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Funding Awarded

5 awards

  • What is Alpha-1?

    Alpha-1 antitrypsin deficiency (Alpha-1) is a genetic disorder that affects the lungs. Typically people with Alpha-1 present with chronic obstructive pulmonary disease (COPD) or severe asthma. Ireland has one of the highest rates of AATD in the world. 1 in 25 Irish people are carriers for the condition and are at risk of lung disease,...

  • Exploring clinical learning environments for postgraduate medical education and training

    After graduation from medical school, doctors continue to train under the supervision, for several years, until they are ready to practice independently. These trainee doctors learn while they work, providing care to patients. Their working environments, therefore, need to support learning. It is difficult for those charged with the...

  • Imbuing Medical Professionalism (IMP)

    This project aims to encourage and support medical graduates to become good doctors. Medical professionalism is essentially a set of values, enacted through behaviours and relationships, which underpin the public's trust in doctors. Employers and healthcare organisations govern the settings where doctors train and work and they have a...

  • Altered lipid raft cholesterol content contributes to the dysregulated activity of neutrophils in alpha-1 antitrypsin deficiency

    Alpha-1-antitrypsin (AAT) deficiency (AATD) is largely unrecognized and under diagnosed. This hereditary disorder results in the rapid progression of lung disease, especially in smokers. Specific treatment for this disorder is available in the form of weekly intravenous injections of AAT. This is referred to as augmentation therapy and...

  • Alpha-1 antitrypsin deficiency: Which is important phenotype, level, activity or all three?

    Alpha-1 antitrypsin (AAT) deficiency (AATD) is generally regarded as a rare condition but more recently, evidence points towards it being a condition that is relatively common but rarely diagnosed. The most severe form of this genetic disorder, where people carry two bad AAT genes (Z) is known as ZZ-AATD and this affects around 2000...