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Atlantic Technological University DCU Department of Agriculture, Food and Marine Dublin City University Dublin Dental University Hospital Dublin Institute of Technology Economic and Social Research Institute Family Carers Ireland Fondazione Telethon Fraunhofer ITMP Health Information and Quality Authority Health Research Charities Ireland HSE - St. Luke's Hospital (Rathgar) Institute of Technology Sligo IPPOSI Irish Blood Transfusion Service, National Blood Centre Irish Clinical Oncology Research Group Ltd Irish Platform for Patients Organisations Science and Industry Irish Platform for Patients' Organisations, Science and Industry Ltd Irish Platform for Patients’ Organisations, Science and Industry Katholieke Universiteit Leuven Limerick Institute of Technology Maynooth University Medical Research Charities Group Ltd National University of Ireland Galway National University of Ireland, Galway Our Lady's Hospice Queen’s University Belfast RCSI Royal College of Physicians of Ireland Royal College of Surgeons in Ireland TCD Teagasc Technological University Dublin The Alzheimer Society of Ireland The Children's Hospital of Philadelphia Trinity College Dublin UCD University College Cork University College Dublin University Hospitals Leuven & KU Leuven University of Auckland University of California San Francisco University of Cambridge University of Galway University of Limerick University of Oxford UPMC Whitfield
Funding Awarded
15 awards
WHO Solidarity Trial Ireland
WHO Solidarity Trial Ireland
Mapping Parkinson's Disease needs and services in Ireland to inform service planning
There is evidence that Parkinson's disease (PD) is on the rise. The number of people living with Parkinson's in the world is set to double between 2015 and 2040. Despite this, there has not been enough investment made in healthcare services to improve care for people with Parkinson's in Ireland. Also, under-staffing can be a problem in...
Autophagy induction as a novel therapeutic strategy for MSD
The lysosomal degradation pathway of autophagy has a crucial role in different pathophysiological conditions, such as infection, neurodegenerative disorders, cancer and ageing. In particular, autophagy plays an important role in the pathophysiology of a family of inborn errors of metabolism due to defect in the activity of lysosomal...
The microbiome as an environmental trigger for autoimmune epilepsy (MICA)
Autoimmune epilepsy is a rare form of drug-resistant epilepsy characterised by frequent seizures in later life. Patients may respond to immune therapy, but causation of disease is poorly understood, and more targeted treatments are required. This gap in knowledge is the major priority for epilepsy specialists, and the area of greatest...
Elucidation of the role of SARM1 in retinal homeostasis and oxidative stress induced retinal degeneration
Photoreceptor cells found in the back of our eyes convert light into signals that allow us to see. Death of these cells and the cells that nourish them, called RPE cells, is termed retinal degeneration and is characteristic of blinding diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa. Millions of people...
Towards novel anti-infective with enhanced wound-healing for diabetic foot infections : Co2 releasing star shaped micro biocidal polymers
It is estimated that 422 million people worldwide are living with diabetes and among them, a common and serious problem is the development of diabetic foot infection. One in five patients with diabetes are hospitalised with a diabetic foot wound (DFW) at least once in their lives. Infected DFWs are treated by removal of infected tissue...
Combining Electrochemotherapy with a Toll Like receptor agonist for the treatment of lung cancer
Successful cancer treatment aims to totally eliminate the entire tumour and the risk of recurrence. Treatment currently relies on removal of the primary tumour by surgery or radiotherapy followed by control of the remaining dispersed cancer cells in the whole body usually by chemotherapy. At the Cork Cancer Research Centre (CCRC) we...
Preoperative Exercise to Improve Fitness in Patients Undergoing Complex Surgery for Cancer of the Lung or Oesophagus
Treatment for people with cancer of the lung or the oesophagus (food-pipe) often involves surgery. This surgery is complex and there is a high risk that patients will develop severe complications afterwards, mainly lung or heart problems, leading to a longer hospital stay and higher hospital costs, and impacting greatly on recovery and...
Evaluation of the role of MxA and ISGylation in chemosensitivity in oesophageal cancer
Many oesophageal cancers develop resistance to the drugs currently used to treat this disease. This allows the cancer cells to survive and the cancer can come back again at variable times after the initial treatment. Research already performed by this group has identified genetic differences between cancer cells that respond well to...
Incorporation of sensor technology to provide clinical meaningfulness for existing standardised measurement scales in Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) also known as Motor Neurone Disease (MND) is a progressive and ultimately fatal neurodegenerative disease for which there is no cure. People with ALS experience loss of mobility and arm function, breathlessness and chest infections, loss of speech and swallow and in 30-50%, cognitive and behavioural...
Novel Neurophysical Biomarkers of Heterogeneous Network Degeneration in Motor Neuron Disease for Quantifying the Progression and Outcome in Clinical Trials
Motor Neurone Disease (MND)/Amyotrophic Lateral Sclerosis (ALS) is a terminal neurological condition in which the neurones (neural cells) that control movement degenerate. Despite encouraging results from studies in animals, translation of new treatments to humans has been disappointing. The aim of this study is to provide scientific...
Evaluating a novel macrolide based early intervention in the clinical management of chronic infections and inflammation in Cystic Fibrosis
Chronic persistent respiratory disease is a leading cause of death worldwide. Despite years of global research, the clinical management of respiratory disease, including the life-limiting genetic disease cystic fibrosis (CF), remains a significant challenge. Treatment options are extremely limited, due in part to the increased pathogen...
Gold-drug: Targeting a novel dual inhibitor drug with gold nanoparticles for improving radiation response in oesophageal cancer
Oesophageal cancer (cancer of the food pipe) has low survival rates and a very poor response to treatment. Sadly, this cancer type is on the rise in Ireland and is linked with increasing obesity rates. Unlike many other cancer types, we are still only using treatments that have existed for decades - chemotherapy drugs with radiation...
The role of sialylated-alpha-1 antitrypsin in resolution of acute and chronic inflammation
Alpha-1-antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that results in the rapid progression of lung disease, especially in smokers. Specific treatment for this disorder is available in the form of weekly intravenous injections of AAT. This is referred to as augmentation therapy and studies have shown that augmentation...
Compound library screening in a zebrafish model of MSD to identify novel therapeutic compounds
Multiple Sulfatase Deficiency (MSD) is currently an untreatable disease and while we know some of the processes inside cells that cause or influence the disease, there is still much to be understood. While progress has been made from studying simple cell culture systems, this does not tell us about how different disease changes may...