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Host Institution
Atlantic Technological University DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Family Carers Ireland Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Katholieke Universiteit Leuven Limerick Institute of Technology Maynooth University Medical Research Charities Group Ltd National University of Ireland Galway National University of Ireland, Galway Our Lady's Hospice Queen’s University Belfast RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford UPMC Whitfield
Funding Awarded
14 awards
A functional genomics pipeline for genetic discovery in diabetic kidney disease
Diabetes is responsible for a large proportion of chronic kidney disease (CKD), end-stage kidney disease (ESKD), blindness, amputation, heart disease and stroke. Tight glycemic control in type 1 diabetes (T1D) or type 2 diabetes (T2D) can delay or arrest the progression of microvascular complications. How hyperglycemia...
Social Circumstances and Epigenomics: Promoting Health in Three Countries
This project proposes an integrated set of aims and analyses of existing social and epigenetic data from three national studies of aging in the family of Health and Retirement studies (the US Health and Retirement Study (HRS), the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), and the Irish Longitudinal Study of...
Uncovering the neural architecture underlying decisions abstracted from movements
Decision making is a core component of normal and abnormal cognitive function. Understanding the neural mechanisms of decision-making will lead to advances in the diagnosis, classification and future treatments of disorders affecting thought and control. Mathematical models of the decision process, based on bounded evidence...
Plasma-based therapies for bone infection
Orthopaedic infection is life-threatening and current treatments are only sparingly successful. Despite aggressive peri-operative antibiotic treatments, 1.5% of knee revisions, 0.7 to 11.9%, of spinal infections (depending on the complexity of the procedure) and up to 27% of open fractures become infected. Moreover, the complexity of...
Treating Primary aldosteronism-induced hypertension via microwave thermal therapy
In this tripartite US-Ireland R&D partnership program R01 research plan, we propose the development, optimization, and evaluation of a minimally-invasive microwave thermal therapy (MWT) system for definitive treatment of primary aldosteronism. Primary aldosteronism (PA) accounts for 5 - 12% of all hypertension and confers a higher...
Targeting the compromised brain endothelial barrier function during cerebral malaria with AT2 receptor agonists.
Strengthening of inter-cellular junctions of endothelial cells would facilitate important translational applications for a variety of diseases where endothelial integrity is compromised. As a first model, we have chosen cerebral malaria (CM), which remains the deadliest manifestation of malaria. It is caused by Plasmodium falciparum...
Study of queuosine salvage and function in eukaryotes; a forgotten micronutrient
Queuine is a largely forgotten bacterial-derived micronutrient that is obtained exclusively from the gut; a preeminent small-molecule of the gut-brain axis. Our contention is that queuine is important in metabolism and development—mammals are born sterile and queuine free—and induces long-lasting effects into adulthood, particularly in...
Food-based biomarkers, diet quality and cardiometabolic health
Accurate assessment of human diet is the cornerstone of nutritional epidemiology. Biomarkers that are sensitive and specific to food intake can provide objective information that improves the characterization of diet. Advances in metabolomic profiling techniques now permit the discovery of novel food biomarkers, although, thus far,...
Systems modelling of tumor heterogeneity & therapy response in colorectal cancer
Colorectal cancer (CRC) has one of the highest worldwide incidences (>1.3 million new cases) and mortality rates (~610,000 deaths per year). Genotoxic chemotherapy in stage II and III confers minimal treatment benefit (improved survival in 3-4% stage II and 15-20% of stage III patients), and predictive markers to select...
PPI Ignite Award - National University of Ireland Galway
The Public and Patient Involvement (PPI) Ignite Awards aim to promote PPI in health research in Ireland. Our NUI Galway Primary Care PPI group of patients and members of the public were asked to describe what a successful PPI Ignite project would look like (Figure 3). They responded by saying that success would be creating an...
PPI Ignite Award - University College Dublin
UCD in collaboration with 10 partner organisations will develop a PPI network and resource platform called UCD PPI Ignite Connect that will seek to firmly embed patient and public involvement in UCD's research,learning and teaching activities and in its academic processes. The partner organisations include the Ireland East Hospital...
PPI Ignite Award - Dublin City University
Patient and public involvement means carrying out research with or by members of the public rather than to, about or for them. This PPI Ignite award plans to improve patient and public involvement in health and social care research. We will do this by bringing people who use health services (patients, carers, and/or their...
PPI Ignite Award - University of Limerick
PPI Ignite at the University of Limerick will serve as a rallying point within the university and the wider community it serves, to build capacity for research conducted "with" or "by" patients and members of the public rather than "to", "about" or "for" them. PPI Ignite UL will accomplish this among a coalition of academic,...
PPI Ignite Award - Trinity College Dublin
Research is considered "engaged" when it is developed in collaboration with patients, community members and partnering organisations rather than for or about them. Such public and patient involvement improves the relevancy of the research question, the quality of the approach, and the likelihood that what is discovered through the...