Risk prediction models for familial breast cancer: a systematic review

The majority of breast-cancers are sporadic, however, 20-30% are considered familial (occur in the context of a significant family-history of the disease). Women suspected of being at higher risk of breast-cancer than the general-population based on their family-history are frequently referred to a "family-risk" clinic for riskassessment and management (Evans et al, 1996). Reliable estimation of an individual's risk is important as it aids clinicians in recommending particular risk-management strategies and assists individuals themselves in reaching decisions about which, if any, risk-reducing measures (risk-reducing surgery, chemoprevention, surveillance etc.) to opt for. It is known that the greatest benefit from breast-cancer prevention strategies is obtained through treating women who are at high-risk of the disease (Powles 2002). This further highlights the need for accurate risk-assessment so that women can be appropriately stratified for breast-cancer preventionstrategies according to their estimated-risk.


Award Date
15 September 2016
Award Value
Principal Investigator
Professor Sarah McGarrigle
Host Institution
Trinity College Dublin
Cochrane Training Fellowships