Funding Awarded

Developing an innovative patient-centred xenograft model of multiple myeloma and its use in testing novel antagonists of JAM-A signalling

Multiple myeloma (MM) is an incurable cancer in which uncontrolled plasma cell proliferation disrupts the bone marrow environment and impairs immune function. With poor 5-year patient survival (<50%), better clinical models and pipelines for targeted therapies are urgently required. This proposal will focus on both. Firstly, an MSc...

Development of mRNA Vaccines for Children with High-Risk Neuroblastoma

Neuroblastoma is one of the most aggressive childhood cancers contributing to 15% of cancer related childhood deaths. At diagnosis half of the patients have a metastatic tumour and recurrence is very common. Despite advances in available therapies, children with drug-resistant and relapsed neuroblastoma have a dismal outlook with...

Sustaining increased and improved access to opioid substitution treatment (OST) in Ireland: a mixed-methods study to evaluate the impact of national contingency OST guidelines on process and client outcomes, and identify quality indicators for the continued and safe delivery of OST throughout and beyond COVID-19.

People who use heroin have a risk of death six times higher than the general population. The most effective treatment for heroin use is the prescription of legal, substitution medicine, most commonly methadone. This is called opioid substitution treatment or OST. Most people in OST attend a specialist outpatient addiction service,...

Understanding and Enhancing Medication Safety During COVID-19: The CONNECTS (COVID-Nineteen Medication Safety) Toolkit

Medicines are the most common treatment used to maintain and improve health. Due to COVID19, the way in which people access and use medication in their communities has changed rapidly and in an unprecedented way. Many are using technology to avoid potential exposure to COVID19 and we do not yet understand the impact on medicines safety...

Scenario and intervention modelling in Ireland for stroke: Evaluating the effect of alternative policy scenarios and interventions for stroke in Ireland on outcomes and costs

One in every four people in Ireland will have a stroke in their lifetime. People are less likely to die if they have a stroke than in previous decades, partly due to new treatments that prevent further strokes and improve outcomes.  For every three people who survive their stroke, two acquire some type of disability such as...

Maximising the quality of stroke care in Ireland – Development of a National Stroke Audit

Stroke is a leading cause of death and disability. In recent years, improvements in stroke treatment have led to more people surviving stroke and to lower levels of disability. However, outcomes for stroke patients vary depending on the quality of care received. This indicates a need for a National Stroke Audit, involving regular...

Meeting the challenge of childhood obesity treatment in Irish Healthcare: Generating Data to Facilitate Action.

Obesity is caused by the storage of too much fat tissue in the body. When children become obese they can have difficulties with their physical and mental health including:

• high blood pressure;
• painful joints;
• breathing difficulties;
• anxiety and early development of other diseases.
...

• The effect of after action review in enhancing safety culture and second victim experience and its implementation in an Irish hospital

  After Action Review is a discussion of an event with the team involved in the event. Four questions are asked:

  1. what did we expect to happen?
  2. what actually happened?
  3. why was there a difference?
  4. and what have we learnt?

  An independent person guides the process. The purpose is to...