Filter By:

Choose an area from the filter to limit results to that area and show available options for further filtering

Funding Awarded

34 awards

  • MRCG support award

    The Medical Research Charities Group (MRCG) is the national organization of 35 patient groups and foundations which promote an improved environment for medical research in general and for charities in particular, obtain funding for research projects, bring together organizations working in the field and disseminate the outcomes. Its...

  • Anti-inflammatory therapy for preventing stroke and other vascular events after ischaemic stroke or transient ischaemic attack

    To systematically review the randomised clinical trials evaluating anti-inflammatory medications plus standard medical therapy for the prevention of recurrent vascular events after ischaemic stroke / transient ischaemic attack compared with standard medical therapy.

  • Hybrid repair versus conventional open repair for thoracic aortic arch aneurysms

    To evaluate the effectiveness and safety of hybrid technique versus open arch repair in the management of thoracic aortic arch aneurysms.

  • Membrane sweeping for induction of labour

    The objective of this review is to evaluate the effectiveness of amniotic membrane sweep for induction of labour in women at term gestation.

  • Neoadjuvant treatments for malignant and metastatic melanoma

    The objective of this review is to assess the effects of neoadjuvant treatments for stage III and IV melanoma in adults. Historically stage III and IV melanoma have been associated with a very poor prognosis, and available treatments have had very little impact on the disease course.Various clinical options have been explored,...

  • Hospital design for supporting people with dementia and their carers

    The relationship between health and wellbeing and the design of the built environment is becoming an important area of research that is bringing together the medical/clinical community with design professionals such as architects and urban planners. Evidence based medicine already underpins good healthcare, however, evidence based...

  • Interventions for promoting participation in shared decision-making for children and adolescents with cystic fibrosis

    To determine the effectiveness of interventions that promote shared-decision making (SDM) for children and adolescents with cystic fibrosis aged 4 to 18 years of age.Shared decision-making (SDM) is defined as a patient centered, collaborative process that enables individuals and their healthcare providers to make decisions together...

  • Risk prediction models for familial breast cancer: a systematic review

    The majority of breast-cancers are sporadic, however, 20-30% are considered familial (occur in the context of a significant family-history of the disease). Women suspected of being at higher risk of breast-cancer than the general-population based on their family-history are frequently referred to a "family-risk" clinic for...

  • Interventions for improving medication adherence in solid organ transplant recipients

    Organ transplantation is the removal of an organ from one individual and placement within another individual. Solid organ transplantation refers to transplantation of the heart, lungs, kidney, pancreas or liver, and successful transplantation involves collaboration across surgical, medical, legal, political and bioethical disciplines....

  • Interventions for supporting pregnant women's decisions about first caesarean delivery

    This cochrane review will collate the best available evidence about interventions for supporting pregnant women's decision-making for first caesarean delivery thereby influencing current clinical practice, local and national guidelines. More evidence is needed to support the promotion of informed choice, involving the woman as a...

  • Oral hygiene programmes for people with intellectual disabilities

    A systematic review will be undertaken of oral hygiene programmes aimed at training and supporting individuals with an intellectual disability and/or their carers about oral hygiene practices which are likely to improve the oral health of people with an intellectual disability in primary and secondary care settings. These programmes...

  • Role of TWEAK/Fn14 pathway in mediating muscle pathology in SMA

    Spinal muscular atrophy (SMA) is a devastating disease caused by loss of both nerve cells and muscle function. While the nerve is the major affected cell type, therapies specifically aimed at improving muscle function ameliorate survival and/or symptoms in SMA models. Thus,developing muscle-

  • MRCG interim support award

    The Medical Research Charities Group (MRCG) is the national organization of 35 medical research patient-led charities formed to promote dynamic medical research in Ireland. The MRCG works in partnership with key stakeholders, such as the Health Research Board (HRB), to bring added value to the health research landscape. The MRCG is...

  • Telephone interventions, delivered by healthcare professionals, for informal caregivers of adults with diagnosed medical illnesses

    Many people with diagnosed medical conditions are dependent upon family members and informal/lay caregivers to provide support and care. The care provided varies according to the individual's care needs, however, in many instances, people unexpectedly find themselves in a caring role for which they are ill prepared (Corry, 2015)....

  • Interventions for preventing falls in Multiple Sclerosis

    Multiple Sclerosis (MS) is one of the most prevalent diseases of the central nervous system (CNS) and directly affects an estimated 2.5 million people worldwide (MS International Federation 2013) including approximately 8,000 people in Ireland (MS Ireland 2014). It is the most common disabling neurological disorder among young people...

  • Methods to influence the completeness of response to self administered questionnaires

    Questionnaires are one of the most widely used means of collecting data. Self-administered questionnaires are used widely in research as they offer an efficient and cost effective means of collecting data in large target groups. Problems with rates of questionnaire return can pose serious problems for researchers. The issue of overall...

  • Left atrial appendage closure for the prevention of stroke in patients with atrial fibrillation

    The review will assess the effectiveness of left atrial appendage closure (LAAC) for the prevention of stroke in patients with atrial fibrillation (AFib) compared to oral anticoagulation. The review question was chosen because AFib is a common and serious condition. It is the most common arrhythmia seen in clinical practice and is...

  • Interventions targeted outside of workplace settings for reducing sedentary behaviour in adults under 60 years

    Research into sedentary behaviour (SB) in adults is growing rapidly, both in volume and sophistication. SB is defined as waking activity characterised by an energy expenditure ? 1.5 metabolic equivalents and a sitting or reclining posture. A recent overview of systematic reviews concluded that there is strong evidence for a positive...

  • Professional interventions to improve the detection of depression among adolescents in primary care

    Depression is common in adolescence - studies show that 3% - 8% of adolescents suffer from depression at any one time, and that there is a lifetime prevalence of approximately 20% by the end of adolescence, which is similar to that of adulthood. Adolescent depression is associated with considerable impairment in social, academic and...

  • Methods to improve physical health and their efficacy and effectiveness in people with schizophrenia: An overview of Cochrane and non-Cochrane systematic reviews

    Schizophrenia has been termed the "abandoned illness'' (http://www.schizophreniacommission.org.uk/) and can be a devastating diagnosis for individuals, their families and carers. Over time this disease can cause a significant erosion of physical health and well-being. As well as the human suffering associated with this
    ...

  • Interventions for fatigue in inflammatory bowel disease

    Background: Inflammatory bowel disease (IBD) represents a group of chronic, progressive, complex
    inflammatory disorders of the digestive tract, with Crohn's disease and ulcerative colitis the two most commonly recognised forms of IBD. These debilitating diseases are characterised by periods of relapse and remission, where...

  • Botulinum toxin for sialorrhea in people with Parkinson's disease

    The objectives of this review are to establish the efficacy and safety of BoNT aimed at reducing sialorrhea in people with PD and to provide the best evidence to inform clinical practice. Furthermore the review aims to identify clear directions for future clinical trials and intervention studies in this area.

  • Use of fresh frozen plasma to prevent intraventricular haemorrage in premature neonates

    Premature infants are at risk of a range of morbidities which impact significantly on prognosis and outcome,
    including intraventricular haemorrhage, sepsis and DIC. Advances in neonatal care have led to improved survival rates of VLBW and ELBW infants, but they remain at risk of morbidity and mortality associated with IVH and...

  • Different insulin types and regimens for pregnant women with pre-existing diabetes

    Diabetes is the most common pre-existing medical condition complicating pregnancy. Pregnant women with pre-existing type 1 or type 2 diabetes mellitus (DM) are at an increased risk of several adverse maternal, fetal and neonatal complications including preterm delivery, pre-eclampsia, macrosomia, intra-uterine death as well as cardiac,...

  • Parent training to promote spoken language in preschool children with Down Syndrome

    This review aims to systematically inspect the current evidence for parent training aimed at improving the spoken language skills of preschool children with Down syndrome. Experts in the field of Down syndrome argue that "speech and language therapy is the most important part of intervention services for children with Down...

  • Pneumococcal vaccination for prevention of Streptococcus pneumoniae in HIV infected persons

    The purpose of this review is to determine the efficacy and effectiveness of the pneumococcal vaccine as well as different vaccine schedules in HIV-infected individuals (over the age of 2 years) in preventing pneumonia, bacteremia and death. Primarily, this review will study the quality of the evidence base for pneumoccal vaccine...

  • Antiviral agents for infectious mononucleosis

    Review objective: To assess the effectiveness of antiviral therapy in improving outcomes for patients with Infectious Mononucleosis (IM). IM is a clinical syndrome that is usually associated with EBV infection. Although generally not considered a serious illness, IM can lead to significant loss of time from school or work due to...

  • Institutional smoking bans for reducing smoking prevalence and tobacco consumption

    Review objective: The objectives of this new review are twofold. The proposed new review will explore evidence specifically focusing on the impact of institutional smoking bans in workplaces, health care facilities and in other public places, so-called meso-level data. The update of the original review will assess the evidence since...

  • Aspirin and anti-inflammatory drugs for the prevention of dementia

    Review objective: To evaluate the effects of aspirin and other non-steroidal anti-inflammatory drugs in the prevention of dementia. In view of the perceived association between inflammation and Alzheimer's disease and stroke or multiple strokes arising from multiple infarcts in vascular dementia, research has focused on assessing...

  • Wound cleansing for treating venous leg ulcers

    Review objective: To explore the impact of wound cleansing on the healing rate of venous leg ulcers. Leg ulcers are a major health care problem, in terms of treatment, cost, recurrence and chronicity (Posnett and Franks, 2008). Indeed, for venous leg ulcers, with a prevalence of 49,000-1.3 million in the EU 27, the annual associated...

  • Interventions to improve end-of-life care in dementia

    Review objective: To determine the effectiveness of interventions to improve end-of-life care for people with dementia. For the purposes of this review, end-of-life care is defined as the care required when death is imminent for those with advanced dementia and for those with dementia of any severity who are in the terminal phase of an...

  • Interventions for breast cancer awareness amongst women of all ages

    Review objective: To assess the effects of interventions to develop breast cancer awareness amongst women. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females globally (Jemal et al., 2011). Early diagnosis of breast cancer is linked to more favourable outcomes and longer survival...

  • Patient Education for the prevention of venous leg ulceration

    Review objective: To determine the impact of patient educational interventions on the prevention of venous leg ulceration. The population for this review will include people over 18 years with a history of venous leg ulceration in any healthcare setting. Venous leg ulceration occurs as a result of impaired return of venous blood from...

  • Non-steroidal anti-inflammatory drugs (NSAIDS) for perineal pain in the early postpartum period

    Review objective: To determine the efficacy and safety of Non-steroidal anti-inflammatory drugs (NSAIDs) in relieving perineal pain in the early postpartum period. Perineal pain is commonly experienced by women after childbirth, particularly, although not exclusively, following episiotomy, spontaneous tears or bruising (Lawn and...