Environmental and genetic epidemiology of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a rare condition that is thought to be; caused by a combination of genetic and environmental influences. The lifetime risk of the condition is 1 in 300, and approximately 250 people in Ireland suffer from the condition. Ireland has a population based registers of ALS that has captured all new cases since 1994. The Irish ALS group collaborates with similar population based registers in Holland and Italy, and is a partner in an European study entitled EUROMOTOR. This project will interrogate data from the Irish Register to determine whether particular regions in the country have higher rates of ALS. Using data from the EUROMOTOR collaboration, the project will also examine the geographic distribution of ALS in Holland and Italy, and will determine whether specific geographic or occupational exposures are more common in people with ALS compared to controls that are matched for age and region. Using genetic data from the Irish and EUROMOTOR studies, the project will also seek to determine whether those with ALS share particular genetic makers to a greater extent than would be expected by chance. On completion, the project will improve our understanding of the link between environmental exposures, ALS and genetics.

Award Date
15 May 2014
Award Value
Principal Investigator
Dr James Rooney
Host Institution
Trinity College Dublin
Research Training Fellowships for Healthcare Professionals