women suspected of being at higher risk of breast-cancer than the general-population based on their family-history are frequently referred to a "family-risk" clinic for...

  • Interventions for improving medication adherence in solid organ transplant recipients

    Organ transplantation is the removal of an organ from one individual and placement within another individual. Solid organ transplantation refers to transplantation of the heart, lungs, kidney, pancreas or liver, and successful transplantation involves collaboration across surgical, medical, legal, political and bioethical disciplines....

  • Interventions for supporting pregnant women's decisions about first caesarean delivery

    This cochrane review will collate the best available evidence about interventions for supporting pregnant women's decision-making for first caesarean delivery thereby influencing current clinical practice, local and national guidelines. More evidence is needed to support the promotion of informed choice, involving the woman as a...

  • Oral hygiene programmes for people with intellectual disabilities

    A systematic review will be undertaken of oral hygiene programmes aimed at training and supporting individuals with an intellectual disability and/or their carers about oral hygiene practices which are likely to improve the oral health of people with an intellectual disability in primary and secondary care settings. These programmes...

  • Uncovering the role of ER-shaping proteins in neurodegenerative disease

    WT Scheme: Seed Award in Science

    Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders characterised by degeneration of the longest motor neurons which leads to muscle weakness and spasticity in the lower limbs. There are currently no treatments to cure or even to slow the course ofthese...

  • Identifying Interventions to prevent and manage chronic kidney disease

    WT Scheme: Postdoctoral Training Fellowships for Clinicians

    Chronic kidney disease (CKD) affects almost 500million people worldwide is increasingly prevalent,associated with morbidity and mortality, and interventions (dialysis or transplant) are expensive and unavailable in some regions. Developing programs to reduce CKD...

  • Determining the mechanism of action of a novel histone deacetylase 6 specific inhibitor that kills chemoresistant breast cancer

    WT Scheme: Seed Award in Science

    The majority of cytotoxic agents used to treat patients kill tumour cells via the mitochondrial pathway of cell death. Previously, the applicant found that primary tumours that are chemoresistant in vivo usually contain mitochondria that are resistant to apoptotic signalling. Therefore, we...

  • Modelling of pharmacokinetics into ischemic heart tissue from an implantable, replenishable therapy reservoir

    WT Scheme: Seed Award in Science

    Precisely controlled delivery of drugs, bioagents and cells directly to the heart has the potential to dramatically improve regenerative cardiac therapy for ischemic heart failure. Likewise, localized therapy delivery to ischemic tissue can increase retention at the target site and reduce...

  • Artificial neural networks, genomic data and case-control classification

    WT Scheme: Seed Award in Science

    Genome wide association studies have now reached the scale where one can hope to extract information relevant to clinical applications and public health. The large and complex nature of current datasets will benefit from new and more powerful methods of analysis. We propose to investigate...

  • Sound-based observation of neonatal brain growth and status

    WT Scheme: Seed Award in Science

    Neurological problems are more likely to happen in the early neonatal period than at any other time of life. 85% of neonatal deaths worldwide occurred in developing countries with neonatal encephalopathy due to the birth asphyxia being one of the major causes of high child mortality. The...

  • Metabolic reprogramming in innate immunity

    WT Scheme: Investigator Award in Science.

    Immune cells undergo metabolic reprogramming during activation which directly impacts on their phenotype (1,2). Glycolysis is a key feature of M1 macrophages and Th17 cells, whilst oxidative phosphorylation is more apparent in M2 macrophages and Treg cells. Signals regulated by the...

  • Telephone interventions, delivered by healthcare professionals, for informal caregivers of adults with diagnosed medical illnesses

    Many people with diagnosed medical conditions are dependent upon family members and informal/lay caregivers to provide support and care. The care provided varies according to the individual's care needs, however, in many instances, people unexpectedly find themselves in a caring role for which they are ill prepared (Corry, 2015)....

  • Interventions for preventing falls in Multiple Sclerosis

    Multiple Sclerosis (MS) is one of the most prevalent diseases of the central nervous system (CNS) and directly affects an estimated 2.5 million people worldwide (MS International Federation 2013) including approximately 8,000 people in Ireland (MS Ireland 2014). It is the most common disabling neurological disorder among young people...

  • Methods to influence the completeness of response to self administered questionnaires

    Questionnaires are one of the most widely used means of collecting data. Self-administered questionnaires are used widely in research as they offer an efficient and cost effective means of collecting data in large target groups. Problems with rates of questionnaire return can pose serious problems for researchers. The issue of overall...

  • Left atrial appendage closure for the prevention of stroke in patients with atrial fibrillation

    The review will assess the effectiveness of left atrial appendage closure (LAAC) for the prevention of stroke in patients with atrial fibrillation (AFib) compared to oral anticoagulation. The review question was chosen because AFib is a common and serious condition. It is the most common arrhythmia seen in clinical practice and is...

  • Interventions targeted outside of workplace settings for reducing sedentary behaviour in adults under 60 years

    Research into sedentary behaviour (SB) in adults is growing rapidly, both in volume and sophistication. SB is defined as waking activity characterised by an energy expenditure ? 1.5 metabolic equivalents and a sitting or reclining posture. A recent overview of systematic reviews concluded that there is strong evidence for a positive...

  • Professional interventions to improve the detection of depression among adolescents in primary care

    Depression is common in adolescence - studies show that 3% - 8% of adolescents suffer from depression at any one time, and that there is a lifetime prevalence of approximately 20% by the end of adolescence, which is similar to that of adulthood. Adolescent depression is associated with considerable impairment in social, academic and...

  • Validation of FcgRlla as a potential drug target in sepsis

    WT Scheme: Seed Award in Science.

    Sepsis is characterised by a severe coagulopathy which is responsible for the high mortality in this disease. This coagulopathy is due to extensive platelet activation and consumption which leads to bleeding due to the subsequent thrombocytopenia and thrombosis due to the platelet...

  • Electrophysiological investigations on the molecular mechanisms underlying gut-to-brain signalling evoked by colonic microbiota

    WT Scheme: Seed Award in Science.

    The concept of the 'microbiota-gut-brain' signalling axis has been proposed recently, with headline-grabbing studies demonstrating how altering the intestinal microbiome with commensal probiotics has beneficial effects both on gut function but more intriguingly, on central nervous system...

  • The genomic architecture of human nucleolar organizer regions and its role in nucleolar biology

    WT Scheme: Investigator Award in Science.


    The nucleolus is the largest functional domain in the nucleus of all human cells. Its primary role is the biogenesis of ribosomes, the complex machines that translate the language of nucleic acids (DNA and RNA) in to proteins. Nucleoli form around arrays of genes that encode the...

  • Methods to improve physical health and their efficacy and effectiveness in people with schizophrenia: An overview of Cochrane and non-Cochrane systematic reviews

    Schizophrenia has been termed the "abandoned illness'' (http://www.schizophreniacommission.org.uk/) and can be a devastating diagnosis for individuals, their families and carers. Over time this disease can cause a significant erosion of physical health and well-being. As well as the human suffering associated with this
    ...

  • Interventions for fatigue in inflammatory bowel disease

    Background: Inflammatory bowel disease (IBD) represents a group of chronic, progressive, complex
    inflammatory disorders of the digestive tract, with Crohn's disease and ulcerative colitis the two most commonly recognised forms of IBD. These debilitating diseases are characterised by periods of relapse and remission, where...

  • Botulinum toxin for sialorrhea in people with Parkinson's disease

    The objectives of this review are to establish the efficacy and safety of BoNT aimed at reducing sialorrhea in people with PD and to provide the best evidence to inform clinical practice. Furthermore the review aims to identify clear directions for future clinical trials and intervention studies in this area.

  • Use of fresh frozen plasma to prevent intraventricular haemorrage in premature neonates

    Premature infants are at risk of a range of morbidities which impact significantly on prognosis and outcome,
    including intraventricular haemorrhage, sepsis and DIC. Advances in neonatal care have led to improved survival rates of VLBW and ELBW infants, but they remain at risk of morbidity and mortality associated with IVH and...

  • Different insulin types and regimens for pregnant women with pre-existing diabetes

    Diabetes is the most common pre-existing medical condition complicating pregnancy. Pregnant women with pre-existing type 1 or type 2 diabetes mellitus (DM) are at an increased risk of several adverse maternal, fetal and neonatal complications including preterm delivery, pre-eclampsia, macrosomia, intra-uterine death as well as cardiac,...

  • Parent training to promote spoken language in preschool children with Down Syndrome

    This review aims to systematically inspect the current evidence for parent training aimed at improving the spoken language skills of preschool children with Down syndrome. Experts in the field of Down syndrome argue that "speech and language therapy is the most important part of intervention services for children with Down...

  • Pneumococcal vaccination for prevention of Streptococcus pneumoniae in HIV infected persons

    The purpose of this review is to determine the efficacy and effectiveness of the pneumococcal vaccine as well as different vaccine schedules in HIV-infected individuals (over the age of 2 years) in preventing pneumonia, bacteremia and death. Primarily, this review will study the quality of the evidence base for pneumoccal vaccine...

  • The cognitive thalamus: more than a relay

    WT Scheme: Investigator Award in Science.

    How do brain circuits support different but complementary aspects of event memory? The answer lies in distributed networks across the medial temporal lobe, prefrontal cortex and parietal cortex. Via their widespread connectivity, nuclei within the rostral thalamus support these...

  • The impact of genetic heterogeneity on synthetic lethality in cancer

    WT Scheme: Sir Henry Wellcome Postdoctoral Fellowship

    Synthetic lethal interaction occurs when the function of one gene only becomes essential for viability in the presence of a mutation in another gene. In cancer treatment this phenomenon can be exploited to selectively kill tumour cells that have specific genetic...

  • Antiviral agents for infectious mononucleosis

    Review objective: To assess the effectiveness of antiviral therapy in improving outcomes for patients with Infectious Mononucleosis (IM). IM is a clinical syndrome that is usually associated with EBV infection. Although generally not considered a serious illness, IM can lead to significant loss of time from school or work due to...

  • Institutional smoking bans for reducing smoking prevalence and tobacco consumption

    Review objective: The objectives of this new review are twofold. The proposed new review will explore evidence specifically focusing on the impact of institutional smoking bans in workplaces, health care facilities and in other public places, so-called meso-level data. The update of the original review will assess the evidence since...

  • Aspirin and anti-inflammatory drugs for the prevention of dementia

    Review objective: To evaluate the effects of aspirin and other non-steroidal anti-inflammatory drugs in the prevention of dementia. In view of the perceived association between inflammation and Alzheimer's disease and stroke or multiple strokes arising from multiple infarcts in vascular dementia, research has focused on assessing...

  • Wound cleansing for treating venous leg ulcers

    Review objective: To explore the impact of wound cleansing on the healing rate of venous leg ulcers. Leg ulcers are a major health care problem, in terms of treatment, cost, recurrence and chronicity (Posnett and Franks, 2008). Indeed, for venous leg ulcers, with a prevalence of 49,000-1.3 million in the EU 27, the annual associated...

  • Interventions to improve end-of-life care in dementia

    Review objective: To determine the effectiveness of interventions to improve end-of-life care for people with dementia. For the purposes of this review, end-of-life care is defined as the care required when death is imminent for those with advanced dementia and for those with dementia of any severity who are in the terminal phase of an...

  • Interventions for breast cancer awareness amongst women of all ages

    Review objective: To assess the effects of interventions to develop breast cancer awareness amongst women. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females globally (Jemal et al., 2011). Early diagnosis of breast cancer is linked to more favourable outcomes and longer survival...

  • Patient Education for the prevention of venous leg ulceration

    Review objective: To determine the impact of patient educational interventions on the prevention of venous leg ulceration. The population for this review will include people over 18 years with a history of venous leg ulceration in any healthcare setting. Venous leg ulceration occurs as a result of impaired return of venous blood from...

  • Non-steroidal anti-inflammatory drugs (NSAIDS) for perineal pain in the early postpartum period

    Review objective: To determine the efficacy and safety of Non-steroidal anti-inflammatory drugs (NSAIDs) in relieving perineal pain in the early postpartum period. Perineal pain is commonly experienced by women after childbirth, particularly, although not exclusively, following episiotomy, spontaneous tears or bruising (Lawn and...